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1. 发明申请

US20160368859A1 PROCESS FOR THE SYNTHESIS OF AGOMELATINE 有权
标题翻译：合成方法
公开(公告)号：US20160368859A1
公开(公告)日：2016-12-22
申请号：US15100782
申请日：2014-12-04
申请人： LES LABORATOIRES SERVIER
发明人： Jean-François BRIERE , Raphaël LEBEUF , Vincent LEVACHER , Christophe HARDOUIN , Jean-Pierre LECOUVE
IPC分类号： C07C231/12 , C07C303/28 , C07C231/06 , C07C309/66 , C07C309/73
CPC分类号： C07C231/12 , C07C41/16 , C07C41/18 , C07C41/26 , C07C41/32 , C07C43/23 , C07C45/30 , C07C213/02 , C07C217/58 , C07C217/60 , C07C231/02 , C07C231/06 , C07C231/065 , C07C231/10 , C07C235/34 , C07C253/30 , C07C303/28 , C07C303/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07D307/92 , C07C255/37 , C07C233/18 , C07C43/215 , C07C47/277
摘要： Process for the industrial synthesis of the compound of formula (I):
摘要翻译：本发明涉及一种用于工业合成式（I）化合物的方法。

2. 发明申请

US20150259272A1 PROCESS FOR PRODUCING MMA AND/OR MAA FROM ACETONE CYANOHYDRIN AND SULFURIC ACID 有权
标题翻译：从ACETONE CYANOHYDRIN和硫酸生产MMA和/或MAA的方法
公开(公告)号：US20150259272A1
公开(公告)日：2015-09-17
申请号：US14430648
申请日：2013-09-09
申请人： ROHM AND HAAS COMPANY
发明人： Andrew M. Lemonds , Minh N. Ngo , Muhunthan Sathiosatham , Donald Lee Zolotorofe
IPC分类号： C07C51/06 , C07C231/06 , C07C67/08
CPC分类号： C07C51/06 , C07C67/08 , C07C67/20 , C07C231/06 , C07C231/12 , C07C303/24 , C07C235/06 , C07C305/06 , C07C233/09 , C07C57/04 , C07C69/54
摘要： A multistage process for the preparation of methacrylic acid and esters thereof via the hydrolysis of ACH, cracking the hydrolysis products, and converting the cracked products to the desired acid or ester, wherein the average temperature in the first hydrolysis reactor is from 55 C to 70 C.
摘要翻译：用于通过ACH的水解制备甲基丙烯酸及其酯的多阶段方法，裂解水解产物，并将裂化产物转化为所需的酸或酯，其中第一水解反应器中的平均温度为55℃至70℃ C。

3. 发明授权

US08975440B2 Method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid 有权
标题翻译：由羰基化合物和氢氰酸制备羧酸酰胺的方法
公开(公告)号：US08975440B2
公开(公告)日：2015-03-10
申请号：US13131462
申请日：2009-10-29
申请人： Alexander May , Martin Koestner , Joerg Becker , Joerg Schallenberg , Hermann Siegert , Bernd Vogel
发明人： Alexander May , Martin Koestner , Joerg Becker , Joerg Schallenberg , Hermann Siegert , Bernd Vogel
IPC分类号： C07C231/06 , C07C253/30 , C07C67/327 , C07C253/06 , C07C255/13 , C07C69/54 , C07C231/14 , C07C253/00
CPC分类号： C07C231/06 , C07C231/065 , C07C231/14 , C07C253/00 , C07C233/09 , C07C255/16
摘要： The invention relates to a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid, comprising the steps of A) reacting a carbonyl compound with hydrocyanic acid to produce a hydroxycarboxylic acid nitrile, B) hydrolysis of the hydroxycarboxylic acid nitrile obtained in step A) in the presence of a catalyst comprising manganese dioxide, wherein a molar excess of carbonyl compound is used in relation to the hydrocyanic acid to react the carbonyl compound with hydrocyanic acid according to step A), and the reaction mixture obtained in step A) is not purified by distillation before the hydrolysis according to step B) is carried out. The invention furthermore relates to a method for producing alkyl(meth)acrylates from polymers, moulding compounds and moulded bodies, wherein a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid is carried out in accordance with the method described above.
摘要翻译：本发明涉及一种由羰基化合物和氢氰酸制备羧酸酰胺的方法，包括以下步骤：a）使羰基化合物与氢氰酸反应生成羟基羧酸腈，B）水解得到的羟基羧酸腈步骤A）在包含二氧化锰的催化剂存在下，其中相对于氢氰酸使用摩尔过量的羰基化合物以使羰基化合物与氢氰酸根据步骤A）反应，并将步骤A中获得的反应混合物）在根据步骤B）进行水解之前未经蒸馏纯化。本发明还涉及从聚合物，成型化合物和成型体制备（甲基）丙烯酸烷基酯的方法，其中根据上述方法由羰基化合物和氢氰酸制备羧酸酰胺的方法。

