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1. 发明授权

US06844935B2 Multi-function opto-electronic detection apparatus 有权
标题翻译：多功能光电检测仪
公开(公告)号：US06844935B2
公开(公告)日：2005-01-18
申请号：US10761116
申请日：2004-01-20
申请人： Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu , Chii-Wann Lin , Shiming Lin
发明人： Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu , Chii-Wann Lin , Shiming Lin
IPC分类号： G01B11/00 , G01B9/02
CPC分类号： G01B11/00
摘要： A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.
摘要翻译：一种用于检测试样的分子特性的多功能光电检测装置。该装置包括功能模式子系统，包括用于产生用于照亮测试样本的采样光束的检测光源子系统; 用于将采样光束对准到测试样品的操纵光学子系统; 目标信号处理子系统，用于分析从采样光束的照明产生的从测试样本出射的目标光束; 以及用于保持测试样本的样本固定子系统。检测光源子系统，操作光学子系统和目标信号处理子系统被组合成用于测试样本的检测特性的几种可能的光学采样设置之一。功能模式设置至少包括椭圆计，共焦图像扫描仪，光子隧道扫描显微镜和干涉仪。

2. 发明授权

US06590667B1 Method and an apparatus for measuring the flying height with sub-nanometer resolution 有权
标题翻译：用亚纳米分辨率测量飞行高度的方法和装置
公开(公告)号：US06590667B1
公开(公告)日：2003-07-08
申请号：US09624685
申请日：2000-07-24
申请人： Jau-Hu Lee , Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu
发明人： Jau-Hu Lee , Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu
IPC分类号： G01B1102
CPC分类号： G11B7/1387 , G01B11/14 , G11B5/6011 , G11B7/122 , G11B7/22
摘要： A method and apparatus is claimed for measuring the distance between a slider and a transparent disk with sub-nanometer resolution. The flying height is measured by applying ellipsometry. The measurement is done by: providing a sampling light beam with adjustable initial polarization state by phase modulation, and with variable incident angles relative to the air film and reflecting the sampling light off of the specimen at a detection site forming a reflected light beam that is then reflected at the detection site again and then guided to both detectors for detecting the intensity and phase change of the light beam to determine the gap's thickness as well as passing some light to a microscope used for observation of the detecting site on the specimen.
摘要翻译：要求的方法和装置用于测量滑块和具有亚纳米分辨率的透明盘之间的距离。飞行高度通过应用椭偏仪测量。测量是通过以下方式完成的：通过相位调制提供具有可调初始极化状态的采样光束，并且相对于空气膜具有可变的入射角，并在形成反射光束的检测位置处反射取样光，然后再次在检测部位反射，然后引导到两个检测器，用于检测光束的强度和相位变化，以确定间隙的厚度，以及将一些光通过用于观察样品上检测部位的显微镜。

3. 发明授权

US06288841B1 Optical mechanism for precisely controlling the angle of an incident light beam within a large incident angle range 有权
标题翻译：用于在大的入射角度范围内精确地控制入射光束的角度的光学机构
公开(公告)号：US06288841B1
公开(公告)日：2001-09-11
申请号：US09475001
申请日：1999-12-30
申请人： Solomon J. H. Lee , Chih-Kung Lee , Tony C. H. Lin , Shih-Jui Chen , Shu-Sheng Lee , Shuen-Chen Shiue
发明人： Solomon J. H. Lee , Chih-Kung Lee , Tony C. H. Lin , Shih-Jui Chen , Shu-Sheng Lee , Shuen-Chen Shiue
IPC分类号： G02B2710
CPC分类号： G01N21/211 , G01N2021/214 , G01N2201/0636 , G01N2201/0637 , G02B21/08 , G02B26/0816
摘要： An optical path overlapping type incident angle changeable optical mechanism according to the invention allows an incident light beam to be incident onto a measured range of a sample within a large incident angle range. The optical mechanism includes a reflecting prism reflecting the incident light beam to generate a reflected light beam having an angle of 90° with respect to the incident light beam; a concave parabolic cylindric mirror guiding the reflected light beam coming from the reflecting prism to a measured range of a detect-waiting sample to thereby be further reflected to generate a detect-waiting light beam; a concave cylindric mirror used to make the detect-waiting light beam incident onto/reflected by the reflecting prism so as to overlap with the incident light beam; and a light beam splitting means used to separate the detect-waiting light beam from the incident light beam.
摘要翻译：根据本发明的光路重叠型入射角可变光学机构允许入射光束入射到大的入射角范围内的样品的测量范围。光学机构包括反射入射光束的反射棱镜，以产生相对于入射光束具有90°角的反射光束; 将来自反射棱镜的反射光束引导到检测等待样本的测量范围的凹面抛物线圆柱镜，从而进一步反射以产生检测等待光束; 用于使入射到反射棱镜/反射的检测等待光束与入射光束重叠的凹圆柱镜; 以及用于将检测等待光束与入射光束分离的光束分离装置。

