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1. 发明授权

US06194383B1 Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof 失效
标题翻译：来自动物平面的脂肽具有药理作用，其制备方法及其用途
公开(公告)号：US06194383B1
公开(公告)日：2001-02-27
申请号：US08811843
申请日：1997-03-05
申请人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
发明人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
IPC分类号： A61K3800
CPC分类号： C07K7/60 , A61K38/00 , Y10S435/827
摘要： The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.
摘要翻译：本发明涉及具有非常同源的氨基酸序列但不同脂肪酸残基（脂质部分）的脂肽，其由Actinoplanes sp。在发酵过程中释放到培养基中，从分离来自培养基中的脂肽并纯化它们的方法，使用脂肽作为药理活性物质，特别是抗革兰氏阳性细菌，以及使用Actinoplanes sp。 DSM 7358用于生产上述脂肽。

2. 发明授权

US5053329A Process for preparation of novel angiotensin II antagonists 失效
标题翻译：新型血管紧张素II拮抗剂的制备方法
公开(公告)号：US5053329A
公开(公告)日：1991-10-01
申请号：US678774
申请日：1991-04-01
申请人： Shieh-Shung T. Chen , Byron H. Arison
发明人： Shieh-Shung T. Chen , Byron H. Arison
IPC分类号： C07D471/04 , C12P17/18
CPC分类号： C07D471/04 , C12P17/182 , Y10S435/827
摘要： Novel biotransformation compounds I and II are prepared by fermenting 3-[(2'-tetrazol-5-yl-biphenyl-4-yl)methyl]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine in a culture of Actinoplanacete sp., Accession No. ATCC 53771. ##STR1##
摘要翻译：通过发酵3 - [（2'-四唑-5-基 - 联苯-4-基）甲基] -7-甲基-2-丙基-3H-咪唑并[4,5-b]制备新的生物转化化合物I和II ]吡啶在Actinoplanacete sp。，登录号ATCC 53771的培养物中。 I II

3. 发明授权

US4256838A Method of purification of glucose isomerase 失效
标题翻译：葡萄糖异构酶纯化方法
公开(公告)号：US4256838A
公开(公告)日：1981-03-17
申请号：US93569
申请日：1979-11-13
申请人： Denise M. Jackson , Yoshihisa Tsuda , Vida Winans
发明人： Denise M. Jackson , Yoshihisa Tsuda , Vida Winans
IPC分类号： C12N9/00 , C12N9/92
CPC分类号： C12N9/92 , C12N9/00 , Y10S435/814 , Y10S435/815 , Y10S435/827 , Y10S435/853 , Y10S435/886
摘要： A process for purifying an enzyme such as glucose isomerase which comprises precipitating nucleic acids from a cell-free, heat-treated enzyme solution in a suitable buffer and chromatographing the supernatant on a cellulosic medium. Subsequent chromatography on a hydrophilic, molecular-sieve medium affords enzyme of about 90% purity.
摘要翻译：一种纯化诸如葡萄糖异构酶的酶的方法，其包括在合适的缓冲液中从无细胞的经热处理的酶溶液中沉淀核酸，并在纤维素介质上色谱分离上清液。随后在亲水性分子筛介质上进行色谱提供约90％纯度的酶。

