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1. 发明申请

US20210124904A1 Smart Microscope System for Radiation Biodosimetry 有权
公开(公告)号：US20210124904A1
公开(公告)日：2021-04-29
申请号：US17137317
申请日：2020-12-29
申请人： Peter Keith Rogan , Yanxin Li , Jin Liu
发明人： Peter Keith Rogan , Yanxin Li , Jin Liu
IPC分类号： G06K9/00 , G06T5/50 , G01T1/02 , G06T5/00
摘要： Automation of microscopic pathological diagnosis relies on digital image quality, which, in turn, affects the rates of false positive and negative cellular objects designated as abnormalities. Cytogenetic biodosimetry is a genotoxic assay that detects dicentric chromosomes (DCs) arising from exposure to ionizing radiation. The frequency of DCs is related to radiation dose received, so the inferred radiation dose depends on the accuracy of DC detection. To improve this accuracy, image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When sufficient numbers of high quality images are found, the microscope system is directed to terminate metaphase image collection for a sample. The International Atomic Energy Agency recommends at least 500 images be used to estimate radiation dose, however often many more images are collected in order to select the metaphase cells with good morphology for analysis. Improvements in DC recognition increase the accuracy of dose estimates, by reducing false positive (FP) DC detection. A set of chromosome morphology segmentation methods selectively filtered out false DCs, arising primarily from extended prometaphase chromosomes, sister chromatid separation and chromosome fragmentation. This reduced FPs by 55% and was highly specific to the abnormal structures (≥97.7%). Additional procedures were then developed to fully automate image review, resulting in 6 image-level filters that, when combined, selectively remove images with consistently unparsable or incorrectly segmented chromosome morphologies. Overall, these filters can eliminate half of the FPs detected by manual image review. Optimal image selection and FP DCs are minimized by combining multiple feature based segmentation filters and a novel image sorting procedure based on the known distribution of chromosome lengths. Consequently, the average dose estimation error was reduced from 0.4 Gy to

2. 发明授权

US09868649B2 Process and apparatus for purifying water 有权
公开(公告)号：US09868649B2
公开(公告)日：2018-01-16
申请号：US13805571
申请日：2011-06-24
申请人： William Peter Keith Kennedy , Andrew James Hermann , Thomas Andrew Wood
发明人： William Peter Keith Kennedy , Andrew James Hermann , Thomas Andrew Wood
IPC分类号： C02F1/24 , B01D17/02 , C02F1/00 , C02F1/32 , C02F1/78 , C02F103/00
CPC分类号： C02F1/24 , B01D17/0205 , C02F1/004 , C02F1/32 , C02F1/78 , C02F2103/002 , C02F2209/38 , C02F2209/40
摘要： The invention relates to a process and apparatus that treats waste water, in particular waste water containing surfactants and including grey water, for local reuse. According to the invention, the process comprises a) collecting waste water in a reservoir; b) injecting gas into waste water from the reservoir to form bubbles in the waste water; c) separating the bubbles, and any entrained contaminants, from the waste water; d) drying the separated bubbles and returning any water recovered from the dried bubbles to the waste water undergoing treatment; e) optionally repeating steps b) to d) to achieve the desired purification of the waste water; and f) collecting the purified waste water. The invention provides a robust process and a mechanically simple apparatus that does not require regular replacement of chemicals or filters, yet is capable of treating waste water locally, and in particular grey water for household reuse.

