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1. 发明授权

US5766204A Curable fiber composite stent and delivery system 失效
标题翻译：可固化纤维复合支架和输送系统
公开(公告)号：US5766204A
公开(公告)日：1998-06-16
申请号：US928550
申请日：1997-09-12
申请人： Christopher H. Porter , Robert Van Tassel , Curtis Amplatz , Michael Kasinkas
发明人： Christopher H. Porter , Robert Van Tassel , Curtis Amplatz , Michael Kasinkas
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/86 , A61M29/00
CPC分类号： A61F2/82 , A61F2/86 , A61F2/958 , A61F2210/0004 , A61F2220/005 , A61F2230/0091 , A61F2250/0067
摘要： A stent for supporting a selected portion of a body lumen, comprising a fibrous material which is treated with a curable material to form a curable fiber composite. The fiber composite is positioned within a body lumen and, upon curing of the curable material, forms a rigid support structure.
摘要翻译：一种用于支撑体腔的选定部分的支架，包括用可固化材料处理以形成可固化纤维复合材料的纤维材料。纤维复合材料定位在体腔内，并且在可固化材料固化时形成刚性支撑结构。

2. 发明授权

US5591199A Curable fiber composite stent and delivery system 失效
标题翻译：可固化纤维复合支架和输送系统
公开(公告)号：US5591199A
公开(公告)日：1997-01-07
申请号：US477759
申请日：1995-06-07
申请人： Christopher H. Porter , Robert Van Tassel , Curtis Amplatz , Michael Kasinkas
发明人： Christopher H. Porter , Robert Van Tassel , Curtis Amplatz , Michael Kasinkas
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/86 , A61M29/00
CPC分类号： A61F2/82 , A61F2/86 , A61F2/958 , A61F2210/0004 , A61F2220/005 , A61F2230/0091 , A61F2250/0067
摘要： A stent for supporting a selected portion of a body lumen, comprising a fibrous material which is treated with a curable material to form a curable fiber composite. The fiber composite is positioned within a body lumen and, upon curing of the curable material, forms a rigid support structure.
摘要翻译：一种用于支撑体腔的选定部分的支架，包括用可固化材料处理以形成可固化纤维复合材料的纤维材料。纤维复合材料定位在体腔内，并且在可固化材料固化时形成刚性支撑结构。

3. 发明授权

US5964751A Light delivery system with blood flushing capability 失效
标题翻译：具有血液冲洗能力的轻型输送系统
公开(公告)号：US5964751A
公开(公告)日：1999-10-12
申请号：US140116
申请日：1998-08-25
申请人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
发明人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
IPC分类号： A61B17/22 , A61B18/22 , A61M1/00 , A61M29/02 , A61B17/36
CPC分类号： A61B17/22 , A61B18/22 , A61B2017/22051 , A61B2018/2261 , A61M1/00 , A61M25/104 , A61M29/02
摘要： A light delivery system for use in irradiating vascular tissue includes a balloon catheter with a working lumen for receiving an optical fiber therein and an inflation/flushing lumen adapted to receive a liquid at a proximal end and leading to a space defined within the balloon member attached to a distal end of the catheter. The balloon member has a pattern of holes or pores in the wall thereof through which the saline may flow when the balloon is inflated, causing any blood or other absorbing substances that may interfere with good radiant energy transmission to be flushed away from the treatment site.
摘要翻译：用于照射血管组织的光输送系统包括球囊导管，其具有用于在其中接收光纤的工作腔，以及适于在近端接收液体并且导致限定在所述球囊构件附近的空间的充气/冲洗腔到导管的远端。气球构件在其壁中具有孔或孔的图案，当气囊膨胀时，盐可以通过该孔或孔流动，导致可能干扰良好的辐射能量传递的任何血液或其它吸收物质从治疗部位冲洗掉。

4. 发明授权

US5833682A Light delivery system with blood flushing capability 失效
公开(公告)号：US5833682A
公开(公告)日：1998-11-10
申请号：US697530
申请日：1996-08-26
申请人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
发明人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
IPC分类号： A61B17/22 , A61B18/22 , A61B18/24 , A61M1/00 , A61M29/02 , A61B17/36
CPC分类号： A61B18/24 , A61B2017/22051 , A61B2018/2261 , A61M25/104
摘要： A light delivery system for use in irradiating vascular tissue includes a balloon catheter with a working lumen for receiving an optical fiber therein and an inflation/flushing lumen adapted to receive a liquid at a proximal end and leading to a space defined within the balloon member attached to a distal end of the catheter. The balloon member has a pattern of holes or pores in the wall thereof through which the saline may flow when the balloon is inflated, causing any blood or other absorbing substances that may interfere with good radiant energy transmission to be flushed away from the treatment site.

5. 发明授权

US06200307B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06200307B1
公开(公告)日：2001-03-13
申请号：US09083358
申请日：1998-05-22
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： A method for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. The treatment method includes irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The method can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射来治疗支架内再狭窄的方法，或以其它方式去除已经增殖或可能增殖的平滑肌细胞，所述平滑肌细胞在即，在体腔内的支架内，围绕或邻近）导致（或潜在地引起）至少部分阻塞内腔。治疗方法包括在非消融性细胞毒性辐射（例如紫外线辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而不会对周围组织造成进一步的损害。

