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1. 发明授权

US09826983B2 Medical device for controlled nail penetration 有权
公开(公告)号：US09826983B2
公开(公告)日：2017-11-28
申请号：US14320694
申请日：2014-07-01
申请人： Rolf Lewis Thomas
发明人： Rolf Lewis Thomas
IPC分类号： A61B17/54 , A61B17/16 , A61B90/00
CPC分类号： A61B17/1626 , A61B17/1662 , A61B17/54 , A61B90/03 , A61B2090/064
摘要： The present invention relates to a device for penetrating human nails as a part of treatment for Onychomycosis, commonly known as fungal nail. The device comprises a reusable electromechanical system and a single use cutting component. The electromechanical system incorporates an electrical motor and drive train to advance the cutting component through the nail. The electromechanical system also incorporates sensors for measuring the cutting resistance for the purpose of preventing the cutting device from overrunning into the nail bed. The device can be used to penetrate the nail in a controlled manner which will create a portal through the nail without penetrating the nail bed below the nail.

2. 发明申请

US20140371751A1 Medical Device for Controlled Nail Penetration 审中-公开
标题翻译：用于控制指甲渗透的医疗装置
公开(公告)号：US20140371751A1
公开(公告)日：2014-12-18
申请号：US14320694
申请日：2014-07-01
申请人： Rolf Lewis Thomas
发明人： Rolf Lewis Thomas
IPC分类号： A61B17/16
CPC分类号： A61B17/1626 , A61B17/1662 , A61B17/54 , A61B90/03 , A61B2090/064
摘要： The present invention relates to a device for penetrating human nails as a part of treatment for Onychomycosis, commonly known as fungal nail. The device comprises a reusable electromechanical system and a single use cutting component. The electromechanical system incorporates an electrical motor and drive train to advance the cutting component through the nail. The electromechanical system also incorporates sensors for measuring the cutting resistance for the purpose of preventing the cutting device from overrunning into the nail bed. The device can be used to penetrate the nail in a controlled manner which will create a portal through the nail without penetrating the nail bed below the nail.
摘要翻译：本发明涉及穿透人指甲作为甲真菌病治疗的一部分的装置，通常称为真菌指甲。该装置包括可重复使用的机电系统和单次使用的切割部件。机电系统包括电动马达和传动系，以使切割部件通过指甲推进。机电系统还包括用于测量切割阻力的传感器，以防止切割装置超过甲床。该装置可以以受控的方式穿透指甲，这将通过钉子形成通过钉子的入口，而不穿透指甲下方的甲床。

3. 发明申请

US20130326912A1 FOOTWEAR 有权
标题翻译：足球
公开(公告)号：US20130326912A1
公开(公告)日：2013-12-12
申请号：US13985754
申请日：2012-02-15
申请人： Leslie Lindsay , Rolf Lewis Thomas
发明人： Leslie Lindsay , Rolf Lewis Thomas
IPC分类号： A43B3/00
CPC分类号： A43B3/00 , A43B3/0005 , A43B7/146 , A43B13/203
摘要： The present invention relates to footwear and in particular, but not necessarily restricted thereto, relates to footwear for those with diabetes and, in particular, with ulcers of the sole. The present invention seeks to address some of the problems encountered by prior art limb compression devices and methods. In particular the present invention seeks to provide a boot which can stimulate blood flow. A further object to the invention is to provide a boot with a sole which is adaptable to conform with various shapes and conditions of human feet. The present invention also seeks to provide a new type of footwear that has a therapeutic benefit for diabetic patients with circulatory problems in their foot, and also enables the technique of “off loading” the foot to assist in the healing of any wounds present. The present invention relates to a method for aiding arterial and venous flow from the limb of an ambulatory patient comprising the step of applying pressure to one or more areas of the soft tissue of an underside portion of the foot.
摘要翻译：本发明涉及鞋类，特别是但不一定限于此，涉及用于糖尿病患者的鞋类，尤其涉及鞋底的溃疡。本发明寻求解决现有技术肢体压缩装置和方法遇到的一些问题。特别地，本发明寻求提供一种可以刺激血液流动的护罩。本发明的另一个目的是提供一种具有适合于符合人脚的各种形状和状况的鞋底的鞋底。本发明还寻求提供一种新的类型的鞋类，其对于在其脚中具有循环问题的糖尿病患者具有治疗益处，并且还使得能够“卸载”脚以辅助任何存在的伤口的愈合的技术。本发明涉及一种帮助来自流动患者肢体的动脉和静脉流动的方法，包括向脚的下侧部分的软组织的一个或多个区域施加压力的步骤。

