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1. 发明申请

US20070156046A1 Method of enriching hyperpolarized atom nuclei and an apparatus for implementing the method 审中-公开
标题翻译：丰富超极化原子核的方法及其实现方法
公开(公告)号：US20070156046A1
公开(公告)日：2007-07-05
申请号：US10586569
申请日：2004-12-08
申请人： Friedrich Hasing , Stephan Appelt , Kerstin Munnemann
发明人： Friedrich Hasing , Stephan Appelt , Kerstin Munnemann
IPC分类号： A61B5/05
CPC分类号： G01R33/28 , A61K49/1806 , A61K49/1815 , C01B23/0089 , C01B2210/0037
摘要： The invention relates to a method for enriching hyperpolarized nuclei. According to the inventive method, hyperpolarized atomic nuclei flowing in a gaseous mixture are dissolved in a solvent which is cooled at less than 293 K. A device for carrying out the method comprises at least one chamber with means for the degassing of hyperpolarized atomic nuclei which are dissolved in a solvent which is located in the chamber. The device comprises means for forming a magnetic field of 0.04 T maximum. Die Erfindung betrifft ein Verfahren zur Anreicherung von hyperpolarisienen Atomkernen. Das Ver-fahren sieht vor, in einem Gasgemisch stromende hyperpolarisierte Atomkeme in einem unterhalb 293 K gekühlten Lösungsmittel zu lösen. Eine Vorrichtung zur Durchführung des Verfahrens umfasst mindestens eine Kammer mit Mitteln zur Entgasung von hyperpolarisiente Atomkemen, die in einem in der Kammer befindlichen Lösungsmittel gelöst sind. Die Vorrichtung umfasst Mittel zur Ausbildung eines Magnetfeldes von maximal 0,04 T.
摘要翻译：本发明涉及一种富集超极化核的方法。根据本发明的方法，将在气体混合物中流动的超极化原子核溶解在冷却至低于293K的溶剂中。用于实施该方法的装置包括至少一个具有用于脱极超极化原子核的装置的室，溶解在位于室中的溶剂中。该装置包括用于形成0.04T最大磁场的装置。 Die Erfindung betrifft ein Verfahren zur Anreicherung von hyperpolarisienen Atomkernen。 Das Ver-fahren sieht vor，in einem Gasgemisch stromende hyperpolarisierte Atomkeme in einem unterhalb 293 KgekühltenLösungsmittelzulösen。 Eine Vorrichtung zurDurchführungdes Verfahrens umfasst mindestens eine Kammer mit Mitteln zur Entgasung von hyperpolarisiente Atomkemen，die in einem in der Kammer befindlichenLösungsmittelgelöstsind。 Die Vorrichtung umfasst Mittel zur Ausbildung eines Magnetfeldes von maximal 0,04 T.

2. 发明申请

US20070080684A1 Method for the hyperpolarisation of atomic nuclei and device for carrying out said method 失效
标题翻译：用于实现所述方法的原子核的超极化方法和装置
公开(公告)号：US20070080684A1
公开(公告)日：2007-04-12
申请号：US10586000
申请日：2005-01-13
申请人： Stephan Appelt , Friedrich Hasing , Giovanni D'Orsaneo , Ulrich Sieling
发明人： Stephan Appelt , Friedrich Hasing , Giovanni D'Orsaneo , Ulrich Sieling
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： G01R33/282 , A61K49/1815
摘要： The invention relates to a method for the hyperpolarisation of atomic nuclei by means of optical pumps in a sample cell. Polarisation of an electron spin of an optically pumpable species, which is produced by means of laser light, is transferred to the nucleus spin of an atom which is to be hyperpolarisied. According to the invention, components of the mixture and/or other inert compounds for hyperpolarisation are guided in the sample cell such that the mixture does not come into contact with the inner wall of the sample cell, or does to a small degree. A device for carrying out said method comprises at least one means which guides the components of the mixture of non-optical pumpable species and nuclei which are to be hyperpolarisied, and/or other inert compounds for hyperpolarisation, into the sample cell (5) such that the mixture does not come into contact with the inner wall of the sample cell (5), or does to small degree. As a result, the wall can be prevented from sagging.
摘要翻译：本发明涉及通过样品池中的光泵对原子核进行超极化的方法。通过激光产生的可光泵浦物质的电子自旋的极化被转移到要超极化的原子的核心旋转。根据本发明，用于超极化的混合物和/或其它惰性化合物的组分在样品池中引导，使得混合物不与样品池的内壁接触，或者在很小程度上。用于执行所述方法的装置包括至少一个装置，其将非光可泵送物质的混合物的组分和要超极化的核的组分和/或用于超极化的其它惰性化合物引导到样品池（5）中，混合物不与样品池（5）的内壁接触，或者具有很小的程度。结果，可以防止墙下垂。

