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1. 发明授权

US08401666B2 Modification profiles for posture-responsive therapy 有权
标题翻译：用于姿势反应疗法的修改方案
公开(公告)号：US08401666B2
公开(公告)日：2013-03-19
申请号：US12433856
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan , Dennis Bourget , Duane Bourget , Keith A. Miesel , James Zimmerman
发明人： Dennis M. Skelton , Jon P. Davis , Rajeev Sahasrabudhe , Shyam Gokaldas , Joseph J. Nolan , Dennis Bourget , Duane Bourget , Keith A. Miesel , James Zimmerman
IPC分类号： A61N1/365
CPC分类号： A61N1/37247 , A61B5/1116 , A61B5/1118 , A61B2562/0219 , A61N1/36071 , A61N1/36132 , A61N1/36135 , A61N1/36542 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H50/20 , G16H80/00
摘要： In general, the disclosure describes techniques for modifying therapy provided to a patient by a medical device. The techniques may be applicable to electrical stimulation therapy or other therapies. Modification of therapy may include adjustment of one or more therapy parameter values that define one or more characteristics of stimulation therapy delivered to a patient. The therapy modification may be based on activity of a patient that is detected by an IMD, such as a change in a detected posture state occupied by the patient. Different therapy modifications may be applied for different changes in detected posture state. An IMD may modify therapy based on a transition from one posture state to another posture state, and apply different modifications for different transitions. In some aspects, the modification may include a profile, such as a ramp up or ramp down in a parameter value over a period of time. The profile may be different for different posture transitions. A ramp slope may be steeper for one transition than for another transition. When a patient transitions from an upright to a lying posture state, for example, the profile may be especially abrupt. In some examples, a modification profile may define a dwell time.
摘要翻译：通常，本公开描述了用于修改由医疗装置提供给患者的治疗的技术。这些技术可能适用于电刺激治疗或其他疗法。治疗的修改可以包括调整一个或多个治疗参数值，其定义递送给患者的刺激疗法的一个或多个特征。治疗修改可以基于由IMD检测到的患者的活动，例如患者所占据的检测到的姿势状态的变化。可以对检测到的姿势状态的不同变化应用不同的治疗修改。 IMD可以基于从一个姿势状态到另一个姿势状态的转变来修改治疗，并对不同的转变应用不同的修改。在一些方面，修改可以包括轮廓，例如在一段时间内在参数值中的斜坡上升或下降。对于不同的姿势转换，轮廓可能不同。坡度斜坡对于一个过渡而言可能比另一个过渡更陡峭。当患者从直立状态转变到躺卧状态时，例如，轮廓可能特别突然。在一些示例中，修改简档可以定义驻留时间。

2. 发明申请

US20100312230A1 PATIENT CONTROLLED ACTIVATION WITH IMPLANTABLE DRUG DELIVERY DEVICES 审中-公开
标题翻译：患者控制激活与可移植药物递送设备
公开(公告)号：US20100312230A1
公开(公告)日：2010-12-09
申请号：US12790302
申请日：2010-05-28
申请人： David C. Ullestad , Irfan Ali , Peter Kovach , Duane Bourget
发明人： David C. Ullestad , Irfan Ali , Peter Kovach , Duane Bourget
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/172 , A61M2005/1405 , A61M2005/14208 , A61M2205/3523 , G06F19/3468
摘要： A patient controlled, implantable drug infusion system for administering medicine including a system for administering analgesia to a patient that allows the patient to control the analgesia infusion rates within limits prescribed by a physician for that particular patient. Also disclosed is a closed loop patient feedback system for administering drug therapy including a device and method that links information pertaining to a patient's physical assessment and activity level with a particular drug therapy.
摘要翻译：一种用于给药的患者控制的可植入药物输注系统，包括用于向患者施用镇痛的系统，其允许患者在该特定患者的医师规定的限度内控制镇痛输注速率。还公开了一种用于管理药物治疗的闭环患者反馈系统，其包括将与患者的身体评估和活动水平相关的信息与特定药物治疗相关联的装置和方法。

