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1. 发明申请

US20070045545A1 Hyperspectral sensor using tunable filter 审中-公开
标题翻译：高光谱传感器采用可调滤波器
公开(公告)号：US20070045545A1
公开(公告)日：2007-03-01
申请号：US11215204
申请日：2005-08-26
申请人： David Light , Tommy Lum , William Pittman
发明人： David Light , Tommy Lum , William Pittman
IPC分类号： G01J5/02
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0289 , G01J3/1256 , G01J3/2823 , G01J2003/1247
摘要： A target-seeking-and-tracking system featuring hyperspectral sensing performed by a tunable filter and an infrared focal plane array is programmable to collect and process several hyperspectral bands of infrared radiation emanating from a target scenery. The programming is done by tuning the filter from time to time to collect several hyperspectral bands containing image data corresponding to several objects of interest in the scenery. The image data is further processed in the target recognition unit to identify the objects and aid in the selection and tracking of a particular target object for the ultimate goal of accurate destruction of the object. The programmability of hyperspectral sensing provides a degree of countermeasures immunity by allowing several bands to be combined to achieve the best signal-to-clutter ratio.
摘要翻译：由可调滤波器和红外焦平面阵列执行的具有高光谱感测的寻靶跟踪系统是可编程的，用于收集和处理从目标风景发出的红外辐射的多个高光谱带。编程是通过不时地调整滤波器来收集几个包含与风景中感兴趣的几个对象相对应的图像数据的高光谱带。图像数据在目标识别单元中被进一步处理以识别对象，并帮助特定目标对象的选择和跟踪，以达到准确地破坏对象的最终目的。高光谱传感器的可编程性通过允许多个频带组合以实现最佳的信噪比提供了一定程度的对策抗扰度。

2. 发明授权

US09534092B2 Purification systems and methods 有权
标题翻译：净化系统和方法
公开(公告)号：US09534092B2
公开(公告)日：2017-01-03
申请号：US13371264
申请日：2012-02-10
申请人： Wolfgang Hinz , Ryan Jones , David Light
发明人： Wolfgang Hinz , Ryan Jones , David Light
IPC分类号： B07B1/00 , C08J3/12 , C12N15/10
CPC分类号： C08J3/12 , B07B1/00 , C08J2300/14 , C12N15/1017
摘要： A method of preparing hydrogel particles includes applying a solution including a plurality of hydrogel particles to a stir cell. A retentate side of a filter defines a lower surface of the stir cell. The filter has the retentate side and a permeate side. The method further includes, while stirring the solution within the stir cell, dispensing a buffer solution at a first flow rate to the stir cell and drawing a permeate from the permeate side of the filter using a pump at a second flow rate, the permeate including a subset of the plurality of hydrogel particles.
摘要翻译：制备水凝胶颗粒的方法包括将包含多个水凝胶颗粒的溶液施加到搅拌槽。过滤器的滞留侧限定了搅拌槽的下表面。过滤器具有滞留侧和渗透侧。该方法还包括在搅拌槽内搅拌溶液的同时，以第一流速向缓冲池分配缓冲溶液，并以第二流量使用泵从过滤器的渗透侧抽出渗透物，渗透物包括多个水凝胶颗粒的一个子集。

3. 发明申请

US20120094871A1 Particle Population and Methods of Making and Using 审中-公开
标题翻译：粒子群体及其使用方法
公开(公告)号：US20120094871A1
公开(公告)日：2012-04-19
申请号：US13027355
申请日：2011-02-15
申请人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
发明人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
IPC分类号： C40B40/06
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00722 , C12Q1/6874 , C40B40/08 , C40B50/06 , Y10T428/2982
摘要： The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
摘要翻译：本发明提供了在核酸分析中具有应用的颗粒组合物。本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中粒子与粒子变化的减少。这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

4. 发明授权

US07737145B2 Diamine derivatives as inhibitors of leukotriene A4 hydrolase 有权
标题翻译：二胺衍生物作为白三烯A4水解酶的抑制剂
公开(公告)号：US07737145B2
公开(公告)日：2010-06-15
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A01N43/60 , A61K31/495 , C07D241/36 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D513/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

