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1. 发明申请

US20110171518A1 Three dimensional Battery Architectures and Methods of Making Same 审中-公开
标题翻译：三维电池结构及其制作方法
公开(公告)号：US20110171518A1
公开(公告)日：2011-07-14
申请号：US13052596
申请日：2011-03-21
申请人： Bruce Dunn , Jeffrey W. Long , Debra R. Rolison , Henry S. White , Fred Wudl , Sarah H. Tolbert , Chang-Jin Kim
发明人： Bruce Dunn , Jeffrey W. Long , Debra R. Rolison , Henry S. White , Fred Wudl , Sarah H. Tolbert , Chang-Jin Kim
IPC分类号： H01M4/32 , H01M4/38 , H01M2/02 , H01M10/04
CPC分类号： H01M10/0525 , H01M4/04 , H01M4/244 , H01M4/32 , H01M4/75 , H01M10/0436 , H01M10/058 , H01M2300/0025 , H01M2300/0085 , Y10T29/49108
摘要： A three-dimensional electrode structure for use in a battery comprising a porous three-dimensional substrate formed from a first electrically conductive material, an ion-conducting dielectric material disposed on the porous three dimensional substrate, and a second electrically conductive material disposed on the ion-conducting dielectric material, wherein the ion-conducting dielectric material separates the first electrically conductive material from the second electrically conductive material.
摘要翻译：一种用于电池的三维电极结构，包括由第一导电材料形成的多孔三维基板，设置在多孔三维基板上的离子传导电介质材料和设置在离子上的第二导电材料导电介电材料，其中所述离子传导电介质材料将所述第一导电材料与所述第二导电材料分离。

2. 发明授权

US07849581B2 Nanopore electrode, nanopore membrane, methods of preparation and surface modification, and use thereof 有权
标题翻译：纳米孔电极，纳米孔膜，制备方法和表面改性及其用途
公开(公告)号：US07849581B2
公开(公告)日：2010-12-14
申请号：US11744154
申请日：2007-05-03
申请人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin , Gangli Wang
发明人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin , Gangli Wang
IPC分类号： G01R31/28
CPC分类号： B01D71/04 , B01D67/006 , B01D2325/021 , Y10S977/904 , Y10S977/953 , Y10T29/49 , Y10T29/49002 , Y10T29/49004 , Y10T29/49826
摘要： Provided are fabrication, characterization and application of a nanodisk electrode, a nanopore electrode and a nanopore membrane. These three nanostructures share common fabrication steps. In one embodiment, the fabrication of a disk electrode involves sealing a sharpened internal signal transduction element (“ISTE”) into a substrate, followed by polishing of the substrate until a nanometer-sized disk of the ISTE is exposed. The fabrication of a nanopore electrode is accomplished by etching the nanodisk electrode to create a pore in the substrate, with the remaining ISTE comprising the pore base. Complete removal of the ISTE yields a nanopore membrane, in which a conical shaped pore is embedded in a thin membrane of the substrate.
摘要翻译：提供了纳米棒电极，纳米孔电极和纳米孔膜的制造，表征和应用。这三种纳米结构具有共同的制造步骤。在一个实施例中，盘形电极的制造包括将锐化的内部信号转导元件（“ISTE”）密封到衬底中，随后抛光衬底，直到暴露ISTE的纳米尺寸的盘。纳米孔电极的制造通过蚀刻纳米盘电极以在衬底中产生孔而实现，剩余的ISTE包含孔基。完全去除ISTE产生纳米孔膜，其中锥形孔被嵌入在基底的薄膜中。

3. 发明授权

US08470247B2 Surfaces resistant to non-specific protein adsorption and methods of producing the same 有权
标题翻译：表面抗非特异性蛋白质吸附及其制备方法
公开(公告)号：US08470247B2
公开(公告)日：2013-06-25
申请号：US12254740
申请日：2008-10-20
申请人： Joel M. Harris , Henry S. White , Joshua R. Wayment , Ryan J. White
发明人： Joel M. Harris , Henry S. White , Joshua R. Wayment , Ryan J. White
IPC分类号： G01N15/06
CPC分类号： B05D1/185 , B05D7/52 , B82Y30/00 , B82Y40/00
摘要： A method of preventing non-specific adsorption of proteins onto a surface can include providing a substrate that has a surface on which surface groups are attached. A solution can be applied to the surface that includes a protective reagent having a terminal functional group exhibiting a dipole moment. A monolayer comprising the protective reagent is assembled on the surface by reacting the protective reagent with the surface groups, thereby creating a protected surface. The protective reagent alone is sufficient to confer to the protected surface an increased resistance to adsorption of proteins.
摘要翻译：防止蛋白质非特异性吸附到表面上的方法可以包括提供具有表面连接表面的基底。可以将溶液施加到包括具有显示偶极矩的末端官能团的保护试剂的表面上。通过使保护试剂与表面基团反应，将包含保护试剂的单层组装在表面上，从而形成受保护的表面。单独的保护剂足以赋予受保护的表面增加的蛋白质吸附抗性。

