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1. 发明授权

US08304253B2 Droplet extraction from a liquid column for on-chip microfluidics 有权
标题翻译：从用于片上微流体的液柱提取液滴
公开(公告)号：US08304253B2
公开(公告)日：2012-11-06
申请号：US12090922
申请日：2006-10-19
申请人： Uichong Brandon Yi , Peter Patrick De Guzman , Wayne Liu , Chang-Jin Kim
发明人： Uichong Brandon Yi , Peter Patrick De Guzman , Wayne Liu , Chang-Jin Kim
IPC分类号： B01D57/00 , B01L99/00
CPC分类号： B01L3/502 , B01L3/502761 , B01L3/502792 , B01L2200/027 , B01L2200/10 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0427 , B01L2400/0469 , G01N1/10 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A refill droplet facilitates the extraction of a droplet laterally from a channel in a microfluidic apparatus. Such extraction allows a discrete band of separated particles or solute molecules to be excised from a fluid stream and processed and analyzed separately. An extraction point is located along the length of the channel and includes an EWOD surface or similar microfluidic technology to extract a droplet. An opening in the channel opposite the extraction means is equipped with microfluidic technology to transport a refill droplet to the opening. The refill droplet is moved into the channel or column to occupy the area previously occupied by the extracted droplet. This prevents distortion or mixing of the bands of particles or molecules within the channel and prevents the draining of any portion of the fluidic system.
摘要翻译：补充液滴有助于从微流体装置中的通道横向提取液滴。这种提取允许分离的颗粒或溶质分子的离散带从流体流中切除并分开处理和分析。提取点沿着通道的长度定位并且包括用于提取液滴的EWOD表面或类似的微流体技术。与提取装置相对的通道中的开口配备有微流体技术以将再填充液滴输送到开口。再填充液滴移动到通道或柱中以占据先前被提取的液滴占据的区域。这防止了通道内的颗粒或分子带的变形或混合，并且防止流体系统的任何部分的排出。

2. 发明授权

US07458661B2 Method and apparatus for promoting the complete transfer of liquid drops from a nozzle 有权
标题翻译：促进液滴从喷嘴完全转移的方法和装置
公开(公告)号：US07458661B2
公开(公告)日：2008-12-02
申请号：US11275668
申请日：2006-01-23
申请人： Chang-Jin Kim , Uichong Brandon Yi
发明人： Chang-Jin Kim , Uichong Brandon Yi
IPC分类号： B41J2/14 , B41J2/16
CPC分类号： B41J2/14 , B41J2/005 , B41J2/16 , B41J2/1628 , B41J2/1629 , B41J2/1631 , B41J2/1642 , B41J2/1645 , B41J2002/14395 , B41J2002/14475
摘要： A printhead device for transferring liquid droplets from a nozzle includes a liquid source coupled to a nozzle via a microchannel. The nozzle is formed from an orifice having an inner circumferential surface, wherein at least a portion of the inner circumferential surface is serrated. Liquid droplets are transported from the source to the nozzle using a liquid droplet driver (e.g., employing a plurality of driving electrodes). Transfer of droplets to another surface can be accomplished by contacting a bulging droplet in the nozzle with a printing surface. The surface and/or nozzle are then moved relative to one another to effectuate complete transfer of the liquid drop from the nozzle.
摘要翻译：用于从喷嘴传送液滴的打印头装置包括通过微通道联接到喷嘴的液体源。喷嘴由具有内圆周表面的孔形成，其中内圆周表面的至少一部分是锯齿状的。使用液滴驱动器（例如，采用多个驱动电极）将液滴从源传输到喷嘴。将液滴转移到另一个表面可以通过将喷嘴中的凸起液滴与印刷表面接触来实现。然后表面和/或喷嘴相对于彼此移动以实现液滴从喷嘴的完全转移。

