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1. 发明授权

US07732491B2 Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents 失效
标题翻译：用PARP抑制剂单独或与抗肿瘤剂组合治疗乳腺癌
公开(公告)号：US07732491B2
公开(公告)日：2010-06-08
申请号：US12269024
申请日：2008-11-11
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61K31/166
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

2. 发明申请

US20100009930A1 TREATMENT OF UTERINE CANCER AND OVARIAN CANCER WITH A PARP INHIBITOR ALONE OR IN CONBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗子宫癌和卵巢癌与抗肿瘤药物联合治疗
公开(公告)号：US20100009930A1
公开(公告)日：2010-01-14
申请号：US12502943
申请日：2009-07-14
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61K31/7068 , A61K31/4375 , A61K31/337
CPC分类号： A61K31/505 , A61K31/166 , A61K31/337 , A61K31/513 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C12Q1/6886 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂组合。

3. 发明申请

US20100003192A1 TREATMENT OF BREAST CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗乳腺癌或与抗肿瘤药物联合治疗
公开(公告)号：US20100003192A1
公开(公告)日：2010-01-07
申请号：US12496593
申请日：2009-07-01
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61K51/04 , A61P35/00 , A61K101/02
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

4. 发明申请

US20120130144A1 TREATMENT OF LUNG CANCER WITH A NITROBENZAMIDE COMPOUND IN COMBINATION WITH A GROWTH FACTOR INHIBITOR 审中-公开
标题翻译：用生长因子抑制剂与硝基苯甲酸化合物联合治疗肺癌
公开(公告)号：US20120130144A1
公开(公告)日：2012-05-24
申请号：US13146865
申请日：2010-02-04
申请人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria S. Ossovskaya
IPC分类号： A61N5/00 , A61K39/395 , A61K39/00 , A61K31/519 , A61K31/42 , A61K31/4709 , A61K38/19 , A61K38/12 , A61K31/4985 , A61K31/4545 , A61K31/47 , A61K38/16 , A61K31/444 , A61K38/44 , A61K31/53 , A61K31/58 , A61K31/553 , A61K31/502 , A61K31/506 , A61K31/675 , A61P35/00 , A61K31/454 , A61K31/404 , A61K48/00 , A61K31/517
CPC分类号： A61K45/06 , A61K31/17 , A61K31/404 , A61K31/4375 , A61K31/4709 , A61K31/517 , A61K31/553 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.
摘要翻译：一方面，本发明提供了一种治疗肺癌的方法，包括给予受试者至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。另一方面，本发明提供了一种治疗非小细胞肺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。

5. 发明申请

US20100160442A1 FORMULATIONS FOR CANCER TREATMENT 审中-公开
标题翻译：癌症治疗配方
公开(公告)号：US20100160442A1
公开(公告)日：2010-06-24
申请号：US12510969
申请日：2009-07-28
申请人： Valeria S. OSSOVSKAYA , Barry M. Sherman , Kathy Powell , Stephen Nava , Helen N. Han , Lingyun Li , Richard J. Bastin
发明人： Valeria S. OSSOVSKAYA , Barry M. Sherman , Kathy Powell , Stephen Nava , Helen N. Han , Lingyun Li , Richard J. Bastin
IPC分类号： A61K31/166 , A61P35/00 , A61P31/12 , A61P35/02
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/1635 , A61K9/1652 , A61K9/4858 , A61K31/166 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： The present invention provides compositions of matter, kits, and methods for use in treating cancer and viral conditions. In particular the invention provides for pharmaceutical compositions containing nitrobenzamide compounds that have enhanced solubility in aqueous solutions.
摘要翻译：本发明提供了用于治疗癌症和病毒病症的物质，试剂盒和方法的组合物。特别地，本发明提供含有在水溶液中具有增强的溶解度的硝基苯甲酰胺化合物的药物组合物。

6. 发明授权

US07994222B2 Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds 失效
标题翻译：通过碘 - 硝基苯甲酰胺化合物监测脂肪酸合成的抑制
公开(公告)号：US07994222B2
公开(公告)日：2011-08-09
申请号：US11850624
申请日：2007-09-05
申请人： Valeria S. Ossovskaya , Barry M. Sherman
发明人： Valeria S. Ossovskaya , Barry M. Sherman
IPC分类号： A61K31/165 , A61P3/04
CPC分类号： A61K31/166 , A61K31/197 , A61K31/7012
摘要： The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
摘要翻译：本发明涉及一种治疗脂肪酸合成相关疾病的方法，包括向有需要的患者施用有效量的PARP抑制剂或其代谢物以抑制脂肪酸合成，其中所述脂肪酸合成相关疾病是肥胖症，糖尿病，或心血管疾病。本发明还涉及治疗受试者的癌症的方法，包括：（i）鉴定来自受试者的样品中的脂肪酸水平，和（ii）施用有效量的PARP抑制剂或其代谢物以抑制受试者中的脂肪酸合成，其中所述给药基于脂肪酸的水平，从而治疗受试者的癌症。本发明还涉及通过向有需要的患者施用有效量的PARP抑制剂或其代谢物来抑制脂肪酸合成来治疗Her-2相关癌症的方法。

