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    • 1. 发明授权
    • Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds
    • 二氢吖啶四磷酸的晶体或其盐,晶体的制造方法,以及该化合物的制造方法
    • US06458946B1
    • 2002-10-01
    • US09582642
    • 2000-07-28
    • Hideaki MaedaToshio YamadaHiroshi SatoYutaka Noda
    • Hideaki MaedaToshio YamadaHiroshi SatoYutaka Noda
    • C07H1904
    • C07H19/10C07H21/02
    • The invention provides crystals of p1,P4-di(uridine 5′-) tetraphosphate or a salt thereof; a process for producing the crystals; and a process for producing P1,P4-di(uridine 5′-) tetraphosphate (U2P4) or a salt thereof from UMP serving as a starting material and by use of DPC and PPi, which process comprises at least one of the following treatment steps: (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reaction of UMP-DPP with a PPi-organic alkali salt; (b) carrying out reaction of UMP-DPP with a PPi-organic alkali salt in the presence of a base; and (c) further treating the synthesized U2P4 with an alkali. The crystals of U2P4 or a salt thereof obtained through the process according to the invention have high purity and stability and a less hygroscopicity as compared with a lyophilized product, to thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing U2P4 or a salt thereof according to the invention realizes high yield and enables large-scale synthesis.
    • 本发明提供了p1,P4-二(尿苷5'-)四磷酸盐或其盐的晶体; 制造晶体的方法; 以及由作为起始原料的UMP生产P1,P4-二(尿苷5'-)四磷酸(U2P4)或其盐的方法,并且使用DPC和PPi,该方法包括以下处理步骤中的至少一个 :(a)在UMP-DPP与PPi-有机碱盐反应的步骤期间,分份加入UMP二苯基磷酸酯(UMP-DPP); (b)在碱的存在下进行UMP-DPP与PPi-有机碱盐的反应; 和(c)用碱进一步处理合成的U2P4。 通过本发明的方法获得的U2P4或其盐的结晶与冻干产品相比具有高纯度和稳定性以及较少的吸湿性,从而用作制备药物的有用原料。 根据本发明的制备U2P4或其盐的方法实现高产率并且能够进行大规模合成。
    • 2. 发明授权
    • Processes for producing P1,P4-diuridine-5′-tetraphosphate
    • 生产P1,P4-尿嘧啶-5'-四磷酸的方法
    • US06780988B2
    • 2004-08-24
    • US10120367
    • 2002-04-12
    • Hideaki MaedaToshio YamadaHiroshi SatoYutaka Noda
    • Hideaki MaedaToshio YamadaHiroshi SatoYutaka Noda
    • C07H2102
    • C07H19/10C07H21/02
    • The invention describes a process for producing P1,P4-di(uridine-5′-)tetraphosphate (U2P4) or a salt thereof from uridine 5′-monophosphate (UMP); wherein the process comprises at least one of the steps (a) and (b): (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reacting UMP-DPP with an organic alkali salt of pyrophosphate (PP1) to produce a reaction mixture; wherein at least one equivalent of a first base is present during one portion of the reaction; (b) reacting UMP-DPP with a PPi-organic alkali salt in the presence of at least one equivalent of a second base to produce a reaction mixture, wherein the first base and the second base may be the same or different; (c) subsequently adding water to the reaction mixture to produce an aqueous reaction mixture; and optionally (d) adding an alkali to the aqueous reaction mixture.