4. 发明授权

US4237231A Method of purifying glucose isomerase and a composition for storing same 失效
标题翻译：葡萄糖异构酶的纯化方法及其组合物
公开(公告)号：US4237231A
公开(公告)日：1980-12-02
申请号：US93570
申请日：1979-11-13
申请人： Denise M. Jackson , Yoshihisa Tsuda
发明人： Denise M. Jackson , Yoshihisa Tsuda
IPC分类号： C12N9/92 , C12N9/96
CPC分类号： C12N9/92 , C12N9/96 , Y10S435/814 , Y10S435/816 , Y10S435/827 , Y10S435/853 , Y10S435/886 , Y10S435/89
摘要： A process for purifying glucose isomerase comprises the steps of acid treatment and salt fractionation. An enzyme solution is treated with an acid, such as acetic acid, to a pH from about 3.5 to about 5.0. The proteinaceous solids are collected and extracted with a buffer, such as imidazole, whose solution has a pH of about 6 to about 8. The solution is then collected and a salt, such as ammonium sulfate, is dissolved therein from about 40% to about 50% of its saturation point. The proteinaceous solids which form are removed and additional ammonium sulfate is dissolved to attain from about 41% to about 60% of its saturation point, followed by collection of the solids containing purified enzyme. A composition which preserves enzyme activity upon storage of glucose isomerase and which imparts resistance to thermal deactivation of said enzyme comprises an aqueous solution of glycerol, a buffer whose solution is at a pH of about 6 to about 8, divalent cobalt ions and magnesium ions.
摘要翻译：葡萄糖异构酶的纯化方法包括酸处理和盐分离步骤。用酸（如乙酸）处理酶溶液至约3.5至约5.0的pH。收集蛋白质固体并用缓冲液如咪唑提取其溶液，其pH为约6至约8.然后收集溶液，并将盐如硫酸铵溶解在其中约40％至约其饱和点的50％。除去形成的蛋白质固体并加入另外的硫酸铵以达到其饱和点的约41％至约60％，然后收集含有纯化酶的固体。保存葡萄糖异构酶并赋予对所述酶的热失活抗性的酶活性的组合物包含甘油水溶液，其溶液的pH为约6至约8的缓冲液，二价钴离子和镁离子。

5. 发明授权

US4174390A Antibiotic A-7413 and process for preparation thereof 失效
公开(公告)号：US4174390A
公开(公告)日：1979-11-13
申请号：US932833
申请日：1978-08-11
申请人： Robert L. Hamill , W. Max Stark
发明人： Robert L. Hamill , W. Max Stark
IPC分类号： C12P1/06 , A61K35/00
CPC分类号： C12R1/045 , C12P1/06 , Y10S435/827
摘要： Antibiotic A-7413 complex, comprising a major microbiologically active factor A, and minor active factors B, C, and D, is produced by fermentation of Actinoplanes sp. NRRL 8122. The individual factors are isolated and separated by extraction and chromatography. The A-7413 antibiotics are antibacterial agents. The A-7413 complex and A-7413 antibiotic compounds are also useful as growth-promoting agents and in the control of dental caries and acne.

6. 发明授权

US4065557A Amino sugars and their use in improving the meat:fat ratio in animals 失效
标题翻译：氨基糖及其在改善肉类中的用途：动物中的脂肪比例
公开(公告)号：US4065557A
公开(公告)日：1977-12-27
申请号：US704842
申请日：1976-07-13
申请人： Werner Frommer , Horst Gericke , Uwe Keup , Walter Puls , Delt Schmidt , Otto Wagner
发明人： Werner Frommer , Horst Gericke , Uwe Keup , Walter Puls , Delt Schmidt , Otto Wagner
IPC分类号： A23K1/16 , A23K1/18 , A23K1/22 , C07H15/22 , C12P19/28 , A61K31/71 , A61K31/715 , C12D13/04
CPC分类号： C12P19/28 , A23K20/163 , A23K50/15 , A23K50/30 , C07H15/22 , Y10S435/827 , Y10S435/839 , Y10S435/917
摘要： Glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino)-.alpha.-D-glucopyranose, which are inhibitors of glycoside hydrolases of the digestive tract, favorably improve the meat:fat ratio in animals in favor of a higher proportion of meat. A single amino-sugar or a mixture of amino-sugars can be formulated in combination with an edible carrier and fed to animals. A representative embodiment is a pig feedstuff in admixture with O-{4,6-bisdesoxy-4-[lS-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino]-.alpha.-D-glucopyranoxyl}-(1.fwdarw.4)-O-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-D-glucopyranose.
摘要翻译： 4,6-双脱氧-4-（4,5,6-三羟基-3-羟甲基环己-2-烯-1-基氨基）-α-D-吡喃葡萄糖的吡喃葡萄糖基和低聚葡糖苷衍生物，它们是糖苷水解酶的抑制剂消化道，有利于提高肉类：动物脂肪比例，有利于肉类的比例较高。单一氨基糖或氨基糖的混合物可以与可食用的载体组合配制并喂给动物。代表性的实施方案是与O- {4,6-双脱氧-4- [1S-（1,4,6 / 5）-4,5,6-三羟基-3-羟甲基环己基-2-烯的混合物的猪饲料 -1-基氨基]-α-D-吡喃葡萄糖基} - （1-> 4）-O-α-D-吡喃葡萄糖基 - （1-> 4）-D-吡喃葡萄糖。

