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1. 发明申请

US20070185478A1 Device for local ablation of tissue 审中-公开
标题翻译：局部消融组织的装置
公开(公告)号：US20070185478A1
公开(公告)日：2007-08-09
申请号：US11307452
申请日：2006-02-08
申请人： Phillip Cosentino
发明人： Phillip Cosentino
IPC分类号： A61B18/04
CPC分类号： A61B18/04 , A61B18/08 , A61B2017/00084 , A61B2017/00274 , A61B2017/22064 , A61B2018/00547 , A61B2018/046
摘要： The invention relates to a catheter device including a coil element comprised of NiCr60 alloy material, whose proximal radial end is coiled about the catheter shaft. The coil element and the thermal containment tube are configured so as to emit thermal energy. This is achieved by a catheter device adapted to deliver thermal energy from a source local to the body tissue to be ablated, adapted for connection to a thermal heat source at its distal end, a fluid conduit for passing a fluid into said ports for anchoring and filling the proximal cuff of the thermal energy device, a separate conduit for placement of necessary connective lines to the thermal energy element and monitoring device and a separate conduit for the drainage of bladder fluids during treatment.
摘要翻译：本发明涉及一种导管装置，其包括由NiCr 60合金材料构成的线圈元件，其近端径向端围绕导管轴盘绕。线圈元件和热容器管被配置为发射热能。这通过导管装置来实现，导管装置适于将热能从源局部传递到要消融的身体组织，适于连接到其远端处的热源;流体导管，用于将流体传送到所述端口中以进行锚定;以及填充热能装置的近侧袖带，用于将必要连接线放置到热能元件和监测装置的独立管道以及用于在治疗期间排出膀胱液的单独导管。

2. 发明授权

US5092841A Method for treating an arterial wall injured during angioplasty 失效
标题翻译：用于治疗老年性动脉粥样硬化斑块的方法
公开(公告)号：US5092841A
公开(公告)日：1992-03-03
申请号：US525104
申请日：1990-05-17
申请人： James R. Spears
发明人： James R. Spears
IPC分类号： A61F7/12 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/08 , A61B18/18 , A61B18/28 , A61M25/00 , A61M29/02 , A61M37/00
CPC分类号： A61B17/22 , A61B17/00491 , A61B17/22004 , A61B18/00 , A61B18/082 , A61B18/18 , A61B18/28 , A61B2017/00831 , A61B2017/22002 , A61B2017/22038 , A61B2017/22064 , A61B2017/22082 , A61B2017/22084 , A61B2017/22085 , A61B2017/22087 , A61M2025/105 , A61M25/104 , A61M37/0092
摘要： A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been mechanically injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and small vessels of the arterial wall during apposition of the angioplasty catheter to the arterial wall; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures, thereby coating the luminal surface of the arterial wall with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
摘要翻译：一种用于治疗在其上具有斑块的动脉壁上的病变和腔表面的方法，所述动脉壁在血管成形术程序期间机械损伤，所述动脉壁和所述斑块包括由此产生的裂缝，所述方法包括以下步骤：将血管成形术邻近待治疗病变的导管; 在动脉壁和血管成形术导管之间递送生物保护材料，使得生物保护材料被夹带在其间并且在血管成形术导管附着到动脉壁时渗透到动脉壁的裂缝和小血管中; 将热能施加到病变，从而将生物保护材料粘合到动脉壁和裂缝内; 并移除血管成形术导管，所述生物保护材料残留在动脉壁上和裂缝内，从而用生物保护材料的不溶层涂覆动脉壁的管腔表面，使得不溶层至少提供半永久性保护动脉壁，尽管与其相邻的血液接触。

3. 发明授权

US06200307B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06200307B1
公开(公告)日：2001-03-13
申请号：US09083358
申请日：1998-05-22
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： A method for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. The treatment method includes irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The method can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射来治疗支架内再狭窄的方法，或以其它方式去除已经增殖或可能增殖的平滑肌细胞，所述平滑肌细胞在即，在体腔内的支架内，围绕或邻近）导致（或潜在地引起）至少部分阻塞内腔。治疗方法包括在非消融性细胞毒性辐射（例如紫外线辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而不会对周围组织造成进一步的损害。

