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1. 发明授权

US08248068B2 Hyperpolarization of lithium and other nuclei 失效
标题翻译：锂和其他核的超极化
公开(公告)号：US08248068B2
公开(公告)日：2012-08-21
申请号：US11918853
申请日：2006-03-25
申请人： Stephan Appelt , Wolfgang Häsing , Ulrich Sieling , Holger Kühn
发明人： Stephan Appelt , Wolfgang Häsing , Ulrich Sieling , Holger Kühn
IPC分类号： G01V3/00
CPC分类号： G01R33/282
摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.
摘要翻译：本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。本发明还涉及通常产生具有核自旋极化的物质的方法。根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化进入Li +离子。然后，Li +离子的核自旋极化被传递到阴离子的另一个核。因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。

2. 发明授权

US07541806B2 Method for molecule examination by NMR spectroscopy 失效
标题翻译：通过NMR光谱分析检测方法
公开(公告)号：US07541806B2
公开(公告)日：2009-06-02
申请号：US11681331
申请日：2007-03-02
申请人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
发明人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
IPC分类号： G01V3/00
CPC分类号： G01R33/4608 , G01N24/087 , G01R33/383 , G01R33/445 , G01R33/4633 , G01R33/465 , G01R33/5605
摘要： The invention relates to a method and a device for examining molecules by means of NMR spectroscopy. It is the object of the invention to be able to characterize a sample with a high resolution and comprehensively. The object is solved by a method and an associated device for examining a sample by means of nuclear magnetic spectroscopy by measuring heteronuclear and homonuclear J-couplings in a small magnetic field and by using the measured heteronuclear and homonuclear J-couplings for characterizing the sample.
摘要翻译：本发明涉及通过NMR光谱检测分子的方法和装置。本发明的目的是能够以高分辨率和全面地表征样品。该目的通过一种方法和相关设备来解决，用于通过在小磁场中测量异核和同核J耦合并通过使用测量的异核和同核J耦合来表征样品，通过核磁谱检查样品。

3. 发明授权

US07495435B2 Method for the hyperpolarisation of atomic nuclei and device for implementing the method 失效
标题翻译：原子核超极化方法及其实现方法
公开(公告)号：US07495435B2
公开(公告)日：2009-02-24
申请号：US10586000
申请日：2005-01-13
申请人： Stephan Appelt , Friedrich Wolfgang Häsing , Giovanni D'Orsaneo , Ulrich Sieling
发明人： Stephan Appelt , Friedrich Wolfgang Häsing , Giovanni D'Orsaneo , Ulrich Sieling
IPC分类号： G01V3/00
CPC分类号： G01R33/282 , A61K49/1815
摘要： An apparatus for hyperpolarizing atomic nuclei through optical pumping has a cylindrical optical pumping cell having an inlet and an outlet spaced therefrom. A supply of a mixture of optically pumpable species and hyperpolarizable nuclei is connected to the inlet of the cell. A nozzle at an inlet of the optical pumping cell forms and injects a jet flow of the mixture into the optical pumping cell. It is then drawn out through the outlet such that the mixture touches the inner walls of the optical pumping cell only adjacent the outlet.
摘要翻译：通过光泵浦使原子核超极化的装置具有圆柱形的光泵浦单元，其具有与其间隔开的入口和出口。供应光泵浦物质和超极化核的混合物连接到电池入口。在光泵浦单元的入口处的喷嘴形成并将混合物的喷射流注入到光泵浦单元中。然后通过出口将其抽出，使得混合物仅在出口附近接触光泵浦单元的内壁。

4. 发明授权

US07385395B2 Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis 有权
标题翻译：用于制备用于NMR和MRI分析的超极化惰性气体溶液的装置
公开(公告)号：US07385395B2
公开(公告)日：2008-06-10
申请号：US10940297
申请日：2004-09-13
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： G01V3/00 , G01N24/00 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

5. 发明申请

US20070296412A1 Method For Molecule Examination By NMR Spectroscopy 失效
标题翻译：通过NMR光谱分析检测方法
公开(公告)号：US20070296412A1
公开(公告)日：2007-12-27
申请号：US11681331
申请日：2007-03-02
申请人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
发明人： Stephan Appelt , Holger Kuhn , Ulrich Sieling , Friedrich-Wolfgang Hasing
IPC分类号： G01V3/14
CPC分类号： G01R33/4608 , G01N24/087 , G01R33/383 , G01R33/445 , G01R33/4633 , G01R33/465 , G01R33/5605
摘要： The invention relates to a method and a device for examining molecules by means of NMR spectroscopy. It is the object of the invention to be able to characterize a sample with a high resolution and comprehensively. The object is solved by a method and an associated device for examining a sample by means of nuclear magnetic spectroscopy by measuring heteronuclear and homonuclear J-couplings in a small magnetic field and by using the measured heteronuclear and homonuclear J-couplings for characterizing the sample.
摘要翻译：本发明涉及通过NMR光谱检测分子的方法和装置。本发明的目的是能够以高分辨率和全面地表征样品。该目的通过一种方法和相关设备来解决，用于通过在小磁场中测量异核和同核J耦合并通过使用测量的异核和同核J耦合来表征样品，通过核磁谱检查样品。

