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1. 发明申请

US20070135793A1 Partial aortic occlusion devices and methods for cerebral perfusion augmentation 审中-公开
标题翻译：局部主动脉闭塞装置和脑灌注增强的方法
公开(公告)号：US20070135793A1
公开(公告)日：2007-06-14
申请号：US11655811
申请日：2007-01-18
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61M31/00
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译：为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。可膨胀构件可以包括一个或两个气囊。诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。

2. 发明申请

US20050159640A1 Cerebral perfusion augmentation 有权
标题翻译：脑灌注增强
公开(公告)号：US20050159640A1
公开(公告)日：2005-07-21
申请号：US11042642
申请日：2005-01-24
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61B5/0215 , A61B17/00 , A61B17/12 , A61B17/22 , A61F2/06 , A61M25/00 , A61M25/06 , A61N1/362
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译：为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。可膨胀构件可以包括一个或两个气囊。诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。

3. 发明申请

US20050124849A1 Partial aortic occlusion devices and methods for cerebral perfusion augmentation 有权
标题翻译：局部主动脉闭塞装置和脑灌注增强的方法
公开(公告)号：US20050124849A1
公开(公告)日：2005-06-09
申请号：US11042639
申请日：2005-01-24
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61B5/0215 , A61B17/00 , A61B17/12 , A61B17/22 , A61F2/06 , A61M25/00 , A61M25/06 , A61N1/362 , A61M31/00
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译：为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。可膨胀构件可以包括一个或两个气囊。诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。

4. 发明申请

US20060047262A1 Partial aortic occlusion devices and methods for cerebral perfusion augmentation 有权
公开(公告)号：US20060047262A1
公开(公告)日：2006-03-02
申请号：US11256549
申请日：2005-10-21
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St.Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St.Germain
IPC分类号： A61M31/00
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

5. 发明授权

US08721699B2 Methods and devices for non-invasive cerebral and systemic cooling 有权
标题翻译：非侵入性脑系统冷却的方法和装置
公开(公告)号：US08721699B2
公开(公告)日：2014-05-13
申请号：US12703425
申请日：2010-02-10
申请人： Denise Barbut , Allan Rozenberg , John K Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K Hoffman
IPC分类号： A61F7/12
CPC分类号： A61F7/10 , A61F7/12 , A61F7/123 , A61F2007/0002 , A61F2007/0063 , A61F2007/0064 , A61F2007/0065 , A61F2007/0069 , A61K31/02 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0454 , A61M16/0479 , A61M16/0486 , A61M16/107 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073
摘要： A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.
摘要翻译：一种用于响应于生理参数的变化来提供和调节脑冷却的方法。沸点在38-300℃之间的喷雾剂被输送到患者鼻腔的表面。喷雾通过直接通过鼻咽传播并通过颈动脉和威利斯圈造成血液冷却，导致冷却。监测生理参数，如脑温，脑血流量或脑氧合变化。响应于生理参数调节喷雾的输送速率。

6. 发明授权

US08025674B2 Cannula with associated filter and methods of use during cardiac surgery 有权
标题翻译：插管与相关过滤器和心脏手术中使用的方法
公开(公告)号：US08025674B2
公开(公告)日：2011-09-27
申请号：US12028745
申请日：2008-02-08
申请人： Denise Barbut , Tracy D. Maahs
发明人： Denise Barbut , Tracy D. Maahs
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2250/0003 , A61M2210/127
摘要： Devices and methods for filtering blood. The devices generally comprise a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, and a means to actuate the structure. The methods generally include the steps of introducing a mesh into a blood vessel to entrap embolic material, and removing the mesh and the entrapped foreign matter from the blood vessel.
摘要翻译：用于过滤血液的装置和方法装置通常包括用于过滤血管内流动的血液的筛网，特别是在诸如主动脉的动脉内，适于打开和关闭血管内的网孔的结构，以及致动结构的装置。所述方法通常包括将网状物引入血管以捕获栓塞物质，以及从血管中除去网状物和被截留的异物的步骤。

7. 发明申请

US20090234325A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 审中-公开
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20090234325A1
公开(公告)日：2009-09-17
申请号：US12049945
申请日：2008-03-17
申请人： Allan Rozenberg , Denise Barbut
发明人： Allan Rozenberg , Denise Barbut
IPC分类号： A61B18/02 , A61M29/02
CPC分类号： A61F7/123 , A61M25/0023 , A61M25/003 , A61M25/0032 , A61M25/007 , A61M25/10 , A61M2025/0034 , A61M2025/0036 , A61M2025/1052
摘要： Methods for pharyngeal and cerebral cooling by delivering an ice slurry, slush or super-cooled gel to a patient's nasal cavity, oral cavity and/or throat are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A ice slurry having a temperature between about −5° C. and about 5° C. is delivered through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an expandable member is inserted through the patient's oral cavity and positioned such that when expanded it forms a low pressure seal substantially isolating the nasal and oral cavities from the patient's trachea. An ice slurry is delivered directly to the patient's nasal cavity.
摘要翻译：描述了通过向患者的鼻腔，口腔和/或喉部输送冰浆，冷浆或超冷凝胶来进行咽和脑冷却的方法。在一种方法中，通过病人的鼻孔将冷却组件插入鼻腔。冷却组件包括限定腔室的柔性气囊和具有与腔室流体连通的内腔的第一细长管状构件。具有约-5℃至约5℃温度的冰浆通过第一细长管状构件的内腔被输送到腔室中，其中柔性气囊膨胀以使其与鼻腔接触。在另一种方法中，可扩张构件插入穿过患者的口腔并定位成使得当其膨胀时，其形成基本上将鼻腔和口腔与患者气管隔离的低压密封。将冰浆直接输送到患者的鼻腔。

