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1. 发明申请

US20100096266A1 METHOD AND APPARATUS FOR REAL-TIME FEEDBACK CONTROL OF ELECTRICAL MANIPULATION OF DROPLETS ON CHIP 有权
标题翻译：实时反馈控制方法和装置在芯片上的电磁操作
公开(公告)号：US20100096266A1
公开(公告)日：2010-04-22
申请号：US12513157
申请日：2007-11-01
申请人： Chang-Jin Kim , Jian Gong
发明人： Chang-Jin Kim , Jian Gong
IPC分类号： B01F3/08 , H04N1/034 , B01D57/02
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/089 , B01L2400/0427
摘要： A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase/decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.
摘要翻译：用于产生液滴的装置包括：基底，其包括被配置为保持液体并包括第一电极的储存部位，包括第二电极的液滴产生位置和设置在储存器位置和液滴产生位点之间并且包含电极。该装置包括可操作地耦合到第一，第二和第三电极的控制电路。控制电路被配置为测量电极上的流体体积，并独立地调节所施加的电压以增加/减少流体的量。该设备可以将流体移动到创建现场或返回到油库位置。当流体体积处于期望值或范围时，驱动电压被传送到第一和第二电极以形成新的液滴。该装置可产生具有小于电极的均匀或用户限定尺寸的液滴。

2. 发明申请

US20070023292A1 SMALL OBJECT MOVING ON PRINTED CIRCUIT BOARD 审中-公开
标题翻译：打印电路板上的小物体移动
公开(公告)号：US20070023292A1
公开(公告)日：2007-02-01
申请号：US11460188
申请日：2006-07-26
申请人： Chang-Jin Kim , Jian Gong
发明人： Chang-Jin Kim , Jian Gong
IPC分类号： B03C5/02
CPC分类号： F04B19/006 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427
摘要： A printed circuit board based digital or droplet microfluidic system and method for producing such microfluidic system are disclosed. The digital microfluidic device comprises a printed circuit board having a substrate and a plurality of electrode pads disposed on the top surface of the substrate in a rectangular array. A via extends from each electrode pad through the substrate to other locations on the substrate . A dielectric layer is disposed on the electrode pads. Droplets may be manipulated using electrowetting principles and others by applying a voltage to the desired electrodes. Each electrode pad can be controlled directly and independently from the other electrode pads to modify the surface wettability of the dielectric layer in the vicinity of the electrode pad by applying a voltage to the desired electrode pad(s). In this way, droplets may be formed, moved, mixed, and/or divided or other small objects manipulated while in air or immersed in a liquid on the dielectric surface.
摘要翻译：公开了一种用于生产这种微流体系统的基于印刷电路板的数字或液滴微流体系统和方法。数字微流体装置包括具有衬底的印刷电路板和以矩形阵列布置在衬底的顶表面上的多个电极焊盘。通孔从每个电极焊盘穿过衬底延伸到衬底上的其它位置。电介质层设置在电极焊盘上。可以使用电润湿原理和其它步骤通过向期望的电极施加电压来操纵液滴。每个电极焊盘可以直接和独立于其他电极焊盘进行控制，以通过向期望的电极焊盘施加电压来改变电极焊盘附近的电介质层的表面润湿性。以这种方式，液滴可以被形成，移动，混合和/或分割，或者在空气中被操纵的其它小物体或浸在电介质表面上的液体中。

3. 发明授权

US09266076B2 Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip 有权
标题翻译：用于芯片上液滴的电操作的实时反馈控制的方法和装置
公开(公告)号：US09266076B2
公开(公告)日：2016-02-23
申请号：US12513157
申请日：2007-11-01
申请人： Chang-Jin Kim , Jian Gong
发明人： Chang-Jin Kim , Jian Gong
IPC分类号： B01F13/00 , B01L3/00
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/089 , B01L2400/0427
摘要： A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase/decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.
摘要翻译：用于产生液滴的装置包括：基底，其包括被配置为保持液体并包括第一电极的储存部位，包括第二电极的液滴产生位置和设置在储存器位置和液滴产生位点之间并且包含电极。该装置包括可操作地耦合到第一，第二和第三电极的控制电路。控制电路被配置为测量电极上的流体体积，并独立地调节所施加的电压以增加/减少流体的量。该设备可以将流体移动到创建现场或返回到油库位置。当流体体积处于期望值或范围时，驱动电压被传送到第一和第二电极以形成新的液滴。该装置可产生具有小于电极的均匀或用户限定尺寸的液滴。

