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    • 5. 发明申请
    • Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin
    • 使用卤代羟基二苯醚化合物治疗皮肤
    • US20080260667A1
    • 2008-10-23
    • US12214490
    • 2008-06-19
    • Werner BaschongMarcel Schnyder
    • Werner BaschongMarcel Schnyder
    • A61K8/34A61K8/46A61Q19/02
    • A61Q19/02A61K8/347
    • The use of (a) hydroxydiphenyl ether compounds of formula wherein R1, R2 and R3 are each independently of the others hydrogen; hydroxy; C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; C1-C20alkoxy; C1-C6alkylcarbonyl; phenyl; or phenyl-C1-C3alkyl; R4 is hydrogen, C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C1-C3alkyl; carboxyallyl; C2-C20alkenyl; C1-C6alkylcarbonyl; C1-C3alkylcarbonyl-C1-C3alkyl; phenyl; or phenyl-C1-C3alkyl; and R5 is hydrogen; C1-C20alkoxy; or C1-C6alkylcarbonyl; as melanogenesis inhibitors and for lightening the skin.
    • 使用(a)下式的羟基二苯醚化合物其中R 1,R 2和R 3各自独立地为氢; 羟基; C 1 -C 20烷基; C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; C 1 -C 20烷氧基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; 苯基; 或苯基-C 1 -C 3烷基; R 4是氢,C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; 羟基; 甲酰基 丙酮; 烯丙基 羧基; 羧基-C 1 -C 3烷基; 羧基 C 2 -C 20链烯基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; C 1 -C 3烷基羰基-C 1 -C 3烷基; C 1 -C 3烷基; C 1 -C 3烷基; 苯基; 或苯基-C 1 -C 3烷基; 并且R 5是氢; C 1 -C 20烷氧基; 或C 1 -C 6烷基羰基; 作为黑素生成抑制剂和减轻皮肤。
    • 10. 发明申请
    • Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin
    • 使用卤代羟基二苯醚化合物治疗皮肤
    • US20060216252A1
    • 2006-09-28
    • US10564712
    • 2004-07-07
    • Werner BaschongMarcel Schnyder
    • Werner BaschongMarcel Schnyder
    • A61K8/46A61K8/34
    • A61Q19/02A61K8/347
    • The use of hydroxydiphenyl ether compounds of formula (I), wherein R1, R2 and R3 are each independently of the others hydrogen; hydroxy; C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; C1-C20alkoxy; C1-C6alkylcarbonyl; phenyl; or phenyl-C1-C3alkyl; R4 is hydrogen, C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C1-C3alkyl; carboxyallyl; C2-C20alkenyl; C1-C6alkylcarbonyl; C1-C3alkylcarbonyl-C1-C3alkyl; phenyl; or phenyl-C1-C3alkyl; and R5 is hydrogen; C1-C20alkoxy; or C1-C6alkylcarbonyl; as melanogenesis inhibitors and for lightening the skin.
    • 式(I)的羟基二苯醚化合物(其中R 1,R 2和R 3)各自独立地为氢; 羟基; C 1 -C 20烷基; C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; C 1 -C 20烷氧基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; 苯基; 或苯基-C 1 -C 3烷基; R 4是氢,C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; 羟基; 甲酰基 丙酮; 烯丙基 羧基; 羧基-C 1 -C 3烷基; 羧基 C 2 -C 20链烯基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; C 1 -C 3烷基羰基-C 1 -C 3烷基; C 1 -C 3烷基; C 1 -C 3烷基; 苯基; 或苯基-C 1 -C 3烷基; 并且R 5是氢; C 1 -C 20烷氧基; 或C 1 -C 6烷基羰基; 作为黑素生成抑制剂和减轻皮肤。