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1. 发明授权

US4824987A Method of preparing m-trifluoromethylphenyl acetonitrile 失效
标题翻译：制备三氟甲基苯基乙腈的方法
公开(公告)号：US4824987A
公开(公告)日：1989-04-25
申请号：US197343
申请日：1988-05-23
申请人： Axel Kleemann , Herbert Klenk , Klaus Huthmacher , Dieter Most
发明人： Axel Kleemann , Herbert Klenk , Klaus Huthmacher , Dieter Most
IPC分类号： C07C253/04 , C07C255/32 , C07C255/33 , C07C255/35 , C07C120/00
CPC分类号： C07C255/00
摘要： A method of preparing m-trifluoromethylphenyl acetonitrile of the formula ##STR1## in which m-trifluoromethyl toluene is reacted with cyanogen chloride in the gas phase at 600.degree. to 750.degree. C.
摘要翻译：制备式“IMAGE”的间三氟甲基苯基乙腈的方法，其中间 - 三氟甲基甲苯与氯化氰在气相中在600至750℃下反应。

2. 发明授权

US4914208A Optically active salts of a substituted thiazolidine-4-carboxylate and 3-chloro-2-hydroxypropyltrimethyl ammonium, their preparation and use 失效
标题翻译：取代噻唑烷-4-羧酸酯和3-氯-2-羟丙基三甲基铵的光学活性盐，其制备和用途
公开(公告)号：US4914208A
公开(公告)日：1990-04-03
申请号：US262722
申请日：1988-10-17
申请人： Harald Jakob , Klaus Huthmacher , Herbert Klenk , Axel Kleemann , Gunes Giray
发明人： Harald Jakob , Klaus Huthmacher , Herbert Klenk , Axel Kleemann , Gunes Giray
IPC分类号： C07B57/00 , C07C67/00 , C07C213/00 , C07C213/04 , C07C215/40 , C07D277/06
CPC分类号： C07C215/40 , C07D277/06
摘要： The invention relates to the preparation of optically active salts of the general formula ##STR1## from which the corresponding optically active 3-chloro-2-hydroxypropyltrimethyl ammonium chloride can be obtained by treatment with mineral acid.The L(-) form of this compound is a valuable component for the synthesis of L(-) carnitine.
摘要翻译：本发明涉及制备通式（I）的光学活性盐，通过用无机酸处理可得到相应的光学活性3-氯-2-羟丙基三甲基氯化铵。该化合物的L（ - ）形式是合成L（ - ）肉碱的有价值的成分。

3. 发明授权

US4326056A Process for the production of 4-amino-6-tert. butyl-3-mercapto-1,2,4-triazin-5-one 失效
标题翻译：制备4-氨基-6-叔丁氧基羰基的方法。丁基-3-巯基-1,2,4-三嗪-5-酮
公开(公告)号：US4326056A
公开(公告)日：1982-04-20
申请号：US266147
申请日：1981-05-22
申请人： Axel Kleemann , Bernd Lehamnn , Herbert Klenk
发明人： Axel Kleemann , Bernd Lehamnn , Herbert Klenk
IPC分类号： C07D253/06 , C07D253/075
CPC分类号： C07D253/075
摘要： 4-amino-6-tert.butyl-3-mercapto-1,2,4-triazin-5-one of the formula ##STR1## is produced by reacting pivaloyl cyanide and isobutylene in the presence of acetic acid and sulfuric acid, hydrolyzing the reaction mixture in the presence of water and reacting the trimethyl pyruvic acid formed with thiocarbohydrazide. The triazinone is an important intermediate product in the synthesis of the known herbicide 4-amino-6-tert.butyl-3-methylmercapto-1,2,4-triazin-5-one.
摘要翻译：通过在乙酸和硫酸的存在下使新戊酰氰和异丁烯反应制备式“IMAGE”的4-氨基-6-叔丁基-3-巯基-1,2,4-三嗪-5-酮，水解反应混合物在水存在下反应，并与硫代碳酰肼形成的三甲基丙酮酸反应。三嗪酮是合成已知除草剂4-氨基-6-叔丁基-3-甲基巯基-1,2,4-三嗪-5-酮的重要中间产物。

4. 发明授权

US4716247A Process for the production of thiosemicarbazide 失效
标题翻译：硫代氨基脲生产工艺
公开(公告)号：US4716247A
公开(公告)日：1987-12-29
申请号：US462973
申请日：1983-02-01
申请人： Axel Kleemann , Herbert Klenk , Wolfgang Schulz
发明人： Axel Kleemann , Herbert Klenk , Wolfgang Schulz
IPC分类号： C07C337/06 , C01B21/093 , C01C3/20 , C07C67/00 , C07C325/00 , C07C159/00
CPC分类号： C07C331/02 , C07C335/40 , C07C337/06
摘要： To produce thiosemicarbazide hydrazine is reacted with hydrogen cyanide and sulfur to form hydrazine thiocyanate, and this is then converted into the thiosemicarbazide at an elevated temperature. Advantageously, the reaction is carried out in a polar solvent.
摘要翻译：将氨基硫脲肼与氰化氢和硫反应形成硫氰酸肼，然后在升高的温度下将其转化为氨基硫脲。有利地，反应在极性溶剂中进行。