4. 发明申请

US20100038243A1 NANOPORE BASED ION-SELECTIVE ELECTRODES 有权
标题翻译：基于NANOPORE的离子选择性电极
公开(公告)号：US20100038243A1
公开(公告)日：2010-02-18
申请号：US11852061
申请日：2007-09-07
申请人： Henry S. White , Ryan J. White , Richard B. Brown , Hakhyun Nam , Jun Ho Shim
发明人： Henry S. White , Ryan J. White , Richard B. Brown , Hakhyun Nam , Jun Ho Shim
IPC分类号： G01N27/26 , B29C65/00 , H01B13/00
CPC分类号： G01N27/333 , Y10T156/10
摘要： Nanopore based ion-selective electrodes and methods of their manufacture as well as methods for their use are disclosed and described. The nanopore based ion-selective electrode can include a pore being present in a solid material and having a nanosize opening in the solid material, a metal conductor disposed inside the pore opposite the opening in the solid material, a reference electrode material contacting said metal conductor and disposed inside the pore, a conductive composition in contact with the reference electrode and disposed in the pore, and an ion-selective membrane. The ion-selective membrane can be configured to isolate the metal conductor, reference electrode material, and conductive composition together within the pore.
摘要翻译：公开和描述了基于纳米孔的离子选择性电极及其制造方法及其使用方法。基于纳米孔的离子选择性电极可以包括存在于固体材料中并在固体材料中具有纳米尺寸开口的孔，设置在与固体材料中的开口相对的孔内的金属导体，与金属导体接触的参考电极材料并且设置在孔内，与参考电极接触并设置在孔中的导电组合物和离子选择性膜。离子选择性膜可以被配置为在孔内将金属导体，参比电极材料和导电组合物隔离在一起。

5. 发明授权

US09005425B2 Detection of nucleic acid lesions and adducts using nanopores 有权
标题翻译：使用纳米孔检测核酸损伤和加合物
公开(公告)号：US09005425B2
公开(公告)日：2015-04-14
申请号：US13227212
申请日：2011-09-07
申请人： Cynthia J. Burrows , Henry S. White , Ryuji Kawano , Aaron M. Fleming , Na An
发明人： Cynthia J. Burrows , Henry S. White , Ryuji Kawano , Aaron M. Fleming , Na An
IPC分类号： G01N27/327 , G01N33/487 , B82Y15/00 , C12Q1/68
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6827 , C12Q1/6869 , G01N27/44704 , C12Q2525/101 , C12Q2565/631
摘要： Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
摘要翻译：公开和描述了用于检测修饰的核酸碱基的方法，系统和化合物。所述方法提供了检测核酸损伤并且可以包括将核酸加合物引导到通道中，其中所述核酸加合物包括具有损伤的核酸和与所述病变处的所述核酸（110）偶联的电流调节化合物，以及响应于所述电流调制化合物测量通过所述通道的电流变化以检测所述损伤（112）。该方法可任选地包括形成核酸加合物。还提供了用于鉴定核酸链的至少一部分中的重复核苷酸的数量的方法，在核酸内分配登记标记的方法，以及从核酸获得序列信息的方法，包括分配登记标记在核酸上。

