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1. 发明申请

US20060212111A1 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US20060212111A1
公开(公告)日：2006-09-21
申请号：US11260770
申请日：2005-10-27
申请人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
发明人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

2. 发明申请

US20070004961A1 Methods for modifying vascular vessel walls 有权
标题翻译：改变血管壁的方法
公开(公告)号：US20070004961A1
公开(公告)日：2007-01-04
申请号：US11295866
申请日：2005-12-07
申请人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
发明人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

3. 发明申请

US20060116548A1 Methods for treating valve-associated regions of vascular vessels 有权
标题翻译：治疗血管血管相关区域的方法
公开(公告)号：US20060116548A1
公开(公告)日：2006-06-01
申请号：US11266166
申请日：2005-11-03
申请人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
发明人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2475 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a valve-associated region of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管的瓣膜相关区域。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

4. 发明申请

US20070112411A1 Stent graft devices having collagen coating 有权
标题翻译：支架移植装置具有胶原涂层
公开(公告)号：US20070112411A1
公开(公告)日：2007-05-17
申请号：US11500697
申请日：2006-08-08
申请人： F. Obermiller , Clay Fette
发明人： F. Obermiller , Clay Fette
IPC分类号： A61F2/06
摘要： Described are stent graft devices and methods for their preparation and use. Expandable stent graft devices of the invention include inner and/or outer coverings uniquely applied and associated with surfaces of the stent. In certain described embodiments, bioremodelable materials such as ECM materials are vacuum pressed onto and/or around elements of a stent in the manufacture of a stent graft device.
摘要翻译：描述的是支架移植装置及其制备和使用的方法。本发明的可扩展的支架移植装置包括独特地施加并与支架的表面相关联的内部和/或外部覆盖物。在某些描述的实施例中，生物可重构材料例如ECM材料在支架移植装置的制造中被真空压到支架的元件上和/或周围。

5. 发明申请

US20070098755A1 Tissue augmentation devices and methods 有权
标题翻译：组织增强装置和方法
公开(公告)号：US20070098755A1
公开(公告)日：2007-05-03
申请号：US11481422
申请日：2006-07-05
申请人： Umesh Patel , F. Obermiller , Bhavin Shah , Chad Johnson
发明人： Umesh Patel , F. Obermiller , Bhavin Shah , Chad Johnson
IPC分类号： A61F2/00 , A61M31/00
CPC分类号： A61F2/0059
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译：公开了组织增加装置，以及制造和使用它们的方法。在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内的细长构件的插管部分。细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

6. 发明申请

US20060136047A1 Tissue graft prosthesis devices containing juvenile or small diameter submucosa 审中-公开
标题翻译：包含少年或小直径粘膜下层的组织移植假体装置
公开(公告)号：US20060136047A1
公开(公告)日：2006-06-22
申请号：US10523892
申请日：2003-09-04
申请人： F. Obermiller , Michael Hiles , Jason Hodde
发明人： F. Obermiller , Michael Hiles , Jason Hodde
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/0077 , A61F2/07 , A61F2002/075
摘要： Described are preferred tissue graft materials that incorporate juvenile submucosa tissue from a warm-blooded vertebrate. Preferred materials incorporate juvenile small intestinal submucosa tissue from a mammal such as a porcine mammal, and the constructs are preferably in tubular form and utilized the isolated submucosa tissue in its native, intact tubular form. More preferred devices are multi-laminate and include the juvenile submucosa tissue in addition to at least one, and preferably several other layers providing increased strength or other advantageous properties to the construct.
摘要翻译：描述的是优选的组织移植材料，其包含来自温血脊椎动物的幼年粘膜下层组织。优选的材料包括来自哺乳动物如猪哺乳动物的幼年小肠粘膜下层组织，并且构建体优选为管状形式，并以其天然的完整管状形式使用分离的粘膜下层组织。更优选的装置是多层压的，并且除了至少一个，优选几个其它层之外还包括少年粘膜下层组织，为构建体提供增强的强度或其它有利的性质。