3. 发明授权

US07919330B2 Method of improving sensor detection of target molcules in a sample within a fluidic system 有权
标题翻译：改进流体系统中样品中靶标的传感器检测方法
公开(公告)号：US07919330B2
公开(公告)日：2011-04-05
申请号：US11917655
申请日：2006-06-15
申请人： Peter Patrick de Guzman , Wayne Po-Wen Liu , Uichong Brandon Yi , Chang-Jin Kim
发明人： Peter Patrick de Guzman , Wayne Po-Wen Liu , Uichong Brandon Yi , Chang-Jin Kim
IPC分类号： G01N33/558
CPC分类号： G01N33/54373 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2200/0605 , B01L2200/0678 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2400/0427 , Y10T436/10 , Y10T436/25
摘要： Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve the statistical precision of the analyses.
摘要翻译：公开了改进微流体测定的方法。通过使用无水滴蒸发作为分析物浓度步骤（增强信号）和重复通过洗涤液滴来减少非特异性结合（降噪）的手段，可以改进测定（更好的信噪比）。此外，多次大规模并行分析提高了分析的统计精度。

4. 发明申请

US20090014394A1 DROPLET EXTRACTION FROM A LIQUID COLUMN FOR ON-CHIP MICROFLUIDICS 有权
标题翻译：用于片上微流控液滴的液滴萃取
公开(公告)号：US20090014394A1
公开(公告)日：2009-01-15
申请号：US12090922
申请日：2006-10-19
申请人： Uichong Brandon Yi , Wayne Liu , Chang-Jin Kim
发明人： Uichong Brandon Yi , Wayne Liu , Chang-Jin Kim
IPC分类号： B01D17/00
CPC分类号： B01L3/502 , B01L3/502761 , B01L3/502792 , B01L2200/027 , B01L2200/10 , B01L2300/0816 , B01L2300/089 , B01L2300/161 , B01L2400/0427 , B01L2400/0469 , G01N1/10 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A refill droplet facilitates the extraction of a droplet laterally from a channel in a microfluidic apparatus. Such extraction allows a discrete band of separated particles or solute molecules to be excised from a fluid stream and processed and analyzed separately. An extraction point is located along the length of the channel and includes an EWOD surface or similar microfluidic technology to extract a droplet. An opening in the channel opposite the extraction means is equipped with microfluidic technology to transport a refill droplet to the opening. The refill droplet is moved into the channel or column to occupy the area previously occupied by the extracted droplet. This prevents distortion or mixing of the bands of particles or molecules within the channel and prevents the draining of any portion of the fluidic system.
摘要翻译：补充液滴有助于从微流体装置中的通道横向提取液滴。这种提取允许分离的颗粒或溶质分子的离散带从流体流中切除并分开处理和分析。提取点沿着通道的长度定位并且包括用于提取液滴的EWOD表面或类似的微流体技术。与提取装置相对的通道中的开口配备有微流体技术以将再填充液滴输送到开口。再填充液滴移动到通道或柱中以占据先前被提取的液滴占据的区域。这防止了通道内的颗粒或分子带的变形或混合，并且防止流体系统的任何部分的排出。

5. 发明申请

US20120148931A1 SELF-PUMPING MEMBRANELESS FUEL CELL 有权
标题翻译：自吸式无膜燃料电池
公开(公告)号：US20120148931A1
公开(公告)日：2012-06-14
申请号：US13325451
申请日：2011-12-14
申请人： Chang-Jin Kim , Janet Hur , Desheng Meng
发明人： Chang-Jin Kim , Janet Hur , Desheng Meng
IPC分类号： H01M8/04 , H01M8/24
CPC分类号： H01M8/04201 , H01M8/04186 , H01M8/2455 , H01M8/2459 , Y02E60/50
摘要： The present invention is directed to a device, and method of operation, for a fuel cell which uses bubble-based pumping to self-pump the fuel to the anode, and a single, common channel separating the anode from the cathode through which a mixed fuel and electrolyte flow. The fuel cell includes a single channel having two of its sides formed by the anode and the cathode, each having a suitable catalyst. A bubble generating region is formed in the anode and cathode reaction area of the channel. A one-way valve is located upstream of the bubble generating region. A vent for venting bubbles is disposed over a portion of the channel downstream of the bubble generating region. The fuel cell may be advantageously used to build miniature fuel cells for miniature electronic devices, or scaled to build larger fuel cells for larger electronic devices.
摘要翻译：本发明涉及一种用于燃料电池的装置和操作方法，所述燃料电池使用基于气泡的泵送将燃料自身泵送到阳极，以及将阳极与阴极分开的单个公共通道，混合燃料和电解液流。燃料电池包括单个通道，其两侧由阳极和阴极形成，每个具有合适的催化剂。在通道的阳极和阴极反应区域中形成气泡生成区域。单向阀位于气泡生成区域的上游。用于排出气泡的排气口设置在气泡生成区域下游的通道的一部分上。燃料电池可以有利地用于构建用于微型电子设备的微型燃料电池，或者缩放以构建用于较大电子设备的较大燃料电池。