5. 发明申请

US20070155727A1 Amide inhibitors of leukotriene A4 hydrolase 审中-公开
标题翻译：白三烯A4水解酶的酰胺抑制剂
公开(公告)号：US20070155727A1
公开(公告)日：2007-07-05
申请号：US11644822
申请日：2006-12-22
申请人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
发明人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
IPC分类号： A61K31/551 , A61K31/407 , C07D487/02 , C07D243/08
CPC分类号： C07D207/04 , C07C237/04 , C07C237/06 , C07C237/30 , C07C255/58 , C07C275/40 , C07C275/42 , C07C275/62 , C07C311/05 , C07C311/08 , C07C311/09 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07D211/06 , C07D243/08 , C07D295/04 , C07D295/16 , C07D487/02 , C07D487/08
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4a，R 4， R 4b，R 4c，R 5a，R 5b，R 5c，R 5，R 5， R 6b，R 6b，R 6，R 7，R 8，R 8，R 8，本文描述了本发明的其它药学上可接受的盐，溶剂合物，多晶型物，铵离子，N-氧化物或前体药物; 其是白三烯A 4水解酶抑制剂，因此其可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和使用和制备本发明化合物的方法。

6. 发明授权

US07152311B2 Enhancements in framed sheet processing 失效
公开(公告)号：US07152311B2
公开(公告)日：2006-12-26
申请号：US10032886
申请日：2001-12-26
申请人： Masud Beroz , Thomas H. DiStefano , Matthew T. Hendrickson , David Light , John W. Smith
发明人： Masud Beroz , Thomas H. DiStefano , Matthew T. Hendrickson , David Light , John W. Smith
IPC分类号： B23P19/04
CPC分类号： H01L24/86 , B29C2043/5825 , H01L21/67144 , H01L2224/7965 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01029 , H01L2924/01033 , H01L2924/01042 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/12042 , H01L2924/30105 , Y10S269/909 , Y10T29/53265 , Y10T29/53435 , Y10T428/23 , Y10T428/239 , H01L2924/00
摘要： A flexible sheet used in manufacture of microelectronic components is held on a frame formed from a rigid material so that the frame maintains the sheet under tension during processing and thereby stabilizes the dimensions of the sheet. The frame may be formed from a rigid, light-transmissive material such as a glass, and the bond between the frame and sheet may be made or released by light transmitted through the frame. Preferred features of the framed sheet minimize entrapment of processing liquids such as etch solutions, thereby minimizing carryover of processing solutions between steps. The frame may have contact openings which permit engagement of a metallic layer on the sheet by an electrode carrying electroplating or etching current without disturbing the main portion of the sheet where features are to be formed or treated.

7. 发明申请

US20060275951A1 Microelectronic assemblies having low profile connections 审中-公开
标题翻译：具有薄型连接的微电子组件
公开(公告)号：US20060275951A1
公开(公告)日：2006-12-07
申请号：US11487880
申请日：2006-07-17
申请人： Michael Warner , Masud Beroz , David Light , Delin Li , Dennis Castillo , Hung-ming Wang , John Smith
发明人： Michael Warner , Masud Beroz , David Light , Delin Li , Dennis Castillo , Hung-ming Wang , John Smith
IPC分类号： H01L21/00
CPC分类号： H01L24/10 , H01L23/3128 , H01L23/3135 , H01L23/49816 , H01L23/49827 , H01L23/4985 , H01L23/5389 , H01L24/13 , H01L2224/05001 , H01L2224/05022 , H01L2224/05572 , H01L2224/13 , H01L2224/13022 , H01L2224/13099 , H01L2224/73204 , H01L2224/81193 , H01L2224/8193 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01022 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01079 , H01L2924/01082 , H01L2924/01322 , H01L2924/014 , H01L2924/00 , H01L2224/05644 , H01L2924/00014 , H01L2224/05647 , H01L2224/05655 , H01L2224/05666 , H01L2224/05671 , H01L2224/05124
摘要： A microelectronic assembly includes a first microelectronic element having a first face and contacts accessible at the first face, and a layer of a dielectric material having a bottom surface contacting the first microelectronic element, a top surface facing away from the first microelectronic element and holes extending between the top and bottom faces in alignment with the contacts on the first microelectronic element. The assembly includes conductive protrusions extending through the holes to the contacts, the conductive protrusions projecting beyond the top surface of the dielectric layer. The assembly also has a second microelectronic element having a first surface with conductive elements being accessible at the first surface thereof, the second microelectronic element being assembled with the first microelectronic element so that the contacts of the second microelectronic element are connected with the conductive protrusions and the top surface of the dielectric layer is spaced from the first surface of the second microelectronic element.
摘要翻译：微电子组件包括具有第一面和在第一面可接触的触点的第一微电子元件和具有接触第一微电子元件的底表面的电介质材料层，背离第一微电子元件的顶表面和延伸在顶面和底面之间，与第一微电子元件上的触点对齐。组件包括延伸穿过孔到触头的导电突起，导电突出部突出超过电介质层的顶表面。组件还具有第二微电子元件，其具有第一表面，其导电元件在其第一表面处可访问，第二微电子元件与第一微电子元件组装，使得第二微电子元件的触点与导电突起连接，电介质层的顶表面与第二微电子元件的第一表面间隔开。

