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1. 发明授权

US06734002B2 Nucleotide sequences coding for the chrS protein 失效
标题翻译：编码chrS蛋白的核苷酸序列
公开(公告)号：US06734002B2
公开(公告)日：2004-05-11
申请号：US09948774
申请日：2001-09-10
申请人： Brigitte Bathe , Natalie Schischka , Achim Marx , Walter Pfefferle
发明人： Brigitte Bathe , Natalie Schischka , Achim Marx , Walter Pfefferle
IPC分类号： C12N912
CPC分类号： C12N9/1223 , A01K2217/075 , C07K14/34 , C12P13/08
摘要： The invention provides nucleotide sequences from Coryneform bacteria coding for the ChrS protein and a process for the fermentative preparation of amino acids using bacteria in which the ChrS protein is attenuated.
摘要翻译：本发明提供了编码ChrS蛋白的棒状细菌的核苷酸序列和使用其中ChrS蛋白被减弱的细菌发酵制备氨基酸的方法。

2. 发明授权

US06916636B2 Nucleotide sequences which code for the oxyR gene 失效
标题翻译：编码oxyR基因的核苷酸序列
公开(公告)号：US06916636B2
公开(公告)日：2005-07-12
申请号：US09938641
申请日：2001-08-27
申请人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
发明人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
IPC分类号： C07K14/34 , C12P13/04
CPC分类号： C07K14/34
摘要： The invention relates to polynucleotides corresponding to the oxyR gene from Corynebacterium glutamicum and which encode a OxyR transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having OxyR transcriptional regulator activity.
摘要翻译：本发明涉及对应于谷氨酸棒杆菌的oxyR基因的多核苷酸，其编码OxyR转录调节子，产生L-氨基酸的方法，以及筛选编码具有OxyR转录调节活性的蛋白质的多核苷酸的方法。

3. 发明申请

US20050233424A1 Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 审中-公开
标题翻译：编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列
公开(公告)号：US20050233424A1
公开(公告)日：2005-10-20
申请号：US10898345
申请日：2004-07-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： A23K1/00 , A23K1/16 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/08 , C12P13/12 , C07H21/04 , C12N15/74
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译：来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

4. 发明授权

US07252977B2 Nucleotide sequences which code for the msiK gene 有权
标题翻译：编码msiK基因的核苷酸序列
公开(公告)号：US07252977B2
公开(公告)日：2007-08-07
申请号：US09962618
申请日：2001-09-26
申请人： Brigitte Bathe , Natalie Schischka , Mike Farwick , Walter Pfefferle
发明人： Brigitte Bathe , Natalie Schischka , Mike Farwick , Walter Pfefferle
IPC分类号： C12P13/04 , C12P13/10 , C12N15/00 , C12N1/20 , C07H21/02 , C07K1/00
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sugar import protein K (msiK) gene, and a host-vector system having a coryneform host bacterium in which the msiK gene is present in enhanced form and a vector which carries at least the msiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码糖进入蛋白K（msiK）基因的多核苷酸序列的谷氨酸棒杆菌的分离的多核苷酸，以及具有其中以增强形式存在msiK基因的棒状细胞宿主细菌的宿主 - 载体系统和载体其至少携带根据SEQ ID No 1的msiK基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

5. 发明授权

US06822085B2 Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 有权
标题翻译：编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列
公开(公告)号：US06822085B2
公开(公告)日：2004-11-23
申请号：US09962357
申请日：2001-09-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C07H2104
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译：来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

6. 发明授权

US07129066B2 Nucleotide sequences coding for the citE gene 失效
标题翻译：编码citE基因的核苷酸序列
公开(公告)号：US07129066B2
公开(公告)日：2006-10-31
申请号：US10375355
申请日：2003-02-28
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
IPC分类号： C12P13/08 , C12P13/04 , C12N9/88 , C07H21/04
CPC分类号： C12Y401/03006 , C12N9/88
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.
摘要翻译：本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法，使用含有本发明序列的多核苷酸作为杂交探针。

7. 发明授权

US07074607B2 Polynucleotide sequences which encode the zwa1 gene 失效
标题翻译：编码zwa1基因的多核苷酸序列
公开(公告)号：US07074607B2
公开(公告)日：2006-07-11
申请号：US10640263
申请日：2003-08-14
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
IPC分类号： C12P1/00 , C12N1/20 , C12N15/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/34 , C12N9/00 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID NO：2的氨基酸序列的多肽的至少70％的多核苷酸程度相同 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％的程度相同的氨基酸序列）与a）和b的多核苷酸互补的多核苷酸）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

8. 发明授权

US07144724B2 Process for the production of L-amino acids by fermentation using coryneform bacteria 有权
标题翻译：使用棒状细菌通过发酵生产L-氨基酸的方法
公开(公告)号：US07144724B2
公开(公告)日：2006-12-05
申请号：US11264026
申请日：2005-11-02
申请人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12N1/12 , C12N15/00 , C12N1/20 , C12N15/74 , C07H21/02
CPC分类号： C12N9/0036 , C12P13/08
摘要： A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
摘要翻译：其中生产L-氨基酸的方法，其中发酵其中编码苹果酸醌氧化还原酶的mqo基因的表达减弱的棒状细菌（例如谷氨酸棒杆菌）被发酵以产生所需的氨基酸，并且氨基酸浓缩在培养基或细胞分离。任选地，所需氨基酸的生物合成途径中的其它基因被增强，和/或减少氨基酸形成的代谢途径被抑制。

9. 发明授权

US07262036B2 Process for the preparation of l-amino acids 失效
标题翻译：制备1-氨基酸的方法
公开(公告)号：US07262036B2
公开(公告)日：2007-08-28
申请号：US11419529
申请日：2006-05-22
申请人： Bettina Hädrich , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
发明人： Bettina Hädrich , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
IPC分类号： C12P13/08 , C12N1/20 , C12N15/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/34 , C12N9/00 , C12P13/08
摘要： Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
摘要翻译：本文公开了一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID NO：2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％相同程度的氨基酸序列c）与a）和 b）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

10. 发明授权

US06727086B2 Nucleotide sequences which code for the sigH gene 失效
标题翻译：编码sigH基因的核苷酸序列
公开(公告)号：US06727086B2
公开(公告)日：2004-04-27
申请号：US09942936
申请日：2001-08-31
申请人： Brigitte Bathe , Indra Schröder , Mechthild Rieping , Achim Marx , Mike Farwick , Walter Pfefferle , Thomas Hermann
发明人： Brigitte Bathe , Indra Schröder , Mechthild Rieping , Achim Marx , Mike Farwick , Walter Pfefferle , Thomas Hermann
IPC分类号： C12N120
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigH gene, and a host-vector system having a coryneform host bacterium in which the sigH gene is present in attenuated form and a vector which carries at least the sigH gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码sigH基因的多核苷酸序列的分离的多核苷酸，以及具有其中sigH基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带sigH基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

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