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1. 发明申请

US20080279794A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin 审中-公开
公开(公告)号：US20080279794A1
公开(公告)日：2008-11-13
申请号：US12214998
申请日：2008-06-24
申请人： Werner Baschong , Marcel Schnyder
发明人： Werner Baschong , Marcel Schnyder
IPC分类号： A61K8/49 , A61Q19/02 , A61Q17/04
CPC分类号： A61Q19/02 , A61K8/347
摘要： The use of (a) hydroxydiphenyl ether compounds of formula wherein R1, R2 and R3 are each independently of the others hydrogen; hydroxy; C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; C1-C20alkoxy; C1-C6alkylcarbonyl; phenyl; or phenyl-C1-C3alkyl; R4 is hydrogen, C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C1-C3alkyl; carboxyallyl; C2-C20alkenyl; C1-C6alkylcarbonyl; C1-C3alkylcarbonyl-C1-C3alkyl; phenyl; or phenyl-C1-C3alkyl; and R5 is hydrogen; C1-C20alkoxy; or C1-C6alkylcarbonyl; as melanogenesis inhibitors and for lightening the skin.

2. 发明授权

US06495122B2 Use of mixtures of micropigments for preventing tanning and for lightening skin and hair 有权
标题翻译：使用微胶囊混合物防止鞣制和减轻皮肤和头发
公开(公告)号：US06495122B2
公开(公告)日：2002-12-17
申请号：US10067027
申请日：2002-02-04
申请人： Peter Fankhauser , Helmut Luther , Werner Baschong
发明人： Peter Fankhauser , Helmut Luther , Werner Baschong
IPC分类号： A61K740
CPC分类号： A61K8/898 , A61K8/0241 , A61K8/49 , A61K8/494 , A61K8/4966 , A61K8/60 , A61K2800/412 , A61K2800/57 , A61Q5/00 , A61Q5/08 , A61Q17/04 , A61Q19/02
摘要： The invention describes the use of micronized organic UV filters for preventing tanning and for lightening human skin and hair, and their use in cosmetic and pharmaceutical formulations. The micronized UV filters used according to the invention cover a broad UV spectrum and therefore have excellent sunscreen properties.
摘要翻译：本发明描述了使用微粉化的有机紫外线过滤器来防止鞣制和减轻人体皮肤和头发，以及它们在化妆品和药物制剂中的用途。根据本发明使用的微粉化UV过滤器覆盖广泛的紫外光谱，因此具有优异的防晒性能。

3. 发明申请

US20120093896A1 USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS 审中-公开
标题翻译：使用纳米尺寸来保护化妆品配方中的水溶性成分
公开(公告)号：US20120093896A1
公开(公告)日：2012-04-19
申请号：US12669972
申请日：2008-07-22
申请人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
发明人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
IPC分类号： A61K8/04 , A61K8/66 , A61K8/02 , A61Q19/00 , A61Q5/00 , A61K8/67 , A61Q1/12 , B82Y40/00 , B82Y99/00
CPC分类号： A61K8/676 , A61K8/04 , A61K8/345 , A61K8/375 , A61K8/4993 , A61K8/553 , A61K8/68 , A61K8/86 , A61K8/894 , A61K8/898 , A61K8/90 , A61K2800/413 , A61K2800/52 , A61K2800/522 , A61Q19/00 , B82Y5/00
摘要： The invention describes the use of a nanodispersion, which comprises: a) a membrane-forming molecule, b) a co-emulsifier, c) a lipophilic component, and d) a water-soluble ingredient sensitive to oxidation in cosmetic end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous liquid is obtained (so-called nanodispersion pre-phase), and (β) adding the water or aqueous phase (discontinuous phase) which contains the water-soluble ingredient and optionally the non-aqueous polar organic solvent to the liquid obtained in step (α). Component (d) is preferably ascorbic acid or vitamin C.
摘要翻译：本发明描述了纳米分散体的使用，其包括：a）成膜分子，b）共乳化剂，c）亲脂性组分，和d）在化妆品末端制剂中对氧化敏感的水溶性成分，通过（α）混合组分（a），（b）和（c）直到获得均匀的液体（所谓的纳米分散前相）和（＆bgr）加入水或水相（不连续的）可获得的纳米分散体相），其包含水溶性成分和任选的非水极性有机溶剂与步骤（α）中获得的液体。组分（d）优选为抗坏血酸或维生素C.

