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1. 发明授权

US06998115B2 Biodegradable poly(β-amino esters) and uses thereof 有权
公开(公告)号：US06998115B2
公开(公告)日：2006-02-14
申请号：US09969431
申请日：2001-10-02
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

2. 发明授权

US08557231B2 Biodegradable poly(beta-amino esters) and uses thereof 有权
公开(公告)号：US08557231B2
公开(公告)日：2013-10-15
申请号：US11099886
申请日：2005-04-06
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： A61K31/785 , A61K31/765 , C08G69/08
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

3. 发明授权

US08287849B2 Biodegradable poly(beta-amino esters) and uses thereof 有权
标题翻译：可生物降解的聚（β-氨基酯）及其用途
公开(公告)号：US08287849B2
公开(公告)日：2012-10-16
申请号：US12507999
申请日：2009-07-23
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： A61K31/765 , A61K9/00 , C08F26/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（＆（bgr。 - 氨基酯））。还提供了从市售的原料制备这些聚合物的方法。这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。本发明的聚合物也可以用于包封待递送的其它试剂。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

4. 发明申请

US20100036084A1 BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF 有权
标题翻译：生物可降解聚（氨基甲酸酯）及其用途
公开(公告)号：US20100036084A1
公开(公告)日：2010-02-11
申请号：US12507999
申请日：2009-07-23
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： C08G63/685
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（β-氨基酯）。还提供了从市售的原料制备这些聚合物的方法。这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。本发明的聚合物也可以用于包封待递送的其它试剂。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

5. 发明授权

US06197229B1 Method for high supercoiled DNA content microspheres 失效
标题翻译：高超螺旋DNA含量微球的方法
公开(公告)号：US06197229B1
公开(公告)日：2001-03-06
申请号：US09209032
申请日：1998-12-10
申请人： Shuicho Ando , David Putnam , Robert S. Langer
发明人： Shuicho Ando , David Putnam , Robert S. Langer
IPC分类号： B01J1302
CPC分类号： A61K48/00 , A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K47/183 , A61K47/26
摘要： A method for formulation of high supercoiled DNA content microspheres is described herein. A primary emulsion is formed which optionally contains a DNA nicking inhibitor in addition to DNA with or without buffer. The temperature of the primary emulsion is lowered below the freezing point of the aqueous inner phase which provides increased encapsulation efficiency by decreasing the rate of diffusion of DNA out of the aqueous phase. Thereafter, the primary emulsion is transferred to a water-based surfactant solution and subjected to homogenization to form a secondary microsphere emulsion. The organic phase is removed and the microspheres hardened which are then isolated, frozen and lyophilized.
摘要翻译：本文描述了制备高超螺旋DNA含量微球的方法。除了具有或不具有缓冲液的DNA之外，形成任选含有DNA切口抑制剂的初级乳液。初级乳液的温度降低到内层水相的凝固点以下，通过降低DNA从水相中扩散的速率来提高包封效率。此后，将初级乳液转移到水性表面活性剂溶液中并进行均化以形成二次微球体乳液。除去有机相，然后将微球硬化，然后分离，冷冻并冻干。

6. 发明申请

US20150096358A1 Filter-Cartridge Based Fluid-Sample Preparation and Assay System 审中-公开
标题翻译：基于过滤器的流体样品制备和测定系统
公开(公告)号：US20150096358A1
公开(公告)日：2015-04-09
申请号：US14510104
申请日：2014-10-08
申请人： David Putnam , Jason Putnam , Raymond Putnam
发明人： David Putnam , Jason Putnam , Raymond Putnam
IPC分类号： G01N1/10 , G01N1/28
摘要： The application relates to a device and method for preparing and testing a fluid sample using a filtration procedure for analysis of a filterable constituent of the fluid. In particular the process employs an enclosed pathway whereby the fluid sample may be put into a sealable flexible containment-vessel, and can then be passed through a fluid passageway to a removable enclosable filter cartridge, wherein the filterable constituent may be removed and the resultant filtrate fluid discharged from the cartridge. Once introduced to the flexible vessel, the enclosed pathway system thereby enables the fluid to be filtered and the filterable constituent examined with minimal complications of contamination of the sample through exposure to environmental pollutant external to the fluid sample.A useful objective of the device and method is to enable analyses of microbiological content of a fluid sample.The application further relates to a means of conducting the filtration of a fluid sample without necessarily requiring a pump or vacuum equipment to express or aspirate the fluid from the flexible containment vessel through the filter cartridge.
摘要翻译：本申请涉及使用用于分析流体的可过滤组分的过滤程序来制备和测试流体样品的装置和方法。特别地，该方法采用封闭路径，由此流体样品可以放入可密封的柔性容纳容器中，然后可以通过流体通道进入可移除的可封闭滤筒，其中可以将可过滤组分除去，并将所得滤液从墨盒中排出的液体。一旦引入柔性容器，封闭的通道系统就可以使流体被过滤并且通过暴露于流体样品外部的环境污染物，以最小的样品污染并发症的方式进行检查。该装置和方法的有用目的是能够分析流体样品的微生物含量。本申请还涉及一种进行流体样品过滤的手段，而不一定要求泵或真空设备通过滤筒从柔性容纳容器中表达或吸出流体。

