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1. 发明授权

US06797498B1 B, B-carotene 15, 15′-dioxygenases, nucleic acid sequences coding therefor and their use 失效
标题翻译： B，β-胡萝卜素15,15'-双加氧酶，及其编码的核酸序列及其用途
公开(公告)号：US06797498B1
公开(公告)日：2004-09-28
申请号：US09504393
申请日：2000-02-15
申请人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N902
CPC分类号： C12N9/0069 , C12P23/00
摘要： Nucleic acid sequences coding for a protein having &bgr;,&bgr;-carotene 15,15′ enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the &bgr;,&bgr;-carotene 15,15′ enzyme cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及将β，β-胡萝卜素15,15'酶cDNA引入宿主的方法细胞被公开。

2. 发明授权

US06897051B2 β, β-carotene 15, 15′-monooxygenases, nucleic acid sequences coding therefor and their use 失效
标题翻译： β，β-胡萝卜素15,15'-单加氧酶，对其编码的核酸序列及其用途
公开(公告)号：US06897051B2
公开(公告)日：2005-05-24
申请号：US10053192
申请日：2002-01-15
申请人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N9/02 , C12P23/00 , C07H19/00 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12P23/00 , C12N9/0069
摘要： Nucleic acid sequences coding for a protein having β,β-carotene 15,15′-monooxygenase activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the β,β-carotene 15,15′-monooxygenase cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'-单加氧酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及引入β，β-胡萝卜素15,15'-单加氧酶cDNA的方法公开了宿主细胞。

3. 发明申请

US20050059061A1 Beta, beta-carotene 15,15'-enzymes, nucleic acid sequences coding therefor and their use 审中-公开
标题翻译： β，β-胡萝卜素15,15'-酶，其编码的核酸序列及其用途
公开(公告)号：US20050059061A1
公开(公告)日：2005-03-17
申请号：US10912754
申请日：2004-08-05
申请人： Heinrich Bachmann , Roland Brugger , Arno Friedlein , Gabriele Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Friedlein , Gabriele Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N15/09 , C07K14/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/53 , C12P23/00 , C12Q1/68 , C07H21/04 , C12N9/10
CPC分类号： C12N9/0069 , C12P23/00
摘要： Nucleic acid sequences coding for a protein having β,β-carotene 15,15′ enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the β,β-carotene 15,15′ enzyme cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及将β，β-胡萝卜素15,15'酶cDNA引入宿主的方法细胞被公开。

4. 发明申请

US20070286850A1 Mevalonate Kinase 有权
标题翻译：甲羟戊酸激酶
公开(公告)号：US20070286850A1
公开(公告)日：2007-12-13
申请号：US11793349
申请日：2005-12-12
申请人： Renyuan Bai , Markus Wyss
发明人： Renyuan Bai , Markus Wyss
IPC分类号： C12N9/12 , A61K38/45 , A61P41/00 , C07H21/00 , C12P21/00 , C12P5/00 , C12Q1/48 , C12P21/06 , C12N1/00 , C12N1/20 , C12N15/63
CPC分类号： C12P23/00 , C12N9/1205
摘要： The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a process for producing the modified enzyme and for producing isoprenoid compounds using the modified enzymes.
摘要翻译：本发明涉及对反馈抑制不那么敏感的修饰的甲羟戊酸激酶以及编码它们的多核苷酸。本发明还涉及包含这些多核苷酸的载体和含有这些载体的宿主细胞。本发明提供了一种制备该修饰酶并使用该修饰酶产生类异戊二烯化合物的方法。

