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1. 发明授权

US4278660A Complex or salt of a platinum (II) compound and a nitrogen containing polymer 失效
标题翻译：铂（II）化合物和含氮聚合物的络合物或盐
公开(公告)号：US4278660A
公开(公告)日：1981-07-14
申请号：US958976
申请日：1978-11-09
申请人： Harry R. Allcock , Robert W. Allen , John P. O'Brien
发明人： Harry R. Allcock , Robert W. Allen , John P. O'Brien
IPC分类号： C07F15/00 , A61K31/74 , A61K31/28 , A61K31/555
CPC分类号： C07F15/0093
摘要： A cis- complex or -salt of a square planar platinum compound and a nitrogen containing oligomer or polymer prepared by reacting a platinum (II) compound with a nitrogen containing oligomer or polymer in an organic solvent or an acidic aqueous medium, said complex or salt being useful for treating animal malignant tumor cells sensitive to cis-square planar platinum compounds.
摘要翻译：通过在有机溶剂或酸性水性介质中使铂（II）化合物与含氮低聚物或聚合物反应而制备的正方形平面铂化合物和含氮低聚物或聚合物的顺 - 络合物或盐，所述络合物或盐可用于治疗对顺式平面铂化合物敏感的动物恶性肿瘤细胞。

2. 发明授权

US4151185A Complex or salt of a platinum (II) compound and a nitrogen containing polymer 失效
标题翻译：铂（II）化合物和含氮聚合物的络合物或盐
公开(公告)号：US4151185A
公开(公告)日：1979-04-24
申请号：US792608
申请日：1977-05-02
申请人： Harry R. Allcock , Robert W. Allen , John P. O'Brien
发明人： Harry R. Allcock , Robert W. Allen , John P. O'Brien
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： A cis- complex or -salt of a square planar platinum compound and a nitrogen containing oligomer or polymer prepared by reacting a platinum (II) compound with a nitrogen containing oligomer or polymer in an organic solvent or an acidic aqueous medium, said complex or salt being useful as an anti-cancer agent.
摘要翻译：通过在有机溶剂或酸性水性介质中使铂（II）化合物与含氮低聚物或聚合物反应而制备的正方形平面铂化合物和含氮低聚物或聚合物的顺 - 络合物或盐，所述络合物或盐作为抗癌剂有用。

3. 发明授权

US4288585A Carboranylcyclotriphosphazenes and their polymers 失效
标题翻译：碳硼烷基环三磷腈及其聚合物
公开(公告)号：US4288585A
公开(公告)日：1981-09-08
申请号：US129799
申请日：1980-03-12
申请人： Robert A. Administrator of the National Aeronatuics and Space Administration, with respect to an invention of Frosch , Harry R. Allcock , John P. O'Brien , Angelo G. Scopelianos , Larry L. Fewell
发明人： Robert A. Administrator of the National Aeronatuics and Space Administration, with respect to an invention of Frosch , Harry R. Allcock , John P. O'Brien , Angelo G. Scopelianos , Larry L. Fewell
IPC分类号： C08G79/02 , C08G73/00
CPC分类号： C08G79/025
摘要： Carboranyl-substituted polyphosphazenes are prepared by heat polymerizing a carboranyl halocyclophosphazene at 250.degree. C. for about 120 hours in the absence of oxygen and moisture. The cyclophosphazene is obtained by allowing a lithium carborane, e.g. the reaction product of methyl-o-carborane with n-butyllithium in ethyl ether, to react with e.g. hexachlorocyclotriphosphazene at ambient temperatures and in anhydrous conditions. For greater stability in the presence of moisture, the chlorine substituents of the polymer are then replaced by aryloxy or alkoxy groups, such as CF.sub.3 CH.sub.2 O--.The new substantially inorganic polymers are thermally stable materials which produce a high char yield when exposed to extreme temperatures, and can thus serve to insulate less heat and fire resistant substances.
摘要翻译：碳硼烷基取代的聚磷腈通过在250℃下在不存在氧和水分的情况下将碳硼烷基卤代环磷腈加热聚合约120小时来制备。环磷腈是通过使碳二亚硼酸锂，甲基邻碳硼烷与正丁基锂在乙醚中的反应产物，六氯环三磷腈在环境温度和无水条件下。为了在存在水分的情况下获得更大的稳定性，聚合物的氯取代基然后被芳氧基或烷氧基取代，例如CF 3 CH 2 O-。新的基本上无机的聚合物是热稳定的材料，当暴露在极端温度下时产生高的焦炭产率，并且因此可以用来绝热较少的耐热和耐火物质。

