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1. 发明申请

US20110251416A1 CHIRAL LIGANDS 审中-公开
公开(公告)号：US20110251416A1
公开(公告)日：2011-10-13
申请号：US13128710
申请日：2009-11-13
申请人： Benoit Pugin , Adrian Wyss
发明人： Benoit Pugin , Adrian Wyss
IPC分类号： C07F15/02
CPC分类号： C07F17/02
摘要： Process for preparing ligands of the formula (1), in which R1 is C1-C8-alkyl, unsubstituted cyclopentyl, cyclohexyl, norbornyl or adamantyl, or cyclopentyl or cyclohexyl, substituted by 1 to 3 C1-C4-alkyl or C1-C4-alkoxy, or benzyl, phenyl, naphthyl and anthryl which are unsubstituted or substituted by 1 to 3 C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl or C1-C4-fluoroalkoxy, F and Cl, each of R2 and R3 is independently a C-bonded hydrocarbon radical or a heterohydrocarbon radical, and R4 is C1-C4-alkyl, cyclopentyl, cyclohexyl, phenyl, methylphenyl, methylbenzyl or benzyl, which comprises (a) stereoselective metallation in ortho position to the amine side-chain of a compound of formula (A) in which R4 is as defined above, reaction with a dihalide of formula R1—PX2 in which R1 is as defined above and X is Cl or Br, stereoselective hydrolysis to give a compound containing an SPO group, and reaction with a secondary phosphine of formula H—PR2R3 in which R2 and R3 are as defined above, to give the compounds of formula (1). New ligands obtained by that process and metal complexes thereof.
摘要翻译：制备式（1）配体的方法，其中R 1是被1至3个C 1 -C 4 - 烷基或C 1 -C 4 - 烷基取代的C 1 -C 8 - 烷基，未被取代的环戊基，环己基，降冰片基或金刚烷基或环戊基或环己基，烷氧基或苄基，未被取代或被1至3个C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 氟代烷基或C 1 -C 4 - 氟烷氧基，F和Cl各自取代的苯基，萘基和蒽基，每个R 2 并且R 3独立地是C键合的烃基或杂烃基，R 4是C 1 -C 4 - 烷基，环戊基，环己基，苯基，甲基苯基，甲基苄基或苄基，其包括（a）在邻近位置的立体选择性金属化 - 其中R 4如上定义的式（A）化合物与式R1-PX2的二卤化物反应，其中R 1如上定义，X是Cl或Br，立体选择性水解，得到含有SPO的化合物并与式H-PR2R3的仲膦反应，其中R2和R3如上定义得到式（1）的化合物。通过该方法获得的新配体及其金属络合物。

2. 发明申请

US20110045109A1 NOVEL NUTRACEUTICAL COMPOSITIONS CONTAINING WHOLE-FRUIT ZANTHOXYLUM BUNGEANUM EXTRACT FOR COGNITION 审中-公开
标题翻译：含有全水解硼酸锌提取物的新型营养组合物
公开(公告)号：US20110045109A1
公开(公告)日：2011-02-24
申请号：US12745963
申请日：2008-12-03
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Hasan Mohajeri , Bernd Mussler , Adrian Wyss
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Hasan Mohajeri , Bernd Mussler , Adrian Wyss
IPC分类号： A61K36/758 , A61P25/00
CPC分类号： A61K36/758
摘要： The invention relates to a novel nutraceutical composition containing Zanthoxlyum bungeanum whole-fruit extract as active ingredient. The term “nutraceutical” as used herein denotes usefulness in nutritional, pharmaceutical and veterinary fields of application. The compositions are useful for improvement of cognitive functions, such as learning, memory and alertness, psychotic stability and maintenance.
摘要翻译：本发明涉及一种含有作为活性成分的Zanthoxlyum bungeanum全果提取物的新型营养组合物。本文所用的术语“营养制品”表示在营养，药物和兽医领域的有用性。该组合物可用于改善认知功能，例如学习，记忆和警觉，精神稳定和维持。

3. 发明申请

US20100317728A1 DIETARY AND PHARMACEUTICAL COMPOSITIONS COMPRISING A SAGE EXTRACT CONTAINING A MIXTURE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES AND THEIR USES 审中-公开
标题翻译：含有三聚氰胺混合物及其衍生物及其用途的食品提取物的膳食和药物组合物
公开(公告)号：US20100317728A1
公开(公告)日：2010-12-16
申请号：US12515328
申请日：2007-11-22
申请人： Ann Fowler , Claus Kilpert , Goede Schueler , Christof Wehrli , Adrian Wyss
发明人： Ann Fowler , Claus Kilpert , Goede Schueler , Christof Wehrli , Adrian Wyss
IPC分类号： A61K31/352 , A61K31/192 , A61P25/24 , A61P25/00 , A61P43/00 , A61P25/22
CPC分类号： A61K36/537 , A23L33/105
摘要： The present invention refers to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to III, preferably to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to IV, more preferably to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to V, for use as medicaments for the treatment of a disorder connected to reduced neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及含有式I至III的三环二萜（衍生物）的混合物的鼠尾草提取物，优选为含有式I至IV的三环二萜（衍生物）的混合物的鼠尾草提取物，更优选至含有式I至V的三环二萜（衍生物）的混合物的圣人提取物，用作治疗与减少的神经传递相关的病症的药物，以及膳食和药物组合物及其用途。

