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1. 发明授权

US06825021B2 DSP-15 dual-specificity phosphatase 失效
标题翻译： DSP-15双特异性磷酸酶
公开(公告)号：US06825021B2
公开(公告)日：2004-11-30
申请号：US09955732
申请日：2001-09-18
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N916
CPC分类号： C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-15, and polypeptide variants thereof that stimulate dephosphorylation of DSP-15 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-15 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-15底物去磷酸化的双特异性磷酸酶DSP-15及其多肽变体。多肽可用于例如鉴定抑制DSP-15活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

2. 发明授权

US06767727B2 22438, 23553, 25278, and 26212 novel human sulfatases 失效
标题翻译： 22438,23553,25278和26212新型人类硫酸酯酶
公开(公告)号：US06767727B2
公开(公告)日：2004-07-27
申请号：US10314881
申请日：2002-12-09
申请人： Maria Alexandra Glucksmann , Mark Williamson , Fong Ying Tsai , Laura A. Rudolph-Owen
发明人： Maria Alexandra Glucksmann , Mark Williamson , Fong Ying Tsai , Laura A. Rudolph-Owen
IPC分类号： C12N916
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase polypeptides and polynucleotides, and methods of diagnosing and treating sulfatase-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译：本发明涉及新鉴定的人类硫酸酯酶。特别地，本发明涉及硫酸酯酶多肽和多核苷酸，检测硫酸酯酶多肽和多核苷酸的方法，以及诊断和治疗硫酸酯酶相关病症的方法。还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。

3. 发明授权

US06720014B1 Phytase-containing foodstuffs and methods of making and using them 有权
标题翻译：含植酸酶的食品及其制作和使用方法
公开(公告)号：US06720014B1
公开(公告)日：2004-04-13
申请号：US09580515
申请日：2000-05-25
申请人： Jay M. Short , Keith A. Kretz
发明人： Jay M. Short , Keith A. Kretz
IPC分类号： C12N916
CPC分类号： A21D8/042 , A01K2217/05 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K38/00 , C12N9/16 , C12Y301/03008 , C12Y301/03026 , A23V2300/21
摘要： A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular light of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
摘要翻译：来自大肠杆菌B的纯化的重组植酸酶。该酶具有约47.1千道尔顿的分子量并具有植酸酶活性。该酶可以由天然或重组宿主细胞产生，并且可以用于有助于在需要时消化植酸盐。特别地，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。

4. 发明授权

US06649390B1 Thermophilic alkaline phosphoesterase and its expression 失效
标题翻译：嗜热碱性磷酸酯酶及其表达
公开(公告)号：US06649390B1
公开(公告)日：2003-11-18
申请号：US09530851
申请日：2000-05-04
申请人： Xiaoyu Sheng , Yumin Mao , Youzhong Yuan , Chaoneng Ji , Zongxiang Zhou
发明人： Xiaoyu Sheng , Yumin Mao , Youzhong Yuan , Chaoneng Ji , Zongxiang Zhou
IPC分类号： C12N916
CPC分类号： C12N9/16
摘要： The invention belongs to the field of biological engineering techniques and relates to a thermophilic alkaline phosphoesterase. The invention provides an amino acid sequence of a thermophilic alkaline phosphoesterase of the invention, as well as a DNA fragment encoding the amino acid sequence. The present invention also includes methods for cloning an expression vector containing the DNA fragment or a portion thereof and for producing the recombinant enzyme. The invention also relates to a method for tagging biological macromolecules utilizing the enzyme.
摘要翻译：本发明属于生物工程技术领域，涉及嗜热碱性磷酸酯酶。本发明提供本发明的嗜热碱性磷酸酯酶的氨基酸序列，以及编码氨基酸序列的DNA片段。本发明还包括用于克隆含有DNA片段或其部分并用于产生重组酶的表达载体的方法。本发明还涉及一种利用该酶标记生物大分子的方法。

5. 发明授权

US06642040B2 Human cGMP-stimulated cyclic nucleotide phosphodiesterase 失效
标题翻译：人cGMP刺激的环状核苷酸磷酸二酯酶
公开(公告)号：US06642040B2
公开(公告)日：2003-11-04
申请号：US09883825
申请日：2001-06-18
申请人： Joseph A. Beavo , Kelley J. Bentley , Harry Charbonneau , William K. Sonnenburg
发明人： Joseph A. Beavo , Kelley J. Bentley , Harry Charbonneau , William K. Sonnenburg
IPC分类号： C12N916
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译：本发明涉及编码哺乳动物Ca 2+ /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。

