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1. 发明授权

US07385395B2 Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis 有权
标题翻译：用于制备用于NMR和MRI分析的超极化惰性气体溶液的装置
公开(公告)号：US07385395B2
公开(公告)日：2008-06-10
申请号：US10940297
申请日：2004-09-13
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： G01V3/00 , G01N24/00 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

2. 发明申请

US20080024130A1 SYSTEM AND METHOD FOR PROVIDING A ROTATING MAGNETIC FIELD 失效
标题翻译：用于提供旋转磁场的系统和方法
公开(公告)号：US20080024130A1
公开(公告)日：2008-01-31
申请号：US11740772
申请日：2007-04-26
申请人： Ross Schlueter , Thomas Budinger
发明人： Ross Schlueter , Thomas Budinger
IPC分类号： G01R33/28
CPC分类号： G01R33/381 , G01R33/383
摘要： Disclosed herein are systems and methods for generating a rotating magnetic field. The rotating magnetic field can be used to obtain rotating-field NMR spectra, such as magic angle spinning spectra, without having to physically rotated the sample. This result allows magic angle spinning NMR to be conducted on biological samples such as live animals, including humans.
摘要翻译：这里公开了用于产生旋转磁场的系统和方法。可以使用旋转磁场来获得旋转磁场NMR光谱，例如魔角旋转光谱，而不必物理地旋转样品。该结果允许对诸如活的动物（包括人）的生物样品进行魔角旋转NMR。

3. 发明申请

US20060264755A1 Arterial endothelial function measurement method and apparatus 有权
标题翻译：动脉内皮功能测量方法及装置
公开(公告)号：US20060264755A1
公开(公告)日：2006-11-23
申请号：US11362326
申请日：2006-02-23
申请人： Jonathan Maltz , Thomas Budinger
发明人： Jonathan Maltz , Thomas Budinger
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/488
摘要： A “relaxoscope” (100) detects the degree of arterial endothelial function. Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. An artery (115), such as the brachial artery (BA) is measured for diameter before and after several minutes of either vasoconstriction or vasorelaxafion. The change in arterial diameter is a measure of flow-mediated vasomodification (FMVM). The relaxoscope induces an artificial pulse (128) at a superficial radial artery (115) via a linear actuator (120). An ultrasonic Doppler stethoscope (130) detects this pulse 10-20 cm proximal to the point of pulse induction (125). The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before (160) and after arterial diameter change (170), FMVM may be measured based on the changes in PTT caused by changes in vessel caliber, smooth muscle tone and wall thickness.
摘要翻译： “放宽镜”（100）检测动脉内皮功能的程度。动脉内皮功能的损害是动脉粥样硬化的早期事件，与心血管疾病的主要危险因素相关。在血管收缩或血管收缩几分钟之前和之后测量动脉（115），例如肱动脉（BA）的直径。动脉直径的变化是流量介导的血管扩张（FMVM）的量度。松弛镜通过线性致动器（120）在浅表桡动脉（115）处诱导人造脉冲（128）。超声多普勒听诊器（130）检测脉搏感应点（125）附近的10-20cm脉冲。脉冲施加和检测之间的延迟提供脉冲传播时间（PTT）。通过在（160）之前和动脉直径变化（170）之后测量PTT，可以基于血管口径，平滑肌张力和壁厚变化引起的PTT变化来测量FMVM。

4. 发明申请

US20050030026A1 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 有权
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US20050030026A1
公开(公告)日：2005-02-10
申请号：US10940297
申请日：2004-09-13
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： G01R33/48 , A61B5/055 , A61K49/18 , G01R33/28 , G01R33/62 , G01V3/00 , A61B5/05
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

5. 发明授权

US06426058B1 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 失效
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US06426058B1
公开(公告)日：2002-07-30
申请号：US08825475
申请日：1997-03-28
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

6. 发明授权

US06818202B2 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 失效
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US06818202B2
公开(公告)日：2004-11-16
申请号：US10164324
申请日：2002-06-05
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： A61B5055
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

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