3. 发明授权

US08016776B2 Wearable ambulatory data recorder 有权
标题翻译：可佩戴的卧床数据记录仪
公开(公告)号：US08016776B2
公开(公告)日：2011-09-13
申请号：US11413619
申请日：2006-04-28
申请人： Duane Bourget , Keith A. Miesel , Gregory F. Molnar
发明人： Duane Bourget , Keith A. Miesel , Gregory F. Molnar
IPC分类号： A61B5/103
CPC分类号： A61N1/08 , A61B5/0002 , A61B5/0031 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/112 , A61B5/145 , A61B5/4082 , A61B5/4809 , A61B5/4815 , A61B5/4839 , A61B5/6831 , A61B5/6833 , A61B2560/0223 , A61B2560/0412 , A61B2560/0431 , A61B2562/0219 , A61N1/36021 , A61N1/36071 , A61N1/3702 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： A wearable ambulatory data recorder that senses physiological parameters of a patient, and stores physiological parameter data for later retrieval, as well as techniques for using such a wearable ambulatory data recorder, are described. The data recorder includes one or more sensors located on or within a housing. The data recorder may include an adhesive layer for attachment to a patient. In some embodiments, the housing may be within a patch, e.g., bandage, which includes the adhesive layer. The housing may be waterproof. Features of the data recorder such as size, waterproofness, and inclusion of an adhesive may allow the data recorder to be unobtrusively worn by a patient during a variety of daily activities. The data recorder may be for single use and thereafter disposable.
摘要翻译：描述了感测患者的生理参数并存储用于稍后检索的生理参数数据的可穿戴式步行数据记录器，以及使用这种可穿戴式可动态数据记录器的技术。数据记录器包括位于壳体上或壳体内的一个或多个传感器。数据记录器可以包括用于附接到患者的粘合剂层。在一些实施例中，壳体可以在包括粘合剂层的贴片（例如绷带）内。外壳可能是防水的。诸如尺寸，防水性和包含粘合剂的数据记录器的特征可允许数据记录器在各种日常活动期间被患者不佩服地佩戴。数据记录器可以是单次使用的，然后是一次性的。

4. 发明授权

US07957809B2 Closed-loop therapy adjustment 有权
标题翻译：闭环治疗调整
公开(公告)号：US07957809B2
公开(公告)日：2011-06-07
申请号：US11607454
申请日：2006-12-01
申请人： Duane Bourget , Keith A. Miesel
发明人： Duane Bourget , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/36021 , A61N1/36071 , A61N1/37247
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.
摘要翻译：描述了用于检测感测到的患者参数的值并根据先前与检测值相关联的治疗信息自动地向患者递送治疗的技术。在示例性实施例中，医疗设备从患者接收治疗调节。响应于调整，医疗设备将感测到的患者参数值与基于调整确定的治疗信息相关联。每当随后检测到参数值时，医疗装置根据相关联的治疗信息递送治疗。以这种方式，当患者的感测参数改变时，医疗设备可以“学习”以患者期望的方式自动调整治疗。可以感测用于执行所述技术的示例性患者参数包括姿势，活动，心率，肌电图（EMG），脑电图（EEG），心电图（ECG），温度，呼吸速率和pH。

5. 发明申请

US20110082522A1 CLOSED-LOOP THERAPY ADJUSTMENT 有权
公开(公告)号：US20110082522A1
公开(公告)日：2011-04-07
申请号：US12966827
申请日：2010-12-13
申请人： Duane Bourget , Keith A. Miesel
发明人： Duane Bourget , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/36014 , A61N1/36071 , A61N1/37252
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

6. 发明申请

US20090228071A1 COMMUNICATION BETWEEN A MEDICAL DEVICE AND A LEAD-BORNE DEVICE 有权
标题翻译：医疗器械与引线器件之间的通信
公开(公告)号：US20090228071A1
公开(公告)日：2009-09-10
申请号：US12042813
申请日：2008-03-05
申请人： Duane Bourget
发明人： Duane Bourget
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/37252
摘要： In general, the disclosure describes techniques for communication between at least one lead-borne device of an implantable lead and a medical device to which the lead is connected. The lead-borne device communicates with the medical device by modulating an impedance. The lead-borne device may communicate one or more bits of data to the medical device by selectively presenting either a first impedance or a second impedance to the medical device during one or more bit windows. The first and second impedance values may be respectively associated with first and second binary values, e.g., a high or one and low or zero.
摘要翻译：通常，本公开描述了用于在可植入引线的至少一个引线装置与引线所连接的医疗装置之间进行通信的技术。引线传输器件通过调制阻抗与医疗器件通信。引线传输器件可以在一个或多个位窗口期间通过选择性地向医疗设备呈现第一阻抗或第二阻抗来将一个或多个位数据传送到医疗设备。第一和第二阻抗值可以分别与第一和第二二进制值相关联，例如高或一和低或零。

