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1. 发明申请

US20140191122A1 Mass Analyser 有权
标题翻译：质量分析仪
公开(公告)号：US20140191122A1
公开(公告)日：2014-07-10
申请号：US14117172
申请日：2012-05-14
申请人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
发明人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

2. 发明授权

US08841604B2 Mass analyser 有权
标题翻译：质量分析仪
公开(公告)号：US08841604B2
公开(公告)日：2014-09-23
申请号：US14117172
申请日：2012-05-14
申请人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
发明人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
IPC分类号： H01J49/00 , H01J49/26 , B01D59/44
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyzer comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analyzed, excitation of ions to be analyzed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差异提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

3. 发明授权

US08581185B2 Ion storage device with direction-selective radial ejection 有权
标题翻译：具有方向选择性径向喷射的离子存储装置
公开(公告)号：US08581185B2
公开(公告)日：2013-11-12
申请号：US13226390
申请日：2011-09-06
申请人： Alexander A. Makarov , Eduard V. Denisov , Alexander Kholomeev
发明人： Alexander A. Makarov , Eduard V. Denisov , Alexander Kholomeev
IPC分类号： H01J49/42 , H01J49/26 , B01D59/44
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。射频场通常在离子喷射之前倒塌。在说明性实施例中，RF电源包括RF信号电源; 布置成接收由RF信号电源提供的信号并提供用于向离子存储装置的电极供应的输出RF信号的线圈; 以及分流器，其包括可操作以在第一打开位置和第二关闭位置之间切换的开关，其中分流器使线圈输出短路。

4. 发明授权

US08278618B2 Collision cell 有权
标题翻译：碰撞细胞
公开(公告)号：US08278618B2
公开(公告)日：2012-10-02
申请号：US12996226
申请日：2009-06-03
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/40
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

5. 发明授权

US08716654B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US08716654B2
公开(公告)日：2014-05-06
申请号：US13737771
申请日：2013-01-09
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
IPC分类号： H01J49/26
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，Φ，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，Φ，z）是对于理想场U（r，Φ，z）的扰动W的结果，其在轨道捕获的情况下例如是对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，Φ，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

6. 发明授权

US08288714B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US08288714B2
公开(公告)日：2012-10-16
申请号：US12944357
申请日：2010-11-11
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

7. 发明授权

US08642948B2 Ion trap for cooling ions 有权
标题翻译：离子阱用于冷却离子
公开(公告)号：US08642948B2
公开(公告)日：2014-02-04
申请号：US13062784
申请日：2009-09-11
申请人： Alexander A. Makarov , Eduard V. Denisov
发明人： Alexander A. Makarov , Eduard V. Denisov
IPC分类号： B01D59/44
CPC分类号： H01J49/0481 , G01N27/622
摘要： A method of changing the kinetic energy of ions is provided, comprising: trapping ions in a trapping region of an ion trap; and directing a beam of gas through the trapping region, so as to change the kinetic energy of the trapped ions thereby. Also provided is a method of separating ions, the method comprising: causing ions to enter a trapping region of an ion trap along a first axis of the trapping region; directing a beam of gas along the first axis and applying an electric potential in the direction of the first axis so as to cause separation of the ions based on their ion mobility. An ion trap and a mass spectrometer for performing the methods are also provided.
摘要翻译：提供了改变离子的动能的方法，包括：将离子捕获在离子阱的俘获区中; 并引导一束气体通过捕获区域，从而改变捕获的离子的动能。还提供了分离离子的方法，所述方法包括：使离子沿着捕获区域的第一轴线进入离子阱的俘获区域; 沿着第一轴引导气体束并沿第一轴线的方向施加电势，以便基于离子迁移率使离子分离。还提供了用于执行该方法的离子阱和质谱仪。

8. 发明授权

US08586914B2 Collision cell 有权
公开(公告)号：US08586914B2
公开(公告)日：2013-11-19
申请号：US13617873
申请日：2012-09-14
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/40
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

9. 发明申请

US20110163227A1 Ion Trap for Cooling Ions 有权
标题翻译：离子阱用于冷却离子
公开(公告)号：US20110163227A1
公开(公告)日：2011-07-07
申请号：US13062784
申请日：2009-09-11
申请人： Alexander A. Makarov , Eduard V. Denisov
发明人： Alexander A. Makarov , Eduard V. Denisov
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/0481 , G01N27/622
摘要： A method of changing the kinetic energy of ions is provided, comprising: trapping ions in a trapping region of an ion trap; and directing a beam of gas through the trapping region, so as to change the kinetic energy of the trapped ions thereby. Also provided is a method of separating ions, the method comprising: causing ions to enter a trapping region of an ion trap along a first axis of the trapping region; directing a beam of gas along the first axis and applying an electric potential in the direction of the first axis so as to cause separation of the ions based on their ion mobility. An ion trap and a mass spectrometer for performing the methods are also provided.
摘要翻译：提供了改变离子的动能的方法，包括：将离子捕获在离子阱的俘获区中; 并引导一束气体通过捕获区域，从而改变捕获的离子的动能。还提供了分离离子的方法，所述方法包括：使离子沿着捕获区域的第一轴线进入离子阱的俘获区域; 沿着第一轴引导气体束并沿第一轴线的方向施加电势，以便基于离子迁移率使离子分离。还提供了用于执行该方法的离子阱和质谱仪。

10. 发明申请

US20110084205A1 Collision Cell 有权
标题翻译：碰撞细胞
公开(公告)号：US20110084205A1
公开(公告)日：2011-04-14
申请号：US12996226
申请日：2009-06-03
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/00 , H01J49/26
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

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