4. 发明申请

US20140350284A1 STEREOSELECTIVE SYNTHESIS OF METYROSINE 有权
标题翻译：金属蛋白酶的选择性合成
公开(公告)号：US20140350284A1
公开(公告)日：2014-11-27
申请号：US14455116
申请日：2014-08-08
申请人： Aton Pharma, Inc.
发明人： Kevin John HALLORAN , Alex COMELY , Zhengming CHEN , Shyam KRISHNAN
IPC分类号： C07C255/44 , C07C237/20
CPC分类号： C07C255/44 , C07B2200/07 , C07C227/20 , C07C227/32 , C07C229/36 , C07C231/06 , C07C231/12 , C07C231/18 , C07C231/24 , C07C237/20 , C07C249/02 , C07C251/24 , C07C253/00 , C07C255/43
摘要： Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.
摘要翻译：本文提供了包括基本上非对映体纯的形式的非对映异构体和基本上对映体纯的形式的对映异构体的组合物，以及制备它们并将其转化为甲基酪氨酸的方法。

5. 发明授权

US08853449B2 Process for the synthesis of agomelatine 有权
公开(公告)号：US08853449B2
公开(公告)日：2014-10-07
申请号：US13977799
申请日：2012-01-04
申请人： Samir Zard , Béatrice Sire , Mehdi Boumediene
发明人： Samir Zard , Béatrice Sire , Mehdi Boumediene
IPC分类号： C07C231/06 , C07C255/33 , C07C231/02 , C07C255/40 , C07C255/37 , C07C253/30 , C07C233/18
CPC分类号： C07C231/06 , C07C231/02 , C07C233/18 , C07C253/30 , C07C255/37 , C07C255/40 , C07C2602/10
摘要： Process for the industrial synthesis of the compound of formula (I)

6. 发明授权

US08853445B2 Process for the preparation of protected L-alanine derivatives 有权
公开(公告)号：US08853445B2
公开(公告)日：2014-10-07
申请号：US14162150
申请日：2014-01-23
申请人： Janssen Pharmaceutica, N.V.
发明人： Luigi Anzalone , Penina Feibush , Frank J. Villani
IPC分类号： C07C231/14 , C07C237/42 , C07C271/22 , C07C269/06
CPC分类号： C07C231/06 , C07C231/14 , C07C233/65 , C07C237/42 , C07C269/06 , C07C271/22
摘要： The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.

7. 发明申请

US20140275624A1 PREPARATION OF 4-AMINO-2,4-DIOXOBUTANOIC ACID 有权
标题翻译： 4-氨基-2,4-二氧代丁酸的制备
公开(公告)号：US20140275624A1
公开(公告)日：2014-09-18
申请号：US13828905
申请日：2013-03-14
申请人： Los Alamos National Security, LLC
发明人： Pat J. Unkefer , Rodolfo A. Martinez , David R. Glass
IPC分类号： C07C227/06
CPC分类号： C07C253/30 , C07C231/06 , C07C255/23 , C07C235/80
摘要： A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding 2-cyano-3-hydroxy-butenedioate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.
摘要翻译：合成4-氨基-2,4-二氧代丁酸的方法包括使草酸二乙酯与乙醇钠在乙醇中反应形成反应混合物，然后向反应混合物中加入2-氰基-3-羟基 - 丁烯二酸，并使反应在适于形成式2-氰基-3-羟基 - 丁烯二酸二乙酯的第一反应产物的条件下进行，然后分离氰基-3-羟基 - 丁烯二酸酯，然后使2-氰基-3-羟基 - 丁烯二酸盐与氢氧化钠水溶液在适合形成4-氨基-2,4-二氧代丁酸的条件下反应。