7. 发明申请

US20080262062A1 METHOD OF TREATING DISEASES WITH PARP INHIBITORS 审中-公开
标题翻译：用PARP抑制剂治疗疾病的方法
公开(公告)号：US20080262062A1
公开(公告)日：2008-10-23
申请号：US11940307
申请日：2007-11-14
申请人： Valeria S. Ossovskaya , Barry M. Sherman
发明人： Valeria S. Ossovskaya , Barry M. Sherman
IPC分类号： A61K31/4184 , C12Q1/48 , C12Q1/68 , A61K31/404 , A61P3/00 , A61P29/00 , A61P9/00 , A61P35/00 , A61K31/165 , A61K31/216
CPC分类号： C12Q1/6886 , A61K31/165 , A61K31/216 , A61K31/404 , A61K31/4184 , C12Q1/48 , C12Q2600/112 , C12Q2600/16 , G01N33/57415 , G01N33/57449
摘要： The present invention relates to methods of identifying a disease treatable with PARP modulators by identifying a level of PARP in a plurality of samples from a population, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in a subject population with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatment with PARP inhibitors.The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract, disorder of respiratory system, disorder of female reproductive system, and disorder of male reproductive system.
摘要翻译：本发明涉及通过鉴定来自群体的多个样品中的PARP水平来鉴定可用PARP调节剂治疗的疾病的方法，作出关于鉴定由PARP调节剂可治疗的疾病的决定，其中基于水平进行该决定的PARP。该方法还包括用PARP调节剂治疗受试者群体中的疾病。该方法涉及鉴定疾病中的上调PARP并且用PARP抑制剂来决定治疗该疾病。疾病中PARP上调的程度也有助于确定用PARP抑制剂治疗的疗效。本发明公开了具有上调或下调PARP并可分别用PARP抑制剂或PARP活化剂治疗的各种疾病。疾病的实例包括癌症，炎症，代谢疾病，CVS疾病，CNS疾病，血液系统紊乱，内分泌和神经内分泌紊乱，尿路紊乱，呼吸系统紊乱，女性生殖系统紊乱和男性失调生殖系统。

8. 发明授权

US08143447B2 Treatment of cancer 失效
标题翻译：治疗癌症
公开(公告)号：US08143447B2
公开(公告)日：2012-03-27
申请号：US11850626
申请日：2007-09-05
申请人： Jerome Moore , Bruce Keyt , John Burnier , Barry M. Sherman , Max Totrov , Valeria S. Ossovskaya
发明人： Jerome Moore , Bruce Keyt , John Burnier , Barry M. Sherman , Max Totrov , Valeria S. Ossovskaya
IPC分类号： C07C233/65 , C07C323/42 , C07C323/62
CPC分类号： C07C323/62 , C07C233/65 , C07C235/46 , C07C237/30 , C07C239/18
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

9. 发明申请

US20090275608A1 Methods of diagnosing and treating parp-mediated diseases 审中-公开
标题翻译：诊断和治疗parp介导的疾病的方法
公开(公告)号：US20090275608A1
公开(公告)日：2009-11-05
申请号：US12322551
申请日：2009-02-04
申请人： Valeria S. Ossovskaya , Barry M. Sherman
发明人： Valeria S. Ossovskaya , Barry M. Sherman
IPC分类号： A61K31/47 , C12Q1/68 , A61K31/415 , A61K31/40 , A61K31/04 , A61K31/015
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N2800/52 , Y02A90/26
摘要： Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression of differentially expressed genes, including at least PARP, in a plurality of samples from a population, making a decision regarding identifying the disease treatable by modulators to the differentially expressed genes wherein the decision is made based on the level of expression of the differentially expressed genes. The method can further comprise treating the disease in a subject population with modulators of identified differentially expressed genes. The methods relate to identifying up-regulated expression of identified differentially-expressed genes in a disease and making a decision regarding the treatment of the disease. The level of expression of the differentially expressed genes in a disease can also help in determining the efficacy of the treatment with modulators to the differentially expressed genes.
摘要翻译：公开了通过鉴定来自群体的多个样品中差异表达的基因（包括至少PARP）的表达水平，鉴定在疾病中包括至少PARP调节剂的差异表达基因的调节剂的疾病的方法，使得关于鉴定通过调节剂可治疗的差异表达基因的决定，其中基于差异表达基因的表达水平进行决定。该方法还可以包括用鉴别的差异表达基因的调节剂治疗受试群体中的疾病。该方法涉及鉴定疾病中鉴定的差异表达基因的上调表达并作出关于疾病治疗的决定。差异表达基因在疾病中的表达水平也有助于确定用调节剂处理差异表达基因的功效。

10. 发明申请

US20090123419A1 TREATMENT OF UTERINE CANCER AND OVARIAN CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗子宫癌和卵巢癌与抗肿瘤药物联合治疗
公开(公告)号：US20090123419A1
公开(公告)日：2009-05-14
申请号：US12269833
申请日：2008-11-12
申请人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
发明人： Barry M. Sherman , Charles Bradley , Valeria Ossovskaya
IPC分类号： A61K38/21 , A61K31/166 , A61P35/00 , A61K31/505 , A61K31/337 , A61K31/513 , A61K39/395 , C12Q1/68
CPC分类号： A61K31/505 , A61K31/166 , A61K31/337 , A61K31/513 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C12Q1/6886 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂。另一方面，本发明提供了一种治疗子宫癌，子宫内膜癌或卵巢癌的方法，包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂组合。

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