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1. 发明授权

US06727086B2 Nucleotide sequences which code for the sigH gene 失效
标题翻译：编码sigH基因的核苷酸序列
公开(公告)号：US06727086B2
公开(公告)日：2004-04-27
申请号：US09942936
申请日：2001-08-31
申请人： Brigitte Bathe , Indra Schröder , Mechthild Rieping , Achim Marx , Mike Farwick , Walter Pfefferle , Thomas Hermann
发明人： Brigitte Bathe , Indra Schröder , Mechthild Rieping , Achim Marx , Mike Farwick , Walter Pfefferle , Thomas Hermann
IPC分类号： C12N120
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigH gene, and a host-vector system having a coryneform host bacterium in which the sigH gene is present in attenuated form and a vector which carries at least the sigH gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码sigH基因的多核苷酸序列的分离的多核苷酸，以及具有其中sigH基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带sigH基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

2. 发明授权

US07049106B2 Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene 有权
标题翻译：使用具有减毒mqo基因的棒状细菌通过发酵生产L-氨基酸的方法
公开(公告)号：US07049106B2
公开(公告)日：2006-05-23
申请号：US10118325
申请日：2002-04-09
申请人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12P13/04
CPC分类号： C12N9/0036 , C12P13/08
摘要： A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
摘要翻译：其中生产L-氨基酸的方法，其中将其中编码苹果酸醌氧化还原酶的mqo基因的表达减弱的棒状细菌（例如谷氨酸棒杆菌）被发酵以产生所需的氨基酸，并且氨基酸浓缩在培养基或细胞分离。任选地，所需氨基酸的生物合成途径中的其它基因被增强，和/或减少氨基酸形成的代谢途径被抑制。

3. 发明申请

US20060040317A1 Process for the production of L-amino acids by fermentation using coryneform bacteria 有权
公开(公告)号：US20060040317A1
公开(公告)日：2006-02-23
申请号：US11264026
申请日：2005-11-02
申请人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12Q1/68 , C12P13/04 , C12P13/08 , C12N1/21
CPC分类号： C12N9/0036 , C12P13/08
摘要： The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the mqo gene is attenuated, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and, optionally, bacteria are used in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally enhanced, or bacteria are used in which at least some of the metabolic pathways reducing formation of the desired L-amino acid are excluded.

4. 发明授权

US07144724B2 Process for the production of L-amino acids by fermentation using coryneform bacteria 有权
标题翻译：使用棒状细菌通过发酵生产L-氨基酸的方法
公开(公告)号：US07144724B2
公开(公告)日：2006-12-05
申请号：US11264026
申请日：2005-11-02
申请人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Brigitte Bathe , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12N1/12 , C12N15/00 , C12N1/20 , C12N15/74 , C07H21/02
CPC分类号： C12N9/0036 , C12P13/08
摘要： A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
摘要翻译：其中生产L-氨基酸的方法，其中发酵其中编码苹果酸醌氧化还原酶的mqo基因的表达减弱的棒状细菌（例如谷氨酸棒杆菌）被发酵以产生所需的氨基酸，并且氨基酸浓缩在培养基或细胞分离。任选地，所需氨基酸的生物合成途径中的其它基因被增强，和/或减少氨基酸形成的代谢途径被抑制。

5. 发明授权

US07129066B2 Nucleotide sequences coding for the citE gene 失效
标题翻译：编码citE基因的核苷酸序列
公开(公告)号：US07129066B2
公开(公告)日：2006-10-31
申请号：US10375355
申请日：2003-02-28
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
IPC分类号： C12P13/08 , C12P13/04 , C12N9/88 , C07H21/04
CPC分类号： C12Y401/03006 , C12N9/88
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.
摘要翻译：本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法，使用含有本发明序列的多核苷酸作为杂交探针。

6. 发明授权

US06682915B2 Process for the fermentative preparation of D-pantothenic acid and/or its salts 有权
标题翻译： D-泛酸和/或其盐的发酵制备方法
公开(公告)号：US06682915B2
公开(公告)日：2004-01-27
申请号：US10052388
申请日：2002-01-23
申请人： Thomas Hermann , Achim Marx , Walter Pfefferle , Mechthild Rieping
发明人： Thomas Hermann , Achim Marx , Walter Pfefferle , Mechthild Rieping
IPC分类号： C12P746
CPC分类号： F04B53/143 , A23K20/174 , B60T8/4031 , C12N15/52 , C12P13/02 , F04B1/0408
摘要： A method for the fermentative preparation of D-pantothenic acid and/or its salts or feedstuff additives containing these. Said method comprising, fermentation of Escherichia coli microorganisms wherein the nucleotide sequence(s) coding the glyA gene is overexpressed.
摘要翻译：用于发酵制备含有它们的D-泛酸和/或其盐或饲料添加剂的方法。所述方法包括大肠杆菌微生物的发酵，其中编码glyA基因的核苷酸序列被过表达。

7. 发明授权

US06995000B2 Nucleotide sequences coding for the sigM gene 失效
标题翻译：编码sigM基因的核苷酸序列
公开(公告)号：US06995000B2
公开(公告)日：2006-02-07
申请号：US09942935
申请日：2001-08-31
申请人： Brigitte Bathe , Christine Bastuck , Mike Farwick , Thomas Hermann , Walter Pfefferle
发明人： Brigitte Bathe , Christine Bastuck , Mike Farwick , Thomas Hermann , Walter Pfefferle
IPC分类号： C12P13/04
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sigma factor M (sigM) gene, and a host-vector system having a coryneform host bacterium in which the sigM gene is present in enhanced form and a vector which carries at least the sigM gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码σ因子M（sigM）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中sigM基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和载体，至少携带根据SEQ ID No 1的sigM基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

8. 发明申请

US20060177912A1 Nucleotide sequences which code for the dep34 gene 审中-公开
公开(公告)号：US20060177912A1
公开(公告)日：2006-08-10
申请号：US11274317
申请日：2005-11-16
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
IPC分类号： C12P13/04 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dep34 gene, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

9. 发明授权

US07029904B2 Nucleotide sequences which code for the dep34 gene 失效
标题翻译：编码dep34基因的核苷酸序列
公开(公告)号：US07029904B2
公开(公告)日：2006-04-18
申请号：US09946763
申请日：2001-09-06
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the dep34 efflux protein, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码dep34流出蛋白的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中dep34基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带至少根据SEQ ID NO：1的dep34基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

10. 发明授权

US06890744B2 Methods for producing amino acids in coryneform bacteria using an enhanced sigD gene 失效
标题翻译：使用增强型sigD基因在棒状细菌中产生氨基酸的方法
公开(公告)号：US06890744B2
公开(公告)日：2005-05-10
申请号：US09941945
申请日：2001-08-30
申请人： Brigitte Bathe , Caroline Kreutzer , Monika Martens , Mike Farwick , Thomas Hermann , Walter Pfefferle
发明人： Brigitte Bathe , Caroline Kreutzer , Monika Martens , Mike Farwick , Thomas Hermann , Walter Pfefferle
IPC分类号： C07K14/34 , C12N1/21 , C12N15/54 , C12P13/08 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the sigD gene, and a host-vector system having a coryneform host bacterium in which the sigD gene is present in enhanced form and a vector which carries at least the sigD gene according to SEQ ID No: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码sigD基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中sigD基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带至少 sigD基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

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