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    • 1. 发明授权
    • Cyclic tetrapeptide compound and use thereof
    • 环状四肽化合物及其用途
    • US06656905B1
    • 2003-12-02
    • US09806500
    • 2001-05-04
    • Hiroaki MoriKazutoshi SakamotoYasuhisa TsurumiShigehiro TakaseMotohiro Hino
    • Hiroaki MoriKazutoshi SakamotoYasuhisa TsurumiShigehiro TakaseMotohiro Hino
    • A61K3807
    • A61K38/12C07K5/126
    • A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.
    • 一种环状四肽化合物及其用途。 特别地,化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物,将含有该化合物作为活性成分的药物组合物生产化合物的方法, 与药学上可接受的,基本上无毒的载体或赋形剂的相关联,用作药物的化合物,该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途,该化合物用于制备用于治疗或 预防炎性疾病,糖尿病,糖尿病并发症,纯合地中海贫血,纤维化,肝硬化,急性早幼粒细胞白血病(APL),原生动物感染,器官移植排斥,自身免疫疾病或肿瘤,组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途, 以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物 描述器官移植排斥,自身免疫性疾病或肿瘤。
    • 2. 发明授权
    • Energy usage display unit
    • 能源使用显示单位
    • US08065097B2
    • 2011-11-22
    • US11937904
    • 2007-11-09
    • Keiji KatoHideki KitagawaHiroaki MoriYukihiro Suzuki
    • Keiji KatoHideki KitagawaHiroaki MoriYukihiro Suzuki
    • G01R21/00
    • F24D19/1048F23N5/203F23N2025/22
    • An energy usage display unit for displaying energy usage of gas used for a water heater, water used for the water heater or electricity used in housing where the water heater is set. The energy usage display unit includes a clock section; a counting section for counting usage of gas, water or electricity; a memory section for storing a count value of usage counted by the counting section retroactive to past by a predetermined number with a predetermined time unit; a counting control section for writing the count value of usage at predetermined time; a display control section for reading one or both of the count value and a stored value in the memory section to prepare display data of usage; and a display section for displaying usage based on the display data prepared by the display control section.
    • 一种能量使用显示单元,用于显示用于热水器的气体的能量使用,用于热水器的水或在设置热水器的壳体中使用的电力。 能量使用显示单元包括时钟部分; 用于计算天然气,水或电用量的计数部分; 存储部分,用于以预定时间单位存储由过去追溯到预定数量的计数部分计数的计数值; 计数控制部,用于在预定时间写入使用的计数值; 显示控制部分,用于读取存储器部分中的计数值和存储值中的一个或两个,以准备使用的显示数据; 以及显示部分,用于基于由显示控制部分准备的显示数据显示使用。
    • 6. 发明申请
    • Distortion Detector
    • 失真检测器
    • US20080245157A1
    • 2008-10-09
    • US11663284
    • 2005-09-30
    • Sigehiro YosiutiShusaku KawasakiHiroaki MoriYasunori MatsukawaYasunobu Kobayashi
    • Sigehiro YosiutiShusaku KawasakiHiroaki MoriYasunori MatsukawaYasunobu Kobayashi
    • G01B7/16
    • G01L5/101G01L1/2231
    • A strain detector includes a bridge circuit having at least two strain resistance elements, a substrate, a first fixed member, and a second fixed member. The substrate has a circuit portion electrically connected to the strain resistance elements. The strain resistance elements are arranged on the substrate. The first fixed member is fixed to a center of an area, where an outer periphery of the area is set at a position at which the strain resistance elements are arranged. The second fixed member is fixed outside the position, where the strain resistance elements are arranged at the substrate. A center of an axis of the first fixed member, a center of an axis of the second fixed member, and the center of the area are positioned on a straight line, and the first fixed member and the second fixed member are arranged on two mutually opposed surfaces of the substrate.