4. 发明授权

US06483584B1 Device for measuring the complex refractive index and thin film thickness of a sample 有权
$Device for measuring the complex refractive index and thin film thickness of a sample$
标题翻译：用于测量样品的复折射率和薄膜厚度的装置
公开(公告)号：US06483584B1
公开(公告)日：2002-11-19
申请号：US09549738
申请日：2000-04-14
申请人： Solomon J. H. Lee , Chih-Kung Lee , Shu-Sheng Lee , Yang Yun-Chang , Lin Chan-Ching , Shuen-Chen Shiue
发明人： Solomon J. H. Lee , Chih-Kung Lee , Shu-Sheng Lee , Yang Yun-Chang , Lin Chan-Ching , Shuen-Chen Shiue
IPC分类号： G01J400
CPC分类号： G01N21/21 , G01N21/41 , G01N21/8422
摘要： An ellipsometer for measuring the complex refractive index of a sample and thin film thickness according to the invention. The ellipsometer includes a linear polarized light source, a reference analyzer, a polarization analyzer and a light direction controller. The linear polarized light source used to generate a measuring beam for detecting the sample. The phase modulator used to control the phase of the measuring beam thereby to generate a sampling beam. The reference analyzer used to generate a reference beam according to part of the sampling beam thereby to adjust the intensity of the sampling beam. The polarization analyzer used to analyze the phase, polarization and intensity of the sampling beam after the sampling beam is reflected by the sample. The light direction controller used to control the angle and direction of the sampling beam with respect to the sample, wherein the sampling beam is reflected by the sample to enter the light direction controller, and thereafter the sampling beam is reflected by the light direction controller and re-reflected by the sample to enter the polarization analyzer along an original optical path, but toward an opposite direction.
摘要翻译：用于测量样品的复合折射率的椭偏仪和根据本发明的薄膜厚度。椭偏仪包括线偏振光源，参考分析仪，偏振分析仪和光方向控制器。用于产生用于检测样品的测量光束的线偏振光源。相位调制器用于控制测量光束的相位，从而产生采样光束。参考分析仪用于根据采样束的一部分产生参考光束，从而调整采样光束的强度。用于分析采样光束后的采样光束的相位，极化和强度的偏振分析器被样品反射。用于控制采样光束相对于样本的角度和方向的光方向控制器，其中采样光束被样本反射以进入光方向控制器，此后采样光束被光方向控制器反射，由样品重新反射，沿着原始光路进入偏振分析器，但朝向相反的方向。

5. 发明授权

US07148057B2 Array biochip workstation 失效
标题翻译：阵列生物芯片工作站
公开(公告)号：US07148057B2
公开(公告)日：2006-12-12
申请号：US10216911
申请日：2002-08-13
申请人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
发明人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
IPC分类号： C12M1/34
CPC分类号： B01L9/527 , B01F11/0266 , B01F13/0059 , B01L2200/027 , B01L2300/0819 , G01N1/312 , G01N35/1074 , G01N2035/00158 , G01N2035/1039
摘要： A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.
摘要翻译：一种微阵列生物芯片工作站，用于定位芯片，分子固定，样品溶液混合，分子相互作用以及洗涤和加工定性和定量分析，包括用于保持生物芯片的定位装置，用于作用在样品溶液上的混合装置生物芯片，用于从未反应的生物芯片表面去除样品溶液的泵送装置，以及用于检测生物芯片的反应结果的读取装置。这样构造的工作站提供了一个集成且有效的工作界面。