5. 发明授权

US06683285B2 Hot-air device 有权
标题翻译：热风装置
公开(公告)号：US06683285B2
公开(公告)日：2004-01-27
申请号：US10057013
申请日：2002-01-24
申请人： Markus Wyss , Bruno von Wyl
发明人： Markus Wyss , Bruno von Wyl
IPC分类号： H05B306
CPC分类号： H05B1/0291 , G05D23/1906 , H05B3/44
摘要： Hot-air device with a heating element situated in a stream of air, with a carrier consisting of temperature-resistant material and heating wires located in the air channels, and with at least one metal mount for the carrier, wherein the temperature-resistant material of the carrier comes into at least partial electrical contact with the metal mount, and is connected to a device for interrupting the heating circuit, which, during heating, interrupts the heating circuit when a threshold value is reached owing to the measuring current discharged over the insulating material and the contact element. The direct and very quick measuring principle enables a simple and inexpensive protection of the heating element, as well as control and regulation without additional sensors. It is possible to control or regulate the hot-air temperature of the hot-air device via the measuring current.
摘要翻译：热空气装置具有位于空气流中的加热元件，载体由位于空气通道中的耐温材料和加热丝线组成，并具有用于载体的至少一个金属安装座，其中耐温材料的载体与金属安装座至少部分电接触，并且连接到用于中断加热电路的装置，该加热电路在加热期间中断加热电路，当达到阈值时，由于测量电流在绝缘材料和接触元件。直接和非常快速的测量原理使得加热元件的简单和便宜的保护以及无附加传感器的控制和调节。可以通过测量电流来控制或调节热风装置的热风温度。

6. 发明授权

US07422884B2 Feedback-resistant mevalonate kinases 有权
标题翻译：反馈抗性甲羟戊酸激酶
公开(公告)号：US07422884B2
公开(公告)日：2008-09-09
申请号：US10560726
申请日：2004-06-10
申请人： Renyuan Bai , Markus Huembelin , Martin Lehmann , Rual Lopez-Ulibarri , Markus Wyss
发明人： Renyuan Bai , Markus Huembelin , Martin Lehmann , Rual Lopez-Ulibarri , Markus Wyss
IPC分类号： C12N9/12 , C12N15/63 , C12N1/20 , C12N1/15 , C07H21/04 , C12P21/00 , C12P21/06
CPC分类号： C12N9/1205
摘要： The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds.
摘要翻译：本发明涉及对反馈抑制不那么敏感的修饰的甲羟戊酸激酶以及编码它们的多核苷酸。本发明还涉及包含这些多核苷酸的载体和含有这些载体的宿主细胞。本发明提供了一种制备改性酶的方法和一种生产类异戊二烯化合物的方法。

7. 发明授权

US07326554B2 Phytase variants 失效
标题翻译：植酸酶变体
公开(公告)号：US07326554B2
公开(公告)日：2008-02-05
申请号：US10734510
申请日：2003-12-12
申请人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
发明人： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC分类号： C12N9/16
CPC分类号： C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
摘要翻译：本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。与在多个位置中的至少一个中的模型植酸酶相比，修改了1。优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。

8. 发明授权

US06734004B2 Modified phytases 有权
标题翻译：修饰的植酸酶
公开(公告)号：US06734004B2
公开(公告)日：2004-05-11
申请号：US10062848
申请日：2002-02-01
申请人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
发明人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
IPC分类号： C12N916
CPC分类号： C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
摘要： A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
摘要翻译：公开了生产具有相对于未修饰的植酸酶的性质改进的所需性质的修饰植酸酶的方法，以及修饰的植酸酶，编码修饰的植酸酶的多核苷酸和包括修饰的植酸酶的动物饲料。

9. 发明授权

US06391605B1 Modified phytases 失效
标题翻译：修饰的植酸酶
公开(公告)号：US06391605B1
公开(公告)日：2002-05-21
申请号：US09044718
申请日：1998-03-19
申请人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
发明人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
IPC分类号： C12N916
CPC分类号： C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
摘要： A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
摘要翻译：公开了生产具有相对于未修饰的植酸酶的性质改进的所需性质的修饰植酸酶的方法，以及修饰的植酸酶，编码修饰的植酸酶的多核苷酸，以及包括修饰的植酸酶的动物饲料。

10. 发明授权

US07078183B2 Modified phytases 有权
公开(公告)号：US07078183B2
公开(公告)日：2006-07-18
申请号：US10776104
申请日：2004-02-11
申请人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
发明人： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
IPC分类号： C12Q1/34 , C12Q1/42 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
摘要： A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.

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