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1. 发明申请

US20100312230A1 PATIENT CONTROLLED ACTIVATION WITH IMPLANTABLE DRUG DELIVERY DEVICES 审中-公开
标题翻译：患者控制激活与可移植药物递送设备
公开(公告)号：US20100312230A1
公开(公告)日：2010-12-09
申请号：US12790302
申请日：2010-05-28
申请人： David C. Ullestad , Irfan Ali , Peter Kovach , Duane Bourget
发明人： David C. Ullestad , Irfan Ali , Peter Kovach , Duane Bourget
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M2005/1405 , A61M2005/14208 , A61M2205/3523 , G06F19/3468
摘要： A patient controlled, implantable drug infusion system for administering medicine including a system for administering analgesia to a patient that allows the patient to control the analgesia infusion rates within limits prescribed by a physician for that particular patient. Also disclosed is a closed loop patient feedback system for administering drug therapy including a device and method that links information pertaining to a patient's physical assessment and activity level with a particular drug therapy.
摘要翻译：一种用于给药的患者控制的可植入药物输注系统，包括用于向患者施用镇痛的系统，其允许患者在该特定患者的医师规定的限度内控制镇痛输注速率。还公开了一种用于管理药物治疗的闭环患者反馈系统，其包括将与患者的身体评估和活动水平相关的信息与特定药物治疗相关联的装置和方法。

2. 发明申请

US20090082641A1 PATIENT EVENT INDICATION 有权
标题翻译：患者事件指征
公开(公告)号：US20090082641A1
公开(公告)日：2009-03-26
申请号：US12236316
申请日：2008-09-23
申请人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , David C. Ullestad
发明人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , David C. Ullestad
IPC分类号： A61B5/00
CPC分类号： G06F19/3456 , A61N1/36082 , A61N1/36132 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In addition to or instead of the patient input, the patient event indication may be generated based on a physiological parameter of the patient. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device. The patient input via an event indication button may also help evaluate whether a therapy system is useful for the patient.
摘要翻译：发生患者事件的指示可用于评估至少一个治疗程序的功效和/或调整对患者的治疗递送。在一些示例中，患者事件指示包括可经由编程设备的事件指示按钮接收的患者输入。除了或代替患者输入之外，可以基于患者的生理参数生成患者事件指示。在一些实例中，可以通过调整至少一个治疗参数值，切换治疗程序或治疗程序组或重新启动医疗装置的治疗周期来调整治疗递送。通过事件指示按钮的患者输入也可以帮助评估治疗系统是否对患者有用。

3. 发明授权

US08612055B2 System and method for delivering a therapeutic agent according to default infusion schedule 有权
标题翻译：根据默认输液计划递送治疗剂的系统和方法
公开(公告)号：US08612055B2
公开(公告)日：2013-12-17
申请号：US12761801
申请日：2010-04-16
申请人： Irfan Z. Ali , Steven M. Goetz , David C. Ullestad , Emem D. Akpan , Mark D. Salzwedel , Jiaying Shen
发明人： Irfan Z. Ali , Steven M. Goetz , David C. Ullestad , Emem D. Akpan , Mark D. Salzwedel , Jiaying Shen
IPC分类号： G01M1/38 , G05B15/00 , G05B13/00 , G05D23/00 , A61N1/30 , A61N1/00
CPC分类号： G06F11/0766 , A61M5/14276 , A61M5/16831 , A61M5/172 , A61M2005/14208 , A61M2205/52 , G06F11/0796 , G06F11/1662
摘要： A fluid delivery system comprises a pump configured to deliver a therapeutic agent to a patient, a memory storing a therapy program defining the delivery of the therapeutic agent to the patient by the pump and a default infusion schedule based on the therapy program, and a processor configured to control the pump to deliver the therapeutic agent to the patient according to the therapy program, to determine an error condition that prevents the pump from continuing to deliver therapy according to the therapy program, and, upon determination of the error condition, to control the pump to deliver the therapeutic agent to the patient according to the default infusion schedule.
摘要翻译：流体递送系统包括被配置为将治疗剂递送到患者的泵，存储存储通过泵定义治疗剂递送给患者的治疗程序的存储器和基于治疗程序的默认输注计划，以及处理器，其被配置为控制所述泵，以根据所述治疗程序将所述治疗剂递送至所述患者，以确定阻止所述泵根据所述治疗程序继续进行治疗的错误状况，并且在确定所述错误状况时，控制该泵根据默认的输液计划将治疗剂递送到患者。

