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1. 发明申请

US20100034703A1 MICRO SCALE FLOW THROUGH SORBENT PLATE COLLECTION DEVICE 审中-公开
标题翻译：通过同步板收集装置的微尺度流动
公开(公告)号：US20100034703A1
公开(公告)日：2010-02-11
申请号：US12572807
申请日：2009-10-02
申请人： Eric J. Houser , Robert Andrew McGill , David J. Nagel , Stanley Vincent Stepnowski
发明人： Eric J. Houser , Robert Andrew McGill , David J. Nagel , Stanley Vincent Stepnowski
IPC分类号： B01L3/00
CPC分类号： B01L7/00 , B01L3/502753 , B01L2200/10 , B01L2300/069 , B01L2300/1827 , B82Y30/00 , G01N1/02 , G01N1/2214 , G01N1/2273 , G01N1/40 , G01N1/405 , G01N30/08 , G01N33/0011 , G01N2001/022 , G01N2030/062 , G01N2030/121 , Y10T436/25 , Y10T436/255
摘要： In the invention, a collection device includes a first micro scale plate having a sorbent surface and a through hole. The through hole provides for the passage of an analyte fluid flow through the plate and it has a volume and geometry to provide contact between the fluid and the sorbent surface in an amount effective to absorb a sufficient amount of analyte for subsequent detection of the analyte. The sorbent surface can be provided by a sorbent coating such as an active sensing film, e.g. a conducting or optically active material, examples of which include conducting polymers, polymer/carbon composites, carbon nanotubes. and dye-containing materials. The analyte collection device preferably includes a heating source, e.g. a heating element formed from a resistive trace, or a plurality of resistive traces on or within the first microscale plate, for effecting a thermal release of collected analyte from the plate.
摘要翻译：在本发明中，收集装置包括具有吸附剂表面和通孔的第一微尺度板。通孔提供了分析物流体通过板的通道，并且其具有体积和几何形状以提供流体和吸附剂表面之间的接触，其量有效地吸收足够量的分析物以便随后检测分析物。吸附剂表面可以由吸附剂涂层提供，例如主动感测膜，例如，导电或光学活性材料，其实例包括导电聚合物，聚合物/碳复合材料，碳纳米管。和含染料的材料。分析物收集装置优选地包括加热源，例如，由电阻迹线形成的加热元件或在第一微米板上或第一微米板上的多个电阻迹线，用于实现从板上热收集分析物的释放。

2. 发明授权

US06660230B2 Linear chemoselective carbosilane polymers and methods for use in analytical and purification applications 有权
标题翻译：线性化学选择性碳硅烷聚合物和用于分析和纯化应用的方法
公开(公告)号：US06660230B2
公开(公告)日：2003-12-09
申请号：US09895292
申请日：2001-07-02
申请人： Robert Andrew McGill , Eric J. Houser
发明人： Robert Andrew McGill , Eric J. Houser
IPC分类号： G01N700
CPC分类号： C08G77/24 , B01J20/285 , C08G77/60 , C08L83/16 , Y10T428/31663 , Y10T436/163333 , Y10T436/17
摘要： This invention relates generally to a new class of chemoselective polymer materials. In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatoghraphy, chemical trapping, analyte collection, and chemical sensor applications. These polymers have pendant and terminal aryl, alkyl, alkenyl, and alkynyl groups that are functionalized with halogen substituted alcohol or phenol groups, having the general structure: wherein n is an integer greater than 1; wherein at least one of R1 and R2 is a linear or branched arm having at least one group independently selected from the group consisting of alkyl, alkenyl, alkynyl, and aryl groups, or combinations thereof, and having at least one halogen substituted alcohol or phenol groups attached thereto; wherein any said R1 and R2 aryl groups are attached to said [Si—X—]n either directly or through a short hydrocarbon chain; wherein any remaining said R1 or R2 group is a hydrocarbon or carbosilane group; wherein X is a polymer component selected from the group consisting of alkylene, alkenylene, alkynylene, arylene groups, and combinations thereof; and wherein Z1 and Z2 are end groups independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkyl silanes, aryl silanes, hydroxyl, silicon hydride, alkoxides, halogen substituted alcohol, halogen substituted phenol, organosilyl, and combinations thereof. These polymeric materials are primarily designed to sorb hydrogen bond basic analytes such as organophosphonate esters (nerve agents and precursors) and nitro-substituted compounds (explosives).
摘要翻译：本发明一般涉及一类新的化学选择性聚合物材料。特别地，本发明涉及用于涉及吸收剂聚合物材料的各种分析应用中的线性聚碳硅烷化合物，包括色谱法，化学捕获，分析物收集和化学传感器应用。这些聚合物具有侧链和末端芳基，被卤素取代的醇或酚基官能化的烷基，链烯基和炔基，其具有以下通式结构：其中n是大于1的整数;其中R 1和 R 2是具有至少一个独立地选自烷基，烯基，炔基和芳基的基团或其组合的至少一个基团并且具有至少一个连接到其上的卤素取代的醇或苯酚基团的直链或支链臂; 其中任何所述R 1和R 2芳基直接或通过短的烃链连接到所述[Si-X] n;其中任何剩余的所述R 1或R 2基团是烃或碳硅烷基;其中X是选自亚烷基，亚烯基，亚炔基，亚芳基及其组合的聚合物组分; 并且其中Z 1和Z 2均为独立地选自烷基，烯基，炔基，芳基，烷基硅烷，芳基硅烷，羟基，氢化硅，烷氧基化物，卤素取代的醇，卤素取代的苯酚，有机甲硅烷基，以及它们的组合。这些聚合物材料主要设计用于吸附氢键碱性分析物如有机膦酸酯（神经试剂和前体）和硝基取代的化合物（爆炸物）。

