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1. 发明授权

US06632644B2 Nucleotide sequences which code for the zwa1 gene 失效
标题翻译：编码zwa1基因的核苷酸序列
公开(公告)号：US06632644B2
公开(公告)日：2003-10-14
申请号：US09731909
申请日：2000-12-08
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
IPC分类号： C12P1308
CPC分类号： C07K14/34 , C12N9/00 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含氨基酸序列 b）编码多肽的多核苷酸，其包含与SEQ ID NO 2的氨基酸序列至少70％的程度相同的氨基酸序列，c）与a）和b）和d）多核苷酸互补的多核苷酸，其包含a），b）或c），/或PTEXT的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及发酵在使用棒状细菌中扩增zwa1基因的L-氨基酸的制备

2. 发明授权

US07074607B2 Polynucleotide sequences which encode the zwa1 gene 失效
标题翻译：编码zwa1基因的多核苷酸序列
公开(公告)号：US07074607B2
公开(公告)日：2006-07-11
申请号：US10640263
申请日：2003-08-14
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx , Jörn Kalinowski , Brigitte Bathe , Alfred Pühler
IPC分类号： C12P1/00 , C12N1/20 , C12N15/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/34 , C12N9/00 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID NO：2的氨基酸序列的多肽的至少70％的多核苷酸程度相同 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％的程度相同的氨基酸序列）与a）和b的多核苷酸互补的多核苷酸）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

3. 发明授权

US06713289B2 Nucleotide sequences which code for the eno gene 失效
标题翻译：编码eno基因的核苷酸序列
公开(公告)号：US06713289B2
公开(公告)日：2004-03-30
申请号：US09860768
申请日：2001-05-21
申请人： Bettina Möckel , Walter Pfefferle , Thomas Hermann , Alfred Pühler , Jörn Kalinowski , Brigitte Bathe
发明人： Bettina Möckel , Walter Pfefferle , Thomas Hermann , Alfred Pühler , Jörn Kalinowski , Brigitte Bathe
IPC分类号： C12N1564
CPC分类号： C12R1/15 , C12N9/88 , C12P13/08
摘要： The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids using coryneform bacteria.
摘要翻译：本发明涉及编码细菌烯醇化酶的核苷酸序列。这些序列可用于使用棒状细菌发酵制备氨基酸的改进方法。

4. 发明授权

US07132272B2 Nucleotide sequence encoding corynebacterium glutamicum leucine response regulatory protein 失效
标题翻译：编码谷氨酸棒杆菌亮氨酸响应调节蛋白的核苷酸序列
公开(公告)号：US07132272B2
公开(公告)日：2006-11-07
申请号：US10134640
申请日：2002-04-30
申请人： Brigitte Bathe , Jörn Kalinowski , Alfred Pühler , Bettina Möckel , Walter Pfefferle
发明人： Brigitte Bathe , Jörn Kalinowski , Alfred Pühler , Bettina Möckel , Walter Pfefferle
IPC分类号： C12N1/20 , C12N15/09 , C07H21/04
CPC分类号： C12P13/04 , C07K14/34 , C12P13/08
摘要： The present invention relates to an isolated polynucleotide coding for the lrp gene and to a process for the fermentative production of L-amino acids by altering the expression of this gene.
摘要翻译：本发明涉及编码lrp基因的分离的多核苷酸以及通过改变该基因的表达来发酵生产L-氨基酸的方法。

5. 发明授权

US07118904B2 Nucleotide sequences which code for the eno gene 失效
公开(公告)号：US07118904B2
公开(公告)日：2006-10-10
申请号：US10728947
申请日：2003-12-08
申请人： Bettina Möckel , Walter Pfefferle , Thomas Hermann , Alfred Pühler , Jörn Kalinowski , Brigitte Bathe
发明人： Bettina Möckel , Walter Pfefferle , Thomas Hermann , Alfred Pühler , Jörn Kalinowski , Brigitte Bathe
IPC分类号： C12N1/20 , C12N9/00 , C12N9/24 , C12N1/22 , C07H2/04
CPC分类号： C12R1/15 , C12N9/88 , C12P13/08
摘要： The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids using coryneform bacteria.

6. 发明授权

US07759056B2 Nucleotide sequence encoding the dapC gene and process for the production of L-lysine 有权
标题翻译：编码dapC基因的核苷酸序列和生产L-赖氨酸的方法
公开(公告)号：US07759056B2
公开(公告)日：2010-07-20
申请号：US10745684
申请日：2003-12-29
申请人： Bettina Möckel , Anke Weissenborn , Walter Pfefferle , Michael Hartmann , Jörn Kalinowski , Alfred Pühler
发明人： Bettina Möckel , Anke Weissenborn , Walter Pfefferle , Michael Hartmann , Jörn Kalinowski , Alfred Pühler
IPC分类号： C12Q1/68 , C12P13/08
CPC分类号： C12P13/08 , C12N9/1096
摘要： The invention relates to an isolated polynucleotide from coryneform bacteria containing at least one polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide which encodes a polypeptide containing the amino acid sequence according to SEQ ID no. 2, b) polynucleotide which encodes a polypeptide which contains an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequences of a), b) or c), and to a process for the fermentative production of L-amino acids, in particular L-lysine.
摘要翻译：本发明涉及来自棒状细菌的分离的多核苷酸，其含有至少一种多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码含有根据SEQ ID No.3所述的氨基酸序列的多肽的多核苷酸至少70％相同。 2，b）编码多肽的多核苷酸，其含有与SEQ ID NO：1的氨基酸序列至少70％相同的氨基酸序列。 2）c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及d）发酵生产的方法的L-氨基酸，特别是L-赖氨酸。

