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1. 发明授权

US08546380B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08546380B2
公开(公告)日：2013-10-01
申请号：US13243971
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D279/00 , C07D265/00 , A61K31/535 , A61K31/541
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有式（I）表示的化合物：其中环A为任选取代的杂环基; E为低级亚烷基; X是S; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 或其药学上可接受的盐。

2. 发明授权

US08633188B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08633188B2
公开(公告)日：2014-01-21
申请号：US13243874
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/535 , A61K31/541 , C07D279/00 , C07D265/00
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

3. 发明授权

US08173642B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08173642B2
公开(公告)日：2012-05-08
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

4. 发明申请

US20090082560A1 AMINODIHYDROTHIAZINE DERIVATIVES 有权
标题翻译：氨基酸衍生物
公开(公告)号：US20090082560A1
公开(公告)日：2009-03-26
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D267/06 , C07D417/12 , C07D279/06 , C07D277/18
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

5. 发明申请

US20100160290A1 PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US20100160290A1
公开(公告)日：2010-06-24
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/554 , C07D417/02 , A61K31/541 , C07D279/06 , C07D277/18 , A61K31/426 , C07D239/02 , A61K31/506 , C07D281/02 , A61P25/28
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

6. 发明授权

US08653067B2 Pharmaceutical composition for treating Alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US08653067B2
公开(公告)日：2014-02-18
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
IPC分类号： A61K31/554 , A61K31/541 , A61K31/426 , A61K31/506 , C07D417/02 , C07D279/06 , C07D277/18 , C07D239/02
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

7. 发明授权

US06218522B1 DNA molecule relating to suppression of gene expression and novel protein 失效
标题翻译：与抑制基因表达和新蛋白有关的DNA分子
公开(公告)号：US06218522B1
公开(公告)日：2001-04-17
申请号：US08933803
申请日：1997-09-19
申请人： Akihiko Saiga , Satoshi Orita , Hisanaga Igarashi , Kouichi Okumura , Gaku Sakaguchi
发明人： Akihiko Saiga , Satoshi Orita , Hisanaga Igarashi , Kouichi Okumura , Gaku Sakaguchi
IPC分类号： C07H2102
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/14022
摘要： A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.
摘要翻译：存在于存在于表达p21Xm RNA但存在于完整前病毒基因组中的突变型原病毒中缺失的区域中的人T细胞白血病病毒I型（HTLV-I）的基因表达抑制功能的DNA分子，并提供包含DNA分子的质粒。此外，提供了特异性结合U5RE和蛋白质结构基因的新蛋白（TRP-1），其可用于阐明转录抑制活性和阐明神经细胞的肿瘤形成机制，其中转录抑制涉及存在于人类T细胞白血病病毒I型基因LTR的U5区域中的区域（U5RE）。此外，提供了包含该基因的表达载体，其中引入了表达载体的转化体和使用该转化体产生TRP-1蛋白的方法。

8. 发明授权

US6090783A DNA molecule relating to suppression of gene expression and novel protein 失效
标题翻译：与抑制基因表达和新蛋白有关的DNA分子
公开(公告)号：US6090783A
公开(公告)日：2000-07-18
申请号：US121321
申请日：1998-07-23
申请人： Akihiko Saiga , Satoshi Orita , Hisanaga Igarashi , Kouichi Okumura , Gaku Sakaguchi
发明人： Akihiko Saiga , Satoshi Orita , Hisanaga Igarashi , Kouichi Okumura , Gaku Sakaguchi
IPC分类号： A61K38/00 , C07K14/15 , C07K14/435 , C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/14022
摘要： A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.
摘要翻译：存在于存在于表达p21Xm RNA但存在于完整前病毒基因组中的突变型原病毒中缺失的区域中的人T细胞白血病病毒I型（HTLV-I）的基因表达抑制功能的DNA分子，并提供包含DNA分子的质粒。此外，提供了特异性结合U5RE和蛋白质结构基因的新蛋白（TRP-1），其可用于阐明转录抑制活性和阐明神经细胞的肿瘤形成机制，其中转录抑制涉及存在于人类T细胞白血病病毒I型基因LTR的U5区域中的区域（U5RE）。此外，提供了包含该基因的表达载体，其中引入了表达载体的转化体和使用该转化体产生TRP-1蛋白的方法。

9. 发明申请

US20110237576A1 2-AMINOPYRIMIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVES BOTH HAVING BACE1-INHIBITING ACTIVITY 有权
标题翻译：具有BACE1抑制活性的2-氨基嘧啶-4-酮和2-氨基吡啶衍生物
公开(公告)号：US20110237576A1
公开(公告)日：2011-09-29
申请号：US13123761
申请日：2009-10-22
申请人： Shuji Yonezawa , Yuusuke Tamura , Yuuji Kooriyama , Gaku Sakaguchi
发明人： Shuji Yonezawa , Yuusuke Tamura , Yuuji Kooriyama , Gaku Sakaguchi
IPC分类号： A61K31/538 , C07D401/12 , A61K31/513 , C07D405/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14 , C07D409/14 , C07D413/12 , C07D239/22 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04 , A61K31/519 , C07D401/14 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/4439 , C07D213/74 , A61K31/44 , A61P25/28
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.
摘要翻译：本发明提供了具有抑制淀粉样蛋白的作用的化合物。并且可用作由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病的治疗剂。蛋白质。本发明涉及由式（I）表示的化合物或其药学上可接受的盐或溶剂合物：其中A是任选取代的碳环二基或任选取代的杂环二基; B是任选取代的碳环基团或任选取代的杂环基团; R1是任选取代的低级烷基的基团; R2是氢，并且R3a和R3b各自独立地为诸如氢的基团，条件是排除以下化合物。

10. 发明授权

US08703785B2 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity 有权
标题翻译：具有BACE1抑制活性的2-氨基嘧啶-4-酮和2-氨基吡啶衍生物
公开(公告)号：US08703785B2
公开(公告)日：2014-04-22
申请号：US13123761
申请日：2009-10-22
申请人： Shuji Yonezawa , Yuuji Kooriyama , Gaku Sakaguchi
发明人： Shuji Yonezawa , Yuuji Kooriyama , Gaku Sakaguchi
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.
摘要翻译：本发明提供了具有抑制淀粉样蛋白的作用的化合物。并且可用作由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病的治疗剂。蛋白质。本发明涉及由式（I）表示的化合物或其药学上可接受的盐或溶剂合物：其中A是任选取代的碳环二基或任选取代的杂环二基; B是任选取代的碳环基团或任选取代的杂环基团; R1是任选取代的低级烷基的基团; R2是氢，并且R3a和R3b各自独立地为诸如氢的基团，条件是排除以下化合物。

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