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1. 发明授权

US06739478B2 Precision fluid dispensing system 失效
标题翻译：精密流体分配系统
公开(公告)号：US06739478B2
公开(公告)日：2004-05-25
申请号：US10180710
申请日：2002-06-25
申请人： David T. Bach , Muniswamappa Anjanappa , Gayathri S. Ragavan , Tao Song
发明人： David T. Bach , Muniswamappa Anjanappa , Gayathri S. Ragavan , Tao Song
IPC分类号： G01F1106
CPC分类号： B01L3/0206 , B01F5/12 , B01L3/0227 , B01L2400/0622 , F04B7/04 , F04B13/00
摘要： A precision fluid dispensing system containing at least one two-piece pump and a precision closed loop controller drive system to address the small volume precision dispensing requirements of bioscience applications. A multiple diameter pump can be combined with a pump having multiple inlet and outlet ports to allow for precision multiple outlet dispenses in a single pump that finds use with microtiter plate pipetting and other precision dispensing. Inlet ports can be located on the smaller diameter of the cylinder with outlet ports on the larger diameter of the cylinder. A micro-controller with closed loop feedback provides exact linear positioning and motion of the pump piston as well as optional control of a nozzle to provide exact micro-dispensing of fluids.
摘要翻译：精密流体分配系统，包含至少一个两件式泵和精密闭环控制器驱动系统，以解决生物科学应用的小体积精密分配要求。多直径泵可以与具有多个入口和出口的泵组合，以允许精确的多个出口分配在单个泵中，其可用于微量滴定板移液和其它精确分配。入口端口可以位于气缸的较小直径上，出口端口在气缸的较大直径上。具有闭环反馈的微控制器提供了泵活塞的精确线性定位和运动，以及喷嘴的可选控制，以提供精确的微分配流体。

2. 发明授权

US07160730B2 Method and apparatus for cell sorting 失效
标题翻译：细胞分选方法和装置
公开(公告)号：US07160730B2
公开(公告)日：2007-01-09
申请号：US10688331
申请日：2003-10-17
申请人： David T. Bach , Muniswamappa Anjanappa
发明人： David T. Bach , Muniswamappa Anjanappa
IPC分类号： G01N33/48 , C12M1/34
CPC分类号： G01N15/1459 , G01N15/1456 , G01N2015/1006 , G01N2015/149 , G01N2035/0462 , Y10T436/25375 , Y10T436/2575
摘要： A cell sorter system that includes a precision pump that causes fluid containing cells to enter an inlet port where the fluid is exposed to source light of one or more wavelengths and where cells scatter light or produce fluorescence by known means, and the scattered light and/or fluorescence is used to detect the presence and position of desired cells. The fluid is passed into a select gate that can be magnetostrictive where it is cause to exit one of a plurality of ports, at least one of these ports receiving the desired cells. A controller controls the precision pump, the detection system, and the select gate so that cells are selected from the fluid. An optional vacuum system can be used to pull fluid or cells out of the selected exit port.
摘要翻译：一种细胞分选器系统，其包括精密泵，其使得含有细胞的流体进入入口端口，在该入口端口中流体暴露于一个或多个波长的源光，并且其中细胞通过已知的方式散射光或产生荧光，并且散射光和/ 或荧光用于检测所需细胞的存在和位置。流体被传送到可以是磁致伸缩的选择栅极，其中它导致退出多个端口中的一个，这些端口中的至少一个端口接收期望的单元。控制器控制精密泵，检测系统和选择门，以便从流体中选择细胞。可选的真空系统可用于将流体或细胞从选定的出口吸出。

3. 发明授权

US06991698B2 Magnetostrictive film actuators using selective orientation 失效
标题翻译：使用选择性取向的磁致伸缩膜致动器
公开(公告)号：US06991698B2
公开(公告)日：2006-01-31
申请号：US10690766
申请日：2003-10-22
申请人： Muniswamappa Anjanappa , David T. Bach
发明人： Muniswamappa Anjanappa , David T. Bach
IPC分类号： B32B31/28
CPC分类号： H01L41/12 , H01L41/47
摘要： A method of making beams, clamps and other structures by curing a polymer containing a magnetostrictive material. A magnetostrictive material like TERFENOL-D™ is placed in a polymer. This mixture is put onto a slide in a film. The mixture is cured by UV light (or other means) so that it cross-links. A second layer of polymer with no magnetostrictive material can be cured on top of the first layer. This leads to a beam structure which exhibits a bending moment in an applied magnetic field. By aligning the magnetostrictive particles before curing with a magnetic field, a beam or other structure can be produced with aligned particles. A mask can be used to selectively cure regions where the magnetostrictive particles have different alignments on the same layer. It is possible to build up multiple layer structures with layers of magnetostrictive particles aligned in different directions.
摘要翻译：通过固化含有磁致伸缩材料的聚合物来制造光束，夹子和其它结构的方法。将诸如TERFENOL-D TM的磁致伸缩材料置于聚合物中。将该混合物放在胶片中的载玻片上。混合物通过紫外线（或其他方式）固化，使其交联。可以在第一层的顶部固化第二层无磁致伸缩材料的聚合物。这导致在所施加的磁场中呈现弯曲力矩的梁结构。通过将固化前的磁致伸缩颗粒与磁场对准，可以用对准的颗粒产生束或其它结构。可以使用掩模来选择性地固化磁致伸缩颗粒在同一层上具有不同对准的区域。可以建立具有沿不同方向排列的磁致伸缩颗粒层的多层结构。