4. 发明申请

US20120283704A1 DRUG INFUSION SYSTEM AND METHOD ADAPTED TO START DURING PROGRAMMING CYCLE 有权
标题翻译：药物灌注系统和方法适用于编程周期开始
公开(公告)号：US20120283704A1
公开(公告)日：2012-11-08
申请号：US13551945
申请日：2012-07-18
申请人： Irfan Z. Ali , David C. Ullestad
发明人： Irfan Z. Ali , David C. Ullestad
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Drug infusion system capable of delivering a fluid medication to a patient and method for doing same is described. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.
摘要翻译：描述了能够向患者输送流体药物的药物输注系统和用于进行相同的方法。可植入药物递送装置能够以在开始时间开始的多个时隙中具有多个步骤的原始编程周期的控制下以可编程速率将流体药物递送给患者。编程周期指定多个步骤中的每个步骤的可编程速率。外部控制器能够在编程时将代表原始编程周期的程序存储在可植入药物递送装置中。药物注射系统调整可植入药物递送装置，使得原始编程周期将在针对编程时间调整的原始编程周期期间的一个时间开始。

5. 发明授权

US4908623A Apparatus and method for range control and supply voltage compensation in a dual slope analog to digital converter 失效
标题翻译：双斜率模数转换器的范围控制和电源电压补偿的装置和方法
公开(公告)号：US4908623A
公开(公告)日：1990-03-13
申请号：US230083
申请日：1988-08-08
申请人： David C. Ullestad
发明人： David C. Ullestad
IPC分类号： H03M1/12 , H03M1/52
CPC分类号： H03M1/129 , H03M1/52
摘要： Apparatus for control of the range of input voltage values to be measured and for compensation of the changes in the supply voltage of an analog to digital dual slope converter circuit is described. The selection of a range for input voltage measurements in the analog to digital converter circuit permits the conversion to take place over a relatively long time period, thereby increasing the resolution of the resulting conversion. Changes in the supply voltage are combined with the input analog signal (during the capacitance charging period) and with the reference voltage (during the capacitance discharge cycle) providing compensation for the effects of time, temperature and the tolerance of the supply voltage.
摘要翻译：描述了用于控制要测量的输入电压值的范围和用于补偿模数 - 数字双斜率转换器电路的电源电压的变化的装置。在模拟数字转换器电路中选择输入电压测量的范围允许在相对长的时间段内进行转换，从而增加所得到的转换的分辨率。电源电压的变化与输入模拟信号（电容充电期间）和参考电压（电容放电周期期间）相结合，为时间，温度和电源电压的公差提供补偿。

6. 发明授权

US06579280B1 Generic multi-step therapeutic treatment protocol 有权
公开(公告)号：US06579280B1
公开(公告)日：2003-06-17
申请号：US09302613
申请日：1999-04-30
申请人： Peter J. Kovach , Craig R. Lang , David C. Ullestad
发明人： Peter J. Kovach , Craig R. Lang , David C. Ullestad
IPC分类号： A61K922
CPC分类号： A61M5/14276 , A61M5/172 , A61M2005/14208 , A61M2205/3523 , A61N1/3605 , G06F19/00 , G06F19/3468 , G06F19/3481
摘要： A generic treatment protocol is disclosed for therapeutically treating a patient via an implantable treatment device. Treatment steps can be defined to start and end at absolute times, or can be programmed via telemetry to start a certain amount of time after termination of a previously executed treatment step. Treatment steps have a treatment rate or dose attribute and a duration attribute. Treatment steps may optionally enable patient-activated bolus overlays. Patient-activated rate or dosage adjustments can also optionally be enabled. Repeated-execution treatment-step groups are also provided. Such treatment-step groups can have start and end times, a group duration, and a group total dose, each defined in a manner similar to that for a treatment step. Treatment-step groups include a repetition count, which could be set to a value that causes the group to repeat forever. Single execution treatment steps can, accordingly, be programmed to execute before and/or after a repeated-execution treatment-step group.

7. 发明授权

US4657179A Distributed environmental/load control system 失效
标题翻译：分布式环境/负载控制系统
公开(公告)号：US4657179A
公开(公告)日：1987-04-14
申请号：US686320
申请日：1984-12-26
申请人： John R. Aggers , Ralph C. Brindle , Kenneth B. Kidder , David C. Ullestad
发明人： John R. Aggers , Ralph C. Brindle , Kenneth B. Kidder , David C. Ullestad
IPC分类号： G05D23/19 , H02J1/00
CPC分类号： G05D23/1905 , Y10T307/469
摘要： A distributed environmental/load control system comprising a thermostat operable to supply signals indicative of sensed and desired values of a parameter in an environmentally controlled space to a first controller operable to control condition changing equipment for regulating the parameter, the signals being transmitted over a communications link between the thermostat and first controller. A second controller which is operable to control a plurality of loads in accordance with predetermined criteria to limit energy consumed by the loads is connected to the communications link through an interface device operable to process the signals produced by the thermostat in response to instructions furnished by the second controller and to supply the processed signals to the first controller.
摘要翻译：一种分布式环境/负载控制系统，包括恒温器，其可操作以将指示环境受控空间中的参数的感测和期望值的信号提供给可操作以控制条件改变设备以调节参数的第一控制器，所述信号通过通信恒温器和第一控制器之间的连接。可操作以根据预定标准控制多个负载以限制由负载消耗的能量的第二控制器通过接口装置连接到通信链路，接口装置可操作以响应于由恒温器所提供的指令来处理由恒温器产生的信号并且将经处理的信号提供给第一控制器。