3. 发明授权

US08248068B2 Hyperpolarization of lithium and other nuclei 失效
标题翻译：锂和其他核的超极化
公开(公告)号：US08248068B2
公开(公告)日：2012-08-21
申请号：US11918853
申请日：2006-03-25
申请人： Stephan Appelt , Wolfgang Häsing , Ulrich Sieling , Holger Kühn
发明人： Stephan Appelt , Wolfgang Häsing , Ulrich Sieling , Holger Kühn
IPC分类号： G01V3/00
CPC分类号： G01R33/282
摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.
摘要翻译：本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。本发明还涉及通常产生具有核自旋极化的物质的方法。根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化进入Li +离子。然后，Li +离子的核自旋极化被传递到阴离子的另一个核。因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。

4. 发明申请

US20080231268A1 Imaging Method Based on Fractal Surface-Filling or Space-Filling Curves 失效
标题翻译：基于分形表面填充或空间填充曲线的成像方法
公开(公告)号：US20080231268A1
公开(公告)日：2008-09-25
申请号：US10586083
申请日：2004-12-17
申请人： Richard Patzak , Daniel Gembris , Stephan Appelt , Friedrich-Wolfgang Hasing , Horst Halling
发明人： Richard Patzak , Daniel Gembris , Stephan Appelt , Friedrich-Wolfgang Hasing , Horst Halling
IPC分类号： G01R33/48
CPC分类号： G01R33/4822 , G01R33/445 , G01R33/48 , G01R33/4806 , G01R33/5615
摘要： The present invention relates to an imaging method and device for nuclear magnetic resonance. On the one hand, the method provides an image coding by means of an additional field which has, for each point of a two-dimensional grating surface within the sample, a different field strength value that occurs only once, as is the case, e.g., in fields based on fractal, surface-filling and space-filling curves. On the other hand, the read-out of the resonance behavior of a sample along a space-filling and/or surface-filling curve can be provided. In the first variant, a magnetic resonance (MR) image with a single high-frequency excitation without a time-varying gradient can be recorded, which in turn advantageously prevents the sound generation associated therewith. In the second variant, the sounds generated during read-out are advantageously shifted to another frequency range in which the human hearing is less sensitive. Furthermore, the device is relieved and the technical requirements with regard to it are reduced. In addition, it can be executed with known and existing devices.
摘要翻译：本发明涉及用于核磁共振的成像方法和装置。一方面，该方法通过附加场提供图像编码，对于样本内的二维光栅表面的每个点，其具有仅出现一次的不同场强值，例如，，在基于分形，表面填充和空间填充曲线的领域。另一方面，可以提供沿空间填充和/或曲面填充曲线读取样本的共振特性。在第一变型中，可以记录具有不具有时变梯度的单个高频激励的磁共振（MR）图像，这又有利地防止与之相关联的声音生成。在第二变型中，在读出期间产生的声音有利地被移动到人听觉不太敏感的另一个频率范围。此外，该装置得到缓解，并且减少了对其的技术要求。此外，它可以用已知和现有的设备执行。

