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1. 发明申请

US20080047836A1 Configurable Microfluidic Substrate Assembly 审中-公开
标题翻译：可配置微流体基板组件
公开(公告)号：US20080047836A1
公开(公告)日：2008-02-28
申请号：US10537690
申请日：2003-12-05
申请人： David Strand , David Barrow
发明人： David Strand , David Barrow
IPC分类号： B01D57/02 , B01J19/00 , G01N25/20 , G01N27/00
CPC分类号： B01L3/502715 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0816 , B01L2300/0887 , G01N30/6047 , G01N30/6095
摘要： A microfluidic substrate assembly includes a substrate body having at least one fluid inlet port. At least one microscale fluid flow channel in the substrate is in fluid communication with the inlet port for transport of a fluid to be tested. The substrate body also has a plurality of sockets, with each of one or sockets configured to receive an operative component. At least one socket is in communication with the microscale fluid flow channel.
摘要翻译：微流体衬底组件包括具有至少一个流体入口的衬底本体。衬底中的至少一个微流体流动通道与入口端口流体连通，用于输送被测流体。衬底主体还具有多个插座，其中一个或多个插座中的每一个被配置为接收操作部件。至少一个插座与微型流体流动通道连通。

2. 发明申请

US20070140041A1 Fluid-handling apparatus and methods 失效
标题翻译：流体处理设备和方法
公开(公告)号：US20070140041A1
公开(公告)日：2007-06-21
申请号：US11506771
申请日：2006-08-10
申请人： Graham Sparey-Taylor , David Strand , David Barrow
发明人： Graham Sparey-Taylor , David Strand , David Barrow
IPC分类号： B01F11/02 , B81B7/00
CPC分类号： B01L3/5027 , B01F11/0241 , B01F13/0059 , B01F2215/0431 , B01J19/0093 , B01J19/10 , B01J2219/00783 , B01J2219/00889 , B01J2219/00932 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0439 , B01L2400/0496 , G01N2035/00554 , Y10S366/04
摘要： Fluid processing apparatus comprises a fluid-handling manifold comprising a manifold body having at least a first fluid duct and a second fluid duct. The first and second fluid ducts are in fluid communication with each other at a microfluidic junction of the fluid-handling manifold. The manifold body further comprises a transducer operative to generate ultrasonic acoustic traveling wave radiation into fluid in the microfluidic junction from an active surface toward a non-reflective boundary of the microfluidic junction. The microfluidic junction is operative to pass fluid received from the first and second duct, with micro-mixing effected by the traveling wave radiated into the junction during the fluid flow.
摘要翻译：流体处理装置包括流体处理歧管，其包括具有至少第一流体管道和第二流体管道的歧管主体。第一和第二流体管道在流体处理歧管的微流体连接处彼此流体连通。歧管主体还包括传感器，其可操作以将超声波行波辐射从微流体结的有源表面朝向非反射边界的微流体结中的流体中产生。微流体结可操作以通过从第一和第二管道接收的流体，在流体流动期间，通过辐射到接头中的行波进行微混合。

3. 发明授权

US07846382B2 Method and device for ultrasonically manipulating particles within a fluid 失效
标题翻译：用于超声波操纵流体内颗粒的方法和装置
公开(公告)号：US07846382B2
公开(公告)日：2010-12-07
申请号：US10516599
申请日：2003-06-03
申请人： David Strand , David Barrow , Joseph Cefai
发明人： David Strand , David Barrow , Joseph Cefai
IPC分类号： C02F1/32
CPC分类号： B01D21/283 , B01D49/006 , B01D51/08 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0631 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2400/0433 , B01L2400/0439 , B01L2400/086 , G01N2015/0288 , G01N2015/1415 , G01N2015/142 , G01N2015/149
摘要： Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.
摘要翻译：用于流体传播颗粒的超声操作的流体处理方法和装置包括在歧管内限定超声波腔的流体处理歧管和超声波粒子操纵器。引入到歧管中的流体颗粒通过在超声腔处控制超声波驻波来操纵。在歧管内具有不均匀构型，不对称驻波和/或多个超声腔的腔可用于控制流体传播颗粒的运动，任选地包括收集和保持这种颗粒，将颗粒从一个通道转移到另一个通道固相萃取（SPE）颗粒，生物颗粒和其它流体传导的颗粒可在流体处理歧管内操纵。

