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1. 发明授权

US09777053B2 Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy 有权
公开(公告)号：US09777053B2
公开(公告)日：2017-10-03
申请号：US11672571
申请日：2007-02-08
申请人： Seok-Hyun Yun
发明人： Seok-Hyun Yun
IPC分类号： A61B5/00 , C07K14/705 , G01J3/44 , G01N21/47 , G01N21/63
CPC分类号： C07K14/70503 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/4795 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between −100 GHz and 100 GHz, excluding zero.

2. 发明申请

US20170190319A1 TOTAL-REFLECTION-TYPE RAIN SENSOR USING MIRROR 审中-公开
公开(公告)号：US20170190319A1
公开(公告)日：2017-07-06
申请号：US15315191
申请日：2014-05-30
申请人： ACCENDO MOTION RESEARCH CO., LTD , DREAMTECH CO., LTD
发明人： Young-Ho KIM , Jin Sang LEE , Yong Pyo HONG , Nam Joon YOO
IPC分类号： B60S1/08 , G01J1/42 , G01W1/14 , G01N21/17
CPC分类号： B60S1/0837 , B60S1/0822 , B60S1/0833 , B60S1/0844 , G01J1/42 , G01J2001/4238 , G01N21/1717 , G01N2021/1725 , G01N2021/1742 , G01W1/14
摘要： The present invention relates to a total reflection type rain sensor using a mirror, which is attached to a glass of a vehicle to detect raindrops falling onto the glass of the vehicle and outputs a signal capable of controlling speed and cycle of a wiper of the vehicle according to the amount and falling frequency of raindrops detected.

3. 发明申请

US20160011049A1 CHEMICAL MAPPING USING THERMAL MICROSCOPY AT THE MICRO AND NANO SCALES 有权
标题翻译：在微米和纳米尺度上使用热显微镜进行化学测绘
公开(公告)号：US20160011049A1
公开(公告)日：2016-01-14
申请号：US14748430
申请日：2015-06-24
申请人： Robert Furstenberg , Chris Kendziora , Michael Papantonakis , R. Andrew McGill , Viet K. Nguyen , Graham K. Hubler
发明人： Robert Furstenberg , Chris Kendziora , Michael Papantonakis , R. Andrew McGill , Viet K. Nguyen , Graham K. Hubler
IPC分类号： G01J3/28 , G01J3/443 , G01J3/02 , G01J3/45
CPC分类号： G01J3/2823 , G01J3/02 , G01J3/0202 , G01J3/443 , G01J3/45 , G01J5/60 , G01J2003/2826 , G01N21/171 , G01N21/3563 , G01N21/41 , G01N21/45 , G01N2021/1714 , G01N2021/1725 , G01N2021/1731 , G01N2021/393 , G02B21/0028 , G02B21/008
摘要： A non-destructive method for chemical imaging with ˜1 nm to 10 μm spatial resolution (depending on the type of heat source) without sample preparation and in a non-contact manner. In one embodiment, a sample undergoes photo-thermal heating using an IR laser and the resulting increase in thermal emissions is measured with either an IR detector or a laser probe having a visible laser reflected from the sample. In another embodiment, the infrared laser is replaced with a focused electron or ion source while the thermal emission is collected in the same manner as with the infrared heating. The achievable spatial resolution of this embodiment is in the 1-50 nm range.
摘要翻译：用于化学成像的非破坏性方法，具有〜1 nm至10μm的空间分辨率（取决于热源的类型），无需样品制备和非接触式。在一个实施例中，样品使用IR激光进行光热加热，并且用具有从样品反射的可见激光的IR检测器或激光探针测量所得到的热发射增加。在另一个实施例中，红外激光被聚焦的电子或离子源代替，同时以与红外线加热相同的方式收集热发射。该实施例的可实现的空间分辨率在1-50nm范围内。