7. 发明申请

US20070026225A1 Primer composition for high temperature belts 审中-公开
标题翻译：高温带底漆组成
公开(公告)号：US20070026225A1
公开(公告)日：2007-02-01
申请号：US11192632
申请日：2005-07-29
申请人： Jiann-Hsing Chen , Joseph Pavlisko , David Putnam , Robert Lancaster
发明人： Jiann-Hsing Chen , Joseph Pavlisko , David Putnam , Robert Lancaster
IPC分类号： B32B27/38 , B32B27/34 , B32B27/08 , B32B33/00
CPC分类号： B32B27/38 , C08G59/42 , C08G69/32 , C08G73/1053 , C08G73/14 , C09D163/00 , G03G15/2057 , Y10T428/265 , Y10T428/269 , Y10T428/31515 , Y10T428/3154 , Y10T428/31544 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725
摘要： A fuser belt comprising in order a substrate comprising a high temperature thermoset polymer, an epoxy primer layer comprising an epoxy resin having the following structure: where R1 and R2 are each independently H or an alkyl group containing 1 to about 4 carbon atoms, and R3 and R4 are each independently H, F, or an alkyl group containing 1 to about 4 carbon atoms, Z is a carbonyl cross-linking group, and x is an integer from 1 to about 10 and said epoxy priming layer also comprising an anhydride crosslinking agent cyclic mono anhydride or dianhydride having the following structure: and mixture thereof where R is an alkyl group containing 6 to about 8 carbon atoms and a low surface energy polymeric release coating.
摘要翻译：一种定影带，包括按照包括高温热固性聚合物的基底，包含具有以下结构的环氧树脂的环氧底漆层：其中R 1和R 2各自为独立地是H或含有1至约4个碳原子的烷基，R 3和R 4各自独立地为H，F或含有1至约4个碳原子的烷基碳原子，Z是羰基交联基团，x是1至约10的整数，并且所述环氧起始层还包含具有以下结构的酸酐交联剂环状单酸酐或二酐：及其混合物，其中R是含有6至约8个碳原子的烷基和低表面能聚合物脱模涂层。

8. 发明授权

US09605403B1 Vented precipitation guarding manhole cover assemblies 有权
公开(公告)号：US09605403B1
公开(公告)日：2017-03-28
申请号：US14728016
申请日：2015-06-02
申请人： David Putnam
发明人： David Putnam
IPC分类号： E02D29/00 , E02D29/14
CPC分类号： E02D29/1436 , E02D29/14 , E02D29/149
摘要： Vented precipitation guarding manhole cover assemblies include a manhole cover having a manhole cover protrusion. The manhole cover protrusion has a protrusion edge, a protrusion surface contiguous with and extending from the protrusion edge and a protrusion apex contiguous with the protrusion surface. A manhole cover vent opening extends through the manhole cover protrusion and the manhole cover.

9. 发明授权

US08916143B2 Polymer compositions of dihydroxyacetone and uses thereof 有权
标题翻译：二羟基丙酮的聚合物组合物及其用途
公开(公告)号：US08916143B2
公开(公告)日：2014-12-23
申请号：US13127464
申请日：2009-11-03
申请人： David Putnam , Peter Zaweneh , Jason Spector
发明人： David Putnam , Peter Zaweneh , Jason Spector
IPC分类号： A61K31/765 , A61K38/00 , A61K31/06 , A61K47/34 , A61P17/02 , C08G16/00 , A61L26/00
CPC分类号： A61K31/765 , A61L26/0019 , A61L26/008 , C08G64/42 , C08L61/02
摘要： The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.
摘要翻译：本公开提供了可注射的合成和可生物降解的聚合物生物材料，其有效地预防血清肿，这是消融和重建手术后常见的术后并发症。提供的生物材料包括触变性，显示快速链松弛的物理交联水凝胶，容易地通过窄规格的针挤出，生物降解成惰性产物，被软组织良好耐受，并有效地预防乳腺乳腺切除术动物模型中的血清。

10. 发明授权

US08851791B1 Manhole cover venting and precipitation guarding devices 有权
标题翻译：人孔盖通风和降水防护装置
公开(公告)号：US08851791B1
公开(公告)日：2014-10-07
申请号：US14024221
申请日：2013-09-11
申请人： David Putnam
发明人： David Putnam
IPC分类号： E02D29/14 , E03F5/08
CPC分类号： E03F5/08 , E02D29/14
摘要： A manhole cover venting and rain guarding device for a manhole cover having an exterior manhole cover surface and an interior manhole cover surface includes a device housing adapted for attachment to the manhole cover. The device housing includes manhole cover venting and precipitation guarding device includes a device housing adapted for attachment to the manhole cover, the device housing including a head portion having a head portion surface adapted to protrude beyond an entire plane of the exterior manhole cover surface and a device bore extending through the head portion and adapted to communicate with the interior manhole cover surface of the manhole cover.
摘要翻译：用于具有外部人孔盖表面和内部人孔盖表面的人孔盖的人孔盖通风和雨水防护装置包括适于附接到人孔盖的装置壳体。装置壳体包括人孔盖通气，并且沉淀防护装置包括适于附接到人孔盖的装置壳体，装置壳体包括具有适于突出超过外部人孔盖表面的整个平面的头部部分表面的头部部分，以及装置孔延伸穿过头部并且适于与人孔盖的内部人孔盖表面连通。

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