5. 发明授权

US06666047B1 High pressure polarizer for hyperpolarizing the nuclear spin of noble gases 失效
标题翻译：用于超极化惰性气体核旋转的高压偏振器
公开(公告)号：US06666047B1
公开(公告)日：2003-12-23
申请号：US10049721
申请日：2002-03-27
申请人： Nadim Joni Shah , Stephan Appelt , Timur Unlu , Horst Halling , Karl Zilles
发明人： Nadim Joni Shah , Stephan Appelt , Timur Unlu , Horst Halling , Karl Zilles
IPC分类号： F25J300
CPC分类号： G01R33/282 , G21K1/16
摘要： The invention relates to a polarizer for noble gases comprising a glass sample cell and a pressure chanter in which the sample cell is located. High pressure and accompanying broadband or narrow-band lasers can be similarly provided in an optimal manner. To this end, the polarizer is operated at pressures of 30 bar and higher.
摘要翻译：本发明涉及一种用于惰性气体的偏振器，其包括玻璃样品池和样品池所在的压力传感器。可以以最佳方式类似地提供高压和伴随的宽带或窄带激光器。为此，偏振器在30巴和更高的压力下运行。

6. 发明申请

US20090261822A1 Hyperpolarization of lithium and other nuclei 失效
标题翻译：锂和其他核的超极化
公开(公告)号：US20090261822A1
公开(公告)日：2009-10-22
申请号：US11918853
申请日：2006-03-25
申请人： Stephan Appelt , Wolfgang Haesing , Ulrich Sieling , Holger Kuehn
发明人： Stephan Appelt , Wolfgang Haesing , Ulrich Sieling , Holger Kuehn
IPC分类号： G01R33/26
CPC分类号： G01R33/282
摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.
摘要翻译：本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。本发明还涉及通常产生具有核自旋极化的物质的方法。根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化进入Li +离子。然后，Li +离子的核自旋极化被传递到阴离子的另一个核。因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。

7. 发明授权

US06589793B1 Measurement device for the measurement of the absolute polarisation of alkali metal atoms 失效
标题翻译：用于测量碱金属原子绝对极化的测量装置
公开(公告)号：US06589793B1
公开(公告)日：2003-07-08
申请号：US09590533
申请日：2000-06-08
申请人： Stephan Appelt , Timur Unlu , Nadim Jone Shah
发明人： Stephan Appelt , Timur Unlu , Nadim Jone Shah
IPC分类号： G01N3320
CPC分类号： G01N21/21 , Y10T436/24
摘要： The invention concerns a device for the determination of the absolute polarisation of alkali metal atoms. The device can inter alia be used for the diagnosis of alkali metal polarisation in a polariser for inert gases. The device includes a detection laser, which together with a &lgr;/4 plate creates circularly polarised light. A sensor for the measurement of the light absorbed by the sample of the polariser is provided. A Helmholtz coil pair serves for the creation of a static magnetic field B0. An oscillating magnetic field is created with an RF coil. A gradient coil serves for the creation of a linear magnetic field gradient. Various optical components are present. An electronic processor effects the determination of the absolute polarisation of the alkali metal atoms. All the said components with the exception of the Helmholtz coils are firmly mounted onto a platform which can be moved parallel to the direction of the B0 field. Means for controlling the temperature of the laser for the detection of the polarisation of the alkali metal atoms are provided. The means for controlling the temperature of the laser for the detection of the polarisation of the alkali metal atoms include a temperature sensor, with which the temperature of the laser is measured, a heating/cooling device, with which the laser is heated or cooled, and also a control device, which controls the heating/cooling device depending on the measured temperature of the laser, so that the temperature of the laser is held constant. Compared to the state of the art, faster and better measurement results can thus be achieved.
摘要翻译：本发明涉及一种用于确定碱金属原子的绝对极化的装置。该装置尤其可用于诊断用于惰性气体的偏振器中的碱金属极化。该装置包括检测激光器，其与羔羊/ 4板一起产生圆偏振光。提供了用于测量由偏振器的样品吸收的光的传感器。亥姆霍兹线圈对用于创建静态磁场B0。用RF线圈产生振荡磁场。梯度线圈用于产生线性磁场梯度。存在各种光学部件。电子处理器可以确定碱金属原子的绝对极化。除了亥姆霍兹线圈之外的所有组件都被牢固地安装在平台上，平台可以平行于B0场的方向移动。提供了用于控制用于检测碱金属原子的极化的激光器的温度的装置。用于控制用于检测碱金属原子的极化的激光的温度的装置包括：测量激光的温度的温度传感器，激光被加热或冷却的加热/冷却装置，以及控制装置，其根据激光的测量温度控制加热/冷却装置，使得激光器的温度保持恒定。与现有技术相比，可以实现更快更好的测量结果。