3. 发明授权

US07153582B2 Hyperbranched chemoselective silicon-based polymers for chemical sensor applications 有权
标题翻译：用于化学传感器应用的超支化化学选择性硅基聚合物
公开(公告)号：US07153582B2
公开(公告)日：2006-12-26
申请号：US10672272
申请日：2003-09-26
申请人： Eric J Houser , Robert Andrew McGill
发明人： Eric J Houser , Robert Andrew McGill
IPC分类号： G01N30/00
CPC分类号： G01N29/036 , C08G77/50 , C08G77/60 , G01N2291/0257 , Y10T428/31663 , Y10T436/163333 , Y10T436/17
摘要： The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a hyperbranched compound having: (1) a polymer backbone portion that is at least partly randomly branched; (2) at least one pendant group extending from the polymer backbone portion; and (3) at least one halogen substituted alcohol or phenol group substituted at the pendant group(s) of the polymer backbone portion. The compound of the invention preferably has the general formula: wherein A is the hyperbranched backbone portion of the polymer; L and M are independently selected pendant groups of said polymer backbone; X and Y are independently selected halogen substituted alcohol or phenol groups; q and r are independently selected and at least 1; and n is at least 3.
摘要翻译：本发明提供了一种用于选择性分子识别的装置，该装置包括感测部分，其中所述感测部分包括其上涂覆有包含超支化化合物的层的基底，其具有：（1）至少部分地随机分支的聚合物主链部分; （2）至少一个从聚合物主链部分延伸的侧基; 和（3）在聚合物主链部分的侧基取代的至少一个卤素取代的醇或苯酚基团。本发明的化合物优选具有以下通式：其中A是聚合物的超支化骨架部分; L和M独立地选自所述聚合物骨架的侧基; X和Y独立地选择卤素取代的醇或苯酚基团; q和r独立地选择并且至少为1; n为3以上。

4. 发明授权

US07132294B2 Functionalized small molecules for use in chemical sensors 有权
公开(公告)号：US07132294B2
公开(公告)日：2006-11-07
申请号：US10080403
申请日：2002-02-25
申请人： Eric J. Houser , Robert Andrew McGill
发明人： Eric J. Houser , Robert Andrew McGill
IPC分类号： G01N33/00 , G01N33/22 , G01N29/24 , C07F7/08 , C07F7/02 , C07F7/12 , C07C33/46 , C07C33/24
CPC分类号： C07F7/081 , Y10T436/14 , Y10T436/16 , Y10T436/163333 , Y10T436/170769 , Y10T436/173076
摘要： The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two pendant and terminal unsaturated groups, each being functionalized with at least one halogen substituted alcohol or phenol functional group. The compound of the invention preferably has one of the following general formulae: wherein A is a core moiety; B is a pendant and terminal unsaturated group;q is at least 1;r is at least 2;X is a linking group; andn is an integer designating the number of repeating units from 1 to 3, with the proviso that, if n is greater than 1, then the B groups differ from each other in at least two of the repeating units.The device is used to detect the molecules of a hydrogen bond accepting vapor such as an organophosphonate or nitroaromatic vapor.