4. 发明申请

US20150338212A1 PHOTOREFLECTANCE DEVICE 有权
标题翻译：光电设备
公开(公告)号：US20150338212A1
公开(公告)日：2015-11-26
申请号：US14651414
申请日：2013-12-09
申请人： NEXCIS , UNIVERSITE D'AIX-MARSEILLE
发明人： Antonin MOREAU , Véronica BERMUDEZ , Ludovic ESCOUBAS , Jean-Jacques SIMON
IPC分类号： G01B11/30
CPC分类号： G01B11/303 , G01N21/1717 , G01N2021/1725 , G01N2201/065
摘要： A photoreflectance device for characterizing a rough surface includes a pump beam emitter to emit a pump beam; a probe beam emitter to emit a probe beam; a detector to detect the probe beam reflected by the surface; an integrating sphere to collect the probe beam reflected by the surface, the integrating sphere including: a first output connected to the detector, and disposed so as to receive a majority of the probe beam reflected by the surface; a second output arranged so as to receive a majority of the pump beam reflected by the surface.
摘要翻译：用于表征粗糙表面的光反射装置包括：泵浦光束发射器，用于发射泵浦光束; 用于发射探测光束的探测光束发射器; 用于检测由表面反射的探测光束的检测器; 用于收集由表面反射的探测光束的积分球，所述积分球包括：连接到所述检测器的第一输出，并且被设置为接收由所述表面反射的所述探测光束的大部分; 布置成接收由表面反射的泵浦光束的大部分的第二输出。

5. 发明授权

US09166358B2 Systems and methods for lasing from a molecular gas 有权
标题翻译：从分子气体射出的系统和方法
公开(公告)号：US09166358B2
公开(公告)日：2015-10-20
申请号：US13546888
申请日：2012-07-11
申请人： Richard B. Miles , Arthur Dogariu , James B. Michael
发明人： Richard B. Miles , Arthur Dogariu , James B. Michael
IPC分类号： H01S3/097 , G01N21/17 , H01S3/094 , H01S3/22 , G01N21/65 , H01S3/00 , H01S3/23
CPC分类号： H01S3/097 , G01N21/1717 , G01N21/65 , G01N2021/1725 , G01N2021/1793 , G01N2021/655 , H01S3/0014 , H01S3/094092 , H01S3/22 , H01S3/2391
摘要： Systems and methods for lasing molecular gases, and systems and methods of detecting molecular species are provided. The systems and methods can include the use of an excitation laser tuned to a wavelength associated with oxygen or nitrogen. The lasing can occur in both the forward and reverse directions relative to the excitation laser beam. Reverse lasing can provide a laser beam that propagates back toward the excitation laser source, and can provide a method for remote sampling of molecular species contained in the air. For example, systems and methods of detecting a molecular species of interest can be achieved by using the properties of the backward or forward propagating air laser to indicate a change in a pulse from the source of laser pulses caused by a modulation laser tuned to interact with the molecular species of interest.
摘要翻译：提供了用于激发分子气体的系统和方法，以及检测分子种类的系统和方法。该系统和方法可以包括使用调谐到与氧气或氮气相关联的波长的激发激光器。激光可以相对于激发激光束在正向和反向方向上发生。反向激光可以提供向激发激光源传播的激光束，并且可以提供用于远程采样包含在空气中的分子物质的方法。例如，可以通过使用反向或正向传播的空气激光器的特性来表示检测感兴趣的分子种类的系统和方法，以指示由调制的激光脉冲源引起的脉冲的变化，所述调制激光器被调谐以与感兴趣的分子物种。

