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1. 发明申请

US20100160290A1 PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US20100160290A1
公开(公告)日：2010-06-24
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuuji Kooriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/554 , C07D417/02 , A61K31/541 , C07D279/06 , C07D277/18 , A61K31/426 , C07D239/02 , A61K31/506 , C07D281/02 , A61P25/28
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

2. 发明授权

US08546380B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08546380B2
公开(公告)日：2013-10-01
申请号：US13243971
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D279/00 , C07D265/00 , A61K31/535 , A61K31/541
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有式（I）表示的化合物：其中环A为任选取代的杂环基; E为低级亚烷基; X是S; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 或其药学上可接受的盐。

3. 发明授权

US08633188B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08633188B2
公开(公告)日：2014-01-21
申请号：US13243874
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： A61K31/535 , A61K31/541 , C07D279/00 , C07D265/00
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

4. 发明授权

US08173642B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08173642B2
公开(公告)日：2012-05-08
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

5. 发明申请

US20090082560A1 AMINODIHYDROTHIAZINE DERIVATIVES 有权
标题翻译：氨基酸衍生物
公开(公告)号：US20090082560A1
公开(公告)日：2009-03-26
申请号：US12089409
申请日：2006-10-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D267/06 , C07D417/12 , C07D279/06 , C07D277/18
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有通式（I）表示的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; E为低级亚烷基; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 其药学上可接受的盐或其溶剂合物。

6. 发明授权

US08653067B2 Pharmaceutical composition for treating Alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US08653067B2
公开(公告)日：2014-02-18
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
IPC分类号： A61K31/554 , A61K31/541 , A61K31/426 , A61K31/506 , C07D417/02 , C07D279/06 , C07D277/18 , C07D239/02
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

7. 发明申请

US20120015961A1 ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY 审中-公开
标题翻译：具有BACE1抑制活性的异基因衍生物或异构体衍生物
公开(公告)号：US20120015961A1
公开(公告)日：2012-01-19
申请号：US13260103
申请日：2010-03-29
申请人： Yuusuke Tamura , Shinji Suzuki , Sae Matsumoto , Akihiro Hori , Yuuji Kooriyama
发明人： Yuusuke Tamura , Shinji Suzuki , Sae Matsumoto , Akihiro Hori , Yuuji Kooriyama
IPC分类号： A61K31/44 , C07D241/24 , A61K31/4965 , C07D401/12 , A61K31/497 , C07C335/32 , A61K31/21 , C07D239/42 , A61K31/505 , A61K31/444 , C07D405/12 , A61P25/28 , A61P25/00 , A61P27/02 , A61P25/16 , C07D213/85
CPC分类号： C07D213/81 , C07C275/70 , C07C335/32 , C07D213/85 , C07D239/42 , C07D241/24 , C07D241/28 , C07D401/12 , C07D405/12 , C07D413/12
摘要： The present invention provides, for example, a compound of the following formula (I): wherein R1 is substituted amino and the like, R2 is halogen and the like, R3 is substituted or unsubstituted lower alkyl and the like, RA and RB are each independently hydrogen, substituted or unsubstituted lower alkyl and the like, RC and RD are each independently hydrogen, substituted or unsubstituted lower alkyl, or RC and RD together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, and ring A is a carbocycle or a heterocycle, its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-βproteins.
摘要翻译：本发明提供例如下式（I）的化合物：其中R1是取代氨基等，R2是卤素等，R3是取代或未取代的低级烷基等，RA和RB各自独立地是氢，取代或未取代的低级烷基等，RC和RD各自独立地为氢，取代或未取代的低级烷基或RC和RD与它们所连接的碳原子一起形成取代或未取代的碳环，并且环 A是碳环或杂环，其药学上可接受的盐或其溶剂合物作为由淀粉样蛋白质的蛋白质的产生，分泌和/或沉积诱导的疾病的治疗剂。

8. 发明申请

US20110190279A1 SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING BETA SECRETASE INHIBITORY ACTIVITY 有权
标题翻译：具有硫蛋白含量的具有BETA分泌酶抑制活性的杂环衍生物
公开(公告)号：US20110190279A1
公开(公告)日：2011-08-04
申请号：US12997802
申请日：2009-06-11
申请人： Akihiro Hori , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno , Terukazu Kato
发明人： Akihiro Hori , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno , Terukazu Kato
IPC分类号： A61K31/541 , C07D403/12 , A61K31/497 , C07D401/12 , A61K31/4439 , C07D417/12 , C07D417/14 , A61P25/28
CPC分类号： C07D417/12 , A61K9/0019 , A61K9/1623 , A61K9/2018 , C07D279/06 , C07D417/10 , C07D417/14 , C07D487/04
摘要： The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example, a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
摘要翻译：提供以下化合物作为治疗由淀粉样蛋白的生产，分泌和/或沉积引起的疾病的药剂; 蛋白质，例如由式（I）表示的化合物：其中环A是任选取代的碳环基或任选取代的杂环基，R 1是任选取代的低级烷基等，R 2a和R 2b各自独立地为氢，任选地取代的低级烷基等，R3a和R3c各自独立地为氢，卤素，羟基，任选取代的低级烷基等，或其药学上可接受的盐或其溶剂合物。