    • 本发明描述了从尿苷5'-单磷酸(UMP)生产P 1,P 4 - 二(尿苷-5' - )四磷酸(U2P4)或其盐的方法; 其中所述方法包括步骤(a)和(b)中的至少一个步骤:(a)在使UMP-DPP与焦磷酸酯(PP1)的有机碱金属盐反应的步骤期间,分开加入UMP二苯基磷酸酯(UMP-DPP) 以产生反应混合物; 其中在反应的一部分期间存在至少一当量的第一碱基; (b)在至少一当量的第二碱的存在下使UMP-DPP与PPi-有机碱金属盐反应以产生反应混合物,其中第一碱和第二碱可以相同或不同; (c)随后向反应混合物中加入水以产生水性反应混合物; 和(d)向反应混合物中加入碱。
    • 6. 发明授权
    • Semiconductor integrated circuit device
    • 半导体集成电路器件
    • US07486544B2
    • 2009-02-03
    • US11826636
    • 2007-07-17
    • Ryo MoriToshio YamadaTetsuya Muraya
    • Ryo MoriToshio YamadaTetsuya Muraya
    • G11C11/00G11C5/14
    • G11C11/412
    • The present invention provides a semiconductor integrated circuit device having an SRAM in which leak current is reduced. In an SRAM comprising a plurality of memory cells each constructed by a storage in which input and output terminals of two inverter circuits are cross-connected and a selection MOSFET provided between the storage and complementary bit lines and whose gate is connected to a word line, a substrate bias switching circuit is provided. In normal operation, the substrate bias switching circuit supplies a power source voltage to an N-type well in which a P-channel MOSFET of a memory cell is formed and supplies a ground potential of the circuit to a P-type well in which an N-channel MOSFET is formed. In the standby state, the substrate bias switching circuit supplies a predetermined voltage which is lower than the power source voltage and by which a PN junction between the N-type well and the source of the P-channel MOSFET is not forward biased to the N-type well, and supplies a predetermined voltage which is higher than the ground potential and by which a PN junction between the P-type well and the source of the N-channel MOSFET is not forward biased to the P-type well.
    • 本发明提供一种半导体集成电路器件,其具有泄漏电流降低的SRAM。 在包括多个存储单元的SRAM中,每个存储单元由两个反相器电路的输入和输出端子交叉存储的存储器构成,以及设置在存储和互补位线之间并且其栅极连接到字线的选择MOSFET, 提供了衬底偏置开关电路。 在正常操作中,衬底偏置开关电路将电源电压提供给形成存储单元的P沟道MOSFET的N型阱,并将电路的接地电位提供给P型阱,其中, 形成N沟道MOSFET。 在待机状态下,衬底偏置开关电路提供低于电源电压的预定电压,并且N型阱和P沟道MOSFET的源极之间的PN结未被正向偏置到N 并且提供比地电位高的预定电压,并且P型阱和N沟道MOSFET的源极之间的PN结未被正向偏置到P型阱。
    • 9. 发明申请
    • Honeycomb catalytic body and process for manufacturing honeycomb catalytic body
    • 蜂窝催化体及蜂窝催化体制造工艺
    • US20070049492A1
    • 2007-03-01
    • US11511461
    • 2006-08-29
    • Yukio MiyairiToshio Yamada
    • Yukio MiyairiToshio Yamada
    • B01J23/00
    • B01J35/04B01J23/40B01J23/63B01J35/002B01J35/10B01J37/0215B01J37/343
    • A honeycomb catalyst body includes: porous partition walls having a large number of pores and disposed to form a plurality of cells communicating between two end faces, plugged portions disposed to plug each of the cells on one of the end faces, and catalyst layers loaded in layers on an inner surface of the cells and an inner surface of the pores and containing a noble metal. Mass (Mc) of the noble metal contained in the catalyst layer loaded on the inner surface of the cells and mass (Mp) of the noble metal contained in the catalyst layer loaded on the inner surface of the pores satisfy the relation of (Mp)/(Mc)≧4. The honeycomb catalyst body is excellent in purification efficiency, has low pressure loss, and is mountable even in a limited space.
    • 一种蜂窝状催化剂体,具有:具有多个孔的多孔分隔壁,并且设置成形成在两个端面之间连通的多个单元,设置成堵塞其中一个端面上的每个单元的堵塞部分,以及装载在 在细胞的内表面上的层和孔的内表面并含有贵金属。 包含在负载在电池内表面上的催化剂层中的贵金属的质量(M SUB)和催化剂中所含的贵金属的质量(M> P) 填充在孔的内表面上的层满足(M p>)))/>>)= 4的关系。 蜂窝状催化剂体的净化效率优异,压力损失小,即使在有限的空间也能够安装。