7. 发明授权

US06670156B1 Polynucleotide encoding a diaminopimelate epimerase from Corynebacterium glutamicum 有权
标题翻译：编码谷氨酸棒杆菌的二氨基庚二酸差向异构酶的多核苷酸
公开(公告)号：US06670156B1
公开(公告)日：2003-12-30
申请号：US09427548
申请日：1999-10-27
申请人： Bettina Möckel , Walter Pfefferle , Brigitte Bathe , Jorn Kalinowski , Oliver Kirchner , Michael Hartmann , Alfred Pühler
发明人： Bettina Möckel , Walter Pfefferle , Brigitte Bathe , Jorn Kalinowski , Oliver Kirchner , Michael Hartmann , Alfred Pühler
IPC分类号： C12P1308
CPC分类号： C12R1/15 , C12N9/90 , C12N15/77 , C12P13/08
摘要： The present application is directed to a diaminopimelate epimerase from Corynebacterium glutamicum and to polynucleotides encoding this enzyme. The gene has been given the designation “dapF.”
摘要翻译：本申请涉及来自谷氨酸棒杆菌的二氨基庚二酸差向异构酶和编码该酶的多核苷酸。该基因被命名为“dapF”。

8. 发明授权

US06972190B2 Nucleotide sequences which code for the cstA gene 失效
标题翻译：编码cstA基因的核苷酸序列
公开(公告)号：US06972190B2
公开(公告)日：2005-12-06
申请号：US09935799
申请日：2001-08-24
申请人： Bettina Möckel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
发明人： Bettina Möckel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
IPC分类号： C07K14/34 , C12N1/21 , C12N15/12 , C12N15/31 , C12P13/08 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the carbon starvation protein A (cstA) gene, and a host-vector system having a coryneform host bacterium in which the cstA gene is present in enhanced form and a vector which carries at least the cstA gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码碳饥饿蛋白A（cstA）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中cstA基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和携带至少根据SEQ ID NO：1的cstA基因的载体，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

9. 发明授权

US06825030B2 Nucleotide sequences encoding a sensor kinase, citA, from corynebacterium glutamicum 失效
标题翻译：编码来自谷氨酸棒杆菌的传感器激酶citA的核苷酸序列
公开(公告)号：US06825030B2
公开(公告)日：2004-11-30
申请号：US09804060
申请日：2001-03-13
申请人： Bettina Möckel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Bettina Möckel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12N120
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The present invention is related to nucleotide sequences encoding a sensor kinse, citA, from Corynebacterium glutamicum.
摘要翻译：本发明涉及编码来自谷氨酸棒杆菌的传感器kinse（citA）的核苷酸序列。

10. 发明授权

US06623946B1 Nucleotide sequences encoding the sucC and sucD genes 失效
标题翻译：编码sucC和sucD基因的核苷酸序列
公开(公告)号：US06623946B1
公开(公告)日：2003-09-23
申请号：US09728498
申请日：2000-11-27
申请人： Bettina Möckel , Walter Pfefferle , Achim Marx
发明人： Bettina Möckel , Walter Pfefferle , Achim Marx
IPC分类号： C12N916
CPC分类号： C12N9/93 , C12P13/04 , C12P13/14
摘要： Polynucleotides that contain polynucleotide sequences encoding the sucC and sucD genes, selected from the group a) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:2, b) a polynucleotide that is at least 70% identical to a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID NO:3, c) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:2, d) a polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:3, e) a polynucleotide that is complementary to one of the polynucleotides of a), b), c) or d), and f) a polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b), c), d) or e), a process for the fermentative production of L-amino acids using coryneform bacteria in which the genes are present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
摘要翻译：含有编码sucC和sucD基因的多核苷酸序列的多核苷酸，选自组a）与编码含有SEQ ID NO：2的氨基酸序列的多肽的多核苷酸至少70％同一性的多核苷酸，b）多核苷酸与编码含有SEQ ID NO：3的氨基酸序列的多肽的多核苷酸至少70％相同，c）编码包含与氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸 SEQ ID NO：2的d氨基酸序列，d）编码含有与SEQ ID NO：3的氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸，e）与 a），b），c）或d）的多核苷酸，和f）包含a），b），c），d）或e）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，发酵生产的方法的L-氨基酸其中基因以减毒形式存在的干细胞，以及多核苷酸序列用作杂交探针。

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