8. 发明授权

US06426058B1 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 失效
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US06426058B1
公开(公告)日：2002-07-30
申请号：US08825475
申请日：1997-03-28
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

9. 发明授权

US07541806B2 Method for molecule examination by NMR spectroscopy 失效
标题翻译：通过NMR光谱分析检测方法
公开(公告)号：US07541806B2
公开(公告)日：2009-06-02
申请号：US11681331
申请日：2007-03-02
申请人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
发明人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
IPC分类号： G01V3/00
CPC分类号： G01R33/4608 , G01N24/087 , G01R33/383 , G01R33/445 , G01R33/4633 , G01R33/465 , G01R33/5605
摘要： The invention relates to a method and a device for examining molecules by means of NMR spectroscopy. It is the object of the invention to be able to characterize a sample with a high resolution and comprehensively. The object is solved by a method and an associated device for examining a sample by means of nuclear magnetic spectroscopy by measuring heteronuclear and homonuclear J-couplings in a small magnetic field and by using the measured heteronuclear and homonuclear J-couplings for characterizing the sample.
摘要翻译：本发明涉及通过NMR光谱检测分子的方法和装置。本发明的目的是能够以高分辨率和全面地表征样品。该目的通过一种方法和相关设备来解决，用于通过在小磁场中测量异核和同核J耦合并通过使用测量的异核和同核J耦合来表征样品，通过核磁谱检查样品。

10. 发明授权

US07495435B2 Method for the hyperpolarisation of atomic nuclei and device for implementing the method 失效
标题翻译：原子核超极化方法及其实现方法
公开(公告)号：US07495435B2
公开(公告)日：2009-02-24
申请号：US10586000
申请日：2005-01-13
申请人： Stephan Appelt , Friedrich Wolfgang Häsing , Giovanni D'Orsaneo , Ulrich Sieling
发明人： Stephan Appelt , Friedrich Wolfgang Häsing , Giovanni D'Orsaneo , Ulrich Sieling
IPC分类号： G01V3/00
CPC分类号： G01R33/282 , A61K49/1815
摘要： An apparatus for hyperpolarizing atomic nuclei through optical pumping has a cylindrical optical pumping cell having an inlet and an outlet spaced therefrom. A supply of a mixture of optically pumpable species and hyperpolarizable nuclei is connected to the inlet of the cell. A nozzle at an inlet of the optical pumping cell forms and injects a jet flow of the mixture into the optical pumping cell. It is then drawn out through the outlet such that the mixture touches the inner walls of the optical pumping cell only adjacent the outlet.
摘要翻译：通过光泵浦使原子核超极化的装置具有圆柱形的光泵浦单元，其具有与其间隔开的入口和出口。供应光泵浦物质和超极化核的混合物连接到电池入口。在光泵浦单元的入口处的喷嘴形成并将混合物的喷射流注入到光泵浦单元中。然后通过出口将其抽出，使得混合物仅在出口附近接触光泵浦单元的内壁。

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