6. 发明授权

US06661520B1 Sensor system of surface plasmon resonance (SPR) and measuring method thereof 有权
标题翻译：表面等离子体共振（SPR）传感器系统及其测量方法
公开(公告)号：US06661520B1
公开(公告)日：2003-12-09
申请号：US10153459
申请日：2002-05-22
申请人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
发明人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A sensor system of a surface plasmon resonance (SPR) for analyzing a characteristic of a substance and the measuring method thereof are provided. The system includes an optical device for generating a first light beam and a second light beam in sequence; a sensor device for respectively generating a first plasmon wave and a second plasmon wave in response to an optical characteristic change of the first light beam and the second light beam with respective to the substance, in which a resonance is generated from the first plasmon wave and the second plasmon wave respectively generating a first reflective signal and a second reflective signal; and a measuring device for measuring spectra of the first reflective signal and the second reflective signal and obtaining the measured value which is substituted into an operational formula to calculate a reference value used for analyzing the characteristic of the substance.
摘要翻译：提供了用于分析物质的特性的表面等离子体共振（SPR）的传感器系统及其测量方法。该系统包括依次产生第一光束和第二光束的光学装置; 传感器装置，用于响应于所述第一光束和所述第二光束的光学特性变化分别产生第一等离子体激元波和第二等离子体波，所述第一等离子体波和所述第二等离子体波相对于从所述物质产生的所述物质的光学特性变化，所述第二等离子体波分别产生第一反射信号和第二反射信号; 以及测量装置，用于测量第一反射信号和第二反射信号的光谱，并获得被代入操作公式的测量值，以计算用于分析物质特征的参考值。

7. 发明授权

US06688751B2 Polarization splitting backlight module 失效
标题翻译：极化分离背光模块
公开(公告)号：US06688751B2
公开(公告)日：2004-02-10
申请号：US09908061
申请日：2001-07-18
申请人： Chih-Kung Lee , Jiun-Yan Wu , Shu-Sheng Lee , Ching-Heng Tang
发明人： Chih-Kung Lee , Jiun-Yan Wu , Shu-Sheng Lee , Ching-Heng Tang
IPC分类号： F21V914
CPC分类号： G02B6/0038 , G02B5/305 , G02B6/0051 , G02B6/0056 , G02B27/283 , G02F1/133615 , G02F1/13362
摘要： A polarization splitting backlight module for efficiently converting a non-polarized light beam emitted from the light source into a single polarization state is disclosed. The polarization splitting backlight module of the present invention comprises an under plate with a ridged lower surface, a light source, a special reflection film, a scattering structure, a substrate and a polarization splitting film. The light beam emitted from the light source is introduced into the scattering structure between the under plate and the substrate. After a series of processes, such as scattering, reflection, phase retardation and polarization beam-splitting, the light beam will pass through the polarization splitting film being of a single polarization state such that it could be utilized by electro-optical systems, such as liquid crystal displays. The present invention converts light beams into a single polarization state, and the efficiency thus is higher than that of a conventional backlight module. The present invention achieves brightness levels that are almost twice that of conventional backlight module.
摘要翻译：公开了一种用于将从光源发射的非偏振光束有效地转换成单极化状态的偏振分束背光模块。本发明的偏振分束背光模块包括具有带脊下表面的底板，光源，特殊反射膜，散射结构，基板和偏振分束膜。从光源发射的光束被引入到底板和基板之间的散射结构中。在诸如散射，反射，相位延迟和偏振光束分裂的一系列处理之后，光束将通过偏振分束膜为单一极化状态，使得其可以被电光系统使用，例如液晶显示器。本发明将光束转换成单极化状态，因此效率高于常规背光模块的效率。本发明实现的亮度水平几乎是传统背光模块的两倍。

8. 发明授权

US07671995B2 Method for improving surface plasmon resonance by using conducting metal oxide as adhesive layer 有权
标题翻译：通过使用导电金属氧化物作为粘合剂层来改善表面等离子体共振的方法
公开(公告)号：US07671995B2
公开(公告)日：2010-03-02
申请号：US12048238
申请日：2008-03-14
申请人： Chii-Wann Lin , Nan-Fu Chiu , Wei-Yi Feng , Chia-Chen Chang , Kuo-Chuan Ho , Chih-Kung Lee , Kuang-Chong Wu
发明人： Chii-Wann Lin , Nan-Fu Chiu , Wei-Yi Feng , Chia-Chen Chang , Kuo-Chuan Ho , Chih-Kung Lee , Kuang-Chong Wu
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Surface plasmon resonance (SPR) sensing technique which provides high specificity and accuracy has been an important method for molecular sensing technology. In the past, in order to affix 45 nm gold film onto glass or silicon substrate, several nanometers of chromium (Cr) or titanium (Ti) has been used as adhesive layer for the attachment of Au film. However, the existence of Cr or Ti thin film deteriorates the performance of SPR sensor due to their characteristic optical absorption. Our experimental results have confirmed the uses of conducting metal oxide, specifically, ITO and Zinc Oxide (ZnO) can be used to replace Cr or Ti for better performance in terms of SPR resonant properties (resonant angle and HMBW) and sensitivity enhancement for 3 to 15 times than traditional ones. It would contribute significantly to the SPR applications in both biosensors and gas sensors.
摘要翻译：提供高特异性和准确度的表面等离子体共振（SPR）感测技术已成为分子感测技术的重要方法。在过去，为了将45nm金膜贴在玻璃或硅衬底上，已经使用几纳米的铬（Cr）或钛（Ti）作为用于附着Au膜的粘合剂层。然而，Cr或Ti薄膜的存在由于其特征性光吸收而使SPR传感器的性能劣化。我们的实验结果证实了导电金属氧化物的用途，特别是ITO和氧化锌（ZnO）可以用于替代Cr或Ti，以获得更好的SPR谐振特性（谐振角和HMBW）性能，灵敏度提高为3〜比传统的15倍。这将有助于生物传感器和气体传感器中的SPR应用。

