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1. 发明授权

US5688672A Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids 失效
标题翻译：以2-羟基-3-噻吩基丙烯酸为对映体纯形式生物技术制备L-噻吩丙氨酸的方法
公开(公告)号：US5688672A
公开(公告)日：1997-11-18
申请号：US460873
申请日：1995-06-05
申请人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
发明人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
IPC分类号： C07D233/64 , C07D333/24 , C07D333/28 , C07D333/42 , C07D409/06 , C07K1/00 , C12P13/04 , C12P13/06 , C12P17/00 , C12R1/01 , C12R1/19 , C12N9/10
CPC分类号： C07D409/06 , C07D333/24 , C07D333/28 , C07D333/42 , C12P13/04 , C12P17/00 , Y10S435/829 , Y10S435/849 , Y10S435/875 , Y10S435/88 , Y10S435/886 , Y10S435/898
摘要： Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
摘要翻译：通过2-羟基-3-噻吩基丙烯酸以对映体纯的形式生物技术制备L-噻吩丙氨酸的方法L-噻吩丙氨酸通过乙内酰脲或吖内酯途径制备。用于生物转化的起始物质是2-羟基-3-噻吩基丙烯酸。创新的步骤在于2-羟基-3-噻吩基丙烯酸的烯醇形式的转氨基化，借助于生物转化得到L-噻吩基丙氨酸。转氨酶在L-天冬氨酸或L-谷氨酸作氨基供体存在下进行。

2. 发明授权

US5780640A Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids and their use 失效
标题翻译：以2-羟基-3-噻吩基丙烯酸为对映体纯形式生物技术制备L-噻吩丙氨酸的方法及其用途
公开(公告)号：US5780640A
公开(公告)日：1998-07-14
申请号：US465311
申请日：1995-06-05
申请人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
发明人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
IPC分类号： C07D233/64 , C07D333/24 , C07D333/28 , C07D333/42 , C07D409/06 , C07K1/00 , C12P13/04 , C12P13/06 , C12P17/00 , C12R1/01 , C12R1/19 , C07D239/10 , C07D333/04
CPC分类号： C07D409/06 , C07D333/24 , C07D333/28 , C07D333/42 , C12P13/04 , C12P17/00 , Y10S435/829 , Y10S435/849 , Y10S435/875 , Y10S435/88 , Y10S435/886 , Y10S435/898
摘要： Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use. L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
摘要翻译：从2-羟基-3-噻吩基丙烯酸以对映异构体纯形式生物技术制备L-噻吩丙氨酸的方法及其应用。通过乙内酰脲或吖内酯途径制备L-噻吩丙氨酸。用于生物转化的起始物质是2-羟基-3-噻吩基丙烯酸。创新的步骤在于2-羟基-3-噻吩基丙烯酸的烯醇形式的转氨基化，借助于生物转化得到L-噻吩基丙氨酸。转氨酶在L-天冬氨酸或L-谷氨酸作氨基供体存在下进行。

3. 发明授权

US5480786A Process for the biotechnological preparation of l-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use 失效
标题翻译：从2-羟基-3-噻吩基丙烯酸以对映异构体纯形式生物技术制备1-噻吩丙氨酸的方法及其用途
公开(公告)号：US5480786A
公开(公告)日：1996-01-02
申请号：US99352
申请日：1993-07-29
申请人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
发明人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
IPC分类号： C07D233/64 , C07D333/24 , C07D333/28 , C07D333/42 , C07D409/06 , C07K1/00 , C12P13/04 , C12P13/06 , C12P17/00 , C12R1/01 , C12R1/19 , C12N9/10
CPC分类号： C07D409/06 , C07D333/24 , C07D333/28 , C07D333/42 , C12P13/04 , C12P17/00 , Y10S435/829 , Y10S435/849 , Y10S435/875 , Y10S435/88 , Y10S435/886 , Y10S435/898
摘要： L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
摘要翻译：通过乙内酰脲或吖内酯途径制备L-噻吩丙氨酸。用于生物转化的起始物质是2-羟基-3-噻吩基丙烯酸。创新的步骤在于2-羟基-3-噻吩基丙烯酸的烯醇形式的转氨基化，借助于生物转化得到L-噻吩基丙氨酸。转氨酶在L-天冬氨酸或L-谷氨酸作氨基供体存在下进行。

