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1. 发明授权

US5639277A Embolic coils with offset helical and twisted helical shapes 失效
标题翻译：具有偏移螺旋和扭曲螺旋形状的栓塞线圈
公开(公告)号：US5639277A
公开(公告)日：1997-06-17
申请号：US538557
申请日：1995-09-29
申请人： Michael J. Mariant , Gregory E. Mirigian , Nga T. Van , Roberto L. Orellana , Christopher G. M. Ken
发明人： Michael J. Mariant , Gregory E. Mirigian , Nga T. Van , Roberto L. Orellana , Christopher G. M. Ken
IPC分类号： A61M25/00 , A61B17/12 , A61F2/82 , A61L27/00 , F16F1/04 , A61M29/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12109 , A61B17/12145 , F16F1/04
摘要： This is a surgical device that, in particular, is for forming a vasoocclusion or embolism. Typically, it is a helically wound coil in which the helix is wound in such a way as to have multiple axially offset, longitudinal or focal axes. Another important facet of the invention is the presence of small diameter secondary coil windings adjacent large diameter coil windings. The device is sufficiently flexible and small that it may be delivered to a site within the vasculature of the human body using a pusher and a catheter. The device is generally linear when within the catheter but relaxes to form the multi-focal form after delivery from the distal end of the catheter lumen. Various mechanical connections may also be used to discharge the inventive coil from its pusher. Similarly, the coil may be attached to a pusher using a sacrificial joint, which sacrificial joint is dissolved by imposition of a small voltage within the human body. The device may be used alone or in conjunction with other coils or with a fibrous thrombotic attachments or the substrate to localize subsequent infusion of tissue adhesives, other particulate embolization devices, or chemotherapeutic agents in abnormal blood vessels and tissues.
摘要翻译：这是一种手术装置，特别是用于形成血栓栓塞或栓塞。通常，它是螺旋缠绕的线圈，其中螺旋线被卷绕成具有多个轴向偏移的纵向或焦点轴线。本发明的另一个重要方面是存在与大直径线圈绕组相邻的小直径次级线圈绕组。该装置具有足够的柔性和小度，使得其可以使用推动器和导管将其输送到人体脉管系统内的部位。该装置在导管内通常是线性的，但是在从导管腔的远端递送之后松弛以形成多焦点形式。也可以使用各种机械连接来从其推动器排出本发明的线圈。类似地，线圈可以使用牺牲接头附接到推动器，该牺牲接头通过在人体内施加小的电压而被溶解。该装置可以单独使用或与其它线圈一起使用，或与纤维性血栓形成附着物或基质一起使用，以便将异常血管和组织中的组织粘合剂，其它颗粒栓塞装置或化学治疗剂的随后输注定位。

2. 发明授权

US5549624A Fibered vasooclusion coils 失效
标题翻译：纤维血管闭塞线圈
公开(公告)号：US5549624A
公开(公告)日：1996-08-27
申请号：US265188
申请日：1994-06-24
申请人： Gregory E. Mirigian , Nga T. Van
发明人： Gregory E. Mirigian , Nga T. Van
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/1215
摘要： This invention is a vasoocclusive device. It is placed in the vasculature of an animal to form thrombus in a selected site such as an aneurysm or AVM. The device uses a central coil having thrombogenic fibers placed on the coil in a specified fashion. The coil will pass through the lumen of a vascular catheter and form a convolution when ejected from the catheter's distal end. The fibers are attached to the coil and cooperate with the coil so that upon ejection from the catheter, the convoluted coil forms a shape in which the central region contains the majority of these fibers.
摘要翻译：本发明是血管闭塞装置。将其置于动物的脉管系统中，以在选定的部位如动脉瘤或AVM中形成血栓。该装置使用具有以特定方式放置在线圈上的血栓形成纤维的中心线圈。线圈将穿过血管导管的内腔，并在从导管的远端喷射时形成卷积。纤维连接到线圈并与线圈配合，使得当从导管喷射时，卷积的线圈形成中心区域包含大多数这些纤维的形状。

3. 发明授权

US08048060B2 Medical device 有权
标题翻译：医疗装置
公开(公告)号：US08048060B2
公开(公告)日：2011-11-01
申请号：US11505119
申请日：2006-08-16
申请人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
发明人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译：一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

4. 发明申请

US20090177261A1 Detachment mechanisms for implantable devices 审中-公开
标题翻译：可植入装置的分离机构
公开(公告)号：US20090177261A1
公开(公告)日：2009-07-09
申请号：US12319255
申请日：2009-01-05
申请人： Clifford Teoh , Michael Williams , Gregory E. Mirigian , Kirsten Carroll , James M. Anderson , Jay Rassat , Benjamin Arcand , Derek Sutermeister
发明人： Clifford Teoh , Michael Williams , Gregory E. Mirigian , Kirsten Carroll , James M. Anderson , Jay Rassat , Benjamin Arcand , Derek Sutermeister
IPC分类号： A61M29/00 , A61F2/06 , A61B19/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209
摘要： Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.
摘要翻译：本文公开了一种用于血管闭塞装置的分离机构，其允许快速操作者控制将血管闭塞装置释放到选定部位。还公开了包括这些分离机构的血管闭塞组件和使用这些分离机构和血管闭塞组件的方法。

