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1. 发明申请

US20110076395A1 METHOD FOR IMPARTING TOPICAL HOLOGRAPHIC EFFECT TO A POLYMERIC FILM SUBSTRATE 审中-公开
标题翻译：用于将局部全息影响的方法用于聚合薄膜基底
公开(公告)号：US20110076395A1
公开(公告)日：2011-03-31
申请号：US12889568
申请日：2010-09-24
申请人： Haiyan Sun , Jing Zhang
发明人： Haiyan Sun , Jing Zhang
IPC分类号： B05D5/06
CPC分类号： G03H1/0236 , G03H1/0011 , G03H1/0244 , G03H1/0252 , G03H2001/184 , G03H2001/187 , G03H2210/54 , G03H2250/40 , G03H2250/42
摘要： A method for imparting topical holographic effect to a polymeric film substrate comprising a first surface and a second surface. The method comprises the steps of embossing the first surface of the polymeric film substrate to impart a holographic effect to the polymeric film substrate; and printing the embossed first surface of the polymeric film substrate with ink and/or varnish on selected area which is intended not to have holographic effect and leaving the unprinted embossed area to provide a holographic effect.
摘要翻译：一种赋予包括第一表面和第二表面的聚合物薄膜基材的局部全息效应的方法。该方法包括以下步骤：将聚合物膜基材的第一表面压花以赋予聚合物膜基材全息效应; 以及在预期不具有全息效应的选定区域上用油墨和/或清漆印刷聚合物膜基材的压花的第一表面，并留下未印刷的压花区域以提供全息效果。

2. 发明申请

US20130040331A1 LABEL-FREE METHODS RELATED TO hERG POTASSIUM ION CHANNELS 审中-公开
标题翻译：与无机磷离子通道相关的无标记方法
公开(公告)号：US20130040331A1
公开(公告)日：2013-02-14
申请号：US13519246
申请日：2010-12-16
申请人： Ye Fang , Haiyan Sun
发明人： Ye Fang , Haiyan Sun
IPC分类号： C12Q1/02 , G01N27/26
CPC分类号： G01N33/6872 , G01N2500/10
摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.
摘要翻译：公开了使用无标记生物传感器分类人类醚转运相关基因（hERG）离子通道调节剂的方法。公开了使用无标记谐振波导光栅（RWG）生物传感器来显示三种类型的细胞系（内源性表达hERG的天然细胞系，没有hERG的天然细胞系的天然细胞系及其工程化的hERG调节剂的DMR信号的模式细胞系稳定表达hERG），以及调节剂分子对作用于一组标志物/细胞的hERG激活剂的相应调节指数，特别是两种hERG表达细胞系中已知的hERG活化剂mallotoxin DMR信号。

3. 发明公开

US20240150441A1 MONOCLONAL ANTIBODIES AGAINST SARS-COV-2 AND VARIANTS 审中-公开
公开(公告)号：US20240150441A1
公开(公告)日：2024-05-09
申请号：US18500684
申请日：2023-11-02
申请人： Qiang Chen , Haiyan Sun , Collin Jugler
发明人： Qiang Chen , Haiyan Sun , Collin Jugler
IPC分类号： C07K16/10 , A01H6/82 , A61P31/14 , C12N15/63
CPC分类号： C07K16/1003 , A01H6/823 , A61P31/14 , C12N15/63 , C07K2317/14
摘要： The present invention provides monoclonal antibodies against SARS-CoV-2 and methods of use and making thereof.

4. 发明申请

US20120289432A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，RHO激酶调节剂及其鉴定和使用方法
公开(公告)号：US20120289432A1
公开(公告)日：2012-11-15
申请号：US13519271
申请日：2010-12-16
申请人： Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Haiyan Sun , Elizabeth Tran
发明人： Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Haiyan Sun , Elizabeth Tran
IPC分类号： C12Q1/48 , C40B30/06 , G01N21/41
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
摘要翻译：公开了使用无标记细胞测定来表征PI3K抑制剂和Rho激酶抑制剂的方法。还公开了表征细胞是否具有失去PI3K通路的方法。

5. 发明授权

US08179132B2 Method and system for integrating eddy current inspection with a coordinate measuring device 有权
标题翻译：将涡流检测与坐标测量装置集成的方法和系统
公开(公告)号：US08179132B2
公开(公告)日：2012-05-15
申请号：US12372881
申请日：2009-02-18
申请人： Yanyan Wu , Thomas James Batzinger , Nicholas Joseph Kray , Changting Wang , Haiyan Sun , Francis Howard Little , David Paul Lappas , David Michael Dombrowski
发明人： Yanyan Wu , Thomas James Batzinger , Nicholas Joseph Kray , Changting Wang , Haiyan Sun , Francis Howard Little , David Paul Lappas , David Michael Dombrowski
IPC分类号： G01N27/82
CPC分类号： G01B7/008 , G01B7/28 , G01N27/90 , G01N27/9046
摘要： A method for integrating a measurement device for use in measuring a machine component includes providing a coordinate measuring machine (CMM) and combining eddy current (EC) capabilities and CMM capabilities to form an inspection probe. The method further includes installing the inspection probe on the CMM so that the inspection probe measures external boundaries of the machine component with the CMM capabilities and substantially simultaneously measures at least one of internal boundaries, internal defects, surface defects, and material properties of the machine component with the EC capabilities, which are directly linked to actual component dimensional information provided by CMM. The inspection data can be simultaneously linked to and/or displayed with a CAD model to enable a direct comparison between the inspection data and the nominal requirements specified on the CAD model.
摘要翻译：用于集成用于测量机器部件的测量装置的方法包括提供坐标测量机（CMM）并组合涡流（EC）能力和CMM能力以形成检查探针。该方法还包括将检查探针安装在CMM上，使得检查探针以CMM能力测量机器部件的外部边界，并且基本上同时测量机器的内部边界，内部缺陷，表面缺陷和材料特性中的至少一个具有EC功能的组件，其直接与CMM提供的实际组件尺寸信息相关联。检查数据可以与CAD模型同时链接和/或显示，以便能够直接比较检验数据和CAD模型上规定的标称要求。