5. 发明授权

US06630560B2 Linear and branched chemoselective siloxane polymers and methods for use in analytical and purification applications 有权
标题翻译：线性和分支化学选择性硅氧烷聚合物和用于分析和纯化应用的方法
公开(公告)号：US06630560B2
公开(公告)日：2003-10-07
申请号：US09895293
申请日：2001-07-02
申请人： Robert Andrew McGill , Eric J. Houser , Todd Mlsna
发明人： Robert Andrew McGill , Eric J. Houser , Todd Mlsna
IPC分类号： C08G7724
CPC分类号： C08G77/24 , B01J20/285 , C08G77/60 , C08L83/16 , Y10T428/31663 , Y10T436/163333 , Y10T436/17
摘要： This invention relates generally to a new class of chemoselective polymer materials. In particular, the invention relates to linear and branched polysiloxane compounds for use in various analytical applications involving sorbent polymer materials, including chromatography, chemical trapping, analyte collection, and chemical sensor applications. These polymers have pendant and terminal aryl, alkyl, alkenyl, and alkynyl groups that are functionalized with halogen substituted alcohol or halogen substituted phenol groups, having the general structure: wherein: n is an integer greater than 1; wherein at least one of R1 and R2 includes an alkyl, alkenyl, alkynyl, or aryl group having at least one halogen substituted alcohol or halogen substituted phenol group attached thereto; wherein any said R1 and R2 aryl groups are attached to said [Si—O—]n, the polymer backbone, directly or through a short hydrocarbon chain; wherein any remaining R1 or R2 group is an alkyl, alkenyl, alkynyl, or aryl group having between one and sixteen carbons; and Z is a polymer end group independently selected from the group consisting of saturated hydrocarbons, unsaturated hydrocarbons, alkyl silanes, aryl silanes, hydroxyl, hydride, alkoxides, halogen substituted alcohol, halogen substituted phenol, and combinations thereof. These polymeric materials are primarily designed to sorb hydrogen bond basic analytes such as organophosphonate esters (nerve agents and precursors) and nitro-substituted compounds (explosives).
摘要翻译：本发明一般涉及一类新的化学选择性聚合物材料。特别地，本发明涉及用于涉及吸收剂聚合物材料的各种分析应用中的直链和支链聚硅氧烷化合物，包括色谱法，化学捕获法，分析物收集法和化学传感器应用。这些聚合物具有侧链和末端芳基，被卤素取代的醇或卤素取代的酚基官能化的烷基，烯基和炔基，其具有以下通式：其中：n是大于1的整数;其中R' 1＆gt;和R 2包括具有至少一个卤素取代的醇或卤素取代的苯酚基团的烷基，烯基，炔基或芳基，其中任何所述R 1和R 2芳基连接到所述[Si-O-] n，聚合物主链，直接或通过短的烃链;其中任何残留的R 1或R 2基团是具有1至16个的烷基，烯基，炔基或芳基碳; 和Z是独立地选自饱和烃，不饱和烃，烷基硅烷，芳基硅烷，羟基，氢化物，醇盐，卤素取代的醇，卤素取代的苯酚及其组合的聚合物端基。这些聚合物材料主要设计成吸附氢键碱性分析物如有机膦酸酯（神经药物和前体）和硝基取代的化合物（爆炸物）。

6. 发明授权

US06320295B1 Diamond or diamond like carbon coated chemical sensors and a method of making same 失效
标题翻译：钻石或钻石如碳涂层化学传感器及其制造方法
公开(公告)号：US06320295B1
公开(公告)日：2001-11-20
申请号：US09195147
申请日：1998-11-18
申请人： Robert Andrew McGill , Paul Christopher Dorsey , Douglas Brian Chrisey
发明人： Robert Andrew McGill , Paul Christopher Dorsey , Douglas Brian Chrisey
IPC分类号： H01L4108
CPC分类号： G01N29/2462 , G01N29/022 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , Y10T29/42
摘要： A water vapor insensitive and corrosion resistant chemical or biochemical sensor device, including a transducer, coated with a protective coating of diamond or a diamond-like carbon, preferably by a pulsed laser deposition technique. The surface of the protective coating is coated with a chemoselective or bioselective absorption material or film.
摘要翻译：一种水蒸汽不敏感和耐腐蚀的化学或生物化学传感器装置，包括用金刚石或类金刚石碳的保护涂层涂覆的传感器，优选地通过脉冲激光沉积技术。保护涂层的表面涂有化学选择性或生物选择性吸收材料或膜。