6. 发明授权

US08123922B2 Nanopore based ion-selective electrodes 有权
标题翻译：基于纳米孔的离子选择性电极
公开(公告)号：US08123922B2
公开(公告)日：2012-02-28
申请号：US11852061
申请日：2007-09-07
申请人： Henry S. White , Ryan J. White , Richard B. Brown , Hakhyun Nam , Jun Ho Shim
发明人： Henry S. White , Ryan J. White , Richard B. Brown , Hakhyun Nam , Jun Ho Shim
IPC分类号： G01N27/333
CPC分类号： G01N27/333 , Y10T156/10
摘要： Nanopore based ion-selective electrodes and methods of their manufacture as well as methods for their use are disclosed and described. The nanopore based ion-selective electrode can include a pore being present in a solid material and having a nanosize opening in the solid material, a metal conductor disposed inside the pore opposite the opening in the solid material, a reference electrode material contacting said metal conductor and disposed inside the pore, a conductive composition in contact with the reference electrode and disposed in the pore, and an ion-selective membrane. The ion-selective membrane can be configured to isolate the metal conductor, reference electrode material, and conductive composition together within the pore.
摘要翻译：公开和描述了基于纳米孔的离子选择性电极及其制造方法及其使用方法。基于纳米孔的离子选择性电极可以包括存在于固体材料中并在固体材料中具有纳米尺寸开口的孔，设置在与固体材料中的开口相对的孔内的金属导体，与金属导体接触的参考电极材料并且设置在孔内，与参考电极接触并设置在孔中的导电组合物和离子选择性膜。离子选择性膜可以被配置为在孔内将金属导体，参比电极材料和导电组合物隔离在一起。

7. 发明申请

US20100025263A1 NANOPORE PARTICLE ANALYZER, METHOD OF PREPARATION AND USE THEREOF 审中-公开
标题翻译：纳米粒子分析仪，其制备方法和用途
公开(公告)号：US20100025263A1
公开(公告)日：2010-02-04
申请号：US11743536
申请日：2007-05-02
申请人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin
发明人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin
IPC分类号： C12Q1/06 , G01N27/28 , G01N27/26 , B23P11/00
CPC分类号： G01N33/48721 , B82Y15/00 , G01N15/12 , Y10T29/49826
摘要： Provided are the preparation, characterization, and application of a nanopore membrane device. The nanopore device comprises a thin membrane prepared from glass, fused silica, ceramics or quartz, containing one or more nanopores ranging from about 2 nm to about 500 nm. The nanopore is prepared by a template method using sharpened metal wires and the size of the pore opening can be controlled during fabrication by an electrical feedback circuit. The nanopore device is particularly useful for counting and analyzing nanoparticles of radius less than 400 nm.
摘要翻译：提供纳米孔膜装置的制备，表征和应用。纳米孔装置包括由玻璃，熔融石英，陶瓷或石英制备的薄膜，其含有一个或多个范围为约2nm至约500nm的纳米孔。通过使用尖锐金属线的模板法制备纳米孔，并且可以通过电反馈电路在制造期间控制孔隙的尺寸。纳米孔装置对于计数和分析半径小于400nm的纳米粒子是特别有用的。

8. 发明申请

US20080121534A1 NANOPORE ELECTRODE, NANOPORE MEMBRANE, METHODS OF PREPARATION AND SURFACE MODIFICATION, AND USE THEREOF 有权
标题翻译： NANOPORE ELECTRODE，NANOPORE MEMBRANE，METHODS OF PROBARATION AND SURFACE MODIFICATION，AND USE THEREOF
公开(公告)号：US20080121534A1
公开(公告)日：2008-05-29
申请号：US11744154
申请日：2007-05-03
申请人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin , Gangli Wang
发明人： Henry S. White , Bo Zhang , Ryan J. White , Eric N. Ervin , Gangli Wang
IPC分类号： G01N27/26 , B32B38/10 , C23F1/00
CPC分类号： B01D71/04 , B01D67/006 , B01D2325/021 , Y10S977/904 , Y10S977/953 , Y10T29/49 , Y10T29/49002 , Y10T29/49004 , Y10T29/49826
摘要： Provided are fabrication, characterization and application of a nanodisk electrode, a nanopore electrode and a nanopore membrane. These three nanostructures share common fabrication steps. In one embodiment, the fabrication of a disk electrode involves sealing a sharpened internal signal transduction element (“ISTE”) into a substrate, followed by polishing of the substrate until a nanometer-sized disk of the ISTE is exposed. The fabrication of a nanopore electrode is accomplished by etching the nanodisk electrode to create a pore in the substrate, with the remaining ISTE comprising the pore base. Complete removal of the ISTE yields a nanopore membrane, in which a conical shaped pore is embedded in a thin membrane of the substrate.
摘要翻译：提供了纳米棒电极，纳米孔电极和纳米孔膜的制造，表征和应用。这三种纳米结构具有共同的制造步骤。在一个实施例中，盘形电极的制造包括将锐化的内部信号转导元件（“ISTE”）密封到衬底中，随后抛光衬底直至暴露出ISTE的纳米尺寸的盘。纳米孔电极的制造通过蚀刻纳米盘电极以在衬底中产生孔而实现，剩余的ISTE包含孔基。完全去除ISTE产生纳米孔膜，其中锥形孔被嵌入在基底的薄膜中。