6. 发明申请

US20220298211A1 PLANT-PRODUCED mABs AGAINST CHIKUNGUNYA VIRUS WITH ENHANCED EFFECTOR FUNCTION AND EFFICACY 有权
公开(公告)号：US20220298211A1
公开(公告)日：2022-09-22
申请号：US17615803
申请日：2020-06-04
申请人： Qiang Chen , Jonathan Hurtado , Haiyan Sun , Huafang Lai
发明人： Qiang Chen , Jonathan Hurtado , Haiyan Sun , Huafang Lai
IPC分类号： C07K14/415 , C07K16/10 , C12N15/82
摘要： Disclosed are monoclonal antibodies against Chikungunya virus having enhanced effector function and efficacy, methods of producing them, and methods of treatment of Chikungunya viral infection using the antibodies.

7. 发明授权

US08962880B2 Amorphous asiatic tromethamine salt and preparation method thereof 有权
标题翻译：无定形亚洲氨丁三醇盐及其制备方法
公开(公告)号：US08962880B2
公开(公告)日：2015-02-24
申请号：US14006198
申请日：2012-03-21
申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
发明人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
IPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/00
CPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/008
摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
摘要翻译：一种无定形亚洲氨丁三醇盐及其制备方法。该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

8. 发明申请

US20130030742A1 METHOD AND SYSTEM FOR MONITORING A SYNCHRONOUS MACHINE 审中-公开
标题翻译：同步机监控方法与系统
公开(公告)号：US20130030742A1
公开(公告)日：2013-01-31
申请号：US13558890
申请日：2012-07-26
申请人： Arijit Banerjee , Somakumar Ramachandrapanicker , Haiyan Sun , Subhra Samanta , Srinivas Satya Sai Mallampalli
发明人： Arijit Banerjee , Somakumar Ramachandrapanicker , Haiyan Sun , Subhra Samanta , Srinivas Satya Sai Mallampalli
IPC分类号： G01R23/02 , G01R23/14 , G06F19/00
CPC分类号： G01R31/343
摘要： A method for monitoring a synchronous machine is described. The method includes injecting a narrowband sinusoidal signal at a first end of a field winding of the synchronous machine. The method further includes monitoring a voltage at a second end of the field winding with respect to ground. The method then identifies a resonant frequency based on the monitored voltage, and generates a winding health indicator based on the identified resonant frequency and an expected resonant frequency.
摘要翻译：描述了一种监视同步电机的方法。该方法包括在同步电机的励磁绕组的第一端处注入窄带正弦信号。该方法还包括监测场绕组相对于地的第二端的电压。该方法然后基于所监视的电压识别谐振频率，并且基于所识别的谐振频率和期望的谐振频率来生成绕组健康指示器。

9. 发明申请

US20120295965A1 FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：作为EGFR / VEGFR的双重抑制剂的FUSED THIOPHENES及其在治疗癌症中的用途
公开(公告)号：US20120295965A1
公开(公告)日：2012-11-22
申请号：US13519431
申请日：2010-12-16
申请人： Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Mingqian He , Weijun Niu , Haiyan Sun , Elizabeth Tran , Ying Wei
发明人： Huayun Deng , Ye Fang , Ann MeeJin Ferrie , Mingqian He , Weijun Niu , Haiyan Sun , Elizabeth Tran , Ying Wei
IPC分类号： A61K31/381 , G01N21/55 , A61P35/00 , C07D495/04 , C07D495/14
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

10. 发明申请

US20110246078A1 MITOCHONDRIA KATP ION CHANNEL AS A DRUG TARGET FOR PREVENTING LIVER DISEASES AND METHODS TO SCREEN MITOCHONDRIA KATP MODULATORS 审中-公开
标题翻译： MITOCHONDRIA KATP离子通道作为预防肝脏疾病的药物目标和筛选MITOCHONDRIA KATP调节剂的方法
公开(公告)号：US20110246078A1
公开(公告)日：2011-10-06
申请号：US13069987
申请日：2011-03-23
申请人： Ye Fang , Joydeep Lahiri , Haiyan Sun , Ying Wei
发明人： Ye Fang , Joydeep Lahiri , Haiyan Sun , Ying Wei
IPC分类号： G06F19/00
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of KATP channels and methods of treating liver disorders by modulating KATP and mito-KATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

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