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1. 发明授权

US07589176B2 Antifungal polypeptides 有权
标题翻译：抗真菌多肽
公开(公告)号：US07589176B2
公开(公告)日：2009-09-15
申请号：US11657710
申请日：2007-01-24
申请人： Daniel J. Altier , Irina Ellanskaya , Natalia Ellanskaya, legal representative , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
发明人： Daniel J. Altier , Irina Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
IPC分类号： C07K14/00 , C07K14/415 , C07K17/00
CPC分类号： C12N15/8282 , A01N37/46 , A01N63/04 , C07K14/37
摘要： The invention relates to antifungal compositions and methods for protecting a plant from a fungal pathogen. Compositions including antifungal polypeptides isolated from a fungal fermentation broth are provided.
摘要翻译：本发明涉及用于保护植物免受真菌病原体的抗真菌组合物和方法。提供包括从真菌发酵液中分离的抗真菌多肽的组合物。

2. 发明授权

US07700832B2 Isolated nucleic acids encoding antipathogenic polypeptides and uses thereof 有权
标题翻译：编码抗病原体多肽的分离的核酸及其用途
公开(公告)号：US07700832B2
公开(公告)日：2010-04-20
申请号：US12265461
申请日：2008-11-05
申请人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Natalia Ellanskaya, legal representative , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
发明人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
IPC分类号： C12N15/09 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8282
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from fungal fermentation broths. Nucleic acids that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括从真菌发酵液中分离的抗病原体多肽的氨基酸序列及其变体和片段。也提供了编码抗病原多肽的核酸。还提供使用本文公开的核苷酸序列在植物中诱导病原体抗性的方法。该方法包括向植物中引入包含可操作地连接到编码本发明的抗病原体多肽的核苷酸序列的启动子的表达盒。还提供包含抗病原体多肽或包含本发明的核酸与载体组合的转化微生物的组合物，以及使用这些组合物保护植物免受病原体的方法。还公开了包含编码本发明的抗病原体多肽的核苷酸序列的转化植物，植物细胞，种子和微生物。

3. 发明授权

US07598346B1 Antifungal polypeptides 有权
标题翻译：抗真菌多肽
公开(公告)号：US07598346B1
公开(公告)日：2009-10-06
申请号：US11748994
申请日：2007-05-15
申请人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Natalia Ellanskaya, legal representative , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
发明人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
IPC分类号： C07K14/385 , A01N65/00 , C12N5/04
CPC分类号： C12N15/8282
摘要： The invention relates to compositions including amino acid sequences isolated from fungal fermentation broths and methods for protecting a plant from a pathogen, particularly a fungal pathogen.
摘要翻译：本发明涉及包含从真菌发酵肉汤中分离的氨基酸序列的组合物和用于保护植物免受病原体，特别是真菌病原体的方法。

4. 发明申请

US20090089895A1 ANTIFUNGAL POLYPEPTIDES 有权
标题翻译：抗菌多糖
公开(公告)号：US20090089895A1
公开(公告)日：2009-04-02
申请号：US12265461
申请日：2008-11-05
申请人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani , Natalia Ellanskaya
发明人： Daniel J. Altier , Virginia C. Crane , Irina Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric J. Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani , Natalia Ellanskaya
IPC分类号： A01H1/00 , C07H21/00 , C12N15/63 , C12N5/04 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8282
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from fungal fermentation broths. Nucleic acids that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括从真菌发酵液中分离的抗病原体多肽的氨基酸序列及其变体和片段。也提供了编码抗病原多肽的核酸。还提供使用本文公开的核苷酸序列在植物中诱导病原体抗性的方法。该方法包括向植物中引入包含可操作地连接到编码本发明的抗病原体多肽的核苷酸序列的启动子的表达盒。还提供包含抗病原体多肽或包含本发明的核酸与载体组合的转化微生物的组合物，以及使用这些组合物保护植物免受病原体的方法。还公开了包含编码本发明的抗病原体多肽的核苷酸序列的转化植物，植物细胞，种子和微生物。