8. 发明授权

US6165199A Medical device for removing thromboembolic material from cerebral arteries and methods of use 有权
标题翻译：用于从脑动脉中去除血栓栓塞材料的医疗装置和使用方法
公开(公告)号：US6165199A
公开(公告)日：2000-12-26
申请号：US228718
申请日：1999-01-12
申请人： Denise Barbut
发明人： Denise Barbut
IPC分类号： A61B17/22 , A61B17/00
CPC分类号： A61B17/22 , A61B17/320758 , A61B2017/22067 , A61B2017/22082 , A61B2017/320716
摘要： The invention provides a medical device having an elongate catheter, a balloon occluder mounted on a distal end of the catheter, and optionally a chopping mechanism associated with an aspiration port of the catheter. Continuous or intermittent suction can be applied to the aspiration port which is distal to the occluder to dislodge thromboembolic material in a carotid or cerebral artery. Oxygenated blood or other fluid, which may be hypothermic, can be perfused through at least one perfusion port proximal to the occluder to maintain and augment perfusion of the collateral vasculature proximal to the occlusive lesion. The flow rate of blood or fluid can be controlled by rotating two cylindrical members. Neuroprotective agents or t-PA can also be infused distal to the occluder through the aspiration port or an infusing port. Methods of using the devices in treating patients with acute stroke or occlusive cerebrovascular disease are also disclosed.
摘要翻译：本发明提供一种医疗装置，其具有细长的导管，安装在导管的远端上的气囊闭塞器，以及可选地与导管的抽吸端口相关联的斩波机构。连续或间歇抽吸可以施加到远离封堵器的抽吸口，以移除颈动脉或大脑动脉中的血栓栓塞材料。氧化血液或其他可能是低温的液体可以通过靠近闭塞器的至少一个灌注口灌注，以保持和增加靠近闭塞性病变的附带血管的灌注。可以通过旋转两个圆柱形构件来控制血液或流体的流速。神经保护剂或t-PA也可以通过吸入口或输注口输注到封堵器的远端。还公开了使用该装置治疗急性中风或闭塞性脑血管病患者的方法。

9. 发明授权

US6161547A Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use 有权
公开(公告)号：US6161547A
公开(公告)日：2000-12-19
申请号：US232438
申请日：1999-01-15
申请人： Denise Barbut
发明人： Denise Barbut
IPC分类号： A61B17/22 , A61F2/958 , A61M1/36 , A61M37/00
CPC分类号： A61M25/1011 , A61B17/3207 , A61M1/3613 , A61M1/3621 , A61M1/369
摘要： The invention provides a medical device having first and second elongate tubular members. Each member comprises a manometer at a distal end and a lumen communicating with a port at the distal end. An expandable occlusive member is optionally mounted on either or both tubular members proximal to the distal port. A proximal end of each tubular member is adapted for attachment to an oxygenator and/or a pump for aspirating blood from an artery or a symptomatic carotid artery through the first tubular member and perfusing the blood into the contralateral carotid artery through the second tubular member, thereby providing a means of augmenting the collateral vasculature and maintaining perfusion distal to the offending lesion. The flow rate of blood can be controlled by inflating or deflating the balloon occluder. The device may employ a neuroprotective agent, hypothermic perfusion, and an atherectomy device or an extracorporeal pumping mechanism to remove a vascular occlusion and reestablish cerebral perfusion. Methods of using the devices in treating patients with acute stroke or occlusive cerebrovascular disease are also disclosed.

10. 发明授权

US5895399A Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries 失效
公开(公告)号：US5895399A
公开(公告)日：1999-04-20
申请号：US728035
申请日：1996-10-09
申请人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
发明人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
IPC分类号： A61B10/00 , A61B10/02 , A61B10/06 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61F2/01 , A61M25/00
CPC分类号： A61B17/320783 , A61B17/22031 , A61B17/221 , A61B17/3207 , A61F2/01 , A61F2/013 , A61B10/06 , A61B17/32056 , A61B17/32075 , A61B2010/0225 , A61B2017/00287 , A61B2017/22068 , A61B2017/22069 , A61B2017/2215 , A61B2017/306 , A61B2017/32004 , A61B2017/320064 , A61B8/0808 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/008 , A61M2210/127 , A61M25/00
摘要： An arterial catheter system for removing plaque from the aorta and other arteries is disclosed. The system typically includes an elongate catheter member, a filtration apparatus disposed within the distal region, and an atherectomy assembly which includes a mechanism for trapping and holding mobile or fixed plaque and an excising mechanism for removing the plaque. In use, the catheter is positioned so that the atherectomy assembly lies within a region of interest, the filtration apparatus is deployed downstream of the region of interest, the plaque is trapped and held by a snare, vacuum, or other trapping means, and then the excising mechanism is activated to remove the plaque. Methods are also disclosed for removing plaque from the aorta and other arteries.

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