8. 发明申请

US20140134683A1 METHOD FOR PRODUCING ACRYLAMIDE 有权
标题翻译：生产丙烯酰胺的方法
公开(公告)号：US20140134683A1
公开(公告)日：2014-05-15
申请号：US14122052
申请日：2012-05-29
申请人： Makoto Kanou , Kiyonobu Niwa
发明人： Makoto Kanou , Kiyonobu Niwa
IPC分类号： C12P13/02
CPC分类号： C12P13/02 , C07C231/06 , C07C233/09
摘要： The present invention relates to a method for producing acrylamide comprising: supplying a raw material water to a reactor, supplying acrylonitrile to the reactor, and hydrating acrylonitrile using a biocatalyst, wherein a temperature of the raw material water in the supplying step of the raw material water to the reactor is equal to or more than freezing point of the raw material water and lower than the reaction temperature by 5° C. or more. The present invention can be provided to the method of producing acrylamide which can be removed the reaction heat produced at the hydration reaction of acrylonitrile effectively with a low cost.
摘要翻译：本发明涉及一种丙烯酰胺的制造方法，其特征在于，将原料水供给反应器，向所述反应器供给丙烯腈，使用生物催化剂使丙烯腈水合，所述原料水的供给工序中的原料水的温度反应器的水等于或大于原料水的凝固点，低于反应温度5℃以上。本发明可以提供给制造丙烯酰胺的方法，其可以以低成本有效地除去丙烯腈的水合反应产生的反应热。

9. 发明授权

US08722912B2 Metal complex compound and process for producing amides utilizing the metal complex compound 有权
标题翻译：金属络合物和利用金属络合物生成酰胺的方法
公开(公告)号：US08722912B2
公开(公告)日：2014-05-13
申请号：US13813725
申请日：2011-07-29
申请人： Toshiyuki Oshiki , Makoto Muranaka
发明人： Toshiyuki Oshiki , Makoto Muranaka
IPC分类号： C07F9/30 , C07F15/00 , B01J31/00 , C07C231/00
CPC分类号： B01J31/24 , B01J31/1845 , B01J31/185 , B01J31/2295 , B01J2531/821 , C07C231/06 , C07C231/065 , C07F9/1411 , C07F9/145 , C07F9/46 , C07F15/0033 , C07F15/0046 , C07F15/0073 , C07F17/02 , C07F19/00 , C07C233/05 , C07C233/09 , C07C233/65
摘要： A catalyst contains a metal complex compound represented by the following general formula (I). In the formula (I), M is a metal ion such as ruthenium, L1 is a cyclic or acyclic, neutral or minus 1-valent unsaturated hydrocarbon group of 1 to 30 carbon atoms which may have a substituent, L2 and L3 are each independently chlorine or the like, and L4 is a compound bonded to M through phosphorus or arsenic and represented by the following general formula (IIa) or (IIb). In the formulas (IIa) and (IIb), E is phosphorus or arsenic, Y1 is oxygen or sulfur, Y2, Y3 and Y4 are each independently a hydrogen atom, an aryl group or the like, and H is a hydrogen atom.
摘要翻译：催化剂含有下述通式（I）表示的金属络合物。式（I）中，M为钌等金属离子，L1为可具有取代基的1〜30个碳原子的环状或非环状，中性或负1价的不饱和烃基，L2和L3各自独立地表示氯等，L4是通过磷或砷键合到M的化合物，由以下通式（IIa）或（IIb）表示。在式（IIa）和（IIb）中，E是磷或砷，Y1是氧或硫，Y2，Y3和Y4各自独立地是氢原子，芳基等，H是氢原子。

10. 发明申请

US20140087434A1 METHOD FOR PRODUCING AQUEOUS ACRYLAMIDE SOLUTION 有权
标题翻译：生产水性丙烯酰胺溶液的方法
公开(公告)号：US20140087434A1
公开(公告)日：2014-03-27
申请号：US14117754
申请日：2012-05-21
申请人： Makoto Kanou , Norifumi Hagiya
发明人： Makoto Kanou , Norifumi Hagiya
IPC分类号： C12P13/02
CPC分类号： C12P13/02 , C07C231/06 , C07C233/09
摘要： There is provided a method for producing an aqueous acrylamide solution by reacting a composition including acrylonitrile with water to produce acrylamide, in which the composition including acrylonitrile includes 3 to 15 mg of propionitrile per 1 kg of the total weight of the composition including acrylonitrile. According to the present invention, a production method with which it is possible to suppress acrylamide polymerization without lowering quality and thereby obtain a stable aqueous acrylamide solution can be provided.
摘要翻译：提供了一种通过使包含丙烯腈的组合物与水反应生成丙烯酰胺来制备丙烯酰胺水溶液的方法，其中包含丙烯腈的组合物包括每1kg包括丙烯腈的组合物总重量的3至15mg丙腈。根据本发明，可以提供可以抑制丙烯酰胺聚合而不降低品质从而得到稳定的丙烯酰胺水溶液的制备方法。

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