4. 发明申请

US20080014594A1 Lung-Expressed Polypeptides 审中-公开
标题翻译：肺表达多肽
公开(公告)号：US20080014594A1
公开(公告)日：2008-01-17
申请号：US10543838
申请日：2004-01-30
申请人： Kevin Hestir , Ernestine Lee , Keting Chu , Yan Wang , Kristen Pierce , Amy L. Tsui Collins , Lewis Thomas Williams
发明人： Kevin Hestir , Ernestine Lee , Keting Chu , Yan Wang , Kristen Pierce , Amy L. Tsui Collins , Lewis Thomas Williams
IPC分类号： G01N33/53
CPC分类号： G01N33/57423 , C07K16/40 , G01N33/574 , G01N2333/70596
摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.
摘要翻译：提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。

5. 发明申请

US20060173312A1 Ultrasonic imaging system 有权
标题翻译：超声波成像系统
公开(公告)号：US20060173312A1
公开(公告)日：2006-08-03
申请号：US11029046
申请日：2005-01-03
申请人： John Jackson , Lewis Thomas , Constantine Simopoulos
发明人： John Jackson , Lewis Thomas , Constantine Simopoulos
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , G03B42/06
摘要： Disclosed are a system and method of selecting one or more operational parameters of an ultrasonic imaging system. In particular, methods and means are disclosed for automatically or semi-automatically determining a best operating frequency, or for determining whether a system should operate in a fundamental imaging mode or a harmonic imaging mode.
摘要翻译：公开了一种选择超声波成像系统的一个或多个操作参数的系统和方法。特别地，公开了用于自动或半自动地确定最佳操作频率或用于确定系统是否应当在基本成像模式或谐波成像模式中操作的方法和装置。

6. 发明申请

US20050228279A1 Coherence factor adaptive ultrasound imaging methods and systems 有权
标题翻译：相干因子自适应超声成像方法和系统
公开(公告)号：US20050228279A1
公开(公告)日：2005-10-13
申请号：US10814959
申请日：2004-03-31
申请人： Kutay Ustuner , Pai-Chi Li , Meng-Lin Li , Lewis Thomas , Albert Gee
发明人： Kutay Ustuner , Pai-Chi Li , Meng-Lin Li , Lewis Thomas , Albert Gee
IPC分类号： A61B8/14 , G01S7/52
CPC分类号： G01S15/8927 , G01S7/52049
摘要： Ultrasound imaging adapts as a function of a coherence factor. Various beamforming, image forming or image processing parameters are varied as a function of a coherence factor to improve detail resolution, contrast resolution, dynamic range or SNR. For example, a beamforming parameter such as the transmit or receive aperture size, apodization type or delay is selected to provide maximum coherence. Alternatively or additionally, an image forming parameter, such as the number of beams for coherent synthesis or incoherent compounding, is set as a function of the coherence factor. Alternatively or additionally an image processing parameter such as the dynamic range, linear or nonlinear video filter and/or linear or nonlinear map may also adapt as a function of the coherence factor.
摘要翻译：超声成像适应相干因子的函数。各种波束成形，图像形成或图像处理参数作为相干因子的函数而变化，以提高细节分辨率，对比度分辨率，动态范围或SNR。例如，选择诸如发射或接收孔径大小，变迹类型或延迟的波束形成参数以提供最大相干性。或者或另外，将诸如用于相干合成或非相干复合的光束的数量的图像形成参数设置为相干因子的函数。替代地或附加地，诸如动态范围，线性或非线性视频滤波器和/或线性或非线性映射的图像处理参数也可以作为相干因子的函数来适应。