6. 发明授权

US08817262B2 Method for determining the doping profile of a partially activated doped semiconductor region 有权
标题翻译：用于确定部分激活的掺杂半导体区域的掺杂分布的方法
公开(公告)号：US08817262B2
公开(公告)日：2014-08-26
申请号：US13689540
申请日：2012-11-29
申请人： IMEC , Katholieke Universiteit Leuven
发明人： Janusz Bogdanowicz
IPC分类号： G01N21/55 , H01L21/66 , G01N21/17
CPC分类号： G01N21/55 , G01N21/1717 , G01N2021/1719 , G01N2021/1725 , G01N2021/1731 , H01L22/12
摘要： A method is disclosed for determining the inactive doping concentration of a semiconductor region using a PMOR method. In one aspect, the method includes providing two semiconductor regions having substantially the same known as-implanted concentration but known varying junction depths. The method includes determining on one of these semiconductor regions the as-implanted concentration. The semiconductor regions are then partially activated. PMOR measures are then performed on the partially activated semiconductor regions to measure (a) the signed amplitude of the reflected probe signal as function of junction depth and (b) the DC probe reflectivity as function of junction depth. The method includes extracting from these measurements the active doping concentration and then calculating the inactive doping concentration using the determined total as-implanted concentration and active doping concentration. The method may also include extracting thermal diffusivity, refraction index, absorption coefficient, and/or SRHF lifetime from these measurements.
摘要翻译：公开了一种使用PMOR方法确定半导体区域的非活性掺杂浓度的方法。在一个方面，该方法包括提供具有基本相同的已知植入浓度但是已知的变化的结深度的两个半导体区域。该方法包括在这些半导体区域中的一个上确定注入的浓度。然后半导体区域被部分激活。然后对部分激活的半导体区域执行PMOR测量，以测量（a）反射探测信号的符号振幅作为结深度的函数，以及（b）DC探针反射率作为结深度的函数。该方法包括从这些测量中提取有源掺杂浓度，然后使用确定的总注入浓度和有源掺杂浓度来计算非活性掺杂浓度。该方法还可以包括从这些测量中提取热扩散率，折射率，吸收系数和/或SRHF寿命。

7. 发明授权

US08312772B2 Characterization with picosecond ultrasonics of metal portions of samples potentially subject to erosion 有权
标题翻译：用可能受到侵蚀的样品的金属部分的皮秒超声波进行表征
公开(公告)号：US08312772B2
公开(公告)日：2012-11-20
申请号：US12449837
申请日：2008-02-28
申请人： Guray Tas , Sean P. Leary , Dario Alliata , Jana Clerico , Priya Mukundhan , Zhongning Dai
发明人： Guray Tas , Sean P. Leary , Dario Alliata , Jana Clerico , Priya Mukundhan , Zhongning Dai
IPC分类号： G01N29/24 , G01N21/00
CPC分类号： G01N21/1717 , G01N21/95684 , G01N29/2418 , G01N2021/1725 , G01N2021/8416 , G01N2021/95638
摘要： A method for evaluating a manufacturing process is described. The method includes generating an optical pump beam pulse and directing the optical pump beam pulse to a surface of a sample. A probe pulse is generated and directed the probe pulse to the surface of the sample. A probe pulse response signal is detected. A change in the probe pulse varying in response to the acoustic signal forms the probe pulse response signal. An evaluation of one or more manufacturing process steps used to create the sample is made based upon the probe pulse response signal. Additionally the method may be used for process control of a CMP process. Apparatus are also described.
摘要翻译：对制造工序的评价方法进行说明。该方法包括产生光泵浦波束脉冲并将光泵浦波束脉冲引导到样品的表面。产生探针脉冲并将探针脉冲引导到样品的表面。探测脉冲响应信号。响应于声信号变化的探针脉冲的变化形成探针脉冲响应信号。基于探针脉冲响应信号进行用于产生样品的一个或多个制造工艺步骤的评估。另外，该方法可以用于CMP过程的过程控制。还描述了装置。