8. 发明申请

US20050014783A1 Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy 审中-公开
标题翻译：使用Rho激酶抑制剂治疗动脉瘤和心脏肥大
公开(公告)号：US20050014783A1
公开(公告)日：2005-01-20
申请号：US10857062
申请日：2004-05-28
申请人： William Dole , David Light , Baby Martin-McNulty , Sabine Schirm , Yi-Xin Wang
发明人： William Dole , David Light , Baby Martin-McNulty , Sabine Schirm , Yi-Xin Wang
IPC分类号： A61K31/4409 , A61K31/47 , A61K31/4725 , A61K31/551 , A61K31/5513 , A61P9/00 , A61P9/10 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention is directed to a method for preventing or decreasing the incidence of or treating aneurysm or cardiac hypertrophy, comprising administering an effective amount of a rho-kinase inhibitor, such as fasudil, to a subject in need thereof.
摘要翻译：本发明涉及一种用于预防或减少动脉瘤或心脏肥大的发生或治疗的方法，包括向有需要的受试者施用有效量的rho激酶抑制剂，如法舒地尔。

9. 发明授权

US06790828B2 Thrombomodulin analogs for pharmaceutical use 失效
标题翻译：用于药物用途的血栓调节蛋白类似物
公开(公告)号：US06790828B2
公开(公告)日：2004-09-14
申请号：US10438648
申请日：2003-05-14
申请人： David Light , Michael John Morser , Mariko Nagashima
发明人： David Light , Michael John Morser , Mariko Nagashima
IPC分类号： A61K3816
CPC分类号： C07K14/7455 , A61K38/00
摘要： The present invention relates to the design, production and use of analogs of thrombomodulin (TM) that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to promote activation of thrombin-activatable fibrinolysis inhibitor (TAFI). These analogs are useful in, for example, antithrombotic therapy.
摘要翻译：本发明涉及血栓调节蛋白（TM）类似物的设计，生产和使用，其具有增强凝血酶介导的蛋白质C活化但能显着降低促凝血酶激活性纤维蛋白溶解抑制剂（TAFI）活化能力的能力）。这些类似物在例如抗血栓治疗中是有用的。

10. 发明申请

US20130259806A1 DIMERIC MOLECULAR COMPLEXES WITH FREE CYSTEINE RESIDUES AND CONJUGATES THEREOF 审中-公开
标题翻译：具有免费CYSTEINE残留的二元分子复合物及其结合
公开(公告)号：US20130259806A1
公开(公告)日：2013-10-03
申请号：US13988133
申请日：2011-12-07
申请人： David Light , Paul Szymanski , Marian Seto , Aline Cornelius
发明人： David Light , Paul Szymanski , Marian Seto , Aline Cornelius
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K51/088 , C07K16/18 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/60 , C07K2317/64 , C07K2317/94 , C07K2319/00 , C07K2319/01
摘要： The invention relates generally to dimeric molecular complexes comprising two fusion proteins. Each fusion protein comprises a biological effector moiety, a polypeptide spacer sequence, and an IgE CH4 dimerization domain. The dimeric molecular complexes may be conjugated, at a defined site, to other molecules including drug moieties, cytotoxic agents, labels (such as detectable labels), or biocompatible polymers.
摘要翻译：本发明一般涉及包含两种融合蛋白的二聚体分子复合物。每个融合蛋白包含生物效应子部分，多肽间隔序列和IgE CH4二聚化结构域。二聚体分子复合物可以在限定的位点与包括药物部分，细胞毒性剂，标记（例如可检测标记）或生物相容性聚合物的其它分子缀合。

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