7. 发明申请

US20080046070A1 CHEMICALLY TREATED EXTRACELLULAR MATRICES FOR AFFECTING THE CELLULAR RESPONSE 审中-公开
标题翻译：用于影响细胞响应的化学处理细胞外基质
公开(公告)号：US20080046070A1
公开(公告)日：2008-02-21
申请号：US11694328
申请日：2007-03-30
申请人： F. Obermiller , Michael Hiles
发明人： F. Obermiller , Michael Hiles
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0066 , A61F2220/0075
摘要： Described are preferred prosthetic valve devices including an extracellular matrix (ECM) material coated with a microtubule inhibiting agent and affixed to a stent. The stent is configured such that the coated ECM material is formed into one or more leaflets. In preferred embodiments, the prosthetic valve devices are configured for use in vascular applications.
摘要翻译：描述了优选的人工瓣膜装置，其包括涂覆有微管抑制剂并固定在支架上的细胞外基质（ECM）材料。支架构造成使得涂覆的ECM材料形成为一个或多个传单。在优选实施例中，假体瓣膜装置被配置用于血管应用。

8. 发明申请

US20080027477A1 FISTULA GRAFTS AND RELATED METHODS AND SYSTEMS USEFUL FOR TREATING GASTROINTESTINAL FISTULAE 有权
标题翻译： FISTULA GRAFTS和相关方法和系统有助于治疗胃肠道炎症
公开(公告)号：US20080027477A1
公开(公告)日：2008-01-31
申请号：US11766606
申请日：2007-06-21
申请人： F. Obermiller , Steve Chen
发明人： F. Obermiller , Steve Chen
IPC分类号： A61M29/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654
摘要： Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.
摘要翻译：描述了用于治疗瘘，特别是肠外瘘的医疗移植产品，系统和方法。本发明的某些产品被配置为具有驻留在消化道壁的主瘘开口内和周围的部分。一种这样的产品包括生物相容性移植物体，其构造成至少阻挡初级开口。移植物主体包括连接到细长插塞构件的封盖构件。封盖构件被构造成接触与初级开口相邻的消化道壁的部分，并且细长插塞构件构造成延伸到至少一部分瘘管中。这种接枝产品可以特别适于允许封盖构件的一部分定位在插塞构件的外部侧表面旁边，例如当放置在输送装置内腔中时。这种封盖构件可以铰接地或非铰接地联接到细长插塞构件。

9. 发明申请

US20080004657A1 Volumetric grafts for treatment of fistulae and related methods and systems 有权
标题翻译：用于治疗瘘的体积移植物及相关方法和系统
公开(公告)号：US20080004657A1
公开(公告)日：2008-01-03
申请号：US11415403
申请日：2006-05-01
申请人： F. Obermiller , Michael Hiles , Matthew Graham , Clay Fette
发明人： F. Obermiller , Michael Hiles , Matthew Graham , Clay Fette
IPC分类号： A61F2/04
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61M27/00
摘要： Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
摘要翻译：描述了可用于治疗瘘的装置，方法和系统，并且在某些实施例中，具有延伸进入消化道的开口的那些，诸如肛门直肠瘘。说明性地，可以通过将体积结构置于瘘的主要开口内来治疗肛门直肠瘘。在某些实施方案中，体积构造可以包括经加工以形成基本上单体的卷状可重塑材料。有益的这种可重塑材料可以包括胶原细胞外基质材料，如小肠粘膜下层。

10. 发明申请

US20070088445A1 Fistula graft with deformable sheet-form material 有权
标题翻译：具有可变形片状材料的瘘移植物
公开(公告)号：US20070088445A1
公开(公告)日：2007-04-19
申请号：US11414682
申请日：2006-04-28
申请人： Umesh Patel , F. Obermiller , Clay Fette , Matthew Graham
发明人： Umesh Patel , F. Obermiller , Clay Fette , Matthew Graham
IPC分类号： A61F2/04
CPC分类号： A61L27/3604 , A61B17/0057 , A61B2017/00641 , A61K35/22 , A61K35/38 , A61L31/005
摘要： Described are medical products, systems, and methods for treating fistulae having a primary opening, such as in the alimentary canal. Certain methods of the invention include providing an implantable material including a compliant sheet form biocompatible material, and forcing this sheet form biocompatible material into the primary opening so as to deform the sheet form biocompatible material to conform to and block the primary opening. The biocompatible material preferably comprises a remodelable material, for example, a remodelable extracellular matrix material such as submucosa.
摘要翻译：描述了用于治疗具有主要开口的瘘的医疗产品，系统和方法，例如在消化道中。本发明的某些方法包括提供可植入材料，其包括顺应性片材形式的生物相容性材料，并且迫使该片材形成生物相容性材料进入主要开口，以使片材形式的生物相容性材料变形以符合和阻止初级开口。生物相容性材料优选包含可重塑材料，例如可重塑的细胞外基质材料，例如粘膜下层。

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