6. 发明授权

US06623946B1 Nucleotide sequences encoding the sucC and sucD genes 失效
标题翻译：编码sucC和sucD基因的核苷酸序列
公开(公告)号：US06623946B1
公开(公告)日：2003-09-23
申请号：US09728498
申请日：2000-11-27
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx
IPC分类号： C12N916
CPC分类号： C12N9/93 , C12P13/04 , C12P13/14
摘要： Polynucleotides that contain polynucleotide sequences encoding the sucC and sucD genes, selected from the group a) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:2, b) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:3, c) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:2, d) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:3, e) a polynucleotide that is complementary to one of the polynucleotides of a), b), c) or d), and f) a polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b), c), d) or e), a process for the fermentative production of L-amino acids using coryneform bacteria in which the genes are present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
摘要翻译：含有编码sucC和sucD基因的多核苷酸序列的多核苷酸，选自组a）与编码含有SEQ ID NO：2的氨基酸序列的多肽的多核苷酸至少70％同一性的多核苷酸，b）多核苷酸与编码含有SEQ ID NO：3的氨基酸序列的多肽的多核苷酸至少70％相同，c）编码包含与氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸 SEQ ID NO：2的d氨基酸序列，d）编码含有与SEQ ID NO：3的氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸，e）与 a），b），c）或d）的多核苷酸，和f）包含a），b），c），d）或e）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，发酵生产的方法的L-氨基酸其中基因以减毒形式存在的干细胞，以及多核苷酸序列用作杂交探针。

7. 发明授权

US06617144B1 Motor proteins and methods for their use 失效
标题翻译：运动蛋白及其使用方法
公开(公告)号：US06617144B1
公开(公告)日：2003-09-09
申请号：US09718854
申请日：2000-11-22
申请人： Christophe Beraud , Richard Freedman
发明人： Christophe Beraud , Richard Freedman
IPC分类号： C12N916
CPC分类号： C12N9/14
摘要： The invention provides isolated nucleic acid and amino acid sequences of HsKif16a, antibodies to HsKif16a, methods of screening for HsKif16a modulators using biologically active HsKif16a, and kits for screening for HsKif16a modulators.
摘要翻译：本发明提供HsKif16a的分离的核酸和氨基酸序列，HsKif16a的抗体，使用生物活性HsKif16a筛选HsKif16a调节剂的方法，以及用于筛选HsKif16a调节剂的试剂盒。

8. 发明授权

US06537790B1 Esterase genes and uses of the same 失效
标题翻译：酯酶基因和用途相同
公开(公告)号：US06537790B1
公开(公告)日：2003-03-25
申请号：US09585468
申请日：2000-06-02
申请人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
发明人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
IPC分类号： C12N916
CPC分类号： C12P17/10 , C12N9/18
摘要： The present invention provides a novel gene encoding a protein having an excellent catalyst ability for producing (S)-N-substituted cyclic imino acid represented by formula (2): and provides a novel method for producing (S)-N-substituted cyclic imino acid represented by formula (2) by an asymmetric hydrolization of the N-substituted cyclic imino acid ester represented by formula (1): in a manner of gene engineering technology utilizing the novel gene provided.
摘要翻译：本发明提供了编码由式（2）表示的（S）-N-取代的环状亚氨酸具有优异的催化能力的蛋白质的新基因：提供了一种制备（S）-N-取代的环状亚氨基由式（2）表示的酸通过式（1）表示的N-取代的环状亚氨基酸酯的不对称水解：以使用所提供的新基因的基因工程技术的方式。

9. 发明授权

US06436685B1 CSAPTP protein molecules and uses therefor 有权
标题翻译： CSAPTP蛋白分子及其用途
公开(公告)号：US06436685B1
公开(公告)日：2002-08-20
申请号：US09221448
申请日：1998-12-28
申请人： Susan L. Acton
发明人： Susan L. Acton
IPC分类号： C12N916
CPC分类号： C12Y301/03048 , C12N9/16
摘要： The invention provides isolated nucleic acid molecules, designated CSAPTP nucleic acid molecules, which encode novel protein tyrosine phosphatases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPTP nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for producing CSAPTP polypeptides.
摘要翻译：本发明提供编码新的蛋白酪氨酸磷酸酶的分离的核酸分子，命名为CSAPTP核酸分子。本发明还提供反义核酸分子，含有CSAPTP核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及生产CSAPTP多肽的方法。

10. 发明授权

US06420152B1 Recombinant DNase B derived from Streptococcus pyogenes 失效
标题翻译：衍生自化脓性链球菌的重组DNA酶B
公开(公告)号：US06420152B1
公开(公告)日：2002-07-16
申请号：US08393889
申请日：1995-02-24
申请人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： C12N916
CPC分类号： C07K16/40 , C12N9/22 , C12Q1/44 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌DNase B的基因，并且已经使用掺入克隆DNA的载体来转化大肠杆菌，从而能够在大肠杆菌中高效快速地生产DNA酶，而不需要生长大量的化脓性链球菌。该酶可以在其氨基末端用前导肽产生。还提供了用于纯化天然存在的化脓性链球菌DNA酶B酶的改进方法。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在化脓性链球菌。

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