4. 发明申请

US20090156563A1 Glucan Compositions 审中-公开
标题翻译：葡聚糖组合物
公开(公告)号：US20090156563A1
公开(公告)日：2009-06-18
申请号：US12085271
申请日：2006-11-20
申请人： Werner Baschong , Sebastien Mongiat , Dietmar Ochs
发明人： Werner Baschong , Sebastien Mongiat , Dietmar Ochs
IPC分类号： A61K31/60 , A61P17/00
CPC分类号： A61Q11/00 , A61K8/345 , A61K8/347 , A61K8/365 , A61K8/43 , A61K8/73 , A61K31/716 , A61Q1/10 , A61Q1/14 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/08
摘要： A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1×106 to 12×106; b) a cosmetically or pharmaceutically acceptable carrier; and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1, compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.
摘要翻译：提供了一种化妆品或药物组合物，其包含：a）以总组合物的重量计0.001至小于0.2重量％的平均分子量为1×10 6至12×10 6的硬皮葡聚糖; b）美容或药学上可接受的载体; 和任选地，c）乳酸，乳酸盐和/或戊二醇。该组合物显示出有益的效果，例如皮肤或粘膜的保湿，并且对皮肤具有抗衰老和振兴作用。当与根据权利要求1所述的某种杀菌剂组合时，含有葡聚糖类的天然多糖的组合物通常特别是组分a）的硬化葡聚糖是非常适合于减少粘膜或口腔环境中细菌的数量并最小化粘附同时保持对粘膜或牙龈的愉悦感。因此可以有效地防止或去除斑块。

5. 发明申请

US20050058610A1 Use of guaiol for treating the skin 失效
标题翻译：使用愈创木酚治疗皮肤
公开(公告)号：US20050058610A1
公开(公告)日：2005-03-17
申请号：US10489645
申请日：2002-09-10
申请人： Werner Baschong , Gerd Heinemann , Dietmar Ochs
发明人： Werner Baschong , Gerd Heinemann , Dietmar Ochs
IPC分类号： A61K8/34 , A61K8/49 , A61Q19/02 , A61Q19/04 , A61K7/42 , A61K35/70
CPC分类号： A61Q19/02 , A61K8/34 , A61K8/494 , A61K8/4966 , A61Q19/04
摘要： The use is described of compositions comprising (a) (−)-guaiol, (b) further skin-lightening active substance(s) and, optionally, (c) one or more UV-A and/or UV-B absorbers as melanogenesis inhibitors and for skin-lightening.
摘要翻译：描述了包含（a）（ - ） - 愈创醇，（b）其它皮肤发光活性物质和（c）一种或多种UV-A和/或UV-B吸收剂作为黑素生成的组合物的用途抑制剂和减轻皮肤。

6. 发明申请

US20090258041A1 Protection of Oxidizable Agents 审中-公开
标题翻译：氧化剂的保护
公开(公告)号：US20090258041A1
公开(公告)日：2009-10-15
申请号：US12083557
申请日：2006-06-21
申请人： Sebastien Mongiat , Werner Baschong , Bernd Herzog
发明人： Sebastien Mongiat , Werner Baschong , Bernd Herzog
IPC分类号： A61K8/02 , A61P17/02
CPC分类号： A61K31/05 , A61K8/11 , A61K8/14 , A61K8/347 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/553 , A61K8/671 , A61K8/676 , A61K31/222 , A61K31/255 , A61K31/34 , A61K31/445 , A61K2800/412 , A61K2800/413 , A61K2800/522 , A61Q1/02 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Formulations for cosmetical or pharmaceutical use contain an antioxidant in encapsulated form and a cosmetically or pharmaceutically acceptable carrier. The antioxidant is selected from carbon bridged hindered phenoles, ester bridged hindered phenoles, amide bridged hindered phenoles, lactones of hindered phenoles, sterically hindered oxylamines and sterically hindered hydroxylamines. The encapsulated antioxidant is of high activity and suitable to protect a further active ingredient, e.g. oxidizable natural substances, vitamins, fragrances, and extracts from plants fungi, algae or animals, from premature degradation, especially when coencapsulated together with the ingredient. The formulations are useful inter alia for the preparation of a cosmetical or pharmaceutical skin care or skin delivery formulation, injectable solution, infusion solution, eye drop, drinking solution, a dietary or enriched food, an oral care formulation, drinking gargles, in-halants, or as a food additive.
摘要翻译：化妆品或药物用途的制剂含有包封形式的抗氧化剂和化妆品或药学上可接受的载体。抗氧化剂选自碳桥接的受阻酚，酯桥接的受阻酚，酰胺桥接的受阻酚，受阻酚的内酯，空间位阻的羟胺和空间位阻羟胺。包封的抗氧化剂具有高活性并且适于保护另外的活性成分，例如，可氧化的天然物质，维生素，香料，以及来自植物真菌，藻类或动物的提取物，过早降解，特别是当与成分一起胶囊时。该制剂尤其用于制备美容或药物皮肤护理或皮肤递送制剂，可注射溶液，输注溶液，滴眼剂，饮用溶液，饮食或富含食物，口腔护理制剂，饮用漱口剂，漱口剂，或作为食品添加剂。