4. 发明授权

US09322055B2 System and method for determining copies-per-unit-volume using PCR and flow control of droplets 有权
标题翻译：使用PCR和液滴的流量控制来确定每单位体积份数的系统和方法
公开(公告)号：US09322055B2
公开(公告)日：2016-04-26
申请号：US14009304
申请日：2012-03-30
申请人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
发明人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , G01N21/6486 , C12Q2537/16 , C12Q2563/143 , C12Q2563/159 , C12Q2565/626
摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.
摘要翻译：提供了用于定量样品中靶核酸的方法和系统。该方法包括形成多个离散的样本部分。多个离散样品部分中的每一个包含样品的一部分和反应混合物。该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。至少一个离散加工的样品部分含有核酸扩增反应产物。从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

5. 发明授权

US08214096B2 Apparatus and method for controlling an accelerator for electric vehicles 有权
标题翻译：用于控制电动车辆的加速器的装置和方法
公开(公告)号：US08214096B2
公开(公告)日：2012-07-03
申请号：US12518731
申请日：2007-12-11
申请人： Yingwu Xu , Xuguang Zhou , Xiaohua Tang , Jian Gong , Nan Liu , Guangming Yang , Ming Yu
发明人： Yingwu Xu , Xuguang Zhou , Xiaohua Tang , Jian Gong , Nan Liu , Guangming Yang , Ming Yu
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： B60L15/20 , B60L2240/12 , B60L2240/16 , B60L2240/423 , B60L2250/28 , B60L2270/145 , Y02T10/645 , Y02T10/7275 , Y10S903/914 , Y10T477/23 , Y10T477/30 , Y10T477/635 , Y10T477/679
摘要： The present invention provides an apparatus and method for controlling an accelerator for electric vehicles. The method comprises steps of: acquiring an actual accelerator pedal depth value and a current vehicle speed; determining a maximum output torque of motor under the current vehicle speed based on the current vehicle speed; and controlling the output torque of motor in such a way that the growth rate of the output torque higher than that of the actual accelerator pedal depth value at the beginning and then closed to that of the actual accelerator pedal depth value during the actual accelerator pedal depth value growing. The invention makes the output torque grown rapidly within the shallow range of accelerator pedal depth, while makes the output torque grown closed to that of the accelerator pedal depth within the relative deep range of accelerator pedal depth. Thus during the initial stage of acceleration, the vehicle may rapidly output a bigger torque, with an excellent dynamic response, to improve the driving comfort.
摘要翻译：本发明提供一种用于控制电动车辆的加速器的装置和方法。该方法包括以下步骤：获取实际加速踏板深度值和当前车速; 基于当前车速确定当前车速下的电动机的最大输出转矩; 并且以这样的方式控制电动机的输出转矩，使得输出转矩的增长率高于开始时的实际加速器踏板深度值的增长速率，然后在实际加速器踏板深度期间闭合至实际加速器踏板深度值价值增长。本发明使得输出扭矩在加速踏板深度的浅范围内快速生长，同时使加速踏板深度的相对深度范围内的输出转矩增加到加速踏板深度的输出转矩。因此，在加速的初始阶段，车辆可以快速输出更大的转矩，具有出色的动态响应，以提高驾驶舒适性。