7. 发明授权

US4013510A Glycoside-hydrolase enzyme inhibitors 失效
标题翻译：糖苷 - 水解酶抑制剂
公开(公告)号：US4013510A
公开(公告)日：1977-03-22
申请号：US493463
申请日：1974-07-31
申请人： Werner Frommer , Walter Puls , Dietmar Schafer , Delf Schmidt
发明人： Werner Frommer , Walter Puls , Dietmar Schafer , Delf Schmidt
IPC分类号： C12P1/04 , C12P1/06 , C12D13/00
CPC分类号： A61K31/70 , C12P1/04 , C12P1/06 , Y10S435/803 , Y10S435/822 , Y10S435/827 , Y10S435/886 , Y10S435/889 , Y10S435/896 , Y10S435/907 , Y10S435/911
摘要： This invention relates to inhibitors for glycosidehydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (arteriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycoside-hydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, adipose, hyperlipidemia (arteriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.
摘要翻译：本发明涉及来自放线菌纲序列的细菌的糖苷水解酶的抑制剂，其生产方法包括在最有利于生长和产生酶抑制剂的条件下，在适当的营养液中培养放线菌纲的微生物，并作为新的产品，糖苷 - 水解酶抑制剂，以及所述酶抑制剂在药学上可接受的治疗组合物中用于治疗指示肥胖，糖尿病，前期糖尿病，胃炎，胃溃疡，高脂血症（动脉硬化）和喜欢。本发明还考虑提供通过在所述碳水化合物和糖苷 - 水解酶的存在下进行所述碳水化合物和糖苷 - 水解酶的反应来抑制碳水化合物和糖苷 - 水解酶，特别是消化道的碳水化合物 - 裂解糖苷 - 水解酶的反应的方法一种衍生自放线菌纲的微生物菌株的糖苷 - 水解酶的糖苷 - 水解酶抑制剂。本发明进一步考虑了提供治疗由肥胖，脂肪，高脂血症（动脉硬化），糖尿病，前期糖尿病，胃炎，胃溃疡，十二指肠溃疡以及由糖苷 - 水解酶和碳水化合物，其改进包括使用由抑制放线菌的微生物菌株产生的糖苷 - 水解酶的酶抑制剂。

8. 发明授权

US3992262A Media containing molasses and corn steep liquor for producing glucose isomerase from Actinoplanes and method 失效
标题翻译：含有从活性淀粉生成葡萄糖异构酶的糖蜜和玉米浆的培养基和方法
公开(公告)号：US3992262A
公开(公告)日：1976-11-16
申请号：US548537
申请日：1975-02-10
申请人： Kenneth K. Shieh
发明人： Kenneth K. Shieh
IPC分类号： C12N9/92 , C12D13/10 , C12B3/04
CPC分类号： C12N9/92 , Y10S435/827
摘要： This disclosure relates to an improved medium for growing organisms (preferably Actinoplanes missouriensis) which produce glucose isomerase. Use of the medium results in increased yields of enzyme in shorter fermentation times. The improved medium contains molasses, corn steep liquor, and an inorganic nitrogen salt.
摘要翻译：本公开涉及一种用于生产葡萄糖异构酶的生长生物体（优选是飞行情报）的改良培养基。在较短的发酵时间内，培养基的使用导致酶的产量增加。改良的培养基含有糖蜜，玉米浆和无机氮盐。

9. 发明授权

USB482660I5 失效
公开(公告)号：USB482660I5
公开(公告)日：1976-02-10
申请号：US48266074
申请日：1974-06-24
IPC分类号： C12N9/99 , A61K38/55 , C12N9/26 , C12P1/06 , C12R1/045
CPC分类号： C12P1/06 , Y10S435/826 , Y10S435/827

10. 发明授权

US3128238A delta1-dehydrogenation of steroids by fermentation with actinoplanaceae 失效
标题翻译：通过用激活藜科发酵的类固醇的δ1-脱氢
公开(公告)号：US3128238A
公开(公告)日：1964-04-07
申请号：US22380662
申请日：1962-09-14
申请人： LILLY CO ELI
发明人： MALLETT GORDON E
IPC分类号： C12P33/00
CPC分类号： C12P33/00 , Y10S435/827 , Y10S435/907 , Y10S435/911

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