6. 发明申请

US20110171518A1 Three dimensional Battery Architectures and Methods of Making Same 审中-公开
标题翻译：三维电池结构及其制作方法
公开(公告)号：US20110171518A1
公开(公告)日：2011-07-14
申请号：US13052596
申请日：2011-03-21
申请人： Bruce Dunn , Jeffrey W. Long , Debra R. Rolison , Henry S. White , Fred Wudl , Sarah H. Tolbert , Chang-Jin Kim
发明人： Bruce Dunn , Jeffrey W. Long , Debra R. Rolison , Henry S. White , Fred Wudl , Sarah H. Tolbert , Chang-Jin Kim
IPC分类号： H01M4/32 , H01M4/38 , H01M2/02 , H01M10/04
CPC分类号： H01M10/0525 , H01M4/04 , H01M4/244 , H01M4/32 , H01M4/75 , H01M10/0436 , H01M10/058 , H01M2300/0025 , H01M2300/0085 , Y10T29/49108
摘要： A three-dimensional electrode structure for use in a battery comprising a porous three-dimensional substrate formed from a first electrically conductive material, an ion-conducting dielectric material disposed on the porous three dimensional substrate, and a second electrically conductive material disposed on the ion-conducting dielectric material, wherein the ion-conducting dielectric material separates the first electrically conductive material from the second electrically conductive material.
摘要翻译：一种用于电池的三维电极结构，包括由第一导电材料形成的多孔三维基板，设置在多孔三维基板上的离子传导电介质材料和设置在离子上的第二导电材料导电介电材料，其中所述离子传导电介质材料将所述第一导电材料与所述第二导电材料分离。

7. 发明授权

US07976286B2 Method and apparatus for pumping liquids using directional growth and elimination bubbles 有权
标题翻译：使用方向生长和消除气泡来泵送液体的方法和装置
公开(公告)号：US07976286B2
公开(公告)日：2011-07-12
申请号：US11814162
申请日：2006-01-23
申请人： Chang-Jin Kim , De-Sheng Meng
发明人： Chang-Jin Kim , De-Sheng Meng
IPC分类号： F04F1/18 , H01M8/00
CPC分类号： F04B19/24 , F04B19/006 , H01M8/04201 , H01M8/1011 , Y02E60/523
摘要： A method and device for the pumping of liquids utilizes the directional growth and elimination of gaseous vesicles or bubbles to provide the motive or pumping force. In one embodiment, the pumping device is a microfluidic pumping mechanism having a channel, a bubble generator for generating a plurality of bubbles within the channel, and a venting membrane disposed over a portion of the channel downstream of the bubble generator. A one-way valve or directional resistance feature is positioned upstream of the bubble generator to introduce directional transport of bubbles within the channel. The method and device may be integrated into micro fuel cells with organic liquid fuel such that liberated gaseous bubbles may be utilized to deliver fresh fuel or circulate reusable fuel without any power-consuming components.
摘要翻译：用于泵送液体的方法和装置利用气泡或气泡的定向生长和消除以提供动力或泵送力。在一个实施例中，泵送装置是具有通道的微流体泵送机构，用于在通道内产生多个气泡的气泡发生器，以及设置在气泡发生器下游的通道的一部分上的通气膜。单向阀或方向阻力特征位于气泡发生器的上游，以引导通道内气泡的定向输送。该方法和装置可以用有机液体燃料集成到微型燃料电池中，使得释放的气泡可用于输送新鲜燃料或循环可重复使用的燃料而没有任何功耗成分。