4. 发明申请

US20070122314A1 Microfluidic substrate assembly and method for making same 审中-公开
标题翻译：微流体基板组件及其制造方法
公开(公告)号：US20070122314A1
公开(公告)日：2007-05-31
申请号：US11490411
申请日：2006-07-18
申请人： David Strand , Joseph Antocci , Peter Myers , David Barrow , Joseph Cefai , Tim Myers
发明人： David Strand , Joseph Antocci , Peter Myers , David Barrow , Joseph Cefai , Tim Myers
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00952 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/545 , B01L2200/027 , B01L2200/10 , B29C65/1612 , B29C65/1616 , B29C65/1635 , B29C65/1677 , B29C65/168 , B29C65/1683 , B29C65/1687 , B29C65/1696 , B29C66/1122 , B29C66/54 , B29C66/55 , B29C66/71 , B29C66/73366 , B29C66/73771 , B29C66/73775 , B29C66/7392 , B29C66/73921 , B29C66/91411 , B29K2071/00 , B29L2031/756 , G01N27/44704 , G01N30/24 , G01N30/6026 , G01N30/6034 , G01N30/6091 , G01N30/6095 , G01N30/88 , G01N35/00732 , G01N2001/021 , G01N2030/8804 , G01N2030/8881 , G06F19/3481 , G16H10/65
摘要： A novel microfluidic substrate assembly and method for making same are disclosed. The substrate assembly comprises a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel within the multi-layer substrate in fluid communication with the inlet port for transport of fluid. The substrate assembly may optionally comprise additional components and elements located within the substrate assembly or attached to the substrate assembly.
摘要翻译：公开了一种新颖的微流体衬底组件及其制造方法。衬底组件包括多层层压衬底，其限定多层衬底内的至少一个流体入口和至少一个微流体流动通道，其与用于输送流体的入口流体连通。衬底组件可以可选地包括位于衬底组件内或附接到衬底组件的附加组件和元件。

5. 发明申请

US20060037915A1 Method and device for ultrasonically manipulating particles within a fluid 失效
标题翻译：用于超声波操纵流体内颗粒的方法和装置
公开(公告)号：US20060037915A1
公开(公告)日：2006-02-23
申请号：US10516599
申请日：2003-06-03
申请人： David Strand , David Barrow , Joseph Cefai
发明人： David Strand , David Barrow , Joseph Cefai
IPC分类号： C02F1/32
CPC分类号： B01D21/283 , B01D49/006 , B01D51/08 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0631 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2400/0433 , B01L2400/0439 , B01L2400/086 , G01N2015/0288 , G01N2015/1415 , G01N2015/142 , G01N2015/149
摘要： Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.
摘要翻译：用于流体传播颗粒的超声操作的流体处理方法和装置包括在歧管内限定超声波腔的流体处理歧管和超声波粒子操纵器。引入到歧管中的流体颗粒通过在超声腔处控制超声波驻波来操纵。在歧管内具有不均匀构型，不对称驻波和/或多个超声腔的腔可用于控制流体传播颗粒的运动，任选地包括收集和保持这种颗粒，将颗粒从一个通道转移到另一个通道固相萃取（SPE）颗粒，生物颗粒和其它流体传导的颗粒可在流体处理歧管内操纵。

