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    • 2. 发明授权
    • Variant CBH I polypeptides
    • 变体CBH I多肽
    • US09234216B2
    • 2016-01-12
    • US13824315
    • 2011-10-06
    • Justin T. StegeAlexander VarvakJohn PolandChris S. LyonShaun HealeyPeter Luginbuhl
    • Justin T. StegeAlexander VarvakJohn PolandChris S. LyonShaun HealeyPeter Luginbuhl
    • C12P7/14C12N9/42C12P19/02C12P19/14
    • C12P7/14C12N9/2437C12P7/10C12P19/02C12P19/14C12Y302/01091Y02E50/16Y02E50/17
    • In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
    • 在替代实施方案中,本发明提供具有木质纤维素分解(木质纤维素)活性的多肽,例如木质素分解和纤维素分解活性,包括例如糖基水解酶,纤维素酶,内切葡聚糖酶,纤维二糖水解酶(cbhl)(例如,外切纤维二糖水解酶 例如具有可以逐步释放纤维二糖单元和-1,4葡萄糖 - 葡萄糖二糖的“外显子”活性,β-葡糖苷酶,木聚糖酶,甘露聚糖,木糖苷酶(例如,(β-谷氨酸) 和/或阿拉伯呋喃糖苷酶活性,编码这些多肽的多核苷酸,以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中,本发明提供了本发明的多肽的热稳定性和耐热性形式,使用本发明的多肽和核酸 在各种制药,农业和工业环境中;例如,作为生物质生物转化的酶,例如木质纤维素残基,i 在一方面,这些糖用作生产乙醇和燃料的化学原料,例如生物燃料,例如合成液体或气体燃料,包括乙醇,甲醇等。
    • 4. 发明申请
    • VARIANT CBH I POLYPEPTIDES
    • 变种CBH多糖
    • US20130203128A1
    • 2013-08-08
    • US13824315
    • 2011-10-06
    • Justin T. StegeAlexander VarvakJohn PolandChris S. LyonShaun HealeyPeter Luginbuhl
    • Justin T. StegeAlexander VarvakJohn PolandChris S. LyonShaun HealeyPeter Luginbuhl
    • C12N9/42C12P19/02
    • C12P7/14C12N9/2437C12P7/10C12P19/02C12P19/14C12Y302/01091Y02E50/16Y02E50/17
    • In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
    • 在替代实施方案中,本发明提供具有木质纤维素分解(木质纤维素)活性的多肽,例如木质素分解和纤维素分解活性,包括例如糖基水解酶,纤维素酶,内切葡聚糖酶,纤维二糖水解酶(cbhl)(例如,外切纤维二糖水解酶 例如,具有可以逐步释放纤维二糖单位β-1,4葡萄糖 - 葡萄糖二糖的“外部”活性),β-葡糖苷酶,木聚糖酶,甘露聚糖,木糖苷酶(例如(β-木糖苷酶)和/ 或阿拉伯呋喃糖苷酶活性,编码这些多肽的多核苷酸,以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中,本发明提供了本发明的多肽的耐热和耐热形式。本发明的多肽和核酸用于 各种制药,农业和工业环境;例如,作为生物质生物转化的酶,例如木质纤维素残基,转化为Fe 可再生糖,其中一方面,这些糖被用作用于生产乙醇和燃料的化学原料,例如生物燃料,例如合成液体或气体燃料,包括乙醇,甲醇等。