5. 发明授权

US08277438B2 Guide catheter with removable support 有权
标题翻译：导管带可移动支撑
公开(公告)号：US08277438B2
公开(公告)日：2012-10-02
申请号：US12797374
申请日：2010-06-09
申请人： Stephen Griffin , Gregory E. Mirigian
发明人： Stephen Griffin , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/104 , A61M2025/0004 , A61M2025/0059 , A61M2025/0681
摘要： Catheters such as guide catheters can be configured for delivery of devices to vasculature portions such as intracranial spaces while retaining a desired level of flexibility. A catheter having an elongate shaft can include removable support means that can provide column support to the elongate shaft. The elongate shaft can include anchoring means that releasably secure the removable support means. The catheter can be deployed within a patient's vasculature, followed by deploying the removable support means.
摘要翻译：诸如引导导管的导管可以被配置为将装置输送到脉管系部分，例如颅内空间，同时保持期望的柔性水平。具有细长轴的导管可以包括可移除的支撑装置，其可以向细长轴提供柱支撑。细长轴可以包括可释放地固定可移除支撑装置的锚固装置。导管可以部署在患者的脉管系统内，随后部署可移除的支撑装置。

6. 发明授权

US07918806B2 Guide wire with adjustable flexibility 有权
标题翻译：导丝可调节灵活
公开(公告)号：US07918806B2
公开(公告)日：2011-04-05
申请号：US11352753
申请日：2006-02-13
申请人： Stephen Griffin , Gregory E. Mirigian
发明人： Stephen Griffin , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/0915 , A61M2025/09175
摘要： A guide wire with a distal portion having adjustable flexibility. The guide wire may include a distal polymeric member and a heat source. The heat source may be activated to cause the polymeric member to increase in temperature and increase in flexibility. The increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate tortuous vasculature to a target site. After the guide wire has been navigated to the target site, the heat source may be deactivated to cause the polymeric member to decrease in temperature and increase in stiffness. The increase in stiffness of the distal portion of the guide wire enhances support provided for devices (e.g., catheters) advanced thereon.
摘要翻译：导丝，其具有可调节的柔性的远端部分。导丝可以包括远端聚合物构件和热源。可以激活热源以使聚合物部件的温度升高并且柔性增加。引导线的远端部分的柔性的增加增强了引导线将弯曲脉管系统导航到目标部位的能力。在引导线已经导航到目标部位之后，热源可以被去活，以使聚合物部件降低温度并增加刚度。引导线的远端部分的刚度的增加增强了对在其上推进的装置（例如，导管）提供的支撑。

7. 发明授权

US08636716B2 Medical device 有权
标题翻译：医疗装置
公开(公告)号：US08636716B2
公开(公告)日：2014-01-28
申请号：US13477755
申请日：2012-05-22
申请人： Stephen A. Griffin , Elaine Lim , Gregory E. Mirigian
发明人： Stephen A. Griffin , Elaine Lim , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译：一种医疗装置，包括具有细长内部构件的轴和设置在所述内部构件的至少一部分上的细长管状加强构件。在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

8. 发明授权

US08182465B2 Medical device 有权
标题翻译：医疗装置
公开(公告)号：US08182465B2
公开(公告)日：2012-05-22
申请号：US12470261
申请日：2009-05-21
申请人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
发明人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译：一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。

9. 发明授权

US07989042B2 Medical devices with highly flexible coated hypotube 有权
标题翻译：具有高柔性涂层海波管的医疗设备
公开(公告)号：US07989042B2
公开(公告)日：2011-08-02
申请号：US10996976
申请日：2004-11-24
申请人： Robert Z. Obara , Gregory E. Mirigian , Huey Quoc Chan , John E. Ortiz , Stephen Griffin
发明人： Robert Z. Obara , Gregory E. Mirigian , Huey Quoc Chan , John E. Ortiz , Stephen Griffin
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61L29/14 , A61L29/085 , Y10T428/1321 , Y10T428/1352 , Y10T428/139 , Y10T428/2913
摘要： Hypotubes such as micromachined hypotubes can include one or more tie layers appropriate for subsequent application of a hydrophilic coating. In particular, a medical device may include a micromachined hypotube having a level of flexibility and a tie layer disposed over the hypotube such that the medical device has a level of flexibility at least substantially equivalent to the level of flexibility of the hypotube.
摘要翻译：诸如微加工的海波管之类的低管可以包括适于随后应用亲水涂层的一个或多个连接层。特别地，医疗装置可以包括具有柔性水平的微加工海波管和设置在海波管上方的连接层，使得医疗装置具有至少基本上等于海波管的柔性水平的柔性水平。

10. 发明授权

US07771369B2 Guide catheter with removable support 有权
标题翻译：导管带可移动支撑
公开(公告)号：US07771369B2
公开(公告)日：2010-08-10
申请号：US10729742
申请日：2003-12-05
申请人： Stephen Griffin , Gregory E. Mirigian
发明人： Stephen Griffin , Gregory E. Mirigian
IPC分类号： A61M25/00 , A61M25/098
CPC分类号： A61M25/01 , A61M25/104 , A61M2025/0004 , A61M2025/0059 , A61M2025/0681
摘要： Catheters such as guide catheters can be configured for delivery of devices to vasculature portions such as intracranial spaces while retaining a desired level of flexibility. A catheter having an elongate shaft can include removable support means that can provide column support to the elongate shaft. The elongate shaft can include anchoring means that releasably secure the removable support means. The catheter can be deployed within a patient's vasculature, followed by deploying the removable support means.
摘要翻译：诸如引导导管的导管可以被配置为将装置输送到脉管系部分，例如颅内空间，同时保持期望的柔性水平。具有细长轴的导管可以包括可移除的支撑装置，其可以向细长轴提供柱支撑。细长轴可以包括可释放地固定可移除支撑装置的锚固装置。导管可以部署在患者的脉管系统内，随后部署可移除的支撑装置。

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