6. 发明授权

US07221448B1 Test cell for a noble gas polarizer 失效
标题翻译：用于惰性气体偏振器的测试电池
公开(公告)号：US07221448B1
公开(公告)日：2007-05-22
申请号：US10018765
申请日：2000-06-07
申请人： Stephan Appelt , Giovanni D'Orsaneo , Nadim Joni Shah
发明人： Stephan Appelt , Giovanni D'Orsaneo , Nadim Joni Shah
IPC分类号： G01N1/10 , G01N21/01 , C12Q1/68 , G02B5/30 , G02B27/28
CPC分类号： G01N21/05 , G01R33/282 , Y10T436/116664
摘要： The invention relates to a sample cell with a glass body comprising a gas inlet and a gas outlet and at least one orifice, a plane glass window is fused into the orifice, the shape and size of the window corresponds to the shape and size of the orifice, the orifice is limited by a rim, the rim is wider than the thickness of the window, the rim of the window is fused with the rim of the orifice.The invention further relates to a method of producing the sample cell. The window is inserted into the orifice. The rim of the orifice is heated several times from the exterior in such a way that the glass melts and a fused joint is formed between the window and the rim of the orifice.The sample cell produced by the method has a particularly rigid joint between the window and the glass body. Therefore, this glass cell is able to withstand pressures above 10 bar and allows the passage of light without lens effects owing to its plane-parallel windows.The sample cell is used in a polarizer for inert gas.
摘要翻译：本发明涉及一种具有玻璃体的样品池，该玻璃体包括气体入口和气体出口以及至少一个孔口，平面玻璃窗口被熔化到孔中，窗口的形状和尺寸对应于孔口由边缘限制，边缘比窗口的厚度更宽，窗口的边缘与孔口的边缘熔合。本发明还涉及一种生产样品池的方法。窗口插入孔中。孔的边缘从外部被加热几次，使得玻璃熔化并且在窗口和孔的边缘之间形成熔接接头。通过该方法制造的样品池在窗口和玻璃体之间具有特别刚性的接头。因此，这种玻璃电池能够承受10巴以上的压力，并且由于其平面平行的窗口而允许通过光而没有透镜效应。样品池用于惰性气体的偏振器。

7. 发明申请

US20050030026A1 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 有权
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US20050030026A1
公开(公告)日：2005-02-10
申请号：US10940297
申请日：2004-09-13
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： G01R33/48 , A61B5/055 , A61K49/18 , G01R33/28 , G01R33/62 , G01V3/00 , A61B5/05
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

8. 发明申请

US20090261822A1 Hyperpolarization of lithium and other nuclei 失效
标题翻译：锂和其他核的超极化
公开(公告)号：US20090261822A1
公开(公告)日：2009-10-22
申请号：US11918853
申请日：2006-03-25
申请人： Stephan Appelt , Wolfgang Haesing , Ulrich Sieling , Holger Kuehn
发明人： Stephan Appelt , Wolfgang Haesing , Ulrich Sieling , Holger Kuehn
IPC分类号： G01R33/26
CPC分类号： G01R33/282
摘要： The invention concerns a method for hyperpolarizing lithium atoms in a mixture by optically pumping, in a sampling cell, atoms of a first type or alkali metal and by spin exchange between the optically pumped electron of the alkali metal and the lithium atom electron. The lithium atoms are preferably oxidized into Li+ ions and accumulated. The nuclear spin polarization of the Li+ ions can be transmitted to a nuclear spin of an anion. The invention also concerns a method for producing substances with nuclear spin polarization in general. In accordance with said method, lithium atoms are optically pumped from atoms of a first type of alkali metal in a sampling cell and hyperpolarized by spin exchange between the optical pumped electron of the alkali metal and the lithium atom electron, the lithium atoms being then oxidized into Li+ ions. Then, the nuclear spin polarization of the Li+ ions is transmitted to another nucleus of an anion. Thus it is possible to obtain hyperpolarized nuclei such as, for example, 13C, 31P or 29Si in solid or liquid phase, in large amounts and at high polarizing levels.
摘要翻译：本发明涉及一种通过在采样单元中光学泵浦第一类型或碱金属原子并通过碱性金属的光泵浦电子与锂原子电子之间的自旋交换来超极化混合物中的锂原子的方法。锂原子优选被氧化成Li +离子并累积。 Li +离子的核自旋极化可以传递到阴离子的核自旋。本发明还涉及通常产生具有核自旋极化的物质的方法。根据所述方法，锂原子在取样室中从第一种碱金属的原子被光泵浦，并通过碱金属的光泵浦电子与锂原子电子之间的自旋交换进行超极化，然后锂原子被氧化进入Li +离子。然后，Li +离子的核自旋极化被传递到阴离子的另一个核。因此，可以在固相或液相中以大量和高极化水平获得超极化核，例如13C，31P或29Si。