7. 发明申请

US20080305055A1 Anti-Radical Agents 审中-公开
标题翻译：抗激剂
公开(公告)号：US20080305055A1
公开(公告)日：2008-12-11
申请号：US11792745
申请日：2005-10-24
申请人： Werner Baschong , Oliver Reich , Sebastien Mongiat
发明人： Werner Baschong , Oliver Reich , Sebastien Mongiat
IPC分类号： A61K8/49 , A61K31/05 , A61K31/216 , A61K31/365 , A61Q17/00 , A61P17/00 , A61K31/165 , A61K31/53 , A61K31/445
CPC分类号： A61K31/05 , A61K8/11 , A61K8/14 , A61K8/347 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/498 , A61K8/553 , A61K8/671 , A61K8/676 , A61K31/165 , A61K31/222 , A61K31/255 , A61K31/34 , A61K31/445 , A61K2800/412 , A61K2800/413 , A61K2800/522 , A61Q1/02 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compounds of the formulae (1), (2) and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of formula (3), wherein Gi is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycloalkyl; phenyl; or C7-C9phenylalkyl; E is oxyl or hydroxyl; V is —O—; or —NH—; a is 0 or 1 or 2; b, c and d and g are each independently of one another 0 or 1; e is an integer from 1 to 4; f, m, n and p are each independently of one another an integer from 1 to 3; q is 0 or an integer from 1 to 3; Q, T and G3 are as defined in claim 1; G4 and G5 are each independently of the other hydrogen; or C1-C22alkyl; exhibit marked antiinflammatory action.
摘要翻译：式（1），（2）的化合物和选择的受阻硝酰基，羟胺和羟胺盐化合物如式（3）化合物，其中G 1是氢; C 1 -C 22烷基; C 1 -C 22烷硫基; C 2 -C 22烷硫基烷基; C5-C7环烷基; 苯基; C7-C9苯基烷基; 或SO3M; G 2是C 1 -C 22烷基; C5-C7环烷基; 苯基; 或C 7 -C 9苯基烷基; E为氧基或羟基; V是-O-; 或-NH-; a是0或1或2; b，c和d和g各自独立地为0或1; e是1至4的整数; f，m，n和p各自独立地为1〜3的整数; q为0或1〜3的整数; Q，T和G3如权利要求1中所定义; G4和G5各自独立于另一个氢; 或C 1 -C 22烷基; 表现出明显的抗炎作用。

8. 发明申请

US20060216252A1 Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin 审中-公开
标题翻译：使用卤代羟基二苯醚化合物治疗皮肤
公开(公告)号：US20060216252A1
公开(公告)日：2006-09-28
申请号：US10564712
申请日：2004-07-07
申请人： Werner Baschong , Marcel Schnyder
发明人： Werner Baschong , Marcel Schnyder
IPC分类号： A61K8/46 , A61K8/34
CPC分类号： A61Q19/02 , A61K8/347
摘要： The use of hydroxydiphenyl ether compounds of formula (I), wherein R1, R2 and R3 are each independently of the others hydrogen; hydroxy; C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; C1-C20alkoxy; C1-C6alkylcarbonyl; phenyl; or phenyl-C1-C3alkyl; R4 is hydrogen, C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C1-C3alkyl; carboxyallyl; C2-C20alkenyl; C1-C6alkylcarbonyl; C1-C3alkylcarbonyl-C1-C3alkyl; phenyl; or phenyl-C1-C3alkyl; and R5 is hydrogen; C1-C20alkoxy; or C1-C6alkylcarbonyl; as melanogenesis inhibitors and for lightening the skin.
摘要翻译：式（I）的羟基二苯醚化合物（其中R 1，R 2和R 3）各自独立地为氢; 羟基; C 1 -C 20烷基; C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; C 1 -C 20烷氧基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; 苯基; 或苯基-C 1 -C 3烷基; R 4是氢，C 1 -C 20烷基; 羟基取代的C 1 -C 20烷基; C 5 -C 7环烷基; 羟基; 甲酰基丙酮; 烯丙基羧基; 羧基-C 1 -C 3烷基; 羧基 C 2 -C 20链烯基; C 1 -C 6烷基羰基; C 1 -C 6烷基羰基; C 1 -C 3烷基羰基-C 1 -C 3烷基; C 1 -C 3烷基; C 1 -C 3烷基; 苯基; 或苯基-C 1 -C 3烷基; 并且R 5是氢; C 1 -C 20烷氧基; 或C 1 -C 6烷基羰基; 作为黑素生成抑制剂和减轻皮肤。