4. 发明授权

US5409483A Direct visualization surgical probe 失效
标题翻译：直观可视化手术探针
公开(公告)号：US5409483A
公开(公告)日：1995-04-25
申请号：US62384
申请日：1993-05-14
申请人： Peter Campbell , Jeffrey H. Reese , Daren L. Stewart
发明人： Peter Campbell , Jeffrey H. Reese , Daren L. Stewart
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B19/00 , A61N5/06 , A61B17/36
CPC分类号： A61N5/0601 , A61B2017/00274 , A61B2017/22064 , A61B2017/22077 , A61B2018/00011 , A61B2018/00547 , A61B90/30 , A61B90/361 , A61N2005/061
摘要： A surgical probe for use in a hollow vessel or other region of the body which comprises a multi-lumen catheter having a transparent, non-compliant balloon coupled to the distal end, such that the balloon has a known shape when inflated. A direct visualization scope is provided in a first lumen of the multi-lumen catheter providing direct visualization into the hollow vessel through the non-compliant balloon. An adapter is coupled to a second lumen of the multi-lumen catheter near the proximal end to supply a transparent fluid through the second lumen to inflate the balloon to the predefined shape. In this aspect, the balloon operates to clear the scope tip by pressing tissue on the walls of the hollow vessel out of the way of the end of the scope. This provides the user of the device a consistent clear view of the tissue at the tip of the scope. A fiber optic is provided in a third lumen of the multi-lumen catheter to deliver light energy to the hollow vessel through the non-compliant balloon. A mechanism is provided for positioning the light emitting tip of the fiber optic within the balloon to establish a known propagation distance to the surface of the balloon for the light energy emitted from the light emitting tip.
摘要翻译：一种用于中空容器或身体其他区域的手术探针，其包括多腔导管，其具有联接到远端的透明的不顺应气囊，使得气囊在充气时具有已知形状。在多腔导管的第一内腔中提供直接可视化范围，通过非顺应性气囊直接观察中空血管。适配器在近端附近耦合到多腔导管的第二腔，以通过第二腔提供透明流体，以将气囊膨胀至预定形状。在这方面，气囊通过在中空容器的壁上按压范围之外的组织而使范围尖端清除。这为设备的使用者提供了在范围的尖端处的组织的一致的清晰视图。光纤设置在多腔导管的第三腔中，以通过非顺应性球囊将光能传递到中空容器。提供了一种用于将光纤的发光尖端定位在气球内的机构，以建立从球形表面的已知传播距离，用于从发光尖端发射的光能。

5. 发明申请

US20180280043A1 CAVITATION CATHETER 审中-公开
公开(公告)号：US20180280043A1
公开(公告)日：2018-10-04
申请号：US15475203
申请日：2017-03-31
申请人： Medtronic Vascular, Inc.
发明人： Michael Donegan
IPC分类号： A61B17/22
CPC分类号： A61B17/22004 , A61B17/22012 , A61B2017/22007 , A61B2017/22025 , A61B2017/22064 , A61B2017/22065 , A61M25/0023 , A61M25/0032 , A61M25/0045 , A61M25/0052 , A61M2025/0073
摘要： In some examples, a catheter includes an elongated body configured for navigation through vasculature of a patient, the elongated body having an inner wall that defines a lumen extending from a proximal portion to a distal portion. The elongated body is configured to pass a fluid through the lumen and out a distal end of the elongated body. At the distal portion, the inner wall defines a convergent-divergent region such that a diameter of the lumen while moving distally within the elongated body converges from a first lumen diameter to a second lumen diameter and then diverges from the second lumen diameter to a third lumen diameter. The convergent-divergent region is configured to cause a fluid flowing through the lumen to cavitate as the fluid flows through the convergent-divergent region.

6. 发明授权

US06520957B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06520957B1
公开(公告)日：2003-02-18
申请号：US09712709
申请日：2000-11-14
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： Methods and systems are disclosed for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. Devices are disclosed for providing such therapeutic radiation at the stent with or without concurrent mechanical (e.g. balloon dilation) angioplasty. Treatment methods are also disclosed which include irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The methods and systems can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：公开了用于使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射治疗支架内再狭窄的方法和系统，或以其它方式去除已经增殖或可能在其中增殖的平滑肌细胞支架在体腔内（即，在其内，周围或邻近）附近，引起（或潜在地引起）至少部分阻塞内腔。公开了用于在具有或不具有并行机械（例如球囊扩张）血管成形术的情况下在支架处提供这种治疗放射线的装置。还公开了治疗方法，其包括在非消融性，细胞毒性辐射（例如UV辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法和系统可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而没有对周围组织的进一步损伤。

