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1. 发明申请

US20100189706A1 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：US20100189706A1
公开(公告)日：2010-07-29
申请号：US12525303
申请日：2008-01-30
申请人： Cathy Chang , Justin T. Stege , Nahla Aboushadi , Gordana Djordjevic , Ellen Burke , Peter Luginbuhl , Mark Dycaico , Toby Richardson , John Poland , Ying Hefner , Stacy Marie Miles
发明人： Cathy Chang , Justin T. Stege , Nahla Aboushadi , Gordana Djordjevic , Ellen Burke , Peter Luginbuhl , Mark Dycaico , Toby Richardson , John Poland , Ying Hefner , Stacy Marie Miles
IPC分类号： A61K38/44 , A61K38/46 , C12N11/16 , A23L1/28 , C12P21/06 , C12P19/34 , C12P7/04 , C12P7/16 , C12P7/06 , C12N11/14 , C12N11/00 , C12N11/08 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/42 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N15/63 , C12P1/00 , D21C3/00 , C40B40/06 , C40B40/10 , C11D7/42 , C07K16/00 , C07H21/04 , A01K67/00 , A01H5/00
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶（例如，α-氧化酶），阿拉伯呋喃糖苷酶，和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。本发明的多肽可用于各种药物，农业和工业环境; 例如，本发明提供了一种可以在糖厂加工的甘蔗的蔗渣组分中水解多糖的多酶体系。本发明提供用于将木质纤维素残基生物转化成可发酵糖的酶; 并且这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料如生物乙醇，生物丙醇，生物丁醇和生物柴油。

2. 发明申请

US20140223602A1 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗细胞凋亡的酶，编码其核酸的酶及其制备和使用它们的方法
公开(公告)号：US20140223602A1
公开(公告)日：2014-08-07
申请号：US14039968
申请日：2013-09-27
申请人： Cathy Chang , Justin T. Stege , Nahla M. Aboushadi , Gordana Djordjevic , Ellen G. Burke , Peter Luginbuhl , Mark Dycaico , Toby H. Richardson , John Poland , Hefner Ying , Stacy M. Miles
发明人： Cathy Chang , Justin T. Stege , Nahla M. Aboushadi , Gordana Djordjevic , Ellen G. Burke , Peter Luginbuhl , Mark Dycaico , Toby H. Richardson , John Poland , Hefner Ying , Stacy M. Miles
IPC分类号： C12P19/14 , C12P19/02 , C12P7/04 , C12N9/42
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.
摘要翻译：本发明提供具有木质纤维素分解活性的多肽，例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶（例如，α-氧化酶），阿拉伯呋喃糖苷酶，和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了可以酶促加工（水解）甘蔗渣，即甘蔗渣降解或用于生物量加工的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供本发明的多肽的耐热性和耐热性形式。

3. 发明授权

US09234216B2 Variant CBH I polypeptides 有权
标题翻译：变体CBH I多肽
公开(公告)号：US09234216B2
公开(公告)日：2016-01-12
申请号：US13824315
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12P7/14 , C12N9/42 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbhl）（例如，外切纤维二糖水解酶例如具有可以逐步释放纤维二糖单元和-1,4葡萄糖 - 葡萄糖二糖的“外显子”活性，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如，（β-谷氨酸）和/或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中，本发明提供了本发明的多肽的热稳定性和耐热性形式，使用本发明的多肽和核酸在各种制药，农业和工业环境中;例如，作为生物质生物转化的酶，例如木质纤维素残基，i 在一方面，这些糖用作生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

4. 发明授权

US09096871B2 Variant CBH I polypeptides with reduced product inhibition 有权
标题翻译：具有减少的产物抑制的变体CBH I多肽
公开(公告)号：US09096871B2
公开(公告)日：2015-08-04
申请号：US13824317
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12N9/42 , C12P7/14 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.
摘要翻译：本公开涉及具有降低的产物抑制的变体CBH I多肽，以及包含变体CBH I多肽的组合物，例如纤维素酶组合物。变体CBH I多肽和相关组合物可用于各种农业和工业应用。本公开还涉及编码变体CBH I多肽的核酸和重组表达变体CBH I多肽的宿主细胞。

5. 发明申请

US20130203128A1 VARIANT CBH I POLYPEPTIDES 有权
标题翻译：变种CBH多糖
公开(公告)号：US20130203128A1
公开(公告)日：2013-08-08
申请号：US13824315
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12N9/42 , C12P19/02
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbhl）（例如，外切纤维二糖水解酶例如，具有可以逐步释放纤维二糖单位β-1,4葡萄糖 - 葡萄糖二糖的“外部”活性），β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如（β-木糖苷酶）和/ 或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中，本发明提供了本发明的多肽的耐热和耐热形式。本发明的多肽和核酸用于各种制药，农业和工业环境;例如，作为生物质生物转化的酶，例如木质纤维素残基，转化为Fe 可再生糖，其中一方面，这些糖被用作用于生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

