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1. 发明授权

US07524657B2 Alleles of the sigA gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的sigA基因的等位基因
公开(公告)号：US07524657B2
公开(公告)日：2009-04-28
申请号：US10498887
申请日：2002-10-16
申请人： Brigitte Bathe , Stephan Hans , Caroline Reynen , Walter Pfefferle
发明人： Brigitte Bathe , Stephan Hans , Caroline Reynen , Walter Pfefferle
IPC分类号： C12P21/06 , C12P13/04 , C12N1/20 , C12N15/00 , C07K14/00 , C07K17/00 , C07H21/04 , C07H21/02
CPC分类号： C12N9/1247 , C07K14/34 , C12P13/08
摘要： The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles.
摘要翻译：本发明涉及来自棒状细菌的sigA基因的等位基因，其编码σ因子A和使用含有这些等位基因的细菌发酵制备L-赖氨酸的方法。

2. 发明授权

US07416863B2 Nucleotide sequences for encoding of the lysR2-gene 失效
标题翻译：编码lysR2基因的核苷酸序列
公开(公告)号：US07416863B2
公开(公告)日：2008-08-26
申请号：US11178485
申请日：2005-07-12
申请人： Bettina Moeckel , Mike Farwick , Thomas Hermann , Caroline Kreutzer , Walter Pfefferle
发明人： Bettina Moeckel , Mike Farwick , Thomas Hermann , Caroline Kreutzer , Walter Pfefferle
IPC分类号： C12P19/34
CPC分类号： C12P13/08 , C07K14/34
摘要： Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c),and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
摘要翻译：分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b）多核苷酸，其编码多肽，其包含与SEQ ID No.2的氨基酸序列至少70％的程度相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少lysR2基因存在于减毒形式，以及使用多核苷酸序列作为杂交探针。

3. 发明授权

US07252977B2 Nucleotide sequences which code for the msiK gene 有权
标题翻译：编码msiK基因的核苷酸序列
公开(公告)号：US07252977B2
公开(公告)日：2007-08-07
申请号：US09962618
申请日：2001-09-26
申请人： Brigitte Bathe , Natalie Schischka , Mike Farwick , Walter Pfefferle
发明人： Brigitte Bathe , Natalie Schischka , Mike Farwick , Walter Pfefferle
IPC分类号： C12P13/04 , C12P13/10 , C12N15/00 , C12N1/20 , C07H21/02 , C07K1/00
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sugar import protein K (msiK) gene, and a host-vector system having a coryneform host bacterium in which the msiK gene is present in enhanced form and a vector which carries at least the msiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码糖进入蛋白K（msiK）基因的多核苷酸序列的谷氨酸棒杆菌的分离的多核苷酸，以及具有其中以增强形式存在msiK基因的棒状细胞宿主细菌的宿主 - 载体系统和载体其至少携带根据SEQ ID No 1的msiK基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

4. 发明授权

US07105321B2 Nucleotide sequences which code for the ccpA2 gene 有权
标题翻译：编码ccpA2基因的核苷酸序列
公开(公告)号：US07105321B2
公开(公告)日：2006-09-12
申请号：US10724827
申请日：2003-12-02
申请人： Bettina Moeckel , Caroline Kreutzer , Thomas Hermann , Mike Farwick , Achim Marx , Walter Pfefferle
发明人： Bettina Moeckel , Caroline Kreutzer , Thomas Hermann , Mike Farwick , Achim Marx , Walter Pfefferle
IPC分类号： C12P13/04 , C12P21/06 , C12P13/06 , C12N1/20 , C12N15/00
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to polynucleotides corresponding to the ccpA2 gene and which encode a CcpA2 catabolite control protein, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having CcpA2 catabolite control activity.
摘要翻译：本发明涉及对应于ccpA2基因并且编码CcpA2分解代谢物控制蛋白质的多核苷酸，产生L-氨基酸的方法，以及筛选编码具有CcpA2分解代谢物控制活性的蛋白质的多核苷酸的方法。

5. 发明授权

US06995000B2 Nucleotide sequences coding for the sigM gene 失效
标题翻译：编码sigM基因的核苷酸序列
公开(公告)号：US06995000B2
公开(公告)日：2006-02-07
申请号：US09942935
申请日：2001-08-31
申请人： Brigitte Bathe , Christine Bastuck , Mike Farwick , Thomas Hermann , Walter Pfefferle
发明人： Brigitte Bathe , Christine Bastuck , Mike Farwick , Thomas Hermann , Walter Pfefferle
IPC分类号： C12P13/04
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sigma factor M (sigM) gene, and a host-vector system having a coryneform host bacterium in which the sigM gene is present in enhanced form and a vector which carries at least the sigM gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码σ因子M（sigM）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中sigM基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和载体，至少携带根据SEQ ID No 1的sigM基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

6. 发明申请

US20060019357A1 Nucleotide sequences which code for the rpsL gene 审中-公开
公开(公告)号：US20060019357A1
公开(公告)日：2006-01-26
申请号：US11197380
申请日：2005-08-05
申请人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
发明人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
IPC分类号： C07H21/04 , C12P21/06 , C12P13/08 , C12N9/10 , C12N15/74 , C12N1/21
CPC分类号： C07K14/34
摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

7. 发明授权

US06946271B2 Nucleotide sequences which code for the menE gene 失效
标题翻译：编码menE基因的核苷酸序列
公开(公告)号：US06946271B2
公开(公告)日：2005-09-20
申请号：US09834722
申请日：2001-04-16
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
IPC分类号： C12N9/00 , C12P13/08
CPC分类号： C12N9/93 , C12P13/08 , C12Y602/01026
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the menE gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含SEQ ID NO： 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少所述menE 基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

8. 发明授权

US06939695B2 Nucleotide sequences which code for the rpsL gene 有权
标题翻译：编码rpsL基因的核苷酸序列
公开(公告)号：US06939695B2
公开(公告)日：2005-09-06
申请号：US10075460
申请日：2002-02-15
申请人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
发明人： Bettina Moeckel , Brigitte Bathe , Stefan Hans , Caroline Kreutzer , Thomas Hermann , Walter Pfefferle , Michael Binder
IPC分类号： C07K14/34 , C12N15/31 , C12P13/04 , C07H21/04
CPC分类号： C07K14/34
摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b）编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少存在rpsL基因增强形式，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

9. 发明授权

US06822085B2 Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 有权
标题翻译：编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列
公开(公告)号：US06822085B2
公开(公告)日：2004-11-23
申请号：US09962357
申请日：2001-09-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C07H2104
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译：来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

10. 发明授权

US06812016B2 Nucleotide sequences which code for the metY gene 有权
标题翻译：编码metY基因的核苷酸序列
公开(公告)号：US06812016B2
公开(公告)日：2004-11-02
申请号：US09919932
申请日：2001-08-02
申请人： Bettina Moeckel , Walter Pfefferle , Klaus Huthmacher , Christian Rueckert , Joern Kalinowski , Alfred Puehler , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Bettina Moeckel , Walter Pfefferle , Klaus Huthmacher , Christian Rueckert , Joern Kalinowski , Alfred Puehler , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C12N914
CPC分类号： C12P13/12 , C12N9/88 , C12P13/08
摘要： The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.
摘要翻译：本发明涉及用O-乙酰高丝氨酸巯基化酶编码蛋白质的分离的多核苷酸，含有多核苷酸的载体和细胞以及L-氨基酸的制备方法。

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