7. 发明授权

US06468244B1 Catheter system having fullerenes and method 有权
标题翻译：具有富勒烯和方法的导管系统
公开(公告)号：US06468244B1
公开(公告)日：2002-10-22
申请号：US09555793
申请日：2000-01-05
申请人： James E. Leone , Pallassana V. Narayanan
发明人： James E. Leone , Pallassana V. Narayanan
IPC分类号： A61M2900
CPC分类号： A61L29/103 , A61B2017/22002 , A61B2017/22064 , A61B2018/2261 , A61M25/10 , A61M2025/105 , A61N5/0601 , A61N5/062 , B82Y30/00
摘要： At least a portion of a catheter system (10) is provided with fullerene material (56) for performing or facilitating a medical procedure. In the case of a balloon catheter, the outer surface of the balloon may have a coating of fullerenes (64), which are preferably photosensitive or activated by light. A light source (60) can be used to illuminate or other wise activate the fullerene material. The light source (60) may be formed by one or more optical fibers extending through the shaft of the catheter, and into the balloon. Various arrangements of the catheter system are possible, whereby the light source may selectively emit light outward through the fullerene material, and associated portions of the catheter system, which may be translucent. When activated by light, the fullerene coating may preferably generate, and give off therapeutic oxygen radicals. These oxygen radicals may affect local cell function to prevent or reduce cell proliferation. This therapy may have many applications, including for example, limiting restenosis after angioplasty.
摘要翻译：导管系统（10）的至少一部分设置有用于执行或促进医疗程序的富勒烯材料（56）。在气囊导管的情况下，球囊的外表面可以具有富勒烯（64）的涂层，其优选是光敏的或被光激活的。光源（60）可用于照亮或以其他方式激活富勒烯材料。光源（60）可以由延伸穿过导管的轴并且进入气囊的一个或多个光纤形成。导管系统的各种布置是可能的，由此光源可以选择性地通过富勒烯材料向外发射光，以及可以是半透明的导管系统的相关部分。当通过光激活时，富勒烯涂层可以优选地产生并释放治疗性氧自由基。这些氧自由基可能会影响局部细胞功能，以预防或减少细胞增殖。该治疗可能有许多应用，例如，限制血管成形术后的再狭窄。

8. 发明授权

US5269753A Method for use in laparoscopic hernia repair 失效
标题翻译：方法用于腹腔镜疝修补术
公开(公告)号：US5269753A
公开(公告)日：1993-12-14
申请号：US913601
申请日：1992-07-14
申请人： Peter J. Wilk
发明人： Peter J. Wilk
IPC分类号： A61B17/00 , A61F2/00 , A61M31/00
CPC分类号： A61F2/0063 , A61B1/00082 , A61B1/00096 , A61B1/3132 , A61B17/0218 , A61B17/00234 , A61B2017/00557 , A61B2017/22059 , A61B2017/22061 , A61B2017/22064
摘要： A method for use in laparoscopic hernia repair comprises the steps of inserting a distal end of a laparoscope through a patient's abdominal muscles to a point outside of the parietal peritoneum, and inserting through the abdominal muscles a distal end of an elongate instrument provided at that distal end with a balloon in a collapsed configuration, the balloon being transparent to optical radiation. Upon disposition of the balloon between the abdominal muscles and the peritoneum, the balloon is inflated and the instrument is subsequently manipulated from outside the patient to push the inflated balloon against connective tissues between the abdominal muscles and the peritoneum to shift the tissues to form a pre-peritoneal space. During the manipulation of the instrument with the balloon, the laparoscope is to view, through and around the inflated balloon, the connective tissues and other organic structures.
摘要翻译：用于腹腔镜疝修补术的方法包括以下步骤：将腹腔镜的远端穿过患者的腹部肌肉插入到顶壁腹膜外部，并且通过腹肌插入设在该远端的细长器械的远端以折叠构型的气球结束，气球对于光辐射是透明的。在腹部肌肉和腹膜之间布置气囊时，气囊被充气，并且随后从患者外部操纵器械，以将充气气囊推向腹肌和腹膜之间的结缔组织以移动组织以形成预先腹膜间隙。在用气球操纵仪器的过程中，腹腔镜是通过充气气球，连接组织和其他有机结构来观察，周围。