9. 发明申请

US20120091005A1 DETECTION OF NUCLEIC ACID LESIONS AND ADDUCTS USING NANOPORES 有权
标题翻译：使用NANOPORES检测核酸乳杆菌和添加剂
公开(公告)号：US20120091005A1
公开(公告)日：2012-04-19
申请号：US13227212
申请日：2011-09-07
申请人： Cynthia J. Burrows , Henry S. White , Ryuji Kawano , Aaron M. Fleming , Na An
发明人： Cynthia J. Burrows , Henry S. White , Ryuji Kawano , Aaron M. Fleming , Na An
IPC分类号： G01N33/559 , C07K2/00 , G01N27/447 , C07H21/00 , C07H23/00 , B82Y99/00 , B82Y5/00
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6827 , C12Q1/6869 , G01N27/44704 , C12Q2525/101 , C12Q2565/631
摘要： Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.
摘要翻译：公开和描述了用于检测修饰的核酸碱基的方法，系统和化合物。所述方法提供了检测核酸损伤并且可以包括将核酸加合物引导到通道中，其中所述核酸加合物包括具有损伤的核酸和与所述病变处的所述核酸（110）偶联的电流调节化合物，以及响应于所述电流调制化合物测量通过所述通道的电流变化以检测所述损伤（112）。该方法可任选地包括形成核酸加合物。还提供了用于鉴定核酸链的至少一部分中的重复核苷酸的数量的方法，在核酸内分配登记标记的方法，以及从核酸获得序列信息的方法，包括分配登记标记在核酸上。

10. 发明申请

US20080218184A1 NANOPORE PLATFORMS FOR ION CHANNEL RECORDINGS AND SINGLE MOLECULE DETECTION AND ANALYSIS 有权
标题翻译：用于离子通道记录的NANOPORE平台和单分子检测和分析
公开(公告)号：US20080218184A1
公开(公告)日：2008-09-11
申请号：US11743472
申请日：2007-05-02
申请人： Henry S. White , Ryan J. White , Eric N. Ervin
发明人： Henry S. White , Ryan J. White , Eric N. Ervin
IPC分类号： G01N27/06 , B32B3/26 , H01T14/00
CPC分类号： G01N33/48721 , B82Y15/00 , Y10T428/249979
摘要： Chemical modification of a glass and fused silica nanopore surfaces results in surface properties that are ideal for localized bilayer formation over a nanopore and subsequent ion channel recording. With no surface modification, one may form a bilayer supported on the glass capillary extending across the nanopore orifice. Changing the surface properties from that of bare glass to a moderately hydrophobic surface produces a lipid monolayer above the glass and spontaneously yields a bilayer across the nanopore orifice, effectively corralling a single protein ion channel in the lipid bilayer region spanning nanopore orifice. The bilayer structure over the modified nanopore is such that current can only flow through the protein ion channel. The protein ion channel is able to diffuse in the bilayer above the pore opening, but cannot leave this area to enter the lipid monolayer. The bilayer formed across the nanopore orifice exhibits high electrical breakdown voltage, is stable to mechanical vibrations, and is long lived. Resistance through the protein channel can be measured electrically and is exploited for stochastic single-molecule detection. Protein ion channels can be inserted and removed from the bilayer by adjusting transmembrane pressure, and adapter molecules can be electrostatically trapped in the ion channel by applying high transmembrane voltages.
摘要翻译：玻璃和熔融二氧化硅纳米孔表面的化学修饰导致表面性质，对于纳米孔上的局部双层形成和随后的离子通道记录是理想的。没有表面改性，可以形成支撑在玻璃毛细管上延伸穿过纳米孔孔的双层。将表面性质从裸玻璃的表面特性改变为适度疏水的表面在玻璃上方产生脂质单层，并自发产生穿过纳米孔孔的双层，有效地将跨越纳米孔孔的脂质双层区域中的单个蛋白质离子通道。改性纳米孔上的双层结构使得电流只能流过蛋白质离子通道。蛋白质离子通道能够在孔开口上方的双层扩散，但不能离开该区域进入脂质单层。跨纳米孔孔形成的双层表现出高的电击穿电压，对于机械振动是稳定的，并且寿命长。通过蛋白质通道的电阻可以被电测量并用于随机单分子检测。蛋白质离子通道可以通过调节跨膜压力从双层插入和移除，并且衔接分子可以通过施加高跨膜电压被静电捕获在离子通道中。

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