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1. 发明申请

US20130274281A1 METHODS OF TREATING METASTATIC BREAST CANCER WITH 4-IODO-3-NITROBENZAMIDE AND IRINOTECAN 审中-公开
标题翻译：用4-碘代-3-硝基苯甲酰胺和紫杉醇治疗异位乳腺癌的方法
公开(公告)号：US20130274281A1
公开(公告)日：2013-10-17
申请号：US13811193
申请日：2011-07-19
申请人： Charles Bradley
发明人： Charles Bradley
IPC分类号： A61K31/4745 , A61K31/166
CPC分类号： A61K31/4745 , A61K31/166 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods, compositions and kits for the treatment of locally advanced or metastatic breast cancer or breast cancer brain metastases. The method comprises administration of 4-iodo-3-nitrobenzamide, a metabolite or salt thereof in combination with irinotecan. The method of treating locally advanced or metastatic breast cancer comprises at least one 21 day treatment cycle.
摘要翻译：本文提供了用于治疗局部晚期或转移性乳腺癌或乳腺癌脑转移的方法，组合物和试剂盒。该方法包括与伊立替康联合施用4-碘-3-硝基苯甲酰胺，其代谢物或盐。治疗局部晚期或转移性乳腺癌的方法包括至少21天的治疗周期。

2. 发明授权

US06221018B1 Medical ultrasonic diagnostic imaging method and apparatus 有权
标题翻译：医用超声诊断成像方法及装置
公开(公告)号：US06221018B1
公开(公告)日：2001-04-24
申请号：US09634115
申请日：2000-08-08
申请人： Bhaskar S. Ramamurthy , Charles Bradley , Ken Sawatari , Danhua Zhao , Stuart L. Carp , Stirling S. Dodd , David J. Hedberg , Samuel H. Maslak , Daniel E. Need
发明人： Bhaskar S. Ramamurthy , Charles Bradley , Ken Sawatari , Danhua Zhao , Stuart L. Carp , Stirling S. Dodd , David J. Hedberg , Samuel H. Maslak , Daniel E. Need
IPC分类号： A61B800
CPC分类号： A61B8/481 , G01S7/5202 , G01S7/52038 , G01S15/8915 , G01S15/8927 , G01S15/895
摘要： A medical diagnostic ultrasonic imaging method and system subdivide the transmit aperture into two or more subapertures, each subaperture having at least four adjacent transducer elements. The subapertures are phased differently with respect to one another to selectively reduce either fundamental components or harmonic components of echoes from tissue. These techniques can be used to improve contrast agent harmonic imaging as well as tissue harmonic imaging, depending upon the phase shift selected.
摘要翻译：医学诊断超声成像方法和系统将发射孔径细分为两个或更多个子孔径，每个子孔径具有至少四个相邻的换能器元件。子孔径相对于彼此不同地相位选择性地降低来自组织的回波的基本分量或谐波分量。这些技术可以用于根据选择的相移来改善造影剂谐波成像以及组织谐波成像。

3. 发明授权

US07732491B2 Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents 失效
标题翻译：用PARP抑制剂单独或与抗肿瘤剂组合治疗乳腺癌
公开(公告)号：US07732491B2
公开(公告)日：2010-06-08
申请号：US12269024
申请日：2008-11-11
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61K31/166
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

4. 发明申请

US20090123419A1 TREATMENT OF UTERINE CANCER AND OVARIAN CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗子宫癌和卵巢癌与抗肿瘤药物联合治疗
公开(公告)号：US20090123419A1
公开(公告)日：2009-05-14
申请号：US12269833
申请日：2008-11-12
申请人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
IPC分类号： A61K38/21 , A61K31/166 , A61P35/00 , A61K31/505 , A61K31/337 , A61K31/513 , A61K39/395 , C12Q1/68
CPC分类号： A61K31/505 , A61K31/166 , A61K31/337 , A61K31/513 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C12Q1/6886 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂组合。