4. 发明授权

US4276403A Process for the preparation of polycarboranylphosphazenes 失效
标题翻译：制备聚碳硼烷基磷腈的方法
公开(公告)号：US4276403A
公开(公告)日：1981-06-30
申请号：US129798
申请日：1980-03-12
申请人： Robert A. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Frosch , Harry R. Allcock , John P. O'Brien , Angelo G. Scopelianos , Larry L. Fewell
发明人： Robert A. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Frosch , Harry R. Allcock , John P. O'Brien , Angelo G. Scopelianos , Larry L. Fewell
IPC分类号： C08G79/02 , C08G73/00
CPC分类号： C08G79/025
摘要： Polydihalophosphazenes, e.g. --N.dbd.P(Cl).sub.2 ].sub.n, are allowed to react at ambient temperatures for at least one hour with a lithium carborane in a suitable inert solvent. The remaining chlorine substituents of the carboranyl polyphosphazene are then replaced with aryloxy or alkoxy groups to enhance moisture resistance. The polymers give a high char yield when exposed to extreme heat and flame and can be used as insulation.
摘要翻译：聚二卤代磷腈，例如 -N = P（Cl）2] n在环境温度下与碳化硼锂在合适的惰性溶剂中反应至少1小时。然后用芳氧基或烷氧基代替碳硼烷基聚磷腈的剩余氯取代基，以增强耐湿性。当暴露于极热和火焰时，聚合物具有高的焦炭产率，可用作绝缘体。

5. 发明授权

US08318659B2 Peptide-based organic sunscreens 失效
标题翻译：基于肽的有机防晒剂
公开(公告)号：US08318659B2
公开(公告)日：2012-11-27
申请号：US11590717
申请日：2006-10-31
申请人： David J. Lowe , John P. O'Brien , Antoinette E. Wilkins
发明人： David J. Lowe , John P. O'Brien , Antoinette E. Wilkins
IPC分类号： A61K38/00 , A61K38/04 , A61K8/00 , A61K8/18 , A61K8/64 , A61K8/65 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/64 , A61K2800/57 , C07K7/06 , C07K7/08
摘要： Peptide-based organic sunscreens, formed by coupling a skin-binding peptide with an organic sunscreen agent, are described. The skin-binding peptide part of the peptide-based organic sunscreen binds strongly to the skin, thus keeping the organic sunscreen agent attached to the skin for long lasting protection. Sunscreen compositions comprising the peptide-based organic sunscreens are also provided.
摘要翻译：描述了通过将皮肤结合肽与有机防晒剂偶联形成的肽类有机防晒剂。基于肽的有机防晒剂的皮肤结合肽部分强烈地与皮肤结合，从而保持有机防晒剂附着在皮肤上以获得持久的保护。还提供了包含基于肽的有机防晒剂的防晒组合物。

6. 发明申请

US20120073886A1 ROBOTIC VEHICLE 有权
标题翻译：机动车
公开(公告)号：US20120073886A1
公开(公告)日：2012-03-29
申请号：US12838824
申请日：2010-07-19
申请人： Adam P. Couture , Richard Page , John P. O'Brien , Mikhail Filippov
发明人： Adam P. Couture , Richard Page , John P. O'Brien , Mikhail Filippov
IPC分类号： B62D55/075 , B60L11/18
CPC分类号： B25J5/005 , B62D25/2054 , B62D55/065 , B62D55/0655
摘要： A robotic vehicle is disclosed, which is characterized by high mobility, adaptability, and the capability of being remotely controlled in hazardous environments. The robotic vehicle includes a chassis having front and rear ends and supported on right and left driven tracks. Right and left elongated flippers are disposed on corresponding sides of the chassis and operable to pivot. A linkage connects a payload deck, configured to support a removable functional payload, to the chassis. The linkage has a first end rotatably connected to the chassis at a first pivot, and a second end rotatably connected to the deck at a second pivot. Both of the first and second pivots include independently controllable pivot drivers operable to rotatably position their corresponding pivots to control both fore-aft position and pitch orientation of the payload deck with respect to the chassis.
摘要翻译：公开了一种机动车辆，其特征在于高度的移动性，适应性以及在危险环境中被远程控制的能力。机器人车辆包括具有前端和后端并支撑在右和左驱动轨道上的底盘。右和左细长鳍状物设置在底盘的相应侧上并可操作以枢转。一个链接将一个配置成支持可移动功能有效载荷的有效载荷甲板连接到机箱。联动装置具有在第一枢轴处可转动地连接到底盘的第一端，以及在第二枢轴处可旋转地连接到甲板的第二端。第一枢轴和第二枢轴都包括可独立控制的枢转驱动器，其可操作以可旋转地定位其对应的枢轴以控制有效载荷甲板相对于底盘的前后位置和俯仰方位。