5. 发明授权

US5455264A RS-thioctic acid with novel morphology 失效
标题翻译： RS-硫辛酸具有新颖的形态
公开(公告)号：US5455264A
公开(公告)日：1995-10-03
申请号：US134695
申请日：1993-10-12
申请人： Thomas Beisswenger , Horst Bethge , Joachim Goede , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller
发明人： Thomas Beisswenger , Horst Bethge , Joachim Goede , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller
IPC分类号： C07D339/04 , A61K31/385
CPC分类号： C07D339/04
摘要： RS-thioctic acid with a novel morphology which is obtained by a recrystallization process.
摘要翻译：具有通过重结晶过程获得的新型形态的RS-硫辛酸。

6. 发明授权

US5760268A Production and use of salts of 6, 8-bis (amidiniumthio) -octanoic acid 失效
标题翻译：制备和使用6,8-双（脒硫代） - 辛酸的盐
公开(公告)号：US5760268A
公开(公告)日：1998-06-02
申请号：US786053
申请日：1997-01-21
申请人： Thomas Beisswenger , Rainer Gewald , Alfred Olbrich , Horst Bethge , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller , Stephan Rautenberg , Gerhard Sator
发明人： Thomas Beisswenger , Rainer Gewald , Alfred Olbrich , Horst Bethge , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller , Stephan Rautenberg , Gerhard Sator
IPC分类号： C07C319/02 , C07C323/52 , C07C335/32 , C07D339/04
CPC分类号： C07D339/04 , C07C319/02 , C07C335/32
摘要： The invention relates to the production and purification of salts of 6,8-bis(amidiniumthio) octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.
摘要翻译：本发明涉及6,8-双（脒硫）辛酸及其对映体（+） - 6,8-双（脒硫）辛酸和（ - ） - 6,8-双（脒硫））辛酸和这些化合物的酯，以及它们用于产生二氢硫辛酸和α-硫辛酸的用途。

7. 发明授权

US4228082A N-Substituted .alpha.-ketocarboxylic acid amides 失效
标题翻译： N-取代的α-酮羧酸酰胺
公开(公告)号：US4228082A
公开(公告)日：1980-10-14
申请号：US56084
申请日：1979-07-09
申请人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
发明人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
IPC分类号： A01N25/00 , A01P3/00 , A01P13/00 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/08 , C07C235/72 , C07D307/54 , C07C103/737 , C07C103/76
CPC分类号： C07D307/54
摘要： Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl group or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III) in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and wherein R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.
摘要翻译：化合物由式（I）制备，其中R'是具有4至18个碳原子的叔烷基，优选叔丁基，叔戊基或叔辛基，R是直链或支链烷基具有1至18个碳原子，优选1至10个碳原子的烷基或被一个或多个苯基或卤素原子，特别是氯原子或具有3至8个碳原子的环烷基特别是环丙基取代的烷基，其可以被一个或多个1至3个碳原子的烷基或一个或多个卤素原子，优选氯，或苯基或萘基或五元杂环基或被卤素原子取代的苯基，萘基或杂环基，硝基，烷基或具有1至5个碳原子的烷氧基，通过在酸性介质中缩合式R-CO-CN（II）的酰基氰，其中R如上定义，与（a）式HO-R'（III ），其中R'如上所定义，或优选（b）下式的烯烃（I） V）其中R 1和R 2相同或不同并且是氢或烷基，并且其中R 3和R 4相同或不同，并且其中每种情况下的烷基可以是1至15个碳原子。一些化合物是新的。它们可用作合成除草剂的中间体，可直接用作杀真菌剂。