    • 应变检测器包括具有至少两个应变电阻元件的桥接电路,基板,第一固定部件和第二固定部件。 基板具有电连接到应变电阻元件的电路部分。 应变电阻元件布置在基板上。 第一固定部件固定在区域的中心,该区域的外周设置在应变电阻元件的排列位置。 第二固定部件固定在位于基板的应变电阻元件的位置之外。 第一固定构件的轴线的中心,第二固定构件的轴的中心和区域的中心位于直线上,并且第一固定构件和第二固定构件相互布置 基板的相对表面。
    • 9. 发明授权
    • Preparation process of fluorenes
    • 芴的制备工艺
    • US06344585B2
    • 2002-02-05
    • US09768621
    • 2001-01-25
    • Hiroaki Mori
    • Hiroaki Mori
    • C07C5976
    • C07C49/675C07C13/567C07C325/02C07C2603/18
    • A tetrahydrofluorene, which is represented by the following formula (I) wherein R1 to R6 each independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R1 and R2 are combined together to represent ═O, ═N or ═S, R7 and R8 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, a hydroxyl group or a carboxyl group, is subjected to a hydrogen transfer reaction in the presence of a hydrogen acceptor and a catalyst, whereby a fluorene and a hydride of the hydrogen acceptor are formed at the same time.
    • 由下式(I)表示的四氢芴,其中R 1至R 6各自独立地表示氢原子或具有1至4个碳原子的烷基,或R 1和R 2组合​​在一起,表示= O,= N或= S,R7和R8各自独立地表示氢原子,具有1至4个碳原子的烷基,具有1至4个碳原子的烷氧基,卤素原子,羟基或羧基,进行氢转移 在氢受体和催化剂的存在下进行反应,由此同时形成氢受体的芴和氢化物。
    • 10. 发明授权
    • Fuel cell system and control method therefor
    • 燃料电池系统及其控制方法
    • US09083266B2
    • 2015-07-14
    • US14129431
    • 2012-06-26
    • Shigeto KajiwaraHiroaki Mori
    • Shigeto KajiwaraHiroaki Mori
    • H02P4/00B60L1/00B60L3/00B60L11/18B60L15/20
    • H02P4/00B60L1/003B60L3/0046B60L11/1803B60L11/1887B60L15/2045B60L2210/14B60L2210/40B60L2240/423B60L2240/547B60L2250/28Y02T10/642Y02T10/645Y02T10/7225Y02T10/7241Y02T10/7283Y02T90/34
    • A fuel cell system (10) includes: a motor (16); a fuel cell (11) and an electrical storage device (13) connected to the motor (16) in parallel with each other; a first voltage converter (12) between the motor (16) and the fuel cell (11); a second voltage converter (14) between the motor (16) and the electrical storage device (13); a load circuit between the motor (16) and both the first (12) and second (14) voltage converters; and a control unit (20). The control unit (20) stops boost operation of the first voltage converter (12) when conditions VFC>VM_min and VFC>VBAT+a whereas the control unit (20) prohibits a stop of the boost operation of the first voltage converter (12) when the conditions are not satisfied, wherein in the conditions, VFC is a fuel cell terminal voltage, VBAT is an electrical storage device terminal voltage and VM_min is a load circuit input terminal voltage, set to minimize a system loss while ensuring a torque required of the motor (16).
    • 燃料电池系统(10)包括:电动机(16); 燃料电池(11)和与电动机(16)并联连接的蓄电装置(13); 电动机(16)和燃料电池(11)之间的第一电压转换器(12); 电动机(16)和蓄电装置(13)之间的第二电压转换器(14); 电动机(16)与第一(12)和第二(14)电压转换器之间的负载电路; 和控制单元(20)。 当条件VFC> VM_min和VFC> VBAT + a时,控制单元(20)停止第一电压转换器(12)的升压操作,而控制单元(20)禁止第一电压转换器(12)的升压操作停止, 当不满足条件时,其中在条件下,VFC是燃料电池端子电压,VBAT是蓄电装置端子电压,VM_min是负载电路输入端子电压,设定为最小化系统损耗,同时确保所需的转矩 马达(16)。