7. 发明授权

US6025036A Method of producing a film coating by matrix assisted pulsed laser deposition 失效
标题翻译：通过基质辅助脉冲激光沉积制备薄膜涂层的方法
公开(公告)号：US6025036A
公开(公告)日：2000-02-15
申请号：US864320
申请日：1997-05-28
申请人： Robert Andrew McGill , Douglas Brian Chrisey
发明人： Robert Andrew McGill , Douglas Brian Chrisey
IPC分类号： A61F2/28 , B05D3/06 , B05D7/24 , C08F2/46 , C23C14/12 , C23C14/28
CPC分类号： B05D1/60 , C23C14/12 , C23C14/28
摘要： A film of a coating material is produced on a substrate by a pulsed laser deposition method in which the material that forms the coating material is first combined with a matrix material to form a target. The target is then exposed to a source of laser energy to desorb the matrix material from the target and lift the coating material from the surface of the target. The target and the substrate are oriented with respect to each other so that the lifted coating material is deposited as a film upon said substrate. The matrix material is selected to have the property of being more volatile than the coating material and less likely than the coating material to adhere to the substrate. The matrix material is further selected as having the property such that when the target is exposed to a source of laser energy, the matrix material desorbs from the target and lifts the coating material from the surface of the target. In another aspect of the invention, a method of making an improved chemical or biochemical sensing device that includes a chemoselective or bioselective coating on a substrate is carried out by coating the substrate by pulsed laser deposition.
摘要翻译：通过脉冲激光沉积方法在基板上制造涂料的膜，其中形成涂料的材料首先与基质材料组合以形成靶。然后将靶暴露于激光能量源以从靶上解吸基质材料并从靶的表面提起涂层材料。靶和基底相对于彼此定向，使得提起的涂层材料作为膜沉积在所述基底上。选择基质材料具有比涂层材料更易挥发的性质，并且不太可能比涂覆材料粘附到基底上。基质材料被进一步选择为具有这样的特性，使得当靶暴露于激光能量源时，基质材料从目标解吸并从涂层表面提起涂层材料。在本发明的另一方面，通过用脉冲激光沉积涂覆基底来进行制造包括化学选择性或生物选择性涂层在内的改进的化学或生化检测装置的方法。

8. 发明授权

US08409510B2 Micro scale flow through sorbent plate collection device 有权
标题翻译：微量流过吸附板收集装置
公开(公告)号：US08409510B2
公开(公告)日：2013-04-02
申请号：US11542453
申请日：2006-10-02
申请人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski , Viet Nguyen
发明人： Robert Andrew McGill , Michael Martin , Mark Crain , Kevin Walsh , Eric Houser , Stanley Vincent Stepnowski , Viet Nguyen
IPC分类号： G01N30/00 , G01N30/08 , G01N30/90
CPC分类号： B01L7/00 , B01L3/502753 , B01L2200/10 , B01L2300/069 , B01L2300/1827 , B82Y30/00 , G01N1/02 , G01N1/2214 , G01N1/2273 , G01N1/40 , G01N1/405 , G01N30/08 , G01N33/0011 , G01N2001/022 , G01N2030/062 , G01N2030/121 , Y10T436/25 , Y10T436/255
摘要： In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
摘要翻译：在本发明中，收集装置包括布置成收集分析物的流过微尺度板。该板包括孔和在板的接触表面上的吸附剂涂层。这些孔通过分析物流体流动，例如分析物蒸汽，使得用于收集的流体流可以大致垂直于吸附剂板。优选的实施例板包括集成加热器迹线。在优选实施例中，高的基本上垂直的流被用于收集和浓缩，并且在解吸和输送期间使用低的基本上平行的流动。选择低流量以满足检测器系统的约束。