6. 发明申请

US20100210008A1 Configurable Microfluidic Substrate Assembly 审中-公开
标题翻译：可配置微流体基板组件
公开(公告)号：US20100210008A1
公开(公告)日：2010-08-19
申请号：US12618349
申请日：2009-11-13
申请人： David Strand , David Barrow
发明人： David Strand , David Barrow
IPC分类号： C12M1/34 , H01J49/26 , G01R33/20 , G01F1/00 , G01L7/00 , G01N29/02 , G01K13/00 , G01R27/08 , G01R19/00 , G01T1/10 , G01N33/00 , G01N27/26
CPC分类号： B01L3/502715 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0816 , B01L2300/0887 , G01N30/6047 , G01N30/6095
摘要： A microfluidic substrate assembly includes a substrate body having at least one fluid inlet port. At least one microscale fluid flow channel in the substrate is in fluid communication with the inlet port for transport of a fluid to be tested. The substrate body also has a plurality of sockets, with each of one or sockets configured to receive an operative component. At least one socket is in communication with the microscale fluid flow channel.
摘要翻译：微流体衬底组件包括具有至少一个流体入口的衬底本体。衬底中的至少一个微流体流动通道与入口端口流体连通，用于输送被测流体。衬底主体还具有多个插座，其中一个或多个插座中的每一个被配置为接收操作部件。至少一个插座与微型流体流动通道连通。

7. 发明授权

US07731412B2 Fluid-handling apparatus and methods 失效
标题翻译：流体处理设备和方法
公开(公告)号：US07731412B2
公开(公告)日：2010-06-08
申请号：US11506771
申请日：2006-08-10
申请人： Graham Sparey-Taylor , David Strand , David Barrow
发明人： Graham Sparey-Taylor , David Strand , David Barrow
IPC分类号： B01F11/02 , B01F7/00
CPC分类号： B01L3/5027 , B01F11/0241 , B01F13/0059 , B01F2215/0431 , B01J19/0093 , B01J19/10 , B01J2219/00783 , B01J2219/00889 , B01J2219/00932 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0439 , B01L2400/0496 , G01N2035/00554 , Y10S366/04
摘要： Fluid processing apparatus comprises a fluid-handling manifold comprising a manifold body having at least a first fluid duct and a second fluid duct. The first and second fluid ducts are in fluid communication with each other at a microfluidic junction of the fluid-handling manifold. The manifold body further comprises a transducer operative to generate ultrasonic acoustic traveling wave radiation into fluid in the microfluidic junction from an active surface toward a non-reflective boundary of the microfluidic junction. The microfluidic junction is operative to pass fluid received from the first and second duct, with micro-mixing effected by the traveling wave radiated into the junction during the fluid flow.
摘要翻译：流体处理装置包括流体处理歧管，其包括具有至少第一流体管道和第二流体管道的歧管主体。第一和第二流体管道在流体处理歧管的微流体连接处彼此流体连通。歧管主体还包括传感器，其可操作以将超声波行波辐射从微流体结的有源表面朝向非反射边界的微流体结中的流体中产生。微流体结可操作以通过从第一和第二管道接收的流体，在流体流动期间，通过辐射到接头中的行波进行微混合。

8. 发明申请

US20070168579A1 DMA transfer and hardware acceleration of PPP frame processing 审中-公开
标题翻译： DMA传输和硬件加速的PPP帧处理
公开(公告)号：US20070168579A1
公开(公告)日：2007-07-19
申请号：US11230414
申请日：2005-09-20
申请人： William Croughwell , David Barrow
发明人： William Croughwell , David Barrow
IPC分类号： G06F13/28
CPC分类号： G06F13/28 , H04L1/0061 , H04L1/0072 , H04L1/18 , H04L49/90 , H04L69/12 , H04L69/324
摘要： PPP frame encapsulation of IP frames—including FCS calculation, character escaping, and HDLC flag insertion—is performed by hardware acceleration circuits within a DMA module as part of a DMA transfer autonomously of a processor. Software may preprocess the IP packets prior to the hardware-accelerated processing. The hardware acceleration in the DMA module may additionally decapsulate PPP frames—including FCS calculation and comparison for error detection, escaped character recovery, and frame boundary detection—to assist in the formation of IP packets. The hardware-accelerated PPP framing may be particularly useful when a mobile terminal provides internet access, through a wireless communication network over packet data channels, to an attached peripheral device, such as a computer.
摘要翻译： IP帧的PPP帧封装（包括FCS计算，字符转义和HDLC标志插入）由DMA模块内的硬件加速电路执行，作为处理器自主的DMA传输的一部分。软件可以在硬件加速处理之前对IP数据包进行预处理。 DMA模块中的硬件加速可以进一步解封装PPP帧，包括用于错误检测，转义字符恢复和帧边界检测的FCS计算和比较，以帮助形成IP数据包。当移动终端通过分组数据信道的无线通信网络向连接的外围设备（诸如计算机）提供因特网接入时，硬件加速的PPP成帧可能是特别有用的。

