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    • 6. 发明申请
    • Staphylococcal immunotherapeutics via donor selection and donor stimulation
    • 葡萄球菌免疫治疗通过供体选择和供体刺激
    • US20060222651A1
    • 2006-10-05
    • US11374065
    • 2006-03-14
    • Joseph PattiTimothy FosterMagnus Hook
    • Joseph PattiTimothy FosterMagnus Hook
    • A61K39/40C07K16/12
    • A61K9/0019A61K39/00A61K2039/505C07K16/1271C07K2317/20C07K2317/76
    • A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host.
    • 提供了感染或易感染葡萄球菌如金黄色葡萄球菌和表皮葡萄球菌感染的患者的被动免疫的方法和组合物,其包括选择或制备具有高抗体滴度的供体血浆池以精心选择的葡萄球菌 粘附素或MSCRAMM,或其片段或组分,或与其基本上同源的序列。 供体血浆池可以通过将具有高于正常滴度的抗体的单个血液或血液成分样品与一种或多种所选择的粘附素或与细胞外基质蛋白结合的其它蛋白质组合,或通过将精心挑选的蛋白质或肽施用于 诱导所需抗体表达的宿主,随后从被处理的宿主中回收增强的高效价血清或血浆池。