9. 发明授权

US06336368B1 Method and apparatus for energy efficient tacking of resonant devices 失效
标题翻译：谐振装置的能量效率的方法和装置
公开(公告)号：US06336368B1
公开(公告)日：2002-01-08
申请号：US09404720
申请日：1999-09-10
申请人： Russell Chung , Robert Andrew McGill
发明人： Russell Chung , Robert Andrew McGill
IPC分类号： G01L100
CPC分类号： B06B1/0648 , G01H11/08 , G10K9/125 , G10K11/36
摘要： A method and apparatus for interrogating a resonator to monitor its resonance characteristics (e.g. resonant frequency) in an especially energy efficient manner, particularly changes to the characteristics over time. The resonator is pulsed and the response thereto sampled. By comparison of samples of the response to sequential pulses, sampled at the same times after pulse initiation, one can infer phase changes between the responses, and hence infer changes in resonance characteristics. Preferably, one calibrates the resonator's time response initially as a reference, which permits subsequent determination of the resonance state with only one digital sample per pulse. In one embodiment, the invention this detection scheme is used as a chemical detector. The resonator is an electo-acoustic device, having plural Bragg gratings, with a different adsorptive material atop each grating which adsorbs one selected chemical particularly well. Absorption causes the weight of material to increase, changing the resonance characteristics of the gratings. A single pulse launched into the SAW will cause reflections from each of the Bragg cells which are staggered in time, and hence separately detectable. The resonance of each grating is then tracked as above described, and changes thereto over time indicates the amount of material adsorbed.
摘要翻译：一种用于询问谐振器以以特别高效的方式监测其谐振特性（例如谐振频率）的方法和装置，特别是随时间的特性的变化。谐振器是脉冲的并且其响应被采样。通过比较脉冲启动后相同时间采样的顺序脉冲的响应样本，可以推断出响应之间的相位变化，从而推断出共振特性的变化。优选地，首先校准谐振器的时间响应作为参考，其允许随后每个脉冲仅使用一个数字样本来确定谐振状态。在一个实施例中，本发明将该检测方案用作化学检测器。谐振器是具有多个布拉格光栅的电声装置，在每个光栅顶上具有不同的吸附材料，其特别好地吸附一个所选择的化学物质。吸收会导致材料的重量增加，改变光栅的共振特性。发射到SAW中的单个脉冲将引起每个布拉格细胞的反射，其随时间交错，因此可以单独检测。然后如上所述跟踪每个光栅的共振，随着时间的推移，其变化表示吸附材料的量。

10. 发明申请

US20130134310A1 CHEMICAL MAPPING USING THERMAL MICROSCOPY AT THE MICRO AND NANO SCALES 有权
标题翻译：在微米和纳米尺度上使用热显微镜进行化学测绘
公开(公告)号：US20130134310A1
公开(公告)日：2013-05-30
申请号：US13684535
申请日：2012-11-25
申请人： Robert Furstenberg , Chris Kendziora , Nabil D. Bassim , Robert Andrew McGill , Viet K. Nguyen
发明人： Robert Furstenberg , Chris Kendziora , Nabil D. Bassim , Robert Andrew McGill , Viet K. Nguyen
IPC分类号： G01J3/28 , G01J3/02
CPC分类号： G01J3/2823 , G01J3/02 , G01J3/0202 , G01J3/443 , G01J3/45 , G01J5/60 , G01J2003/2826 , G01N21/171 , G01N21/3563 , G01N21/41 , G01N21/45 , G01N2021/1714 , G01N2021/1725 , G01N2021/1731 , G01N2021/393 , G02B21/0028 , G02B21/008
摘要： A non-destructive method for chemical imaging with ˜1 nm to 10 μm spatial resolution (depending on the type of heat source) without sample preparation and in a non-contact manner. In one embodiment, a sample undergoes photo-thermal heating using an IR laser and the resulting increase in thermal emissions is measured with either an IR detector or a laser probe having a visible laser reflected from the sample. In another embodiment, the infrared laser is replaced with a focused electron or ion source while the thermal emission is collected in the same manner as with the infrared heating. The achievable spatial resolution of this embodiment is in the 1-50 nm range.
摘要翻译：用于化学成像的非破坏性方法，具有〜1 nm至10 mum的空间分辨率（取决于热源的类型），无需样品制备和非接触式。在一个实施例中，样品使用IR激光进行光热加热，并且用具有从样品反射的可见激光的IR检测器或激光探针测量所得到的热发射增加。在另一个实施例中，红外激光被聚焦的电子或离子源代替，同时以与红外线加热相同的方式收集热发射。该实施例的可实现的空间分辨率在1-50nm范围内。

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