4. 发明授权

US07252212B2 Long-term liquid storage and dispensing system 失效
标题翻译：长期液体储存和分配系统
公开(公告)号：US07252212B2
公开(公告)日：2007-08-07
申请号：US10838407
申请日：2004-05-03
申请人： Muniswamappa Anjanappa , David T. Bach , G. Steven Bova , Steven L. Paul , James J. Bach
发明人： Muniswamappa Anjanappa , David T. Bach , G. Steven Bova , Steven L. Paul , James J. Bach
IPC分类号： B65D88/54
CPC分类号： B01L3/0241 , B01L2200/16 , B01L2400/0478
摘要： A liquid storage and dispensing system, and methods for its use in the storage, shipping, and accurate dispensing by manual or automated methods, of, for example, precious biologic samples such as protein, DNA or RNA, with minimal contamination, oxidation, and evaporation, the system having: an essentially cylindrical storage barrel with a flange at its open end and a port and delivery tip at the closed end; a piston with a seal, where the piston closely matches the shape of the closed end of the barrel to minimize dead volume; and a cover to seal the delivery tip during storage such as cryostorage.
摘要翻译：液体储存和分配系统及其用于通过手动或自动化方法储存，运送和精确分配的方法，例如珍贵的生物样品如蛋白质，DNA或RNA，具有最少的污染，氧化和蒸发，该系统具有：基本上圆柱形的储存桶，其开口端具有凸缘，封闭端具有端口和输送端; 具有密封件的活塞，其中活塞与桶的封闭端的形状紧密匹配以最小化死体积; 以及在诸如cryostorage的存储期间密封输送尖端的盖。

5. 发明申请

US20140322054A1 System and Method for Holding Tubing for a Peristaltic Pump 审中-公开
标题翻译：用于保持蠕动泵的管道的系统和方法
公开(公告)号：US20140322054A1
公开(公告)日：2014-10-30
申请号：US14204841
申请日：2014-03-11
申请人： David T. Bach , James J. Bach
发明人： David T. Bach , James J. Bach
IPC分类号： F04B43/12
CPC分类号： F04B43/1292 , F04B43/1261
摘要： A system and method for holding tubing for a peristaltic pump the prevents tubing stretch or deformation. The present invention compensates for tube stretching and minimizes tube deformation due to peristaltic roller tube expansions.
摘要翻译：用于保持蠕动泵的管道的系统和方法防止管道拉伸或变形。本发明补偿管拉伸，并使由于蠕动辊管膨胀引起的管变形最小化。

6. 发明授权

US07207780B2 Multiple port dual diameter pumps 失效
标题翻译：多端口双直径泵
公开(公告)号：US07207780B2
公开(公告)日：2007-04-24
申请号：US10965287
申请日：2004-10-14
申请人： David T. Bach
发明人： David T. Bach
IPC分类号： F04B43/12
CPC分类号： F04B7/045 , B01L3/0217 , B01L2400/0622 , B01L2400/0644 , F04B13/00 , G01F11/024 , G01N35/1016 , G01N2035/1034
摘要： A multiple port, dual diameter piston fluid dispensing pump which includes multiple input and output ports accessed by rotating at least one of the pistons and a dual or multiple diameter piston or set of pistons that cooperate so that they follow each other. The dispensing piston is of smaller diameter than the pushing piston. This diameter difference permits a longer, controllable stroke to dispense micro-liters of fluid accurately.
摘要翻译：多端口双直径活塞流体分配泵，其包括通过旋转至少一个活塞和双或多个直径的活塞或一组活塞相互接触的多个输入和输出端口。分配活塞的直径小于推动活塞的直径。该直径差允许更长的可控行程精确地分配微升的流体。