4. 发明授权

US5811539A Process for isolating and purifying nucleotide-activated sugars from biological sources 失效
标题翻译：从生物来源分离和纯化核苷酸活化糖的方法
公开(公告)号：US5811539A
公开(公告)日：1998-09-22
申请号：US520690
申请日：1995-08-30
申请人： Andreas Seiffert-Stoeriko , Brigitte Hoersch , Ruediger Marquardt , Gerhard Kretzschmar , Johannes Meiwes
发明人： Andreas Seiffert-Stoeriko , Brigitte Hoersch , Ruediger Marquardt , Gerhard Kretzschmar , Johannes Meiwes
IPC分类号： C07H1/08 , C07H19/06 , C12P19/30 , C07H19/16
CPC分类号： C12P19/305 , C12P19/30
摘要： The present invention relates to an improved process for isolating and purifying sugar nucleotides, in particular cytidine monophosphate-activated N-acetylneuraminic acid (CMP-Nana), from biological sources. The sugar nucleotides can be obtained from a sugar nucleotide-containing solution, which has been freed of proteins by alcoholic precipitation, by means of an improved column-chromatographic method which uses silica gel as the stationary phase, and at a purity level which requires only a subsequent desalting step to obtain a substantially pure product.
摘要翻译：本发明涉及从生物来源分离和纯化糖核苷酸，特别是胞苷苷一磷酸酯活化的N-乙酰神经氨酸（CMP-Nana）的改进方法。糖核苷酸可以通过使用硅胶作为固定相的改进的柱色谱方法从已经通过酒精沉淀而不含蛋白质的含糖核苷酸的溶液获得，并且纯度仅需要随后的脱盐步骤以获得基本上纯的产物。

5. 发明授权

US06194383B1 Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof 失效
标题翻译：来自动物平面的脂肽具有药理作用，其制备方法及其用途
公开(公告)号：US06194383B1
公开(公告)日：2001-02-27
申请号：US08811843
申请日：1997-03-05
申请人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
发明人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
IPC分类号： A61K3800
CPC分类号： C07K7/60 , A61K38/00 , Y10S435/827
摘要： The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.
摘要翻译：本发明涉及具有非常同源的氨基酸序列但不同脂肪酸残基（脂质部分）的脂肽，其由Actinoplanes sp。在发酵过程中释放到培养基中，从分离来自培养基中的脂肽并纯化它们的方法，使用脂肽作为药理活性物质，特别是抗革兰氏阳性细菌，以及使用Actinoplanes sp。 DSM 7358用于生产上述脂肽。

6. 发明申请

US20060138697A1 Method for producing a throttle valve unit in a two-component injection molding process 有权
标题翻译：用于在双组分注射成型工艺中制造节流阀单元的方法
公开(公告)号：US20060138697A1
公开(公告)日：2006-06-29
申请号：US10562909
申请日：2004-06-15
申请人： Christian Lorenz , Wolfram Hasert , Johannes Meiwes , Wolf-Ingo Ratzel , Jochen Kaesser , Roland Schreiber
发明人： Christian Lorenz , Wolfram Hasert , Johannes Meiwes , Wolf-Ingo Ratzel , Jochen Kaesser , Roland Schreiber
IPC分类号： B29C45/14
CPC分类号： B29C45/0055 , B29C45/0017 , B29C45/16 , B29C45/1618 , B29C45/1671 , B29C45/2628 , B29C45/2708 , B29C45/7207 , B29C2045/14868 , B29C2045/1673 , B29K2995/0039 , B29K2995/0041 , B29L2031/7506 , F02D9/101 , F02D9/1015 , F02D9/1065 , F02D9/107
摘要： A method for manufacturing a throttle valve unit having a housing part and a valve flap part that can move in relation to it includes the steps of injection molding the housing part of a first plastic material in a first cavity, transferring the molded housing part to a second cavity spatially decoupled from the first cavity, and injection molding the movable valve flap part out of a second plastic material in a second mold cavity inside the molded housing part. Before the molded housing part is transferred to the second cavity, it is subjected to an intermediate treatment in order to influence the shrinkage behavior, thereby selectively adjusting the gap geometries between the parts.
摘要翻译：一种用于制造具有可相对于其移动的壳体部分和阀瓣部分的节气门单元的方法包括以下步骤：将第一塑料材料的壳体部分注射成型在第一腔体中，将模制的壳体部分转移到第二腔在空间上与第一腔体分离，并且将可移动阀瓣部分从模制的壳体部分内的第二模腔中的第二塑料材料注射成型。在将模制的壳体部件转移到第二腔室之前，对其进行中间处理以影响收缩性能，从而选择性地调节部件之间的间隙几何形状。