9. 发明授权

US08498696B2 Health monitoring device and human electric signal processing method 有权
标题翻译：健康监测装置和人体电信号处理方法
公开(公告)号：US08498696B2
公开(公告)日：2013-07-30
申请号：US12796634
申请日：2010-06-08
申请人： Jia-Yush Yen , Fan-Che Yen , Chih-Kung Lee , Chii-Wann Lin , Kuang-Chong Wu , Ching-En Tseng
发明人： Jia-Yush Yen , Fan-Che Yen , Chih-Kung Lee , Chii-Wann Lin , Kuang-Chong Wu , Ching-En Tseng
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/04017 , A61B5/726
摘要： A health monitoring device is provided and includes a detecting unit for detecting a first electric signal from a human body and a processing unit for performing the following steps: receiving the first electric signal; performing wavelet transform on the first electric signal, to filter frequency bands thereof which include undesired noises, and then perform a reverse wavelet transform to obtain a second electric signal; combining frequency bands of the first electric signal which include primary characteristics and then perform a reverse wavelet transform on the combined frequency bands to obtain a fourth electric signal; and comparing the fourth electric signal with a plurality of electric signal patterns of a database to determine whether the fourth electric signal is an electric signal for healthiness.
摘要翻译：本发明提供一种健康监测装置，其特征在于，包括：检测来自人体的第一电信号的检测部;以及执行以下步骤的处理部：接收所述第一电信号; 对第一电信号执行小波变换，对包括不期望的噪声的频带进行滤波，然后执行反向小波变换以获得第二电信号; 组合包括主要特征的第一电信号的频带，然后对组合的频带执行反向小波变换，以获得第四电信号; 以及将第四电信号与数据库的多个电信号模式进行比较，以确定第四电信号是否是用于健康的电信号。

10. 发明申请

US20100274101A1 WIRELESS MONITORING BIO-DIAGNOSIS SYSTEM 审中-公开
标题翻译：无线监控生物诊断系统
公开(公告)号：US20100274101A1
公开(公告)日：2010-10-28
申请号：US12556675
申请日：2009-09-10
申请人： Chii-Wann Lin , Kuang-Chong Wu , Chih-Kung Lee , Shi-Ming Lin , Shih-Yuan Lee , Fu-Shan Jaw , Chern-Lin Chen , U Lei , Long-Sun Huang , Shey-Shi Lu , Phone Lin , Jia-Yush Yen , Yao-Joe Yang , Lung-Jieh Yang , Wen-Pin Shih , Nan-Fu Chiu
发明人： Chii-Wann Lin , Kuang-Chong Wu , Chih-Kung Lee , Shi-Ming Lin , Shih-Yuan Lee , Fu-Shan Jaw , Chern-Lin Chen , U Lei , Long-Sun Huang , Shey-Shi Lu , Phone Lin , Jia-Yush Yen , Yao-Joe Yang , Lung-Jieh Yang , Wen-Pin Shih , Nan-Fu Chiu
IPC分类号： A61B5/00
CPC分类号： C12Q1/26 , A61B5/0031 , A61B5/024 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61B2562/12 , C12Q1/006 , C12Q1/32 , G01N33/6893 , G01N2800/32
摘要： A MEMS wireless monitoring bio-diagnosis system includes an implantable biosensor system chip, a surface transmitter and an external monitor center. The implantable biosensor system chip contains a biosensor for a cardio-vascular indicator and a wireless transmitter to deliver detected bio-signal data. With the MEMS wireless monitoring bio-diagnosis system, the bio-signal data can be monitored effectively and transmitted to a remote medical unit.
摘要翻译： MEMS无线监测生物诊断系统包括可植入生物传感器系统芯片，表面发射器和外部监视器中心。可植入生物传感器系统芯片包含用于心血管指示器的生物传感器和用于传送检测到的生物信号数据的无线发射器。利用MEMS无线监控生物诊断系统，生物信号数据可以被有效地监控并传输到远程医疗单元。

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