8. 发明申请

US20110105867A1 OPTICAL SENSOR FOR DETERMINING THE CONCENTRATION OF AN ANALYTE 有权
标题翻译：用于确定分析仪浓度的光学传感器
公开(公告)号：US20110105867A1
公开(公告)日：2011-05-05
申请号：US12741350
申请日：2008-10-31
申请人： Peter Schultz , Arkady Amosov , Natalia Izvarina , Sergey Kravetz
发明人： Peter Schultz , Arkady Amosov , Natalia Izvarina , Sergey Kravetz
IPC分类号： A61B5/1455
CPC分类号： G01N21/49 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/7239 , G01N21/1717 , G01N2021/1725
摘要： A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam (B1) to irradiate a portion (130) of tissue of the subject, causing physical and chemical changes in the surface, and causing an initial CPU back scattering (D1) of light. The method further includes periodically emitting a probe beam (B2) which irradiates the portion of tissue and causes periodic back scatterings (D2) of light. The initial and periodic back scatterings are detected and converted into electrical signals of at least the amplitude, frequency or decay time of the physical and chemical changes, the back scatterings being modulated by the physical and chemical changes. By differentiating over time at least one of the amplitude, frequency or decay time of the physical and chemical changes, the concentration of glucose may be determined.
摘要翻译：提供了使用光学激发和检测非侵入性地确定受试者中葡萄糖浓度的方法和装置。该方法包括发射激发光束（B1）以照射被检体的组织的一部分（130），引起表面的物理和化学变化，并引起光的初始CPU反向散射（D1）。该方法还包括周期性地发射照射组织部分并产生光的周期性后向散射（D2）的探针束（B2）。初始和周期性后向散射被检测并转换成至少物理和化学变化的振幅，频率或衰减时间的电信号，后向散射由物理和化学变化调制。通过随时间推移物理和化学变化的幅度，频率或衰减时间中的至少一个，可以确定葡萄糖的浓度。

9. 发明授权

US07920265B1 Apparatus and method for noise reduction in modulated optical reflectance metrology system 有权
标题翻译：调制光学反射计量系统中降噪的装置和方法
公开(公告)号：US07920265B1
公开(公告)日：2011-04-05
申请号：US12182060
申请日：2008-07-29
申请人： Alan George
发明人： Alan George
IPC分类号： G01N21/00
CPC分类号： G01N21/1717 , G01N21/274 , G01N2021/1725
摘要： In a modulated optical reflectance (MOR) system, a laser noise suppression technique utilizes a reference beam split optically from a probe laser prior to injection of a beam from the probe laser into an MOR signal path. The reference beam and a probe beam reflected from the sample are sent to first and second detectors, which produce first and second signals. A signal combiner receives the second signal at a first input and produces a combiner signal that corresponds to a difference between signals applied to the first and a second input. A level balancer receives the first signal and a signal derived from the combiner signal and produces a balancer output that is coupled to the second input of the signal combiner. The combination of the balancer output and the second signal tends to cancel out an average value of the second signal from the combiner signal.
摘要翻译：在调制光反射（MOR）系统中，激光噪声抑制技术利用在将探针激光束的光束注入到MOR信号路径之前从探针激光器光学分离的参考光束。将参考光束和从样本反射的探测光束发送到产生第一和第二信号的第一和第二检测器。信号组合器在第一输入处接收第二信号，并产生对应于施加到第一和第二输入的信号之间的差的组合器信号。电平平衡器接收第一信号和从组合器信号导出的信号，并产生耦合到信号组合器的第二输入端的平衡器输出。平衡器输出和第二信号的组合倾向于抵消来自组合器信号的第二信号的平均值。

10. 发明申请

US20090275016A1 ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF INFLUENZA IMMUNE RESPONSE 有权
标题翻译：用于测量流感免疫反应的阵列检测系统
公开(公告)号：US20090275016A1
公开(公告)日：2009-11-05
申请号：US12434438
申请日：2009-05-01
申请人： Benjamin L. Miller , Tim R. Mosmann , David Topham , Charles R. Mace
发明人： Benjamin L. Miller , Tim R. Mosmann , David Topham , Charles R. Mace
IPC分类号： C12Q1/70 , C12M1/34
CPC分类号： G01N33/56983 , C12N2760/16011 , G01N21/05 , G01N21/211 , G01N21/553 , G01N33/54373 , G01N2021/1725 , G01N2021/558 , G01N2021/5957 , G01N2333/11 , G01N2800/52
摘要： A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.
摘要翻译：一种用于检测针对流感病毒的免疫应答的传感器芯片，所述传感器芯片包括具有表面的底物和与所述底物表面上的离散位置结合的多个血凝素多肽，每个血凝素多肽具有血凝素表位。本文还描述了包含传感器芯片的检测装置和检测流感免疫应答的方法。

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