3. 发明授权

US08605981B2 Centromere detector and method for determining radiation exposure from chromosome abnormalities 有权
标题翻译：着丝粒检测器和确定染色体异常辐射暴露的方法
公开(公告)号：US08605981B2
公开(公告)日：2013-12-10
申请号：US13822289
申请日：2011-11-04
申请人： Peter Keith Rogan , Joan Helen Knoll , Jagath Samarabandu , Akila Subasinghe
发明人： Peter Keith Rogan , Joan Helen Knoll , Jagath Samarabandu , Akila Subasinghe
IPC分类号： G06F19/16
CPC分类号： G06F19/16 , C12Q1/6883
摘要： A method for determining radiation exposure from chromosome abnormalities present in a specimen by determining the location or locations of the centromere of each chromosome in a cell in an image of a metaphase cell by segmentation of an accurately drawn chromosome centerline followed by selection of a longitudinal cross-section with the minimum width or intensity or width and intensity; counting the number of centromeres in each chromosome in each cell; computing the frequency of dicentric chromosomes in a population of cells; and determining the radiation dose by comparing the computed frequency of dicentric chromosomes with a previously determined dose-response curve from a calibrated source.
摘要翻译：一种确定样品中存在的染色体异常的辐射暴露的方法，通过分割准确绘制的染色体中心线，然后选择纵向十字形来确定中期细胞图像中每个染色体的着丝粒的位置或位置具有最小宽度或强度或宽度和强度的截面; 计算每个细胞每个染色体中着丝粒的数量; 计算细胞群中双染色体的频率; 并通过将计算出的双重染色体的频率与来自校准的源的预先确定的剂量 - 响应曲线进行比较来确定辐射剂量。

4. 发明申请

US20130319947A1 Process and Apparatus for Purifying Water 有权
标题翻译：净化水的工艺和设备
公开(公告)号：US20130319947A1
公开(公告)日：2013-12-05
申请号：US13805571
申请日：2011-06-24
申请人： William Peter Keith Kennedy
发明人： William Peter Keith Kennedy
IPC分类号： C02F1/24
CPC分类号： C02F1/24 , B01D17/0205 , C02F1/004 , C02F1/32 , C02F1/78 , C02F2103/002 , C02F2209/38 , C02F2209/40
摘要： The invention relates to a process and apparatus that treats waste water, in particular waste water containing surfactants and including grey water, for local reuse. According to the invention, the process comprises a) collecting waste water in a reservoir; b) injecting gas into waste water from the reservoir to form bubbles in the waste water; c) separating the bubbles, and any entrained contaminants, from the waste water; d) drying the separated bubbles and returning any water recovered from the dried bubbles to the waste water undergoing treatment; e) optionally repeating steps b) to d) to achieve the desired purification of the waste water; and f) collecting the purified waste water. The invention provides a robust process and a mechanically simple apparatus that does not require regular replacement of chemicals or filters, yet is capable of treating waste water locally, and in particular grey water for household reuse
摘要翻译：本发明涉及处理废水，特别是含有表面活性剂的废水和包括灰水在内的方法和设备，用于本地再利用。根据本发明，该方法包括：a）在储存器中收集废水; b）将气体从储层注入废水中，在废水中形成气泡; c）从废水中分离气泡和任何夹带的污染物; d）干燥分离的气泡并将从干燥气泡回收的任何水返回到经过处理的废水; e）任选地重复步骤b）至d）以实现废水的所需净化; 和f）收集纯化废水。本发明提供了一种坚固的方法和机械简单的装置，其不需要定期更换化学品或过滤器，而是能够局部处理废水，特别是用于家庭再利用的灰水

5. 发明申请

US20120290037A1 STIMULUS REGIMENS FOR CARDIOVASCULAR REFLEX CONTROL 审中-公开
标题翻译：用于心脏反射控制的刺激方案
公开(公告)号：US20120290037A1
公开(公告)日：2012-11-15
申请号：US13534237
申请日：2012-06-27
申请人： Robert S. Kieval , David J. Serdar , Bruce J. Persson , Peter Keith
发明人： Robert S. Kieval , David J. Serdar , Bruce J. Persson , Peter Keith
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔，建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔，并产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