4. 发明申请

US20120149766A1 DIETARY AND PHARMACEUTICAL COMPOSITIONS COMPRISING A SAGE EXTRACT CONTAINING A MIXTURE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES AND THEIR USES 审中-公开
标题翻译：含有三聚氰胺混合物及其衍生物及其用途的食品提取物的膳食和药物组合物
公开(公告)号：US20120149766A1
公开(公告)日：2012-06-14
申请号：US13366575
申请日：2012-02-06
申请人： Ann FOWLER , Claus KILPERT , Goede SCHUELER , Christof WEHRLI , Adrian WYSS
发明人： Ann FOWLER , Claus KILPERT , Goede SCHUELER , Christof WEHRLI , Adrian WYSS
IPC分类号： A61K31/366 , A61P25/20 , A61P25/22 , A61P25/00 , A61P25/24
CPC分类号： A61K36/537 , A23L33/105
摘要： The present invention refers to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to III, preferably to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to IV, more preferably to a sage extract containing a mixture of tricyclic diterpene (derivative)s of the formulae I to V, for use as medicaments for the treatment of a disorder connected to reduced neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及含有式I至III的三环二萜（衍生物）的混合物的鼠尾草提取物，优选为含有式I至IV的三环二萜（衍生物）的混合物的鼠尾草提取物，更优选至含有式I至V的三环二萜（衍生物）的混合物的圣人提取物，用作治疗与减少的神经传递相关的病症的药物，以及膳食和药物组合物及其用途。

5. 发明申请

US20110118482A1 BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS 有权
标题翻译：用于催化不对称添加反应的双歧杆菌配体
公开(公告)号：US20110118482A1
公开(公告)日：2011-05-19
申请号：US12734696
申请日：2008-11-14
申请人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Bjõrn Gschwend , Andreas Pfaltz , Felix Spindler
发明人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Bjõrn Gschwend , Andreas Pfaltz , Felix Spindler
IPC分类号： C07F9/6553 , C07F15/00 , C07F17/02 , C07F9/28 , C07F9/655 , C07C67/00 , C07C227/16
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; R0 is methyl or hydroxyl, and R0 is methyl when Z1 is the —P*R0R1 group; and R1 is a C-bonded optically enriched or optically pure chiral, mono- or polycyclic, nonaromatic hydrocarbon or heterohydrocarbon radical which has 3 to 12 ring atoms and 1 to 4 rings and which has a stereogenic carbon atom at least in the a position to the P—C bond; Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C1-C4-亚烷基骨架，其中，基骨架中的次膦基Z1直接键合或在环状基团骨架的情况下直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架中，P手性基团-P * R0R1直接键合到碳上或者在环状基骨架的情况下，直接连接到碳原子上，或者通过C1-C4-亚烷基与碳原子连接，使得磷原子通过1至7个任选被杂原子中断的碳链原子连接由O，S，N，Fe或Si组成; P *是手性磷原子; R 0是甲基或羟基，当Z 1是-P * R 0 R 1基团时，R 0是甲基; 并且R 1是C-键合的光学富集或光学纯的手性，单或多环，非芳族烃或杂烃基，其具有3至12个环原子和1至4个环，并且其具有立体碳原子至少在 P-C键; 这些配体的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。

6. 发明申请

US20100240768A1 NOVEL NUTRACEUTICALCOMPOSITIONS CONTAINING THYMOL AND/OR P-CYMENE OR PLANT EXTRACTS FOR COGNITION 审中-公开
标题翻译：含有THYMOL和/或P-CYMENE或植物提取物的新型营养成分用于认知
公开(公告)号：US20100240768A1
公开(公告)日：2010-09-23
申请号：US12738729
申请日：2008-10-17
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Mayne-Mechan , Hasan Mohajeri , Bernd Mussler , Adrian Wyss
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Mayne-Mechan , Hasan Mohajeri , Bernd Mussler , Adrian Wyss
IPC分类号： A61K31/05 , A61K31/015 , A61P25/00
CPC分类号： A61K31/05 , A61K31/015
摘要： The invention relates to a novel nutraceutical composition containing thymol and/or p-cymene, or a plant extract containing thymol or p-cymene as active ingredient(s). The compositions are useful for improvement of cognitive functions and psycho-social status, such as learning, memory and alertness, psychotic stability and maintenance.
摘要翻译：本发明涉及含有百里酚和/或对异丙基异丙基苯甲酸酯的新型营养组合物，或含有百里酚或对甲基异丙苯作为活性成分的植物提取物。该组合物可用于改善认知功能和心理社会状态，如学习，记忆和警觉，精神稳定和维持。