9. 发明授权

US07194380B2 Classification using probability estimate re-sampling 有权
标题翻译：使用概率估计重采样分类
公开(公告)号：US07194380B2
公开(公告)日：2007-03-20
申请号：US10547014
申请日：2004-02-20
申请人： David Barrow , Maarten Anton Keijzer
发明人： David Barrow , Maarten Anton Keijzer
IPC分类号： G06F15/00 , G06F19/00
CPC分类号： G06K9/6298 , G06Q40/08
摘要： Embodiments of a computer-implemented method of calculating estimates of a joint posterior probability of class membership given combinations of attribute values of a pair of attributes are disclosed. The calculating is performed on the basis of data representing a training set of a plurality of instances defined by attribute values for a plurality of attributes together with a class membership outcome. Embodiments of the method comprise calculating first and second estimates of a posterior probability of class membership given attribute values of a first and second attribute of the pair, respectively, and binning the first and second estimates into a respective plurality of first and second probability range bins. Instances of the training set are mapped to combinations of one of each of the first and second pluralities of probability range bins, and on the basis of the mapping, calculating estimates of a joint posterior probability of class membership.
摘要翻译：公开了一种计算机实现的方法，用于计算一组属性的属性值的组合的类隶属的联合后验概率的估计。基于表示由多个属性的属性值定义的多个实例的训练集合的数据以及类成员资格结果来执行计算。该方法的实施例包括分别计算给定对的第一和第二属性的属性值的类隶属的后验概率的第一和第二估计，并将第一和第二估计合并成相应的多个第一和第二概率范围仓。训练集的实例被映射到第一和第二多个概率范围单元中的每一个的组合，并且基于映射，计算类成员关联后验概率的估计。

10. 发明授权

US07895466B2 DMA assisted data backup and restore 有权
标题翻译： DMA辅助数据备份和还原
公开(公告)号：US07895466B2
公开(公告)日：2011-02-22
申请号：US12202963
申请日：2008-09-02
申请人： David Barrow
发明人： David Barrow
IPC分类号： G06F11/00
CPC分类号： G06F13/28
摘要： An integrated circuit includes a DMA controller for performing conventional DMA transfers and for backing-up and restoring data during low power events. The integrated circuit includes one or more processor components, one or more peripheral components, a power management circuit and the DMA controller. The power management circuit manages power control within the integrated circuit. The DMA controller includes a DMA engine for executing DMA transfers between different ones of the components and memory based on configuration parameters provided to the DMA engine. A detection circuit configured determines if the power management circuit initiates a power state change. The DMA controller also has circuitry for providing a first set of configuration parameters to the DMA engine if no change in power state is detected and overriding the first set of configuration parameters with a second set of configuration parameters if a change in power state is detected.
摘要翻译：集成电路包括用于执行常规DMA传输和用于在低功率事件期间备份和恢复数据的DMA控制器。集成电路包括一个或多个处理器组件，一个或多个外围组件，电源管理电路和DMA控制器。电源管理电路管理集成电路内的功率控制。 DMA控制器包括用于基于提供给DMA引擎的配置参数来执行不同组件和存储器之间的DMA传输的DMA引擎。配置的检测电路确定电源管理电路是否启动电源状态改变。如果检测到功率状态的变化，则DMA控制器还具有用于向DMA引擎提供第一组配置参数的电路，如果没有检测到功率状态的变化并且用第二组配置参数重写第一组配置参数。

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