7. 发明授权

US5872218A Human platelet-derived growth factor receptor extracellular domain antibodies 失效
标题翻译：人血小板衍生生长因子受体细胞外结构域抗体
公开(公告)号：US5872218A
公开(公告)日：1999-02-16
申请号：US460510
申请日：1995-06-02
申请人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
发明人： David Wolf , James E. Tomlinson , Larry J. Fretto , Neill A. Giese , Jaime A. Escobedo , Lewis Thomas Williams
IPC分类号： A61K39/395 , A61K38/00 , C07K7/04 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566
CPC分类号： C07K16/2863 , C07K14/71 , A61K38/00 , C07K2319/00
摘要： This invention provides antibodies that bind to epitopes of human platelet-derived growth factor receptor (hPDGF-R) fragments, wherein the fragments comprise one or more platelet-derived growth factor (PDGF) ligand binding regions from extracellular domains D1, D2, and D3. Also provided are antibodies specific for domain D3, such as monoclonal antibodies directed to the intra-cysteine portion of domain D3.
摘要翻译：本发明提供与人血小板衍生生长因子受体（hPDGF-R）片段的表位结合的抗体，其中所述片段包含来自胞外域D1，D2和D3的一个或多个血小板衍生生长因子（PDGF）配体结合区。还提供了针对结构域D3特异性的抗体，例如针对结构域D3的半胱氨酸部分的单克隆抗体。

8. 发明授权

US4002078A Dynamically tuned gyroscopes 失效
标题翻译：动态调谐陀螺仪
公开(公告)号：US4002078A
公开(公告)日：1977-01-11
申请号：US549676
申请日：1975-02-13
申请人： Ivor Lewis Thomas
发明人： Ivor Lewis Thomas
IPC分类号： G01C19/22 , G01C19/16
CPC分类号： G01C19/22 , Y10T74/12 , Y10T74/1293
摘要： A dynamically tuned gyroscope having a single gimbal has torsion flexures with torsional stiffnesses such that, at its tuned speed, the gyroscope is insensitive to angular vibration at a frequency of twice the rotor rotational speed. The drive shaft is connected to a first torsion flexure having an effective torsional stiffness K.sub.1 of zero, K.sub.1 being made zero by the use of ball races or pivots, by known mechanical methods such as over-center or toggle spring action, or by the use of magnetic or electrostatic systems. The rotor is connected to a second torsion flexure which is orthogonal to the first flexure. The second torsion flexure has a torsional stiffness K.sub.2 equal to 4w.sup.2 r.sub.3.sup.2 m.sub.3 where w is the tuned rotor speed, m.sub.3 is the component mass of a gimbal, on which the torsion flexures are mounted, on an axis through the center of gravity of the gimbal and normal to the plane of the gimbal, and r.sub.3 is the distance of the component mass m.sub.3 from the center of gravity of the gimbal.
摘要翻译：具有单个万向架的动态调谐的陀螺仪具有扭转弯曲，扭转刚度具有扭转刚度，使得在其调谐速度下，陀螺仪对于以两倍于转子旋转速度的频率的角振动不敏感。驱动轴连接到具有零的有效扭转刚度K1为零的第一扭转挠曲件，通过使用球座或枢轴使K1成为零，通过已知的机械方法，例如过中心或肘节弹簧作用，或通过使用的磁性或静电系统。转子连接到与第一弯曲部正交的第二扭转弯曲部。第二扭转挠曲具有等于4w2r32m3的扭转刚度K2，其中w是调谐转子速度，m3是通过万向架和正常重心的轴线上的扭转弯曲所安装的万向节的组件质量到万向架的平面，r3是组件质量m3与万向节重心的距离。

9. 发明授权

US2998976A Equipment for a pitching game 失效
标题翻译：投球设备
公开(公告)号：US2998976A
公开(公告)日：1961-09-05
申请号：US73585358
申请日：1958-05-16
申请人： LEWIS THOMAS W
发明人： LEWIS THOMAS W
IPC分类号： A63F9/02
CPC分类号： A63F9/0204 , A63F2009/0217

10. 发明授权

US1997113A Safe protector 失效
公开(公告)号：US1997113A
公开(公告)日：1935-04-09
申请号：US74329534
申请日：1934-09-08
申请人： LEWIS THOMAS N
发明人： LEWIS THOMAS N
IPC分类号： E05G1/12
CPC分类号： E05G1/12 , Y10T70/5571 , Y10T292/081

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