7. 发明授权

US08450501B2 Bidentate chiral ligands for use in catalytic asymmetric addition reactions 有权
标题翻译：用于催化不对称加成反应的双齿手性配体
公开(公告)号：US08450501B2
公开(公告)日：2013-05-28
申请号：US12734696
申请日：2008-11-14
申请人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Björn Gschwend , Andreas Pfaltz , Felix Spindler
发明人： Benoît Pugin , Matthias Lotz , Heidi Landert , Adrian Wyss , Raphael Aardoom , Björn Gschwend , Andreas Pfaltz , Felix Spindler
IPC分类号： C07D333/26
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton.
摘要翻译：主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性芳族基骨架，二价，非手性二茂铁基骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架。

8. 发明申请

US20110038957A1 NOVEL NUTRACEUTICAL COMPOSITIONS CONTAINING STEVIA EXTRACT OR STEVIA EXTRACT CONSTITUENTS AND USES THEREOF 审中-公开
标题翻译：含有维生素提取物或维生素提取物的新型营养组合物及其用途
公开(公告)号：US20110038957A1
公开(公告)日：2011-02-17
申请号：US12745421
申请日：2008-12-03
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Bernd Mussler , Adrian Wyss
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Bernd Mussler , Adrian Wyss
IPC分类号： A61K31/19 , A61K36/28 , A61P25/00
CPC分类号： A61K31/704 , A23K20/10 , A23K20/163 , A23K50/40 , A23L27/36 , A23L33/105 , A61K36/28
摘要： The invention relates to a novel nutraceutical composition containing Stevia extract or its constituents, such as steviol and stevioside, as active ingredient(s). The term “nutraceutical” as used herein denotes usefulness in nutritional, pharmaceutical and veterinary fields of application. The compositions are useful for improvement of cognitive functions, such as learning, memory and alertness, and psychotic stability.
摘要翻译：本发明涉及含有甜叶菊提取物或其成分如甜菊醇和甜菊苷作为活性成分的新型营养组合物。本文所用的术语“营养制品”表示在营养，药物和兽医领域的有用性。该组合物可用于改善认知功能，例如学习，记忆和警觉性以及精神稳定性。

9. 发明申请

US20100166859A1 NOVEL NUTRACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：新型营养组合物及其用途
公开(公告)号：US20100166859A1
公开(公告)日：2010-07-01
申请号：US12160823
申请日：2006-12-29
申请人： Luppo Edens , Regina Goralczyk , Adrian Wyss
发明人： Luppo Edens , Regina Goralczyk , Adrian Wyss
IPC分类号： A61K38/06 , C07K4/00 , A61P25/24 , A61P25/28 , A61K9/28
CPC分类号： A61K45/06 , A23L33/18 , A61K38/06
摘要： The invention relates to a novel nutraceutical composition containing at least one tripeptide as active ingredient. The term “nutraceutical' as used herein denotes a usefulness in both the nutritional and pharmaceutical field of application. Thus, the novel nutraceutical compositions can find use as supplement to food and beverages, and as pharmaceutical formulations for enteral or parenteral application which may be solid formulations such as capsules or tablets, or liquid formulations, such as solutions or suspensions. As will he evident from the foregoing, the term nutraceutical composition also comprises food and beverages containing the above-specified active ingredients, for example protein hydrolysates which are rich in tripeptides according to the invention. The compositions are useful to improve cognitive functions such as learning, memory and alertness and for the treatment of a disorder connected to impaired neurotransmission and of conditions resulting from hypoxia and for alleviating neuropathic pain.
摘要翻译：本发明涉及含有至少一种三肽作为活性成分的新型营养组合物。本文所用的术语“营养制品”表示在营养和制药领域中的有用性。因此，新型营养食品组合物可以用作食品和饮料的补充剂，以及用作肠内或肠胃外应用的药物制剂，其可以是固体制剂如胶囊或片剂，或液体制剂，例如溶液或悬浮液。从上文可以看出，术语营养药物组合物还包含含有上述活性成分的食品和饮料，例如富含根据本发明的三肽的蛋白质水解产物。该组合物可用于改善认知功能，例如学习，记忆和警觉性，以及治疗与受损的神经传递相关的病症以及由缺氧引起的疾病和减轻神经性疼痛。

10. 发明授权

US06797498B1 B, B-carotene 15, 15′-dioxygenases, nucleic acid sequences coding therefor and their use 失效
标题翻译： B，β-胡萝卜素15,15'-双加氧酶，及其编码的核酸序列及其用途
公开(公告)号：US06797498B1
公开(公告)日：2004-09-28
申请号：US09504393
申请日：2000-02-15
申请人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
发明人： Heinrich Bachmann , Roland Brugger , Arno Martin Friedlein , Gabriele Margarethe Wirtz , Wolf-Dietrich Woggon , Adrian Wyss , Markus Wyss
IPC分类号： C12N902
CPC分类号： C12N9/0069 , C12P23/00
摘要： Nucleic acid sequences coding for a protein having &bgr;,&bgr;-carotene 15,15′ enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the &bgr;,&bgr;-carotene 15,15′ enzyme cDNA into host cells are disclosed.
摘要翻译：编码具有β，β-胡萝卜素15,15'酶活性的蛋白质的核酸序列及其在诊断中的应用，维生素A的合成以及将β，β-胡萝卜素15,15'酶cDNA引入宿主的方法细胞被公开。

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