专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06719778B1 Methods for treatment of aneurysms 失效
标题翻译：治疗动脉瘤的方法
公开(公告)号：US06719778B1
公开(公告)日：2004-04-13
申请号：US09534786
申请日：2000-03-24
申请人： Robert A. Van Tassel , Michael Kasinkas
发明人： Robert A. Van Tassel , Michael Kasinkas
IPC分类号： A61N501
CPC分类号： A61N5/062 , A61N5/0601
摘要： Fibrosis, in at least one layer of a vessel wall, can be used to strengthen a vessel wall. Fibrosis can be induced by irradiating a vessel wall with an energy source, or by inducing injury to the vessel wall. In addition to an energy source, photoactivatable agents can also be used such that the energy activates the photoactivatable agent to cause a thickening of the vessel wall. For example, ultra-violet radiation can be used alone or in conjunction with a photoactivatable agent, such as a psoralen compound, to increase the adventitial volume of a blood vessel. Upon exposure to radiation, preferably ultra-violet A radiation, the photoactivatable agent becomes activated and causes compositional and/or structural changes in the adventitia. The invention provides a method of treating aneurysms by thickening the adventitial layer of the vessel wall at the site of the aneurysm.
摘要翻译：在血管壁的至少一层中的纤维化可用于加强血管壁。可以通过用能量源照射血管壁或通过诱导血管壁的损伤来诱导纤维化。除了能量源之外，还可以使用光活化剂，使得能量激活可光活化剂以引起血管壁的增厚。例如，紫外辐射可以单独使用或与可光活化剂如补骨脂素化合物联合使用，以增加血管的外膜体积。在暴露于辐射，优选紫外线A辐射时，可光活化剂变得活化并引起外膜中的组成和/或结构变化。本发明提供了通过在动脉瘤部位增厚血管壁的外膜层来治疗动脉瘤的方法。

2. 发明授权

US06520957B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06520957B1
公开(公告)日：2003-02-18
申请号：US09712709
申请日：2000-11-14
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： Methods and systems are disclosed for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. Devices are disclosed for providing such therapeutic radiation at the stent with or without concurrent mechanical (e.g. balloon dilation) angioplasty. Treatment methods are also disclosed which include irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The methods and systems can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：公开了用于使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射治疗支架内再狭窄的方法和系统，或以其它方式去除已经增殖或可能在其中增殖的平滑肌细胞支架在体腔内（即，在其内，周围或邻近）附近，引起（或潜在地引起）至少部分阻塞内腔。公开了用于在具有或不具有并行机械（例如球囊扩张）血管成形术的情况下在支架处提供这种治疗放射线的装置。还公开了治疗方法，其包括在非消融性，细胞毒性辐射（例如UV辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法和系统可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而没有对周围组织的进一步损伤。

3. 发明授权

US06200307B1 Treatment of in-stent restenosis using cytotoxic radiation 失效
标题翻译：使用细胞毒性辐射治疗支架内再狭窄
公开(公告)号：US06200307B1
公开(公告)日：2001-03-13
申请号：US09083358
申请日：1998-05-22
申请人： Michael Kasinkas , Robert A. Van Tassel
发明人： Michael Kasinkas , Robert A. Van Tassel
IPC分类号： A61B1818
CPC分类号： A61N5/0601 , A61B17/22 , A61B18/24 , A61B2017/22002 , A61B2017/22059 , A61B2017/22064 , A61B2017/22087 , A61B2018/2261 , A61N2005/0661
摘要： A method for treating in-stent restenosis using radiation having a wavelength sufficient to kill or promote cellular death (e.g., through programmed cell death), or otherwise remove smooth muscle cells which have proliferated, or which might otherwise proliferate, in the proximity of (i.e., within, around or adjacent to) a stent within a body lumen, causing (or potentially causing) at least partial blockage of the lumen. The treatment method includes irradiating smooth muscle cells in the region of the stenosis with non-ablative, cytotoxic radiation, such as UV radiation. A cytotoxic, photoactivatable chromophore may also be delivered to the treatment site prior to irradiation. The method can be used prophylactically or to treat in-stent restenosis after blockage has occurred without further damage to surrounding tissue.
摘要翻译：使用具有足以杀死或促进细胞死亡（例如通过程序性细胞死亡）的波长的辐射来治疗支架内再狭窄的方法，或以其它方式去除已经增殖或可能增殖的平滑肌细胞，所述平滑肌细胞在即，在体腔内的支架内，围绕或邻近）导致（或潜在地引起）至少部分阻塞内腔。治疗方法包括在非消融性细胞毒性辐射（例如紫外线辐射）下在狭窄区域照射平滑肌细胞。在照射之前，细胞毒性的可光活化的发色团也可以被递送到治疗部位。该方法可以预防性地使用或在阻塞发生后治疗支架内再狭窄，而不会对周围组织造成进一步的损害。