6. 发明申请

US20080015497A1 DEVICE AND METHOD FOR TREATING CONSTRICTED SINUS PASSAGEWAY 有权
标题翻译：用于处理有争议的SINUS PASSAGEWAY的装置和方法
公开(公告)号：US20080015497A1
公开(公告)日：2008-01-17
申请号：US11782612
申请日：2007-07-24
申请人： Peter Keith , Thomas Ressemann , Theordore Truitt
发明人： Peter Keith , Thomas Ressemann , Theordore Truitt
IPC分类号： A61M25/10
CPC分类号： A61M29/02 , A61B17/12022 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3421 , A61B17/3468 , A61B90/30 , A61B90/50 , A61B2017/1205 , A61B2090/3945 , A61F2/82 , A61M2029/025 , A61M2210/0618 , A61M2210/0681
摘要： A balloon catheter for treating a constricted sinus passageway of a patient includes an elongate flexible shaft defining a lumen therein, the elongate flexible shaft having a proximal end and distal region. The elongate flexible shaft may include a kink-resistant coil in the distal region. A hub is affixed to the proximal end of the elongate flexible shaft, the hub including a port in communication with the lumen. An expandable member is disposed on the distal region of the elongate flexible shaft, wherein an interior portion of the expandable member is in communication with the lumen.
摘要翻译：用于治疗患者的收缩性窦通道的气囊导管包括在其中限定内腔的细长柔性轴，所述细长柔性轴具有近端和远端区域。细长柔性轴可以在远侧区域中包括耐扭结线圈。毂固定到细长柔性轴的近端，毂包括与内腔连通的端口。可扩张构件设置在细长柔性轴的远侧区域上，其中可扩张构件的内部与内腔连通。

7. 发明申请

US20070255210A1 Emboli protection devices and related methods of use 有权
标题翻译： Emboli保护装置及相关使用方法
公开(公告)号：US20070255210A1
公开(公告)日：2007-11-01
申请号：US11824451
申请日：2007-06-29
申请人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
发明人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
IPC分类号： A61M29/00
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B90/39 , A61B2017/12127 , A61B2017/22067 , A61F2/95
摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. A method of treating a blood vessel, includes providing an elongate member having proximal and distal ends, a lumen therebetween, the distal end having a braided sheath expandable between a reduced and expanded diameter, and a fluid-tight covering. The elongate member is advanced into a blood vessel that supplies blood to the heart. The braided sheath is expanded to engage the endoluminal surface of the blood vessel and stop antegrade flow.
摘要翻译：提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。一种治疗血管的方法，包括提供具有近端和远端的细长构件，其间的腔，所述远端具有可在缩径和扩张直径之间扩张的编织护套和流体密封的覆盖物。细长构件前进到向心脏供应血液的血管。编织的鞘被扩张以接合血管的内腔表面并停止顺行的流动。

8. 发明申请

US20060240096A1 Devices and methods for treating the gastrointestinal system 审中-公开
标题翻译：用于治疗胃肠系统的装置和方法
公开(公告)号：US20060240096A1
公开(公告)日：2006-10-26
申请号：US11408238
申请日：2006-04-21
申请人： Chad Kugler , Robert Atkinson , Peter Keith
发明人： Chad Kugler , Robert Atkinson , Peter Keith
IPC分类号： A61K9/48 , A61N1/30
CPC分类号： A61M31/002 , A61K9/0009 , A61K9/0012 , A61K9/0065 , A61K9/4808 , A61K9/4816 , A61K9/4891 , A61K31/745 , A61K31/75 , A61K31/765 , A61K31/78 , A61K31/785 , A61K33/00 , A61M2210/1042 , A61N5/062
摘要： Devices and methods for less invasively treating the gastrointestinal system, such as the intestinal mucosa of the small bowel. Embodiments described herein may be used to reduce caloric absorption and effectuate weight loss, for example.
摘要翻译：用于较少侵入性治疗胃肠系统的装置和方法，例如小肠的肠粘膜。例如，本文所述的实施方案可用于降低热量吸收和实现减肥。