8. 发明授权

US08562591B2 Drug infusion system and method adapted to start during programming cycle 有权
标题翻译：药物输液系统和方法适用于在编程周期中启动
公开(公告)号：US08562591B2
公开(公告)日：2013-10-22
申请号：US13551945
申请日：2012-07-18
申请人： Irfan Z. Ali , David C. Ullestad
发明人： Irfan Z. Ali , David C. Ullestad
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Drug infusion system capable of delivering a fluid medication to a patient and method for doing same is described. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.
摘要翻译：描述了能够向患者输送流体药物的药物输注系统和用于进行相同的方法。可植入药物递送装置能够以在开始时间开始的多个时隙中具有多个步骤的原始编程周期的控制下以可编程速率将流体药物递送给患者。编程周期指定多个步骤中的每个步骤的可编程速率。外部控制器能够在编程时将代表原始编程周期的程序存储在可植入药物递送装置中。药物注射系统调整可植入药物递送装置，使得原始编程周期将在针对编程时间调整的原始编程周期期间的一个时间开始。

9. 发明申请

US20120330273A1 IMPLANTABLE MEDICAL DEVICE WITH TIME FOR THERAPEUTIC OUTPUT REPLENISHMENT DETERMINATION AND METHOD THEREFORE 审中-公开
标题翻译：具有时间的可植入医疗装置，用于治疗输出检测的确定及方法
公开(公告)号：US20120330273A1
公开(公告)日：2012-12-27
申请号：US13604274
申请日：2012-09-05
申请人： David C. Ullestad , Mark J. Bina
发明人： David C. Ullestad , Mark J. Bina
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/1684 , A61M2205/3379 , A61M2209/045 , G06F19/3468
摘要： An implantable medical device for producing a variable therapeutic output to a patient. A therapeutic output delivery module requires replenishment following delivery of a predetermined amount of the therapeutic output. A calculator is responsive to a measure of an amount of the therapeutic output actually delivered to the patient for determining a parameter representative of a time at which the therapeutic output delivery module of the implantable medical device should be replenished with the therapeutic substance based at least in part upon the amount obtained from the measure. A method determines a parameter representative of a time at which a therapeutic output module of an implantable medical device should be replenished following delivery of a predetermined amount of therapeutic output. An amount of the therapeutic output actually delivered to the patient is measured. The parameter is calculated based at least in part upon the amount obtained in the measuring step.
摘要翻译：一种用于产生对患者的可变治疗输出的可植入医疗装置。治疗输出递送模块在递送预定量的治疗输出后需要补充。计算器响应于实际递送给患者的治疗输出的量的量度，用于确定代表可植入医疗装置的治疗输出递送模块应该用治疗物质补充的时间的参数，所述参数至少基于部分来自该措施获得的数额。一种方法确定代表在输送预定量的治疗输出后补充可植入医疗装置的治疗输出模块的时间的参数。测量实际输送给患者的治疗输出量。该参数至少部分地基于在测量步骤中获得的量来计算。

10. 发明授权

US08241270B2 Drug infusion system and method adapted to start during programming cycle 有权
标题翻译：药物输液系统和方法适用于在编程周期中启动
公开(公告)号：US08241270B2
公开(公告)日：2012-08-14
申请号：US10837500
申请日：2004-04-30
申请人： Irfan Z. Ali , David C. Ullestad
发明人： Irfan Z. Ali , David C. Ullestad
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M2205/3523
摘要： Drug infusion system capable of delivering a fluid medication to a patient and method for doing same. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.
摘要翻译：能够向患者输送流体药物的药物输注系统和进行相同操作的方法。可植入药物递送装置能够以在开始时间开始的多个时隙中具有多个步骤的原始编程周期的控制下以可编程速率将流体药物递送给患者。编程周期指定多个步骤中的每个步骤的可编程速率。外部控制器能够在编程时将代表原始编程周期的程序存储在可植入药物递送装置中。药物注射系统调整可植入药物递送装置，使得原始编程周期将在针对编程时间调整的原始编程周期期间的一个时间开始。

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