5. 发明授权

US07825294B2 Nucleic acids encoding antifungal polypeptides and uses thereof 有权
标题翻译：编码抗真菌多肽的核酸及其用途
公开(公告)号：US07825294B2
公开(公告)日：2010-11-02
申请号：US12503952
申请日：2009-07-16
申请人： Daniel J. Altier , I. A. Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
发明人： Daniel J. Altier , I. A. Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
IPC分类号： A01H5/00 , A01H5/10 , C12N15/09 , C12N15/82
CPC分类号： C12N15/8282 , A01N37/46 , A01N63/04 , C07K14/37
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include an amino acid sequence, and variants and fragments thereof, for an antipathogenic polypeptide that was isolated from a fungal fermentation broth. Nucleic acid molecules that encode the antipathogenic polypeptides of the invention, and antipathogenic domains thereof, are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括从真菌发酵液中分离的抗病原体多肽的氨基酸序列及其变体和片段。还提供了编码本发明的抗病原体多肽的核酸分子及其抗病原结构域。还提供使用本文公开的核苷酸序列在植物中诱导病原体抗性的方法。该方法包括向植物中引入包含可操作地连接到编码本发明的抗病原体多肽的核苷酸序列的启动子的表达盒。还提供包含抗病原体多肽或包含本发明的核酸与载体组合的转化微生物的组合物，以及使用这些组合物保护植物免受病原体的方法。还公开了包含编码本发明的抗病原体多肽的核苷酸序列的转化植物，植物细胞，种子和微生物。

6. 发明申请

US20100031391A1 ANTIFUNGAL POLYPEPTIDES 有权
标题翻译：抗菌多糖
公开(公告)号：US20100031391A1
公开(公告)日：2010-02-04
申请号：US12503952
申请日：2009-07-16
申请人： Daniel J. Altier , I.A. Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
发明人： Daniel J. Altier , I.A. Ellanskaya , Jacob T. Gilliam , Jennie Hunter-Cevera , James K. Presnail , Eric Schepers , Carl R. Simmons , Tamas Torok , Nasser Yalpani
IPC分类号： A01H5/00 , C07H21/04 , C12N5/10 , C12N15/82
CPC分类号： C12N15/8282 , A01N37/46 , A01N63/04 , C07K14/37
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include an amino acid sequence, and variants and fragments thereof, for an antipathogenic polypeptide that was isolated from a fungal fermentation broth. Nucleic acid molecules that encode the antipathogenic polypeptides of the invention, and antipathogenic domains thereof, are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括从真菌发酵液中分离的抗病原体多肽的氨基酸序列及其变体和片段。还提供了编码本发明的抗病原体多肽的核酸分子及其抗病原结构域。还提供使用本文公开的核苷酸序列在植物中诱导病原体抗性的方法。该方法包括向植物中引入包含可操作地连接到编码本发明的抗病原体多肽的核苷酸序列的启动子的表达盒。还提供包含抗病原体多肽或包含本发明的核酸与载体组合的转化微生物的组合物，以及使用这些组合物保护植物免受病原体的方法。还公开了包含编码本发明的抗病原体多肽的核苷酸序列的转化植物，植物细胞，种子和微生物。

7. 发明授权

US08802932B2 Antipathogenic proteins and methods of use 有权
标题翻译：抗病原性蛋白质及其使用方法
公开(公告)号：US08802932B2
公开(公告)日：2014-08-12
申请号：US13205731
申请日：2011-08-09
申请人： Daniel J. Altier , Jacob T. Gilliam , Eric J. Schepers , Nasser Yalpani
发明人： Daniel J. Altier , Jacob T. Gilliam , Eric J. Schepers , Nasser Yalpani
IPC分类号： C12N15/00 , A01N63/00 , C12N15/82 , C12N15/87 , A01H5/00 , A01H5/10
CPC分类号： C07K14/37 , A01N63/04 , C12N15/8282
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括氨基酸序列及其变体和片段，用于新型抗病原体多肽家族的家族成员。也提供了编码抗病原多肽的多核苷酸。还提供使用本文公开的多核苷酸在植物中诱导病原体抗性的方法。包含抗病原体多肽或包含本发明的抗病原体多核苷酸与载体组合的组合物以及使用这些组合物保护植物免受病原体的方法。还公开了包含本发明的抗病原性核苷酸或多肽的植物，植物细胞，种子和微生物。