8. 发明申请

US20090283407A1 METHOD FOR USING MAGNETIC PARTICLES IN DROPLET MICROFLUIDICS 有权
标题翻译：使用磁性颗粒在滴眼液微流体中的方法
公开(公告)号：US20090283407A1
公开(公告)日：2009-11-19
申请号：US12465935
申请日：2009-05-14
申请人： Gaurav Jitendra Shah , Chang-Jin Kim
发明人： Gaurav Jitendra Shah , Chang-Jin Kim
IPC分类号： B03C1/005 , B01D57/02
CPC分类号： B03C1/01 , B01D57/02 , B01D61/427 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/161 , B01L2400/0418 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0436 , B01L2400/0475 , B03C1/288 , B03C5/026 , B03C2201/18 , G01N33/54333
摘要： Methods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of the meniscus lifts the MBs off the solid surface and frees them from various surface forces acting on the MBs. A second method uses chemical additives to reduce the adhesion of MBs to surfaces. Both methods allow the MBs on a solid surface to be effectively moved by magnetic force. Droplets may be driven by various methods or techniques including, for example, electrowetting, electrostatic, electromechanical, electrophoretic, dielectrophoretic, electroosmotic, thermocapillary, surface acoustic, and pressure.
摘要翻译：公开了在基于液滴的（或数字）微流体中使用磁性颗粒或珠粒（MB）的方法。该方法可用于富集或分离过程。第一种方法使用液滴弯液面来帮助液滴微流控操作期间MB的磁集合和定位。半月板的扫掠运动将MB离开固体表面，并将它们从作用在MB上的各种表面力释放出来。第二种方法使用化学添加剂来减少MB对表面的粘附。两种方法都可以通过磁力有效地移动固体表面上的MB。液滴可以通过各种方法或技术来驱动，包括例如电润湿，静电，机电，电泳，介电泳，电渗，热毛细管，表面声和压力。

9. 发明授权

US09266076B2 Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip 有权
标题翻译：用于芯片上液滴的电操作的实时反馈控制的方法和装置
公开(公告)号：US09266076B2
公开(公告)日：2016-02-23
申请号：US12513157
申请日：2007-11-01
申请人： Chang-Jin Kim , Jian Gong
发明人： Chang-Jin Kim , Jian Gong
IPC分类号： B01F13/00 , B01L3/00
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/089 , B01L2400/0427
摘要： A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase/decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.
摘要翻译：用于产生液滴的装置包括：基底，其包括被配置为保持液体并包括第一电极的储存部位，包括第二电极的液滴产生位置和设置在储存器位置和液滴产生位点之间并且包含电极。该装置包括可操作地耦合到第一，第二和第三电极的控制电路。控制电路被配置为测量电极上的流体体积，并独立地调节所施加的电压以增加/减少流体的量。该设备可以将流体移动到创建现场或返回到油库位置。当流体体积处于期望值或范围时，驱动电压被传送到第一和第二电极以形成新的液滴。该装置可产生具有小于电极的均匀或用户限定尺寸的液滴。

10. 发明授权

US08883014B2 Monolithically formed EWOD device and method of making the same 有权
标题翻译：整体形成的EWOD设备及其制作方法
公开(公告)号：US08883014B2
公开(公告)日：2014-11-11
申请号：US13486777
申请日：2012-06-01
申请人： Wyatt C. Nelson , Chang-Jin Kim
发明人： Wyatt C. Nelson , Chang-Jin Kim
IPC分类号： C23F1/00 , B81C1/00 , B01L3/00
CPC分类号： B81C1/00119 , B01L3/502707 , B01L3/502792 , B01L2400/0427 , B81B2201/058
摘要： A monolithic fabrication method of parallel-plate electrowetting-on-dielectric (EWOD) chips for digital microfluidics of picoliter droplets is disclosed. Instead of assembling a second substrate to form a top plate, the top plate is generated in situ as a thin-film membrane that forms a monolithic cavity having a gap height on the order of micrometers with excellent accuracy and uniformity. The membrane is embedded with EWOD driving electrodes and confines droplets against the device substrate to perform digital microfluidic operations. Two main attributes of the monolithic architecture that distinguish it from tradition methods are: (i) it enables excellent control of droplet dimensions down to the micrometer scale, and (ii) it does not require the typical alignment and assembly steps of the two plates.
摘要翻译：公开了一种用于皮秒液滴的数字微流体的平行板电润湿介电（EWOD）芯片的单片制造方法。代替组装第二基板以形成顶板，顶板作为薄膜膜原位产生，其形成具有高度精确度和均匀性的间隔高度为微米级的单片空腔。膜被嵌入EWOD驱动电极并且将液滴限制在器件衬底上以执行数字微流控操作。整体式结构的两个主要特征与传统方法区分开来：（i）它可以很好地控制液滴尺寸，直到微米级，以及（ii）它不需要两个板的典型对准和组装步骤。

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