5. 发明申请

US20070083109A1 Adaptive line synthesis for ultrasound 审中-公开
标题翻译：自适应线合成超声波
公开(公告)号：US20070083109A1
公开(公告)日：2007-04-12
申请号：US11238889
申请日：2005-09-28
申请人： Kutay Ustuner , D-L Liu , Lewis Thomas , Charles Bradley , Anming Cai , Robert Phelps , John Lazenby
发明人： Kutay Ustuner , D-L Liu , Lewis Thomas , Charles Bradley , Anming Cai , Robert Phelps , John Lazenby
IPC分类号： A61B8/00
CPC分类号： G01S7/52046 , G01S7/5209 , G01S7/52095 , G01S15/8959
摘要： Adaptive line synthesis is provided. Line synthesis of collinear receive beams responsive to spatially distinct transmit beams is a function of many parameters, such as spatial or temporal frequency response of one or more of the receive beams, synthesis function, number of receive beams synthesized, or acquisition sequence. One or more of these parameters is set or adapts as a function of processor estimated or user provided information. By adapting the line synthesis, the performance and image quality is optimized as appropriate for the received data or desired imaging, such as detail resolution, contrast resolution, temporal resolution, shift-invariance and penetration.
摘要翻译：提供自适应线合成。响应于空间不同的发射波束的共线接收波束的线路合成是许多参数的函数，例如接收波束中的一个或多个的合成函数，合成函数，接收波束的数量或采集序列的空间或时间频率响应。这些参数中的一个或多个被设置或根据处理器估计或用户提供的信息进行调整。通过适应线路合成，根据接收到的数据或所需的成像（如细节分辨率，对比度分辨率，时间分辨率，偏移不变性和穿透），性能和图像质量得到优化。

6. 发明授权

US07509885B2 Transmission auxiliary unit timed shift inhibitor 有权
标题翻译：变速器辅助单元定时变速抑制器
公开(公告)号：US07509885B2
公开(公告)日：2009-03-31
申请号：US11284668
申请日：2005-11-22
申请人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael J. Huggins , Gerard F. Smith , Michael E. Lemon
发明人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael J. Huggins , Gerard F. Smith , Michael E. Lemon
IPC分类号： F16H59/68
CPC分类号： F16H61/705 , F16H61/16 , F16H61/702 , F16H63/34 , F16H63/36 , F16H2306/20 , Y10T74/19167 , Y10T74/19219 , Y10T74/19223 , Y10T74/19233 , Y10T74/19251 , Y10T74/19284
摘要： An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.
摘要翻译：一个实施例提供了一种换挡抑制装置。范围致动组件的至少一部分可在范围第一比率和范围第二比例之间移动。范围致动组件的部分至少部分地响应于流体压力是可移动的。范围室选择性地与排气口流体连通。换档抑制器包括具有互锁室的主部分中空互锁。主部分中空联锁的至少一部分可在第一状态和第二状态之间移动。互锁室选择性地与排气口流体连通。范围室可以被耗尽，使得范围部分被选择性地从第一比率切换到第二比率。联锁室可以被排出，使得主区段中立互锁从第一状态选择性地切换到第二状态。

7. 发明申请

US20060241454A1 Transmit multibeam for compounding ultrasound data 审中-公开
标题翻译：发送复合超声数据的多波束
公开(公告)号：US20060241454A1
公开(公告)日：2006-10-26
申请号：US11099866
申请日：2005-04-05
申请人： Kutay Ustuner , Anming Cai , Charles Bradley
发明人： Kutay Ustuner , Anming Cai , Charles Bradley
IPC分类号： A61B8/00
CPC分类号： G01S15/8995 , A61B8/00 , A61B8/4483 , G01S7/5209 , G01S7/52092 , G01S7/52095
摘要： Transmit multibeams insonify an object with multiple noncollinear transmit beams fired substantially simultaneously. The noncollinear beams are along different scan lines of same scan geometry, or they belong to scan lines of different scan geometries. One or more receive beams are formed in parallel in response to each of the noncollinear beams. The scan geometry and/or center frequency is varied between the noncollinear transmit beams of a transmit event. By scanning the transmit multibeam, and varying the scan geometry and/or frequency between the noncollinear transmit beams of a transmit event, multiple component images are generated for compounding. The component images are scan-converted (if scan geometries are different), weighted and combined after envelope detection.
摘要翻译：发射多波束使多个基本同时发射的非共线发射波束对象物体失真。非共线光束沿相同扫描几何的不同扫描线，或者它们属于不同扫描几何形状的扫描线。一个或多个接收波束响应于每个非共线波束平行地形成。扫描几何和/或中心频率在发射事件的非共线发射波束之间变化。通过扫描发射多波束，并改变发射事件的非共线发射波束之间的扫描几何形状和/或频率，生成多个分量图像进行复合。组件图像进行扫描转换（如果扫描几何不同），在包络检测后加权和组合。