8. 发明申请

US20120054910A1 Antipathogenic Proteins and Methods of Use 有权
标题翻译：抗病原体蛋白和使用方法
公开(公告)号：US20120054910A1
公开(公告)日：2012-03-01
申请号：US13205731
申请日：2011-08-09
申请人： Daniel J. Altier , Jacob T. Gilliam , Eric J. Schepers , Nasser Yalpani
发明人： Daniel J. Altier , Jacob T. Gilliam , Eric J. Schepers , Nasser Yalpani
IPC分类号： A01H1/00 , C07K14/37 , A61K38/16 , A01H5/10 , C12N1/21 , C12N1/19 , C12N5/10 , A01H5/00 , C12N15/31 , C12N1/00
CPC分类号： C07K14/37 , A01N63/04 , C12N15/8282
摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.
摘要翻译：提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。组合物包括氨基酸序列及其变体和片段，用于新型抗病原体多肽家族的家族成员。也提供了编码抗病原多肽的多核苷酸。还提供使用本文公开的多核苷酸在植物中诱导病原体抗性的方法。包含抗病原体多肽或包含本发明的抗病原体多核苷酸与载体组合的组合物以及使用这些组合物保护植物免受病原体的方法。还公开了包含本发明的抗病原性核苷酸或多肽的植物，植物细胞，种子和微生物。

9. 发明授权

US06835569B2 Amino polyol oxidase amine polynucleotides and related polypeptides and methods of use 失效
标题翻译：氨基多胺胺氧化酶胺多核苷酸及相关多肽及其使用方法
公开(公告)号：US06835569B2
公开(公告)日：2004-12-28
申请号：US09770564
申请日：2001-01-26
申请人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald Crasta , Otto Folkerts
发明人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald Crasta , Otto Folkerts
IPC分类号： C12N1509
CPC分类号： C12N9/0022 , A23K10/14 , A23K10/18 , A23K30/18 , C07K2319/00 , C12N9/16 , C12N15/8209 , C12N15/8242 , C12N15/8282 , G01N2333/906
摘要： The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems.
摘要翻译：本发明提供了从Exophiala spinifera分离的酶APAO的多核苷酸和相关多肽。此外，编码APAO酶的多核苷酸可用于转化通常易受镰刀菌或其它产生毒素的真菌感染敏感的植物细胞。植物可以从转化的植物细胞中再生。另外，本发明提供在转基因植物中表达APAO和伏马菌素酯酶。以这种方式，可以生产具有降解伏马菌素的能力以及产生降解酶的能力的转基因植物。此外，本发明提供了在原核和非植物真核系统中生产APAO酶的方法。

10. 发明授权

US06211435B1 Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use 有权
标题翻译：氨基多胺胺氧化酶多核苷酸及相关多肽及其使用方法
公开(公告)号：US06211435B1
公开(公告)日：2001-04-03
申请号：US09352168
申请日：1999-07-12
申请人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald R. Crasta , Otto Folkerts
发明人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald R. Crasta , Otto Folkerts
IPC分类号： C12N504
CPC分类号： C12N9/0022 , A23K10/14 , A23K10/18 , A23K30/18 , C07K2319/00 , C12N9/16 , C12N15/8209 , C12N15/8242 , C12N15/8282 , G01N2333/906
摘要： The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.
摘要翻译：本发明提供了从Exophiala spinifera分离的酶APAO的多核苷酸和相关多肽。此外，编码APAO酶的多核苷酸可用于转化通常易受镰刀菌或其它产生毒素的真菌感染敏感的植物细胞。植物可以从转化的植物细胞中再生。另外，本发明提供在转基因植物中表达APAO和伏马菌素酯酶。以这种方式，可以生产具有降解伏马菌素的能力以及产生降解酶的能力的转基因植物。此外，本发明提供了在原核和非植物真核系统中生产APAO酶的方法。还公开了谷物，谷物加工，青贮饲料，粮食作物，动物饲料和瘤胃微生物的解毒方法。

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