9. 发明申请

US20100027032A1 EDGE DETECTION METHOD 有权
标题翻译：边缘检测方法
公开(公告)号：US20100027032A1
公开(公告)日：2010-02-04
申请号：US12510591
申请日：2009-07-28
申请人： Masayuki Dohi , Itsuko Sakai , Takayuki Sakai , Shunji Kikuchi , Takuto Inoue , Akihiro Hori , Masayuki Narita
发明人： Masayuki Dohi , Itsuko Sakai , Takayuki Sakai , Shunji Kikuchi , Takuto Inoue , Akihiro Hori , Masayuki Narita
IPC分类号： G01B11/00
CPC分类号： G01B11/028 , H01L21/67259
摘要： An edge detection method includes preparing a transparent substrate which includes a first main face having a first main region and a first peripheral region and a second main face having a second main region and a second peripheral region, the first peripheral region having an inclination angle of θa1 and the second peripheral region having an inclination angle of θa2, causing measuring light to enter the first peripheral region from a direction perpendicular to the first main region, detecting a non-emitting region where the measuring light is not emitted from the second peripheral region, and detecting an edge of the transparent substrate on the basis of the non-emitting region, wherein if a refractive index of the transparent substrate is n, the inclination angles θa1 and θa2 satisfy the following expression: n×sin(θa1+θa2−arcsin(sin θa1/n))≧1
摘要翻译：边缘检测方法包括制备透明基板，其包括具有第一主区域和第一周边区域的第一主面和具有第二主区域和第二周边区域的第二主面，所述第一周边区域具有倾斜角 θa1和第二外围区域具有θa2的倾斜角度，使得测量光从垂直于第一主区域的方向进入第一周边区域，检测测量光不从第二周边区域发射的不发射区域，并且基于所述不发射区域检测所述透明基板的边缘，其中如果所述透明基板的折射率为n，则所述倾斜角度θa1和θa2满足以下表达式：nxsin（θa1+θa2-arcsin（ sinθa1/ n））> = 1

10. 发明申请

US20090096051A1 SOLID STATE IMAGING DEVICE AND METHOD FOR MANUFACTURING SAME, AND SOLID STATE IMAGING MODULE 有权
标题翻译：固态成像装置及其制造方法和固态成像模块
公开(公告)号：US20090096051A1
公开(公告)日：2009-04-16
申请号：US12249438
申请日：2008-10-10
申请人： Hitoshi SUGIYAMA , Atsuko Yamashita , Kazutaka Akiyama , Susumu Harada , Masahiro Sekiguchi , Masayuki Dohi , Kazumasa Tanida , Chiaki Takubo , Hiroshi Yoshikawa , Akihiro Hori
发明人： Hitoshi SUGIYAMA , Atsuko Yamashita , Kazutaka Akiyama , Susumu Harada , Masahiro Sekiguchi , Masayuki Dohi , Kazumasa Tanida , Chiaki Takubo , Hiroshi Yoshikawa , Akihiro Hori
IPC分类号： H01L31/0216 , H01L31/18
CPC分类号： H01L27/14634 , H01L27/14618 , H01L27/14623 , H01L27/14636 , H01L27/14685 , H01L2224/05001 , H01L2224/05009 , H01L2224/05022 , H01L2224/05025 , H01L2224/05147 , H01L2224/0557 , H01L2224/05624 , H01L2224/05666 , H01L2224/05684 , H01L2224/13 , H01L2224/13025 , H01L2224/16 , H01L2924/00014
摘要： A solid state imaging device includes: an imaging device substrate with an imaging device section formed on a first major surface side thereof; a backside interconnect electrode provided on a second major surface side of the imaging device substrate and electrically connected to the imaging device section, the second major surface being on the opposite side of the first major surface; a circuit substrate provided with a circuit substrate electrode opposed to the second major surface; a connecting portion electrically connecting the backside interconnect electrode to the circuit substrate electrode; and a light shielding layer provided coplanar with the backside interconnect electrode or on the circuit substrate side of the backside interconnect electrode.
摘要翻译：固态成像装置包括：具有形成在其第一主表面侧的成像装置部分的成像装置基板; 设置在成像器件基板的第二主表面侧并电连接到成像器件部分的背面互连电极，第二主表面在第一主表面的相对侧上; 电路基板，设置有与第二主表面相对的电路基板电极; 连接部，其将所述背面侧配线电极与所述电路基板电极电连接; 以及与背面配线电极共同设置的遮光层，或背面配线电极的电路基板侧。

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