9. 发明授权

US5645533A Apparatus and method for performing an intravascular procedure and exchanging an intravascular device 失效
标题翻译：用于进行血管内手术和交换血管内装置的装置和方法
公开(公告)号：US5645533A
公开(公告)日：1997-07-08
申请号：US379091
申请日：1995-01-26
申请人： David Blaeser , Janita Burmeister , Peter Keith , Thomas Ressemann
发明人： David Blaeser , Janita Burmeister , Peter Keith , Thomas Ressemann
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0004 , A61M2025/0047 , A61M2025/0079 , A61M2025/0098 , A61M2025/0175 , A61M2025/0183 , A61M2025/1063 , A61M2025/1079 , A61M2025/1093 , A61M25/0067 , A61M25/0069 , A61M25/0075
摘要： A method and apparatus are provided for performing a balloon angioplasty procedure and for exchanging a guide wire and an intravascular catheter during the procedure. An intravascular balloon catheter includes an elongated shaft having a proximal portion adapted to extend outside the body of a patient during use, a distal portion adapted for connection to a dilation balloon and adapted for positioning intravascularly during use, and an inflation lumen extending therethrough in fluid flow communication with the balloon. In one aspect of the invention, an elongated guide lumen is connected to the catheter such that the guide lumen and catheter are movable relative to each other during use. A proximal portion of the guide lumen is adapted to extend outside the body of a patient during use, and a distal portion of the guide lumen is adapted to extend distally of the balloon during use. In another aspect of the invention, one or both of a guide wire and an intravascular device can be withdrawn from the guide lumen while the guide lumen remains substantially stationary. In yet another aspect of the invention, proximal and distal seal members are adapted to provide a substantially sealing fit around an intravascular device to inhibit the egress of fluid from the balloon.
摘要翻译：提供了一种用于执行球囊血管成形术程序并在手术期间更换导丝和血管内导管的方法和装置。血管内气囊导管包括细长轴，其具有适于在使用期间延伸到患者身体外部的近端部分，适于连接到扩张气囊的远端部分，并且适于在使用期间血管内定位，以及在流体中延伸穿过的充气腔与气球的流动通信。在本发明的一个方面，细长的引导腔连接到导管，使得引导腔和导管在使用期间可相对于彼此移动。引导腔的近端部分适于在使用期间延伸到患者身体的外部，并且引导腔的远侧部分适于在使用期间向远端延伸。在本发明的另一方面，引导管和血管内装置中的一个或两个可以在引导腔保持基本上静止的同时从引导腔中取出。在本发明的另一方面，近端和远端密封构件适于提供围绕血管内装置的基本密封配合，以抑制流体从气囊的流出。

10. 发明申请

US20230075871A1 METHOD FOR DETERMINING RADIATION EXPOSURE WITH SENSITIVE AND SPECIFIC GENE EXPRESSION SIGNATURES 有权
公开(公告)号：US20230075871A1
公开(公告)日：2023-03-09
申请号：US17402550
申请日：2021-08-15
申请人： Peter Keith Rogan , Eliseos J. Mucaki
发明人： Peter Keith Rogan , Eliseos J. Mucaki
IPC分类号： G16B20/00 , C12Q1/6883
摘要： The present invention discloses a method for determining improved radiation gene expression profiles by sequential application of sensitive and specific gene signatures. The method involves evaluating a sample of target cells from a patient against a highly sensitive, first radiation gene signature, to determine the radiation exposed gene signature. If the signature does not completely distinguish radiation exposures from other conditions or phenotypes, the sample may be evaluated against a second radiation gene signature, which is a radiation gene signature with high specificity. On sequential application of sensitive and specific gene signatures, any misclassified unirradiated samples remaining in the determined gene signatures are identified and removed. Thus, the method enables rejection of radiation signatures with high false positive radiation diagnosis in conditions that confound the results with the first signature. The method derives individual or sequential sensitive and specific radiation signatures with low misclassification rates due to confounding phenotypes, in either controls and test samples.

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