6. 发明授权

US07642079B2 Proteases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：蛋白酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07642079B2
公开(公告)日：2010-01-05
申请号：US10530643
申请日：2003-10-10
申请人： Michelle Cayouette , Connie Jo Hansen , Amy McClure , May Sun , Svetlana Gramatikova , Mark Dycaico , Nelson R. Barton , Justin T. Stege , Nahla M. Aboushadi
发明人： Michelle Cayouette , Connie Jo Hansen , Amy McClure , May Sun , Svetlana Gramatikova , Mark Dycaico , Nelson R. Barton , Justin T. Stege , Nahla M. Aboushadi
IPC分类号： C12N9/48
CPC分类号： C12N9/52 , A01K2217/05
摘要： The invention is directed to polypeptides having protease activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of diagnostic, therapeutic, and industrial contexts. The polypeptides of the invention can be used as, e.g., an additive for a detergent, for processing foods and for chemical synthesis utilizing a reverse reaction. Additionally, the polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to ethanol diodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in increasing starch yield from corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.
摘要翻译：本发明涉及具有蛋白酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。本发明的多肽可用于多种诊断，治疗和工业背景。本发明的多肽可用作例如用于洗涤剂的添加剂，用于加工食品和利用反向反应进行化学合成。此外，本发明的多肽可用于食品加工，酿造，浴添加剂，醇生产，肽合成，对映选择性，皮革工业中的皮革制备，废物管理和动物降解，摄影工业中的银回收，医疗，丝绸脱胶，生物膜降解，生物质转化为乙醇二聚体，抗微生物剂和消毒剂，个人护理和化妆品，生物技术试剂，用于增加玉米湿法研磨的淀粉产量，以及药物如消化助剂和抗炎（抗炎）剂。

7. 发明申请

US20140147894A1 VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION 有权
公开(公告)号：US20140147894A1
公开(公告)日：2014-05-29
申请号：US13824317
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginhuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginhuhl
IPC分类号： C12N9/42 , C12P7/14 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.

8. 发明申请

US20130244292A1 Polypeptides Having Endoglucanase Activity 审中-公开
标题翻译：具有内切葡聚糖酶活性的多肽
公开(公告)号：US20130244292A1
公开(公告)日：2013-09-19
申请号：US13840091
申请日：2013-03-15
申请人： John Poland , Justin T. Stege
发明人： John Poland , Justin T. Stege
IPC分类号： C12N9/24
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/244 , C12P19/02
摘要： The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.
摘要翻译：本发明涉及具有内切葡聚糖酶活性的家族5糖苷水解酶变体，编码家族5糖苷水解酶变体的多核苷酸，载体，包含多核苷酸的宿主细胞，以及使用5族糖苷水解酶变体的方法。

9. 发明申请

US20090007300A1 SYNTHETIC ZINC FINGER PROTEIN ENCODING SEQUENCES AND METHODS OF PRODUCING THE SAME 有权
标题翻译：合成锌指蛋白编码序列及其生产方法
公开(公告)号：US20090007300A1
公开(公告)日：2009-01-01
申请号：US12127763
申请日：2008-05-27
申请人： Carlos F. BARBAS, III , Justin T. Stege , Xueni Guan , Bipin Dalmia
发明人： Carlos F. BARBAS, III , Justin T. Stege , Xueni Guan , Bipin Dalmia
IPC分类号： A01H5/00 , C12N5/04 , C12N15/82 , C12N15/00
CPC分类号： C12N15/8289 , C07K14/415 , C12N15/8216 , C12N15/8222 , C12N15/8261 , Y02A40/146
摘要： The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.
摘要翻译：本发明涉及植物和农业技术领域。更具体地，本发明涉及锌指蛋白和所述蛋白质的融合物在植物中调节基因表达和代谢途径的用途。

10. 发明授权

US07781645B2 Expression system for synthetic zinc finger proteins and methods of using the same 有权
标题翻译：合成锌指蛋白的表达系统及其使用方法
公开(公告)号：US07781645B2
公开(公告)日：2010-08-24
申请号：US12127763
申请日：2008-05-27
申请人： Carlos F. Barbas, III , Justin T. Stege , Xueni Guan , Bipin Dalmia
发明人： Carlos F. Barbas, III , Justin T. Stege , Xueni Guan , Bipin Dalmia
IPC分类号： C12N15/09 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8289 , C07K14/415 , C12N15/8216 , C12N15/8222 , C12N15/8261 , Y02A40/146
摘要： The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.
摘要翻译：本发明涉及植物和农业技术领域。更具体地，本发明涉及锌指蛋白和所述蛋白质的融合物在植物中调节基因表达和代谢途径的用途。

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