7. 发明授权

US07964180B2 Method for enhancing effects of colorants and conditioners 有权
标题翻译：增强着色剂和调理剂效果的方法
公开(公告)号：US07964180B2
公开(公告)日：2011-06-21
申请号：US12754630
申请日：2010-04-06
申请人： William A. Beck , John P. O'Brien , Hong Wang
发明人： William A. Beck , John P. O'Brien , Hong Wang
IPC分类号： A61Q5/12
CPC分类号： A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q5/10 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/04 , C07K2319/00
摘要： Methods are provided for enhancing the longevity of the binding of various benefit agents to hair and skin. Applications of traditional and non-traditional colorants and conditioners to hair and skin are amended with compositions of hair or skin-binding peptides respectively. The presence of the hair or skin-binding peptide compositions act to increase the longevity of the applied colorant or conditioner on the hair or skin.
摘要翻译：提供了用于增强各种有益剂与头发和皮肤结合的寿命的方法。传统和非传统着色剂和调理剂对毛发和皮肤的应用分别用头发或皮肤结合肽的组合物修饰。头发或皮肤结合肽组合物的存在用于增加所施用的着色剂或护发素在头发或皮肤上的寿命。

8. 发明申请

US20110052508A1 PEPTIDE-BASED ORAL CARE SURFACE REAGENTS FOR PERSONAL CARE 失效
标题翻译：基于肽的口腔护理面部个人护理试剂
公开(公告)号：US20110052508A1
公开(公告)日：2011-03-03
申请号：US12853436
申请日：2010-08-10
申请人： Xueying Huang , John P. O'Brien , Hong Wang
发明人： Xueying Huang , John P. O'Brien , Hong Wang
IPC分类号： A61K8/21 , C07K7/08 , C07K14/00 , C07K7/06 , A61K8/64 , A61Q11/00 , C12N9/96 , B82Y5/00
CPC分类号： A61K8/29 , A61K8/64 , A61K2800/413 , A61K2800/42 , A61K2800/57 , A61K2800/94 , A61Q1/02 , A61Q1/10 , A61Q3/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/04 , B82Y5/00 , C07K7/06 , C07K7/08
摘要： Peptides have been identified that bind to oral surfaces such as teeth and gums. Peptide based oral care reagents have been created by couple such peptides to oral care benefit agents such as whiteners.
摘要翻译：已经鉴定了结合口腔表面如牙齿和牙龈的肽。基于肽的口腔护理试剂已经通过将这些肽与口腔护理有益剂如增白剂相结合而形成。

9. 发明授权

US07858581B2 PMMA binding peptides and methods of use 有权
标题翻译： PMMA结合肽及其使用方法
公开(公告)号：US07858581B2
公开(公告)日：2010-12-28
申请号：US11607732
申请日：2006-12-01
申请人： Scott D. Cunningham , David J. Lowe , John P. O'Brien , Hong Wang , Antoinette E. Wilkins
发明人： Scott D. Cunningham , David J. Lowe , John P. O'Brien , Hong Wang , Antoinette E. Wilkins
IPC分类号： A61K38/02 , C10M145/14
CPC分类号： C07K7/08 , C07K7/06 , C07K14/001
摘要： Combinatorially generated peptides are provided that have binding affinity for polymethylmethacrylate (PMMA). The peptides may be used to deliver benefit agents to various PMMA surfaces.
摘要翻译：提供了对聚甲基丙烯酸甲酯（PMMA）具有结合亲和力的组合产生的肽。肽可以用于将有益剂递送到各种PMMA表面。

10. 发明授权

US07807141B2 Peptide-based oral care surface reagents for personal care 有权
标题翻译：用于个人护理的基于肽的口腔护理表面试剂
公开(公告)号：US07807141B2
公开(公告)日：2010-10-05
申请号：US11971975
申请日：2008-01-10
申请人： Xueying Huang , John P. O'Brien , Hong Wang
发明人： Xueying Huang , John P. O'Brien , Hong Wang
IPC分类号： A61K8/64 , A61K11/00 , C07K7/08
CPC分类号： A61K8/29 , A61K8/64 , A61K2800/413 , A61K2800/42 , A61K2800/57 , A61K2800/94 , A61Q1/02 , A61Q1/10 , A61Q3/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/04 , B82Y5/00 , C07K7/06 , C07K7/08
摘要： Peptides have been identified that bind to oral surfaces such as teeth and gums. Peptide based oral care reagents have been created by couple such peptides to oral care benefit agents such as whiteners.
摘要翻译：已经鉴定了结合口腔表面如牙齿和牙龈的肽。基于肽的口腔护理试剂已经通过将这些肽与口腔护理有益剂如增白剂相结合而形成。

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