8. 发明授权

US4161491A Process for the production of alpha-ketocarboxylic acid amides and cycloaliphatic products 失效
标题翻译：制备α-酮羧酸酰胺和脂环族产物的方法
公开(公告)号：US4161491A
公开(公告)日：1979-07-17
申请号：US802903
申请日：1977-06-02
申请人： Axel Kleemann , Herbert Klenk , Werner Schwarze
发明人： Axel Kleemann , Herbert Klenk , Werner Schwarze
IPC分类号： C07C231/06 , C07C20060101 , C07C67/00 , C07C231/00 , C07C235/72 , C07C235/80 , C07C102/02 , C07C102/08 , C07C103/127 , C07C103/19
CPC分类号： C07C231/06
摘要： There are prepared .alpha.-ketocarboxylic acid amides of the formula ##STR1## where R is hydrogen, R.sub.1 and R.sub.2 are the same or different, R.sub.1 is alkyl of 1 to 18 carbon atoms or haloalkyl, preferably chloroalkyl, of 1 to 18 carbon atoms, and R.sub.2 is hydrogen, alkyl of 1 to 18 carbon atoms or haloalkyl, preferably chloroalkyl, of 1 to 18 carbon atoms or ##STR2## together is a cycloalkyl group of 3 to 8 carbon atoms which can be substituted by one or more 1 to 5 carbon atom alkyl groups or by one or more halogen atoms, preferably chlorine atoms, with the proviso that when ##STR3## form a cycloalkyl group then R can also be alkyl of 1 to 5 carbon atoms. The process comprises saponifying an acyl cyanide of the formula ##STR4## in which R, R.sub.1 and R.sub.2 are as defined above in an organic solvent or mixture of such solvents which is liquid and inert under the reaction conditions, first with gaseous hydrogen chloride and then treating with water at a temperature of about -70.degree. C. to about +70.degree. C. and then isolating the .alpha.-ketocarboxylic acid amide in conventional manner. Several of the cyclic .alpha.-ketocarboxylic acid amides are new compounds.
摘要翻译：制备式（I）的α-酮羧酸酰胺，其中R是氢，R 1和R 2相同或不同，R 1是1至18个碳原子的烷基或卤代烷基，优选氯代烷基，其为1至18 碳原子，R 2是氢，1至18个碳原子的烷基或具有1至18个碳原子的卤代烷基，优选氯代烷基，或者“IMAGE”是3-8个碳原子的环烷基，其可以被一个或多个 1至5个碳原子的烷基或一个或多个卤素原子，优选氯原子，条件是当形成环烷基时，则R也可以是1至5个碳原子的烷基。该方法包括在其中R 1，R 2和R 2如上所定义的式（Ⅶ）的酰基氰在有机溶剂或这种在反应条件下为液体和惰性的溶剂的混合物中，首先用气态氢然后在约-70℃至约+70℃的温度下用水处理，然后以常规方式分离α-酮羧酸酰胺。几种环状α-酮羧酸酰胺是新的化合物。

9. 发明授权

US4339591A Process for the production of caboxylic acid cyanides 失效
标题翻译：生产羧酸氰化氰的方法
公开(公告)号：US4339591A
公开(公告)日：1982-07-13
申请号：US246313
申请日：1981-03-23
申请人： Axel Kleemann , Bernd Lehmann , Herbert Klenk
发明人： Axel Kleemann , Bernd Lehmann , Herbert Klenk
IPC分类号： B01J31/00 , B01J31/02 , C07C20060101 , C07C67/00 , C07C253/00 , C07C255/02 , C07C255/31 , C07C255/45 , C07C255/56 , C07D307/54 , C07D333/24 , C07C120/04
CPC分类号： C07C253/14 , C07C2101/02
摘要： There are produced carboxylic acid cyanides, e.g., acyl cyanides by reacting a carboxylic acid halide with an alkali cyanide or hydrogen cyanide in the presence of a copper (I) salt and a carboxylic acid nitrile. Especially advantageous are glutaric acid dinitrile and 2-methyl glutaric acid dinitrile.
摘要翻译：通过羧酸卤化物与碱金属氰化物或氰化氢在铜（I）盐和羧酸腈的存在下反应，产生羧酸氰化物，例如酰基氰化物。特别有利的是戊二酸二腈和2-甲基戊二酸二腈。

10. 发明授权

US4224226A Process for the production of N-substituted .alpha.-ketocarboxylic acid amides 失效
标题翻译：制备N-取代的α-酮羧酸酰胺的方法
公开(公告)号：US4224226A
公开(公告)日：1980-09-23
申请号：US926322
申请日：1978-07-20
申请人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
发明人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
IPC分类号： A01N25/00 , A01P3/00 , A01P13/00 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/08 , C07C235/72 , C07D307/54 , C07C102/08
CPC分类号： C07D307/54
摘要： Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl groups or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III) in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and wherein R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.
摘要翻译：化合物由式（I）制备，其中R'是具有4至18个碳原子的叔烷基，优选叔丁基，叔戊基或叔辛基，R是直链或支链烷基具有1至18个碳原子，优选1至10个碳原子的烷基或被一个或多个苯基或卤素原子，特别是氯原子或具有3至8个碳原子的环烷基，特别是环丙基取代的烷基，其可以被一个或多个1至3个碳原子的烷基或一个或多个卤素原子，优选氯，或苯基或萘基或五元杂环基或被卤素原子取代的苯基，萘基或杂环基，硝基，烷基或具有1至5个碳原子的烷氧基，通过在酸性介质中缩合式R-CO-CN（II）的酰基氰，其中R如上定义，与（a）式HO-R'（III ），其中R'如上所定义，或优选（b）式“IMAGE”（ IV）其中R 1和R 2相同或不同并且是氢或烷基，并且其中R 3和R 4相同或不同，并且其中每种情况下的烷基可以是1至15个碳原子。一些化合物是新的。它们可用作合成除草剂的中间体，可直接用作杀真菌剂。

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