9. 发明申请

US20120328541A1 Anti-radical agents 审中-公开
标题翻译：抗激剂
公开(公告)号：US20120328541A1
公开(公告)日：2012-12-27
申请号：US13603807
申请日：2012-09-05
申请人： Werner Baschong , Oliver Reich , Sébastien Mongiat
发明人： Werner Baschong , Oliver Reich , Sébastien Mongiat
IPC分类号： A61K31/05 , A61K31/365 , A61K31/165 , A61K31/53 , A61K31/10 , A61K31/4545 , A61K31/235 , A61K31/192 , A61K31/185 , A61K31/452 , A61P17/16 , A61P17/18 , A61P29/00 , A61P37/08 , A61K31/216
CPC分类号： A61K31/05 , A61K8/11 , A61K8/14 , A61K8/347 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/498 , A61K8/553 , A61K8/671 , A61K8/676 , A61K31/165 , A61K31/222 , A61K31/255 , A61K31/34 , A61K31/445 , A61K2800/412 , A61K2800/413 , A61K2800/522 , A61Q1/02 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compounds of the formulae and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of the formula wherein G1 is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9-phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycloalkyl; phenyl; or C7-C9-phenylalkyl; E is oxyl or hydroxyl; V is —O—; or —NH—; a is 0 or 1 or 2; b, c and d and g are each independently of one another 0 or 1; e is an integer from 1 to 4; f, m, n and p are each independently of one another an integer from 1 to 3; q is 0 or an integer from 1 to 3; Q, T and G3 are as defined in claim 1; G4 and G5 are each independently of the other hydrogen; or C1-C22alkyl; exhibit marked antiinflammatory action.
摘要翻译：式的化合物和选择的受阻硝酰基，羟胺和羟胺盐化合物如下式化合物其中G1是氢; C 1 -C 22烷基; C 1 -C 22烷硫基; C 2 -C 22烷硫基烷基; C5-C7环烷基; 苯基; C 7 -C 9 - 苯基烷基; 或SO3M; G 2是C 1 -C 22烷基; C5-C7环烷基; 苯基; 或C 7 -C 9 - 苯基烷基; E为氧基或羟基; V是-O-; 或-NH-; a是0或1或2; b，c和d和g各自独立地为0或1; e是1至4的整数; f，m，n和p各自独立地为1〜3的整数; q为0或1〜3的整数; Q，T和G3如权利要求1中所定义; G4和G5各自独立于另一个氢; 或C 1 -C 22烷基; 表现出明显的抗炎作用。

10. 发明申请

US20100330009A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS 有权
标题翻译：氧化铝类抗氧化剂和紫外线吸收剂
公开(公告)号：US20100330009A1
公开(公告)日：2010-12-30
申请号：US12528357
申请日：2008-02-29
申请人： Barbara Wagner , Sebastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Ohrlein
发明人： Barbara Wagner , Sebastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Ohrlein
IPC分类号： A61K8/60 , A61K31/352 , C07D493/04 , A61K31/7048 , C07H17/04 , A61K31/7084 , A61K31/655 , A61K31/4355 , C07D491/04 , A61K8/92 , A61K8/49 , A61P17/00 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q5/00 , A61Q17/04 , C12P19/60 , C12P17/12 , C12P17/06 , A23L3/34
CPC分类号： C07D493/04 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q17/04 , C07D491/04
摘要： The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.
摘要翻译：本发明涉及具有强大抗氧化性能的1H-吡喃并[4,3-b]苯并呋喃-1-酮结构的衍生物及其在一个分子中与高效UV吸收官能团结合的氮类似物。这些化合物在美容和皮肤病学制剂中特别有用。

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