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1. 发明授权

US06800630B2 Pyrimidine derivatives having antitumor effect 失效
标题翻译：具有抗肿瘤作用的嘧啶衍生物
公开(公告)号：US06800630B2
公开(公告)日：2004-10-05
申请号：US10169993
申请日：2002-07-12
申请人： Hidekazu Tanaka , Kazuo Ueda , Shinji Suzuki , Hideyuki Takenaka
发明人： Hidekazu Tanaka , Kazuo Ueda , Shinji Suzuki , Hideyuki Takenaka
IPC分类号： C07D23942
CPC分类号： C07D413/12
摘要： A compound represented by the formula (I) wherein, for example, R1, R2, R3, and R4 are each independently hydrogen atom, alkyl, and the like, R5 and R6 are each independently hydrogen atom, alkyl, and the like, RB and RC are each independently hydrogen atom, alkyl, and the like, X is —O—, —S—, and the like, Y is 5-membered heteroaryl-diyl and the like, Z is optionally substituted aryl and the like, their pharmaceutically acceptable salts, or their solvates.
摘要翻译：由式（I）表示的化合物，其中例如R 1，R 2，R 3和R 4各自独立地为氢原子，烷基等，R 5，和R 6各自独立地为氢原子，烷基等，R B和R C各自独立地为氢原子，烷基等，X为-O-，-S-，且 Y为5元杂芳基 - 二基等，Z为任选取代的芳基等，其药学上可接受的盐或其溶剂合物。

2. 发明授权

US06420367B1 Pyrimidine derivatives exhibiting antitumor activity 失效
标题翻译：具有抗肿瘤活性的嘧啶衍生物
公开(公告)号：US06420367B1
公开(公告)日：2002-07-16
申请号：US09743721
申请日：2001-01-16
申请人： Kazuo Ueda , Hidekazu Tanaka , Hideyuki Takenaka
发明人： Kazuo Ueda , Hidekazu Tanaka , Hideyuki Takenaka
IPC分类号： A61K31505
CPC分类号： C07D413/12
摘要： A compound represented by the formula (I): wherein, for example, R1, R2, R3, and R4 are each independently hydrogen atom, alky, and the like, R5 and R6 are each independently hydrogen atom, alkyl, and the like, X is —O—, —S—, and the like, Y is 5-membered heteroaryl-diyl and the like, Z is optionally substituted aryl and the like, the prodrugs thereof, or their pharmaceutically acceptable salts, or their solvates.
摘要翻译：由式（I）表示的化合物：其中，例如，R 1，R 2，R 3和R 4各自独立地为氢原子，烷基等，R 5和R 6各自独立地为氢原子，烷基等， X是-O-，-S-等，Y是5元杂芳基 - 二基等，Z是任选取代的芳基等，其前药或其药学上可接受的盐或它们的溶剂合物。

3. 发明申请

US20100160290A1 PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US20100160290A1
公开(公告)日：2010-06-24
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/554 , C07D417/02 , A61K31/541 , C07D279/06 , C07D277/18 , A61K31/426 , C07D239/02 , A61K31/506 , C07D281/02 , A61P25/28
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

4. 发明授权

US08546380B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08546380B2
公开(公告)日：2013-10-01
申请号：US13243971
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D279/00 , C07D265/00 , A61K31/535 , A61K31/541
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有式（I）表示的化合物：其中环A为任选取代的杂环基; E为低级亚烷基; X是S; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 或其药学上可接受的盐。

5. 发明授权

US08633188B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08633188B2
公开(公告)日：2014-01-21
申请号：US13243874
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/535 , A61K31/541 , C07D279/00 , C07D265/00
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

6. 发明授权

US08173642B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08173642B2
公开(公告)日：2012-05-08
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

7. 发明申请

US20090082560A1 AMINODIHYDROTHIAZINE DERIVATIVES 有权
标题翻译：氨基酸衍生物
公开(公告)号：US20090082560A1
公开(公告)日：2009-03-26
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D267/06 , C07D417/12 , C07D279/06 , C07D277/18
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

8. 发明授权

US06268312B1 Oxime derivative and bactericide containing the same as active ingredient 失效
标题翻译：含有与活性成分相同的肟衍生物和杀菌剂
公开(公告)号：US06268312B1
公开(公告)日：2001-07-31
申请号：US09370255
申请日：1999-08-09
申请人： Akira Takase , Hiroyuki Kai , Kuniyoshi Nishida , Tsuneo Iwakawa , Kazuo Ueda , Michio Masuko
发明人： Akira Takase , Hiroyuki Kai , Kuniyoshi Nishida , Tsuneo Iwakawa , Kazuo Ueda , Michio Masuko
IPC分类号： A01N4348
CPC分类号： C07D231/06 , A01N43/50 , C07D231/12 , C07D233/64 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/10 , C07D285/06
摘要： A compound represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate for the production thereof, and a bactericide (fungicide) containing the same as the active ingredient wherein R1 represent optionally substituted aryl, optionally substituted heterocycle, mono- or di-substituted methyleneamino, optionally substituted (substituted imino)methyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, substituted carbonyl or substituted sulfonyl; R2 represents alkyl, alkenyl, alkynyl or cycloalkyl; R3 represents optionally substituted heterocycle; R4 represents hydrogen, alkyl, alkoxy, halogen, nitro, cyano or haloalkyl; M represents oxygen, S(O)i (i being 0, 1 or 2), NR16 (R16 being hydrogen, alkyl or acyl) or a single bond; n represents 0 or 1, provided n represent 1 when R3 represents imidazol-1-yl or 1H-1,2,4-triazol-1-yl; and the symbol˜represents the E form, Z form or a mixture thereof.
摘要翻译：由通式（I）表示的化合物或其盐，其制备方法，其制备中间体和含有该活性成分的杀菌剂（杀真菌剂），其中R 1表示任选取代的芳基，任选取代的取代的亚氨基甲基，任选取代的烷基，任选取代的烯基，任选取代的炔基，取代的羰基或取代的磺酰基; R2代表烷基，烯基，炔基或环烷基; R3表示任选取代的杂环; R4代表氢，烷基，烷氧基，卤素，硝基，氰基或卤代烷基; M表示氧，S（O）i（i为0,1或2），NR 16（R 16为氢，烷基或酰基）或单键; 当R 3表示咪唑-1-基或1H-1,2,4-三唑-1-基时，n表示0或1，条件是n表示1。符号〜表示E形式，Z形式或其混合物。