9. 发明授权

US06589793B1 Measurement device for the measurement of the absolute polarisation of alkali metal atoms 失效
标题翻译：用于测量碱金属原子绝对极化的测量装置
公开(公告)号：US06589793B1
公开(公告)日：2003-07-08
申请号：US09590533
申请日：2000-06-08
申请人： Stephan Appelt , Timur Unlu , Nadim Jone Shah
发明人： Stephan Appelt , Timur Unlu , Nadim Jone Shah
IPC分类号： G01N3320
CPC分类号： G01N21/21 , Y10T436/24
摘要： The invention concerns a device for the determination of the absolute polarisation of alkali metal atoms. The device can inter alia be used for the diagnosis of alkali metal polarisation in a polariser for inert gases. The device includes a detection laser, which together with a &lgr;/4 plate creates circularly polarised light. A sensor for the measurement of the light absorbed by the sample of the polariser is provided. A Helmholtz coil pair serves for the creation of a static magnetic field B0. An oscillating magnetic field is created with an RF coil. A gradient coil serves for the creation of a linear magnetic field gradient. Various optical components are present. An electronic processor effects the determination of the absolute polarisation of the alkali metal atoms. All the said components with the exception of the Helmholtz coils are firmly mounted onto a platform which can be moved parallel to the direction of the B0 field. Means for controlling the temperature of the laser for the detection of the polarisation of the alkali metal atoms are provided. The means for controlling the temperature of the laser for the detection of the polarisation of the alkali metal atoms include a temperature sensor, with which the temperature of the laser is measured, a heating/cooling device, with which the laser is heated or cooled, and also a control device, which controls the heating/cooling device depending on the measured temperature of the laser, so that the temperature of the laser is held constant. Compared to the state of the art, faster and better measurement results can thus be achieved.
摘要翻译：本发明涉及一种用于确定碱金属原子的绝对极化的装置。该装置尤其可用于诊断用于惰性气体的偏振器中的碱金属极化。该装置包括检测激光器，其与羔羊/ 4板一起产生圆偏振光。提供了用于测量由偏振器的样品吸收的光的传感器。亥姆霍兹线圈对用于创建静态磁场B0。用RF线圈产生振荡磁场。梯度线圈用于产生线性磁场梯度。存在各种光学部件。电子处理器可以确定碱金属原子的绝对极化。除了亥姆霍兹线圈之外的所有组件都被牢固地安装在平台上，平台可以平行于B0场的方向移动。提供了用于控制用于检测碱金属原子的极化的激光器的温度的装置。用于控制用于检测碱金属原子的极化的激光的温度的装置包括：测量激光的温度的温度传感器，激光被加热或冷却的加热/冷却装置，以及控制装置，其根据激光的测量温度控制加热/冷却装置，使得激光器的温度保持恒定。与现有技术相比，可以实现更快更好的测量结果。

10. 发明授权

US06426058B1 Enhancement of NMR and MRI in the presence of hyperpolarized noble gases 失效
标题翻译：在超极化稀有气体存在下增强核磁共振和核磁共振
公开(公告)号：US06426058B1
公开(公告)日：2002-07-30
申请号：US08825475
申请日：1997-03-28
申请人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
发明人： Alexander Pines , Thomas Budinger , Gil Navon , Yi-Qiao Song , Stephan Appelt , Angelo Bifone , Rebecca Taylor , Boyd Goodson , Roberto Seydoux , Toomas Room , Tanja Pietrass
IPC分类号： A61B505
CPC分类号： G01R33/5601 , A61K49/1815 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.
摘要翻译：本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

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