8. 发明申请

US20060185456A1 Transmission auxiliary unit timed shift inhibitor 有权
公开(公告)号：US20060185456A1
公开(公告)日：2006-08-24
申请号：US11284668
申请日：2005-11-22
申请人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael Huggins , Gerard Smith , Michael Lemon
发明人： Kurt Gerlofs , Dave Stevens , Mark Hirsch , Charles Bradley , Michael Huggins , Gerard Smith , Michael Lemon
IPC分类号： F16H3/08
CPC分类号： F16H61/705 , F16H61/16 , F16H61/702 , F16H63/34 , F16H63/36 , F16H2306/20 , Y10T74/19167 , Y10T74/19219 , Y10T74/19223 , Y10T74/19233 , Y10T74/19251 , Y10T74/19284
摘要： An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.

9. 发明申请

US20060173313A1 Coherence factor adaptive ultrasound imaging 审中-公开
标题翻译：相干因子自适应超声成像
公开(公告)号：US20060173313A1
公开(公告)日：2006-08-03
申请号：US11046347
申请日：2005-01-27
申请人： D-L Liu , Lewis Thomas , Kutay Ustuner , Charles Bradley , John Lazenby
发明人： D-L Liu , Lewis Thomas , Kutay Ustuner , Charles Bradley , John Lazenby
IPC分类号： A61B8/00
CPC分类号： G01S7/52046 , G01S15/8993
摘要： A set of N×M signals are acquired from an object, where N is the number of array elements and M corresponds to variations in data acquisition and/or processing parameters. The parameters include transmit aperture functions, transmit waveforms, receive aperture functions, and receive filtering functions in space and/or time. A coherence factor is computed as a ratio of the energy of the coherent sum to the energy of the at-least-partially incoherent sum of channel or image signals acquired with at least one different parameter. Partial beamformed data may be used for channel coherence calculation. For image domain coherence, a component image is formed for each different transmit beam or receive aperture function, and a coherence factor image is computed using the set of component images. The coherence factor image is displayed or used to modify or blend other images formed of the same region.
摘要翻译：从对象获取一组NxM信号，其中N是数组元素的数量，M对应于数据采集和/或处理参数中的变化。这些参数包括发射孔径功能，发射波形，接收孔径功能，以及在空间和/或时间中接收滤波功能。相干因子被计算为用至少一个不同参数获取的信道或图像信号的至少部分非相干和的相干和的能量与能量的比率。部分波束形成数据可用于通道相干计算。对于图像域相干性，为每个不同的发射波束或接收孔径函数形成分量图像，并且使用该组分量图像来计算相干因子图像。相干因子图像被显示或用于修改或混合由相同区域形成的其他图像。

10. 发明申请

US20120130144A1 TREATMENT OF LUNG CANCER WITH A NITROBENZAMIDE COMPOUND IN COMBINATION WITH A GROWTH FACTOR INHIBITOR 审中-公开
标题翻译：用生长因子抑制剂与硝基苯甲酸化合物联合治疗肺癌
公开(公告)号：US20120130144A1
公开(公告)日：2012-05-24
申请号：US13146865
申请日：2010-02-04
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61N5/00 , A61K39/395 , A61K39/00 , A61K31/519 , A61K31/42 , A61K31/4709 , A61K38/19 , A61K38/12 , A61K31/4985 , A61K31/4545 , A61K31/47 , A61K38/16 , A61K31/444 , A61K38/44 , A61K31/53 , A61K31/58 , A61K31/553 , A61K31/502 , A61K31/506 , A61K31/675 , A61P35/00 , A61K31/454 , A61K31/404 , A61K48/00 , A61K31/517
CPC分类号： A61K45/06 , A61K31/17 , A61K31/404 , A61K31/4375 , A61K31/4709 , A61K31/517 , A61K31/553 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.
摘要翻译：一方面，本发明提供了一种治疗肺癌的方法，包括给予受试者至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。另一方面，本发明提供了一种治疗非小细胞肺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。

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