6. 发明授权

US08207701B2 Control method of electromotor 有权
标题翻译：电动机控制方法
公开(公告)号：US08207701B2
公开(公告)日：2012-06-26
申请号：US12447429
申请日：2006-10-31
申请人： Xiaohua Tang , Xuguang Zhou , Hongbin Luo , Ming Yu , Nan Liu , Jian Gong , Guangming Yang
发明人： Xiaohua Tang , Xuguang Zhou , Hongbin Luo , Ming Yu , Nan Liu , Jian Gong , Guangming Yang
IPC分类号： H02P23/00
CPC分类号： H02P29/0016 , G01D21/00 , G01P3/48 , H02P21/22
摘要： A control method of the electromotor comprises: setting a target alternating axis current based on the rotor angular velocity of the electromotor and a target direct axis current based on the torque of the motor; simultaneously detecting three-phase currents and current rotor position angle of the electromotor; converting the three-phase currents to an actual alternating axis current and an actual direct axis current by Park and Clark conversions; inputting the difference between the target current and the actual current to a current loop, outputting the required direct axis current and the required alternating axis current; determining the three phase voltages according to the required direct axis current and alternating axis current and the angle of the electromotor rotor position; obtaining PWM control waveform through three-phase voltages, wherein said PWM control waveform is configured to control the conversion from direct current to alternating current and drives the electromotor.
摘要翻译：电动机的控制方法包括：基于电动机的转矩，基于电动机的转子角速度和目标直轴电流来设定目标交变轴电流; 同时检测电动机的三相电流和电流转子位置角; 通过Park和Clark转换将三相电流转换为实际交流轴电流和实际直轴电流; 将目标电流和实际电流之间的差分输入到电流回路，输出所需的直轴电流和所需的交变轴电流; 根据所需的直轴电流和交流轴电流以及电动机转子位置的角度确定三相电压; 通过三相电压获得PWM控制波形，其中所述PWM控制波形被配置为控制从直流到交流的转换并驱动电动机。

7. 发明授权

US08084592B2 Multivalent entrain-and-amplify immunotherapeutics for carcinoma 有权
标题翻译：多重夹带和扩增免疫治疗癌症
公开(公告)号：US08084592B2
公开(公告)日：2011-12-27
申请号：US11455279
申请日：2006-06-16
申请人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
发明人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
IPC分类号： C07H21/02
CPC分类号： A61K39/0011 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K39/00 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70539 , C12N15/8509
摘要： The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译：本发明提供了通过向有需要的受试者提供包含质粒和肽或其类似物的免疫原性组合来治疗细胞增殖性疾病如癌症的方法。在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。

8. 发明授权

US08073583B2 Apparatus and method for controlling energy feedback for electric vehicle 有权
标题翻译：用于控制电动汽车能量反馈的装置和方法
公开(公告)号：US08073583B2
公开(公告)日：2011-12-06
申请号：US12521038
申请日：2007-12-21
申请人： Xiaohua Tang , Xuguang Zhou , Ming Yu , Jian Gong , Nan Liu , Guangming Yang
发明人： Xiaohua Tang , Xuguang Zhou , Ming Yu , Jian Gong , Nan Liu , Guangming Yang
IPC分类号： G05D1/00
CPC分类号： B60L7/18 , B60L7/14 , B60L11/1803 , B60L15/2009 , B60L2240/12 , B60L2240/423 , B60L2240/427 , B60L2250/26 , B60W10/08 , B60W10/18 , B60W2540/12 , Y02T10/645 , Y02T10/7005 , Y02T10/7275
摘要： An apparatus and method for controlling energy feedback for electric vehicles includes acquiring an accelerator-pedal travel value, a brake-pedal travel value and a current vehicle speed value, and determining whether the brake-pedal travel value is equal to 0%. Feedback torque based on the current vehicle speed value and the brake-pedal travel value with various conditions is then calculated. Mechanical energy generated by the feedback torque T is converted into electric energy and transmitted to battery of the electric vehicle for storing. Accordingly, the endurance mileage of electric vehicle may be effectively prolonged and the utilization efficiency of battery is improved.
摘要翻译：用于控制电动车辆的能量反馈的装置和方法包括获取加速踏板行驶值，制动踏板行程值和当前车速值，以及确定制动踏板行程值是否等于0％。然后计算出基于当前车速值和各种条件的制动踏板行程值的反馈转矩。由反馈转矩T产生的机械能转换为电能并传递到电动车辆的蓄电池。因此，能够有效地延长电动汽车的耐久性里程，提高电池的利用效率。