6. 发明授权

US06263236B1 Non-occlusive expandable catheter 失效
标题翻译：非闭塞性可扩张导管
公开(公告)号：US06263236B1
公开(公告)日：2001-07-17
申请号：US09450312
申请日：1999-11-29
申请人： Michael Kasinkas , Robert Ziebol
发明人： Michael Kasinkas , Robert Ziebol
IPC分类号： A61N130
CPC分类号： A61B18/24 , A61B18/245 , A61B2017/22061 , A61B2017/22082 , A61B2017/22087 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N2005/1003 , A61N2005/1021
摘要： Non-occluding catheters and methods for delivering energy to a vessel wall without occluding blood flow through the vessel wall are disclosed. In particular, the invention uses an energy distributor connected to an expansion mechanism and a waveguide. The expansion mechanism causes the distributor to come into close proximity with a target region in the vessel wall, while maintaining at least one fluid passageway for blood flow throughout the instrument.
摘要翻译：公开了一种不堵塞的导管以及将能量传递到血管壁而不阻塞通过血管壁的血流的方法。特别地，本发明使用连接到膨胀机构和波导的能量分配器。膨胀机构使得分配器与容器壁中的目标区域紧密接近，同时保持至少一个用于血液流过整个仪器的流体通道。

7. 发明授权

US08021404B1 Methods for treatment of aneurysms 失效
标题翻译：治疗动脉瘤的方法
公开(公告)号：US08021404B1
公开(公告)日：2011-09-20
申请号：US10798786
申请日：2004-03-10
申请人： Robert A. Van Tassel , Michael Kasinkas
发明人： Robert A. Van Tassel , Michael Kasinkas
IPC分类号： A61N5/01
CPC分类号： A61N5/062 , A61N5/0601
摘要： Fibrosis, in at least one layer of a vessel wall, can be used to strengthen a vessel wall. Fibrosis can be induced by irradiating a vessel wall with an energy source, or by inducing injury to the vessel wall. In addition to an energy source, photoactivatable agents can also be used such that the energy activates the photoactivatable agent to cause a thickening of the vessel wall. For example, ultra-violet radiation can be used alone or in conjunction with a photoactivatable agent, such as a psoralen compound, to increase the adventitial volume of a blood vessel. Upon exposure to radiation, preferably ultra-violet A radiation, the photoactivatable agent becomes activated and causes compositional and/or structural changes in the adventitia. The invention provides a method of treating aneurysms by thickening the adventitial layer of the vessel wall at the site of the aneurysm.
摘要翻译：在血管壁的至少一层中的纤维化可用于加强血管壁。可以通过用能量源照射血管壁或通过诱导血管壁的损伤来诱导纤维化。除了能量源之外，还可以使用光活化剂，使得能量激活可光活化剂以引起血管壁的增厚。例如，紫外辐射可以单独使用或与可光活化剂如补骨脂素化合物联合使用，以增加血管的外膜体积。在暴露于辐射，优选紫外线A辐射时，可光活化剂变得活化并引起外膜中的组成和/或结构变化。本发明提供了通过在动脉瘤部位增厚血管壁的外膜层来治疗动脉瘤的方法。

8. 发明授权

US06719778B1 Methods for treatment of aneurysms 失效
标题翻译：治疗动脉瘤的方法
公开(公告)号：US06719778B1
公开(公告)日：2004-04-13
申请号：US09534786
申请日：2000-03-24
申请人： Robert A. Van Tassel , Michael Kasinkas
发明人： Robert A. Van Tassel , Michael Kasinkas
IPC分类号： A61N501
CPC分类号： A61N5/062 , A61N5/0601
摘要： Fibrosis, in at least one layer of a vessel wall, can be used to strengthen a vessel wall. Fibrosis can be induced by irradiating a vessel wall with an energy source, or by inducing injury to the vessel wall. In addition to an energy source, photoactivatable agents can also be used such that the energy activates the photoactivatable agent to cause a thickening of the vessel wall. For example, ultra-violet radiation can be used alone or in conjunction with a photoactivatable agent, such as a psoralen compound, to increase the adventitial volume of a blood vessel. Upon exposure to radiation, preferably ultra-violet A radiation, the photoactivatable agent becomes activated and causes compositional and/or structural changes in the adventitia. The invention provides a method of treating aneurysms by thickening the adventitial layer of the vessel wall at the site of the aneurysm.
摘要翻译：在血管壁的至少一层中的纤维化可用于加强血管壁。可以通过用能量源照射血管壁或通过诱导血管壁的损伤来诱导纤维化。除了能量源之外，还可以使用光活化剂，使得能量激活可光活化剂以引起血管壁的增厚。例如，紫外辐射可以单独使用或与可光活化剂如补骨脂素化合物联合使用，以增加血管的外膜体积。在暴露于辐射，优选紫外线A辐射时，可光活化剂变得活化并引起外膜中的组成和/或结构变化。本发明提供了通过在动脉瘤部位增厚血管壁的外膜层来治疗动脉瘤的方法。

9. 发明授权

US06520957B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06520957B1
公开(公告)日：2003-02-18
申请号：US09712709
申请日：2000-11-14
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： Methods and systems are disclosed for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. Devices are disclosed for providing such therapeutic radiation at the stent with or without concurrent mechanical (e.g. balloon dilation) angioplasty. Treatment methods are also disclosed which include irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The methods and systems can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：公开了用于使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射治疗支架内再狭窄的方法和系统，或以其它方式去除已经增殖或可能在其中增殖的平滑肌细胞支架在体腔内（即，在其内，周围或邻近）附近，引起（或潜在地引起）至少部分阻塞内腔。公开了用于在具有或不具有并行机械（例如球囊扩张）血管成形术的情况下在支架处提供这种治疗放射线的装置。还公开了治疗方法，其包括在非消融性，细胞毒性辐射（例如UV辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法和系统可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而没有对周围组织的进一步损伤。

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