7. 发明申请

US20150300348A1 Precision Fluid Dispensing Using Peristaltic Roller Control 审中-公开
标题翻译：精密流体分配使用蠕动辊控制
公开(公告)号：US20150300348A1
公开(公告)日：2015-10-22
申请号：US14685161
申请日：2015-04-13
申请人： David T. Bach , James J. Bach
发明人： David T. Bach , James J. Bach
IPC分类号： F04B49/20 , F04B43/12
CPC分类号： F04B49/20 , F04B43/1261 , F04B49/06
摘要： A precision fluid dispensing system that can be effectively used for accurate fluid dispensing in peristaltic pumps if roller control is used. Peristaltic pumps can be combined with pinch valves allowing a dispense tube to be open while a source tube is blocked. Controlled roller movement is used to move the next roller to the same starting position as the previous roller was on the previous dispense, the dispense pinch valve is closed and the source valve is opened. The system uses roller positioning where the each roller is properly positioned so that each dispense cycle starts in the same position. The precision and accuracy is better than 0.3% total.
摘要翻译：精密流体分配系统，如果使用滚子控制，可以有效地用于蠕动泵中精确的流体分配。蠕动泵可以与夹紧阀组合，允许分配管打开，同时源管被阻塞。控制辊运动用于将下一个辊移动到与先前的辊相同的起始位置，分配夹阀闭合并且源阀打开。系统使用滚子定位，其中每个滚子被正确定位，使得每个分配循环从相同的位置开始。精度和精度均优于0.3％。

8. 发明授权

US4988618A Magnetic separation device and methods for use in heterogeneous assays 失效
标题翻译：磁分离装置和用于异种测定的方法
公开(公告)号：US4988618A
公开(公告)日：1991-01-29
申请号：US347544
申请日：1989-05-03
申请人： May K. Li , Jack Kessler , David T. Bach
发明人： May K. Li , Jack Kessler , David T. Bach
IPC分类号： B03C1/28 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： B03C1/288 , C12Q1/68 , G01N33/5302 , G01N33/54326 , G01N2035/1025 , G01N35/0098 , G01N35/1065 , Y10S436/808 , Y10S436/809
摘要： Magnetic separation devices are described for use in immunoassay or hybridization assay procedures. The most preferred embodiments comprise a defined relationship between microtube and microtiter plate receiving orifices and rare earth cobalt magnets having predetermined magnetic field orientations.
摘要翻译：磁分离装置描述用于免疫测定或杂交测定程序。最优选的实施方案包括具有预定磁场取向的微管和微量滴定板接收孔和稀土钴磁体之间的确定的关系。

9. 发明授权

US4867559A Liquid/liquid fiber-optic fluorescence detector and absorbance analyzer 失效
标题翻译：液/液光纤荧光检测器和吸光度分析仪
公开(公告)号：US4867559A
公开(公告)日：1989-09-19
申请号：US141159
申请日：1988-01-06
申请人： David T. Bach
发明人： David T. Bach
IPC分类号： G01N15/14 , G01N21/03 , G01N21/64 , G02B6/032
CPC分类号： G01N21/31 , G01N21/05 , G01N21/64 , G02B6/032 , G01N2015/1411 , G01N2021/0346 , G01N2021/1734 , G01N2021/6467 , G01N2021/6473 , G01N2021/6491 , G01N2201/065
摘要： An apparatus and method are disclosed for measuring the fluorescence and absorbance of a liquid sample. A sample tube is provided that has an external surface and a bore therethrough for containing a sample fluid. A cladding fluid coats the bore of the sample tube to provide a smooth surface adjacent to the sample fluid. Excitation radiation is directed along the bore and detector means are provided to detect the excitation radiation, fluorescent radiation, and non-absorbed radiation. Comparator means compare the signals from the presence and concentration of various constituents in the liquid sample.
摘要翻译：公开了用于测量液体样品的荧光和吸光度的装置和方法。提供样品管，其具有外表面和穿过其中的孔以容纳样品流体。包层流体涂覆样品管的孔，以提供与样品流体相邻的光滑表面。激励辐射沿着孔引导，提供检测器装置以检测激发辐射，荧光辐射和未被吸收的辐射。比较器是指比较来自液体样品中各种成分的存在和浓度的信号。

10. 发明授权

US4861163A Ellipsoidal cylinder fluorescence analyzer 失效
标题翻译：椭圆柱荧光分析仪
公开(公告)号：US4861163A
公开(公告)日：1989-08-29
申请号：US141160
申请日：1988-01-06
申请人： David T. Bach
发明人： David T. Bach
IPC分类号： G01N21/03 , G01N21/64
CPC分类号： G01N21/645 , G01N2021/0346 , G01N2021/6421 , G01N2021/6469
摘要： The present invention provides an apparatus and method for fluorescence detection. An ellipsoidal cylinder having a first focal line, a second focal line and an internal reflective surface is provided. An excitation source is disposed on the first focal line and a sample container is disposed on the second focal line. Filter means are disposed between the excitation source and the sample container. Both fluorescence detector and reference detector means are provided to detect, respectively, the fluorescence radiation and excitation radiation. Comparator means compare the signal from the fluorescence and reference detectors to determine the presence and concentration of fluorescent material within the sample container.
摘要翻译：本发明提供了一种用于荧光检测的装置和方法。提供具有第一焦线，第二焦线和内反射表面的椭圆形圆柱体。励磁源设置在第一焦线上，样品容器设置在第二焦线上。过滤装置设置在激发源和样品容器之间。提供荧光检测器和参考检测器装置以分别检测荧光辐射和激发辐射。比较器意味着比较来自荧光和参考检测器的信号，以确定样品容器内荧光材料的存在和浓度。

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