4. 发明授权

US08021404B1 Methods for treatment of aneurysms 失效
标题翻译：治疗动脉瘤的方法
公开(公告)号：US08021404B1
公开(公告)日：2011-09-20
申请号：US10798786
申请日：2004-03-10
申请人： Robert A. Van Tassel , Michael Kasinkas
发明人： Robert A. Van Tassel , Michael Kasinkas
IPC分类号： A61N5/01
CPC分类号： A61N5/062 , A61N5/0601
摘要： Fibrosis, in at least one layer of a vessel wall, can be used to strengthen a vessel wall. Fibrosis can be induced by irradiating a vessel wall with an energy source, or by inducing injury to the vessel wall. In addition to an energy source, photoactivatable agents can also be used such that the energy activates the photoactivatable agent to cause a thickening of the vessel wall. For example, ultra-violet radiation can be used alone or in conjunction with a photoactivatable agent, such as a psoralen compound, to increase the adventitial volume of a blood vessel. Upon exposure to radiation, preferably ultra-violet A radiation, the photoactivatable agent becomes activated and causes compositional and/or structural changes in the adventitia. The invention provides a method of treating aneurysms by thickening the adventitial layer of the vessel wall at the site of the aneurysm.
摘要翻译：在血管壁的至少一层中的纤维化可用于加强血管壁。可以通过用能量源照射血管壁或通过诱导血管壁的损伤来诱导纤维化。除了能量源之外，还可以使用光活化剂，使得能量激活可光活化剂以引起血管壁的增厚。例如，紫外辐射可以单独使用或与可光活化剂如补骨脂素化合物联合使用，以增加血管的外膜体积。在暴露于辐射，优选紫外线A辐射时，可光活化剂变得活化并引起外膜中的组成和/或结构变化。本发明提供了通过在动脉瘤部位增厚血管壁的外膜层来治疗动脉瘤的方法。

5. 发明授权

US08428729B2 Cardiac stimulation apparatus and method for the control of hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US08428729B2
公开(公告)日：2013-04-23
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

6. 发明申请

US20120041502A1 Cardiac Stimulation Apparatus And Method For The Control Of Hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US20120041502A1
公开(公告)日：2012-02-16
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或在心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

7. 发明授权

US06283983B1 Percutaneous in-situ coronary bypass method and apparatus 有权
标题翻译：经皮原位冠状动脉搭桥方法及装置
公开(公告)号：US06283983B1
公开(公告)日：2001-09-04
申请号：US09192554
申请日：1998-08-10
申请人： Joshua Makower , Robert S. Schwartz , David R. Holmes , Robert A. Van Tassel
发明人： Joshua Makower , Robert S. Schwartz , David R. Holmes , Robert A. Van Tassel
IPC分类号： A61M2900
CPC分类号： A61B17/11 , A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0057 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0004 , A61M2025/0076 , A61M2025/009 , A61M2025/0096 , A61M2025/018 , A61M2025/1052 , A61M2210/125
摘要： Methods and devices for percutaneous, in situ coronary bypass wherein a tissue puncturing catheter is used to form blood flow paths between an artery and an adjacent vein such that arterial blood will flow through a segment of the adjacent vein, thereby bypassing a lesion in the artery. The tissue puncturing catheter comprises a flexible catheter having a tissue puncturing apparatus such as a sharp tipped member, an electro-surgical apparatus or a laser beam passable therefrom to create the desired blood flow paths between the artery and vein. Stents are provided for facilitating blood flow through the blood flow paths and the segment of the vein used as the bypass conduit. One such stent is specially constructed to carry arterial blood in one direction through the vein segment while allowing venous blood to continue to flow in the opposite direction through that venous segment.
摘要翻译：用于经皮的原位冠状动脉旁路的方法和装置，其中组织穿刺导管用于形成动脉和相邻静脉之间的血流路径，使得动脉血液将流过相邻静脉的一段，从而绕过动脉中的病变。组织穿刺导管包括柔性导管，其具有组织穿刺装置，例如尖锐的尖端构件，电外科手术装置或可从其穿过的激光束，以在动脉和静脉之间产生所需的血流路径。提供了用于促进血液流过血流路径和用作旁路导管的静脉段的支架。一种这样的支架被特别构造成通过静脉段沿一个方向携带动脉血，同时允许静脉血继续沿相反方向流过该静脉段。

8. 发明授权

US08579955B2 Anti-arrhythmia devices and methods of use 失效
公开(公告)号：US08579955B2
公开(公告)日：2013-11-12
申请号：US11551670
申请日：2006-10-20
申请人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes, Jr.
发明人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes, Jr.
IPC分类号： A61F2/82
CPC分类号： A61M29/02 , A61F2/07 , A61F2/24 , A61F2/2481 , A61F2/2487 , A61F2/82 , A61F2/848 , A61F2/90 , A61F2002/821 , A61F2002/8483 , A61F2220/0016 , A61M29/00
摘要： An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.

9. 发明授权

US08430861B2 Microvascular obstruction detection and therapy 有权
标题翻译：微血管阻塞检测与治疗
公开(公告)号：US08430861B2
公开(公告)日：2013-04-30
申请号：US12376086
申请日：2007-08-01
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61M31/00
CPC分类号： A61M25/007 , A61B5/02007 , A61B5/0215 , A61B5/055 , A61B8/00 , A61B8/06 , A61M25/10 , A61M25/1011 , A61M37/0092 , A61M2025/0002 , A61M2025/0003 , A61M2025/1052
摘要： A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.
摘要翻译：提供了检测和治疗微血管阻塞的方法。在一个实施例中，提供了用于检测微血管阻塞物和治疗或去除阻塞物的导管。

10. 发明申请

US20090210050A1 Implantable Device For Promoting Repair Of A Body Lumen 审中-公开
标题翻译：用于促进身体内腔修复的植入式装置
公开(公告)号：US20090210050A1
公开(公告)日：2009-08-20
申请号：US12429803
申请日：2009-04-24
申请人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译：提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长细胞以有组织的模式。或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式