7. 发明申请

US20060106512A1 Method and device for monitoring an accelerator sensor 审中-公开
标题翻译：用于监测加速器传感器的方法和装置
公开(公告)号：US20060106512A1
公开(公告)日：2006-05-18
申请号：US10531551
申请日：2003-07-11
申请人： Guido Funcke , Thomas Klotzbuecher , Thomas Linke , Johannes Meiwes , Heinz Fuchs , Karl-Heinrich Weis
发明人： Guido Funcke , Thomas Klotzbuecher , Thomas Linke , Johannes Meiwes , Heinz Fuchs , Karl-Heinrich Weis
IPC分类号： G06F7/00 , G01M17/00
CPC分类号： F02D11/106 , F02D11/107 , F02D2041/285 , F02D2200/602 , F02D2400/08 , G01D3/08
摘要： A partially redundant, contactless pedal-travel sensor is used for controlling a vehicle. This pedal travel sensor generates at least two redundant signals using a contactless sensor and an electronic circuit. These signals are fed to a control and/or regulating unit, where they are subjected to a plausibility check to detect a faulty pedal-travel sensor. To improve safety during a failure of a pedal-travel sensor and to improve the diagnostic options, it is provided that a specific position of the pedal is detected by a switch and a signal is generated by the switch. Then a plausibility comparison of the signal generated by the switch with the signals generated by the pedal-travel sensor is performed.
摘要翻译：部分冗余的非接触踏板行程传感器用于控制车辆。该踏板行程传感器使用非接触传感器和电子电路产生至少两个冗余信号。这些信号被馈送到控制和/或调节单元，在那里它们进行合理性检查以检测故障的踏板行程传感器。为了提高踏板行走传感器故障时的安全性并改善诊断选项，可以通过开关检测踏板的特定位置，并且由开关产生信号。然后执行由开关产生的信号与由踏板行程传感器产生的信号的合理性比较。

8. 发明授权

US06889652B2 Variant-reduced throttle device with interchangeable housing parts 失效
标题翻译：具有可互换的外壳部件的变型减少的节流装置
公开(公告)号：US06889652B2
公开(公告)日：2005-05-10
申请号：US10254912
申请日：2002-09-26
申请人： Johannes Meiwes , Stefan Josten
发明人： Johannes Meiwes , Stefan Josten
IPC分类号： F02D11/10 , F02D9/10
CPC分类号： F02D9/104 , B29L2031/7506 , F02D9/107
摘要： The invention relates to a throttle device for the intake section of an internal combustion engine, wherein the throttle device has a multi-part housing that contains a throttle valve device in movable fashion, which can be actuated by means of an actuating drive unit. A base housing, which is embodied as an injection molded component and accommodates the throttle valve device, can also accommodate first housing parts of different flange patterns as interfaces with the intake section and additional second housing parts, which are accommodated so that they can move in relation to the base housing, in order to modify the air conduction.
摘要翻译：本发明涉及一种用于内燃机的进气段的节流装置，其中节流装置具有多个部分的壳体，该多部分壳体包含可移动的节流阀装置，该节流阀装置可通过致动驱动装置致动。被实施为注射成型部件并且容纳节流阀装置的基座壳体还可以容纳不同凸缘图案的第一壳体部分，作为与进气部分和附加的第二壳体部件的接口，所述第二壳体部件被容纳以便它们可以移动与基座的关系，以改变空气传导。