9. 发明申请

US20100303842A1 PEPTIDE ANALOGUES 审中-公开
标题翻译：肽类似物
公开(公告)号：US20100303842A1
公开(公告)日：2010-12-02
申请号：US12406022
申请日：2009-03-17
申请人： Liping Liu , Adrian Bot , Jian Gong , David Diamond
发明人： Liping Liu , Adrian Bot , Jian Gong , David Diamond
IPC分类号： A61K39/00 , C07K7/06 , C07H21/04 , A61P37/02
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0008 , A61K48/00 , A61K2035/122 , A61K2039/53 , A61K2039/57 , A61K2039/645 , C07K7/06 , C07K14/47 , C07K14/70503
摘要： Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.
摘要翻译：一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代，并且可以赋予改进的，修饰的或有用的免疫学特性。此外，公开了类似物类别，其中各种取代包括非标准残基正亮氨酸和/或正缬氨酸。

10. 发明申请

US20100210411A1 Clutch Engaging Control Method and Control System in Hybrid Power Output Device 有权
标题翻译：混合动力输出装置离合器联动控制方法与控制系统
公开(公告)号：US20100210411A1
公开(公告)日：2010-08-19
申请号：US12670499
申请日：2008-05-22
申请人： Xiaohua Tang , Nan Liu , Jian Gong , Ming Yu , Yingwu Xu , Kai Liu , Xianhong Jiang , Qiaoqiao Wu
发明人： Xiaohua Tang , Nan Liu , Jian Gong , Ming Yu , Yingwu Xu , Kai Liu , Xianhong Jiang , Qiaoqiao Wu
IPC分类号： B60W10/02 , B60W20/00
CPC分类号： B60W20/40 , B60K1/02 , B60K6/442 , B60L2240/421 , B60W10/02 , B60W10/06 , B60W10/08 , B60W20/00 , B60W2510/081 , B60W2510/082 , B60W2710/081 , B60W2710/082 , Y02T10/6234 , Y02T10/6286 , Y02T10/642 , Y10T477/26
摘要： The present invention provides a clutch engaging control method in a hybrid power output device, wherein the device comprises an engine, a first motor, a clutch and a second motor that are connected in sequence, a battery, and a speed reducing mechanism and a drive shaft that are connected to the output end of the second motor; the method comprises: (a) detecting the rotation speed ω2 of the second motor and setting the rotation speed ω2 as the target rotation speed ω0 of the first motor, when the vehicle is driven by the second motor and the engine is required to be started to provide assistance to the second motor; (b) starting the first motor to drive the engine, and controlling the actual rotation speed ω1 of the first motor to be close to the target rotation speed ω0; (c) switching the state of the first motor from a driving motor to a power generator when the actual rotation speed ω1 of the first motor is approximately equal to the target rotation speed ω0; and (d) engaging the clutch. The method can improve the dynamic response time of the engine and suppress impact in the clutch engaging process. The present invention further provides a clutch engaging control system in a hybrid power output device.
摘要翻译：本发明提供了一种混合动力输出装置中的离合器接合控制方法，其中，该装置包括依次连接的发动机，第一马达，离合器和第二马达，电池和减速机构以及驱动轴，其连接到第二电动机的输出端; 该方法包括：（a）当车辆由第二马达驱动并且需要启动发动机时，检测第二马达的转速ω2和将转速ω2设定为第一马达的目标转速ω0 为第二台电机提供协助; （b）启动第一马达驱动发动机，并且控制第一马达的实际转速ω1接近目标转速ω0; （c）当第一电动机的实际转速ω1近似等于目标转速ω0时，将第一电动机的状态从驱动电动机切换到发电机; 和（d）接合离合器。该方法可以改善发动机的动态响应时间并抑制离合器接合过程中的冲击。本发明还提供一种混合动力输出装置中的离合器接合控制系统。

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