9. 发明授权

US5199951A Method of drug application in a transporting medium to an arterial wall injured during angioplasty 失效
标题翻译：在血管成形术期间损伤的动脉壁的运输介质中的药物施用方法
公开(公告)号：US5199951A
公开(公告)日：1993-04-06
申请号：US759223
申请日：1991-09-13
申请人： James R. Spears
发明人： James R. Spears
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/08 , A61B18/18 , A61B18/28 , A61M29/02 , A61M37/00
CPC分类号： A61B17/22 , A61B17/00491 , A61B17/22004 , A61B18/00 , A61B18/082 , A61B18/18 , A61B18/28 , A61B2017/00831 , A61B2017/22002 , A61B2017/22038 , A61B2017/22064 , A61B2017/22082 , A61B2017/22084 , A61B2017/22085 , A61B2017/22087 , A61M2025/105 , A61M25/104 , A61M37/0092
摘要： A method for treating a lesion (27) in an arterial wall (28) having plaque (52) thereon and a luminal surface (29). The arterial wall (28) has typically been mechanically injured during an angioplasty procedure. As a result of that procedure, the arterial wall (28) and the plaque (52) include fissures (24) defined therein. It has been found that those fissures (24) form excellent sites at which a bioprotective material (26) may become bonded upon application of thermal energy. The method comprising the steps of positioning an angioplasty catheter (20) adjacent to the lesion (27) being treated; delivering a soluble sleeve containing bioprotective material (26) between the arterial wall (28) and the angioplasty catheter (20) so that the bioprotective material (26) is entrapped therebetween applying thermal energy to the lesion (27), thereby liquifying the sleeve and bonding the bioprotective material (26) to the arterial wall (28) and within the fissures (24); removing the angioplasty catheter (20), the bioprotective material (26) remaining adherent to the arterial wall (28) and within the fissures (24); cooling the sleeve so that it becomes solidified; releasing and removing the angioplasty catheter (20) from the site being treated, whereupon the soluble sleeve is irrigated away by blood (50) flowing adjacent thereto, leaving an insoluble material semi- or permanently bonded to the fissures (24) of the arterial wall (28), despite contact with blood (50) flowing adjacent thereto.
摘要翻译：一种用于治疗其上具有斑块（52）的动脉壁（28）上的病变（27）和腔表面（29）的方法。在血管成形术过程中，动脉壁（28）通常被机械损伤。作为该过程的结果，动脉壁（28）和斑块（52）包括在其中限定的裂缝（24）。已经发现，这些裂缝（24）形成了在施加热能时生物保护材料（26）可能结合的优良部位。该方法包括以下步骤：将血管成形术导管（20）定位在与待治疗的病变（27）相邻处; 在所述动脉壁（28）和所述血管成形术导管（20）之间递送含有生物保护材料（26）的可溶性套筒，使得所述生物保护材料（26）被夹带在其间，向所述损伤（27）施加热能，从而使所述套管和将生物保护材料（26）粘合到动脉壁（28）和裂缝（24）内; 移除血管成形术导管（20），生物保护材料（26）保持粘附到动脉壁（28）和裂缝（24）内; 冷却套筒使之变得固化; 从所处理的部位释放和移除血管成形术导管（20），由此可溶性套管被邻近流动的血液（50）灌注掉，留下不稳定的物质，半静脉或永久地粘合到动脉壁的裂缝（24）（28），尽管与其相邻的血液（50）接触。

10. 发明授权

US5019075A Method and apparatus for angioplasty 失效
标题翻译：血管成形术的方法和装置
公开(公告)号：US5019075A
公开(公告)日：1991-05-28
申请号：US561360
申请日：1990-07-31
申请人： J. Richard Spears , Donna Bourgelais
发明人： J. Richard Spears , Donna Bourgelais
IPC分类号： A61B17/22 , A61B18/04 , A61B18/06 , A61B18/08 , A61B18/24 , A61F2/06 , A61M29/02
CPC分类号： A61M25/104 , A61B17/22 , A61B18/08 , A61B18/082 , A61B18/245 , A61B2017/22002 , A61B2017/22061 , A61B2017/22062 , A61B2017/22064 , A61B2018/00559 , A61B2018/046 , A61B2018/068 , A61F2/06
摘要： The region surrounding the balloon utilized in percutaneous transluminal coronary angioplasty is heated by means within the balloon or within the skin of the balloon upon inflation of the balloon such that disrupted tissues of the plaque in the arterial wall are heated in order to fuse together fragmented segments of tissue and to coagulate blood trapped within dissected planes of tissue and within fissures created by wall fracture such that upon subsequent balloon deflation a smooth cylindrically-shaped channel results, thereby to prevent collapse of any flap of material which could cause either abrupt arterial closure and an acute myocardial infarction or gradual restenosis at the site of balloon inflation.
摘要翻译：用于经皮冠状动脉血管成形术中的气囊周围的区域通过球囊内的装置或球囊膨胀的气球加热，使得动脉壁中的斑块的破裂的组织被加热，以便熔化碎片段并凝固在组织的解剖平面内和由壁骨折产生的裂缝内的血液，使得在随后的气球放气时，产生光滑的圆柱形通道，从而防止可能引起突然动脉闭合的任何材料瓣的塌陷，气球膨胀部位急性心肌梗死或逐渐再狭窄。

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