7. 发明授权

US07853322B2 Closed-loop therapy adjustment 有权
标题翻译：闭环治疗调整
公开(公告)号：US07853322B2
公开(公告)日：2010-12-14
申请号：US11414625
申请日：2006-04-28
申请人： Duane Bourget , Keith A. Miesel
发明人： Duane Bourget , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36014 , A61N1/36071 , A61N1/37252
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.
摘要翻译：描述了用于检测感测到的患者参数的值并根据先前与检测值相关联的治疗信息自动地向患者递送治疗的技术。在示例性实施例中，医疗设备从患者接收治疗调节。响应于调整，医疗设备将感测到的患者参数值与基于调整确定的治疗信息相关联。每当随后检测到参数值时，医疗装置根据相关联的治疗信息递送治疗。以这种方式，当患者的感测参数改变时，医疗设备可以“学习”以患者期望的方式自动调整治疗。可以感测用于执行所述技术的示例性患者参数包括姿势，活动，心率，肌电图（EMG），脑电图（EEG），心电图（ECG），温度，呼吸速率和pH。

8. 发明申请

US20050061336A1 Apparatus and method for serving medical device application content to a remote computing device 审中-公开
标题翻译：向远程计算设备提供医疗设备应用内容的设备和方法
公开(公告)号：US20050061336A1
公开(公告)日：2005-03-24
申请号：US10949627
申请日：2004-09-23
申请人： Steven Goetz , Duane Bourget , Lance Beall , David Lee
发明人： Steven Goetz , Duane Bourget , Lance Beall , David Lee
IPC分类号： A61B19/00 , G06F19/00
CPC分类号： A61N1/37282 , A61B90/00
摘要： A telemetry interface module according to the invention may be utilized to facilitate remote programming of a patient medical device such as an implantable medical device. The telemetry interface module includes processing logic, memory, and various software/firmware applications that are capable of generating a user interface (“UI”) description for transmission to a remote computing device. The UI description is transmitted in accordance with a standardized data communication protocol, and the remote computing device renders a UI in response to the received UI description. The remote computing device processes and renders the UI using its native operating system and native UI controls, thus eliminating the need for computing hardware customized for the particular medical device telemetry application.
摘要翻译：可以使用根据本发明的遥测接口模块来促进患者医疗装置（例如可植入医疗装置）的远程编程。遥测接口模块包括处理逻辑，存储器和能够产生用于传输到远程计算设备的用户界面（“UI”）描述的各种软件/固件应用。 UI描述根据标准化的数据通信协议进行传输，并且远程计算设备响应于所接收的UI描述呈现UI。远程计算设备使用其本机操作系统和本地UI控制来处理和呈现UI，从而消除对针对特定医疗设备遥测应用定制的计算硬件的需要。

9. 发明授权

US10471264B2 Closed-loop therapy adjustment 有权
公开(公告)号：US10471264B2
公开(公告)日：2019-11-12
申请号：US13154303
申请日：2011-06-06
申请人： Duane Bourget , Keith A. Miesel
发明人： Duane Bourget , Keith A. Miesel
IPC分类号： A61N1/372 , A61N1/36
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

10. 发明授权

US08700157B2 Telemetry head programmer for implantable medical device and system and method 有权
标题翻译：用于植入式医疗设备的遥测头编程器及系统及方法
公开(公告)号：US08700157B2
公开(公告)日：2014-04-15
申请号：US11119423
申请日：2005-04-29
申请人： Steven M. Goetz , Duane Bourget
发明人： Steven M. Goetz , Duane Bourget
IPC分类号： A61N1/00
CPC分类号： A61N1/37264 , A61N1/37211 , A61N1/37235 , A61N1/37247
摘要： System, telemetry head and method for programming an implantable medical device adapted to provide a therapeutic output to a patient, the implantable medical device being programmable through a telemetry interface. A telemetry head is adapted for transcutaneous communication with the implantable medical device through the telemetry interface when the telemetry head is positioned with respect to the implantable medical device. A computing device has computing processing power and a user interface linked with the telemetry head. The computing device processes the computing instructions associated with the implantable medical device. The computing device supplies the user interface based, at least in part, on the computing instructions associated with the implantable medical device. The telemetry head receives programming instructions from the computing device and provides the programming instructions to the implantable medical device using the transcutaneous telemetry interface.
摘要翻译：系统，遥测头和用于编程适于向患者提供治疗输出的可植入医疗装置的方法，所述可植入医疗装置可通过遥测接口进行编程。当遥测头相对于可植入医疗装置定位时，遥测头适于通过遥测接口与可植入医疗装置的经皮通信。计算设备具有与遥测头相连的计算处理能力和用户界面。计算设备处理与可植入医疗设备相关联的计算指令。所述计算设备至少部分地基于与所述可植入医疗设备相关联的计算指令来提供所述用户界面。遥测头从计算设备接收编程指令，并使用经皮遥测接口将编程指令提供给可植入医疗设备。

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