9. 发明授权

US5232197A Control device 失效
标题翻译：控制装置
公开(公告)号：US5232197A
公开(公告)日：1993-08-03
申请号：US910304
申请日：1992-07-21
申请人： Harald Kalippke , Manfred Franz , Erhard Renninger , Johannes Meiwes , Albert Gerhard , Uwe Hammer
发明人： Harald Kalippke , Manfred Franz , Erhard Renninger , Johannes Meiwes , Albert Gerhard , Uwe Hammer
IPC分类号： F02M69/32 , F02D9/16 , F02M3/06 , F02M3/07 , F16K31/06
CPC分类号： F02M3/07 , F02D9/16 , F16K31/0682 , F02M2003/067
摘要： A control device for the control of an opening cross-sectional area of a flow duct, in particular for internal combustion engines, comprising three sub-assemblies, an actuator housing with flow channel and setting window, a rotor with a rotary valve for controlling the window opening, and a drive housing with stator and stator winding. For setting a required air gap between the rotary valve and the setting window, a control section of the rotary valve covering the setting window is designed as a cone envelope segment, and is inclined at an acute angle to the rotor axis. The window lying in a cone envelope plane is located at the same angle of inclination. By means of a spacing disk between the rotor, with the rotary valve affixed thereon, and the actuator housing, the air gap is set and fixed as required.
摘要翻译： PCT No.PCT / DE91 / 00893。 371日期：1992年7月21日 102（e）日期1992年7月21日PCT 1991年11月15日PCT PCT。第WO92 / 10662号公报日期：1992年6月25日。一种用于控制流道的开口横截面积，特别是用于内燃机的控制装置，包括三个子组件，具有流动通道和设置窗的致动器壳体，转子具有用于控制窗口的旋转阀，以及具有定子和定子绕组的驱动器壳体。为了在旋转阀和设置窗口之间设置所需的气隙，覆盖设定窗的旋转阀的控制部分被设计为锥形包络线段，并且与转子轴线成锐角倾斜。位于锥形包络平面中的窗口位于相同的倾斜角度。通过转子与固定在其上的旋转阀之间的间隔盘和致动器壳体，根据需要设定和固定气隙。

10. 发明授权

US5229671A Electromagnetic rotary actuator 失效
标题翻译：电磁旋转执行器
公开(公告)号：US5229671A
公开(公告)日：1993-07-20
申请号：US834278
申请日：1992-02-12
申请人： Klaus Neidhard , Harald Kalippke , Friedrich Wendel , Erhard Renninger , Wolfgang Staudenmaier , Johannes Meiwes , Albert Gerhard , Dieter Dick , Herbert Becker
发明人： Klaus Neidhard , Harald Kalippke , Friedrich Wendel , Erhard Renninger , Wolfgang Staudenmaier , Johannes Meiwes , Albert Gerhard , Dieter Dick , Herbert Becker
IPC分类号： F02D9/02 , F02D9/10 , F02M3/06 , F02M3/07 , F02M69/32
CPC分类号： F02M3/07 , F02M2003/067
摘要： In a rotary actuator (1) with rotary slide valve (3) for controlling a throttle cross-section, the sealing of the pneumatic (16) and of the electrical part (17) is to be improved. For this purpose, the shaft (11) is supported twofold, both on this side and on the other side of the rotary slide valve (3). Both roller bearings (13, 14) are located in a one-piece housing (12). As a result, the tolerance-related width of the air gap between rotary slide valve (3) and control opening (6) is reduced, on the one hand, and, on the other hand, an isolating seal between the parts (16) and (17) is formed by the bearing (13). The rotary actuator (1) is particularly suitable as idle-speed rotary actuator for internal combustion engines.
摘要翻译： PCT No.PCT / DE90 / 00601 Sec。 371日期：1992年2月12日 102（e）日期1992年2月12日PCT提交1990年8月4日PCT公布。出版物WO91 / 02894 日期1991年3月7日。在具有用于控制节流横截面的旋转滑阀（3）的旋转致动器（1）中，气动（16）和电气部件（17）的密封将被改善。为此，轴（11）在旋转滑阀（3）的该侧和另一侧上被双重支撑。两个滚子轴承（13,14）都位于一体式外壳（12）中。结果，一方面减小了旋转滑阀3与控制开口6之间的气隙的公差相对宽度，另一方面减小了部件16之间的隔离密封。和（17）由轴承（13）形成。旋转执行器（1）特别适用于内燃机的怠速转动式致动器。

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