9. 发明授权

US4663382A Non-rigid vinyl chloride polymer resin composition 失效
标题翻译：非刚性氯乙烯聚合物树脂组合物
公开(公告)号：US4663382A
公开(公告)日：1987-05-05
申请号：US795518
申请日：1985-11-06
申请人： Kazuo Kishida , Kazuo Ueda , Kiyokazu Kitai , Tsuruyoshi Matsumoto
发明人： Kazuo Kishida , Kazuo Ueda , Kiyokazu Kitai , Tsuruyoshi Matsumoto
IPC分类号： C08K5/00 , C08L1/00 , C08L7/00 , C08L21/00 , C08L23/00 , C08L27/00 , C08L27/06 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L51/06 , C08L67/00 , C08L101/00 , C08L13/00 , C08L51/04
CPC分类号： C08K5/0016 , C08L27/06 , C08L51/003
摘要： Disclosed is a non-rigid vinyl chloride polymer composition comprising 100 weight parts of a vinyl chloride polymer resin, 5-50 weight parts of a graft copolymer modifier and 10-300 weight parts of a plasticizer. The graft copolymer modifier is obtained by graft-polymerizing 25-150 weight parts of an alkyl ester of methacrylic acid having 1 to 4 carbon atoms in the alkyl group or a monomer mixture composed of at least more than 50% by weight of said alkyl ester of methacrylic acid onto 100 weight parts of an acrylic elastomer having a swelling degree of 5 to 25 so that the grafting ratio is not larger than 50%. The acrylic elastomer is obtained by polymerizing a mixture comprising an alkyl ester of acrylic acid having 2 to 10 carbon atoms in the alkyl group or a monomer mixture composed of at least 50% by weight of said alkyl ester of acrylic acid, and a polyfunctional crosslinking agent. The non-rigid vinyl chloride polymer composition has excellent weatherability and impact resistance, and exhibits a good molding processability.
摘要翻译：公开了一种非刚性氯乙烯聚合物组合物，其包含100重量份的氯乙烯聚合物树脂，5-50重量份的接枝共聚物改性剂和10-300重量份的增塑剂。接枝共聚物改性剂通过在烷基中接枝聚合25-150重量份的具有1至4个碳原子的甲基丙烯酸的烷基酯或由至少大于50重量％的所述烷基酯组成的单体混合物的甲基丙烯酸加入到100重量份的溶胀度为5〜25的丙烯酸类弹性体中，使得接枝率不大于50％。丙烯酸弹性体是通过在烷基中聚合含有2-10个碳原子的丙烯酸烷基酯的混合物或由至少50重量％的所述丙烯酸烷基酯组成的单体混合物和多官能交联代理商非刚性氯乙烯聚合物组合物具有优异的耐候性和耐冲击性，并且表现出良好的成型加工性。

10. 发明授权

US4425895A Air-fuel ratio feedback control system 失效
标题翻译：空燃比反馈控制系统
公开(公告)号：US4425895A
公开(公告)日：1984-01-17
申请号：US294823
申请日：1981-08-21
申请人： Shuzo Yoshida , Hironobu Ono , Masashi Matsuo , Kouich Hoshi , Motoharu Sueishi , Kazuo Ueda
发明人： Shuzo Yoshida , Hironobu Ono , Masashi Matsuo , Kouich Hoshi , Motoharu Sueishi , Kazuo Ueda
IPC分类号： F02D41/34 , F02D41/14 , F02D5/00
CPC分类号： F02D41/1481
摘要： An air-fuel ratio feedback control system for the internal combustion engine produces a fuel supply control signal by delaying a rich or lean signal obtained by comparing the oxygen concentration in the exhaust gas with a reference value. The turning on of an idle switch operatively connected with the engine throttle valve, a predetermined time after the turning off of the idle switch and the engine speed included in a predetermined region are detected in order to delay the rich or lean signal to rich or lean side by an optimum delay time as selected according to the engine operating conditions, thus feedback controlling the amount of fuel supply.
摘要翻译：用于内燃机的空燃比反馈控制系统通过将通过将排气中的氧浓度进行比较而获得的丰富或贫乏信号与参考值相比较来产生燃料供给控制信号。检测到与发动机节流阀可操作地连接的怠速开关的接通，在空转开关关闭之后的预定时间和包括在预定区域中的发动机速度，以将富或贫信号延迟到浓或稀根据发动机工作条件选择最佳延迟时间，从而反馈控制燃料供应量。

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